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Minimally invasive surgical therapies(MISTs)for lower urinary tract symptoms(LUTS):promise or panacea?

Asian Journal of Andrology 2024年第2期26卷 135-143页

作者： Gian Maria Busetto Andrea Checchia Marco Recchia Edoardo Tocci Ugo G Falagario Gennaro Annunziata Pasquale Annese nicola d'Altilia Vito Mancini Matteo Ferro Felice Crocetto Octavian Sabin Tataru Luca Di Gianfrancesco Angelo Porreca Francesco Del Giudice Ettore De Berardinis Carlo Bettocchi Luigi Cormio Giuseppe Carrieri University of Foggia Foggia 71122Italy Department of Urology and Renal Transplantation Policlinico of FoggiaFoggia 71122Italy Urology Unit "G.Tatarlla"HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IE0)IRCcSMilan 20141Italy University of Naples Federico Il Naples 80126Italy G.E.Palade University of Medicine PharmacyScienceand Technology of Targu MuresTargu Mures 540142Romania Department of Oncological Urology Veneto Institute of Oncology(IOv)IRccSPadua 35128Italy Department of Maternal-Infant and Urological Sciences Sapienza Rome UniversityRoma 00161Italy Urology Unit "L.Bonomo"HospitalAndria 76123Italy

The increasing importance of treatment of lower urinary tract symptoms(LUTS),while avoiding side effects and maintaining sexual function,has allowed for the development of minimally invasive surgical therapies(MiSTs).Recently,the European Association of Urology guidelines reported a paradigm shift from the management of benign prostatic hyperplasia(BPH)to the management of nonneurogenic male *** aim of the present review was to evaluate the efficacy and safety of the most commonly used MisTs:ablative techniques such as aquablation,prostatic artery embolization,water vapor energy,and transperineal prostate laser ablation,and nonablative techniques such as prostatic urethral lift and temporarily implanted nitinol device(iTIND).MiSTs are becoming a new promise,even if clinical trials with longer follow-up are still *** of them are still under investigation and,to date,only a few options have been given as a recommendation for *** cannot be considered as standard of care and are not suitable for all *** and disadvantages should be underlined,without forgetting our objective:treatment of LUTS and re-treatment avoidance.

关键词： aquablation iTIND prostatic artery embolization prostatic urethral lift transperineal prostate laser ablation water vapor energy

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Ca^(2+) binding to the C_(2)E domain of otoferlin is required for hair cell exocytosis and hearing

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Protein & Cell 2024年第4期15卷 305-312页

作者： Han Chen Mehar Monga Qinghua Fang Loujin Slitin Jakob Neef Shashank S.Chepurwar Regina Célia Mingroni Netto Karina Lezirovitz Alfredo Tabith,Jr. Fritz Benseler Nils Brose Kathrin Kusch Carolin Wichmann nicola Strenzke Barbara Vona Julia Preobraschenski Tobias Moser Institute for Auditory Neuroscience and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany Collaborative Research Center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and Synaptic Nanophysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttingen Graduate Center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of Membrane Dynamics Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of Synapses Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory Systems Physiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de Genética e Biologia Evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIC Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale Bioimaging Cluster of Excellence(MBExC) University of Göttingen37075 GöttingenGermany Functional Auditory Genomics Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomics Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute of Human Genetics University Medical Center Göttingen37075 GöttingenGermany

Dear Editor,Afferent synapses of cochlear inner hair cells(IHCs)employ a unique molecular machinery(see extended background in Supplementary Materials).Otoferlin is a key player in this machinery and its defects cause human auditory synaptopathy(Moser and Starr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-C_(2)-domain protein(Fig.1Ai)specific to hair cells(Roux et al.,2006),is a member of the ferlin protein family involved in membrane trafficking and repair that are of major disease relevance(Pangršičet al.,2012),also see Supplementary *** is distributed broadly within IHCs(Fig.2Ai-Aiii;Pangrsic et al.,2010;Roux et al.,2006).

关键词： auditory hair

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Dielectric spectroscopy characterization of Naþ ion-conducting polymer nanocomposite system PEO–PVP–NaIO_(4)–TiO_(2)

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Journal of Advanced Dielectrics 2024年第1期14卷 59-73页

作者： Georgi B.Hadjichristov Daniela G.Kovacheva Yordan G.Marinov Daniela B.Karashanova Todor E.Vlakhov nicola Scaramuzza Georgi Nadjakov Institute of Solid State Physics Bulgarian Academy of Sciences 72 Tzarigradsko Chaussee Blvd.BG-1784 SofiaBulgaria Institute of General and Inorganic Chemistry Bulgarian Academy of Sciences Acad.Georgi Bonchev Str. 11 bd.BG-1113 SofiaBulgaria Institute of Optical Materials and Technologies“Acad.Jordan Malinowski” Bulgarian Academy of Sciences Acad.Georgi Bonchev Str.bl.109BG-1113 SofiaBulgaria Dipartimento di Fisica Universita degli Studi della Calabria Via P.BucciCubo 33BRende(CS)IT-87036Italy

We studied the effect of titanium dioxide(TiO_(2))nanoparticles(NPs)on dielectric behavior of Naþion-conducting salt-complexed polymer nanocomposite system formed from a binary polymer blend of poly(ethylene oxide)(PEO)and polyvinyl pyrrolidone(PVP),with the addition of both sodium metaperiodate(NaIO_(4))at concentration 10 wt.%and TiO_(2) NPs of size10 nm,at concentrations 1,2,3,4 and 5 wt.%.Free standing nanocomposite PEO/PVP/NaIO_(4)/TiO_(2) films(150m)were characterized at room-temperature by analyzing their complex electrical impedance and dielectric spectra in the range 1 Hz–1 *** the concentration of 3 wt.%of TiO_(2) NPs,both ion conductivity and dielectric permittivity of the PEO/PVP/NaIO_(4)/TiO_(2) ion-conducting dielectrics reach an enhancement by more than one order of magnitude as compared to nanoadditive-free case.

关键词： Dielectric properties sodium-ion-polymer electrolyte systems titanium dioxide(TiO_(2))nanoparticles nanocomposites KWW model

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Supervised vs home-based exercise program in kidney transplant recipients: A pilot pragmatic non-randomized study

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World Journal of Transplantation 2024年第4期14卷 123-132页

作者： Anna Crepaldi Giovanni Piva nicola Lamberti Michele Felisatti Luca Pomidori Yuri Battaglia Fabio Manfredini Alda Storari Pablo Jesús López-Soto Unit of Nephrology University Hospital of FerraraFerrara 44121Emilia-RomagnaItaly Department of Nursing Instituto Maimónides de Investigación Biomédica de CórdobaCordoba 14004AndalusiaSpain Department of Neuroscience and Rehabilitation University of FerraraFerrara 44121Emilia-RomagnaItaly Esercizio Vita Medical Fitness Ferrara 44124Emilia-RomagnaItaly Department of Medicine University of VeronaVerona 37100VenetoItaly Department of Nursing Maimonides Biomedical Research Institute of CordobaUniversity of CordobaReina Sofía University HospitalCordoba 14004AndalusiaSpain

BACKGROUND Although the benefits of exercise for kidney transplant recipients(KTRs)have been widely demonstrated,these patients experience several barriers in undertaking a structured exercise program in hospital and non-hospital *** To compare the effects of a supervised moderate-intensity gym-based intervention with a home-based low-intensity walking program on exercise capacity in *** KTRs were asked to choose between two six-month *** first group performed a low-intensity interval walking intervention at home-based exercise intervention (HBex). The second group performed a supervised training program at an adapted physical activitygym (Sgym), including aerobic and resistance training. The outcomes, collected at baseline and at the end of theprograms, included the 6-minute walking test, the peak oxygen consumption (VO_(2)peak) during a treadmill test,the 5-time sit-to-stand test, and blood *** patients agreed to participate and self-selected into the HBex (n = 9) and Sgym (n = 8) groups. Twopatients in the Sgym group dropped out because of familial problems. At baseline, patients in the HBex group weresignificantly older and had lower walking distance, VO_(2)peak, and lower limb strength. Primary outcome changeswere significantly greater in the HBex group than in the Sgym group (52 ± 23 m vs 8 ± 34;P = 0.005). No othersignificant differences between groups were observed. Both groups improved most of the outcomes in the withingroupcomparisons, with significant variations in VO_(2) ***-month moderate-intensity supervised or low-intensity home-based training programs effectively improvedexercise capacity in KTRs. Gym-based programs combine aerobic and resistance training;however, in-homewalking may be proposed for frail KTRs.

关键词： Exercise Transplantation Walking Training Nephrology Kidney disease

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逍遥散加味联合曲安奈德治疗口腔扁平苔藓肝郁血瘀证疗效研究

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陕西中医 2024年第7期45卷 918-921页

作者：卓思源 [澳大利亚]nicola Cirillo 杨小如何昕安徽中医药大学第一附属医院安徽合肥230031 墨尔本大学口腔健康学院墨尔本3000 山南市人民医院西藏山南856000 安徽医科大学附属口腔医院安徽合肥230036

目的:探讨逍遥散加味联合曲安奈德治疗口腔扁平苔藓(OLP)肝郁血瘀证的疗效及对唾液炎症因子的影响。方法:选取84例OLP肝郁血瘀证患者按照随机数字表法分为观察组(n=42)和对照组(n=42)。对照组予曲安奈德注射液1 ml混合等量2%盐酸利多卡... 详细信息

目的:探讨逍遥散加味联合曲安奈德治疗口腔扁平苔藓(OLP)肝郁血瘀证的疗效及对唾液炎症因子的影响。方法:选取84例OLP肝郁血瘀证患者按照随机数字表法分为观察组(n=42)和对照组(n=42)。对照组予曲安奈德注射液1 ml混合等量2%盐酸利多卡因注射液于病损边缘局部注射,观察组在对照组治疗基础上予以逍遥散加味治疗,治疗8周后比较两组的临床疗效、症状评分、唾液炎症因子、免疫功能及不良反应发生情况,记录治疗后6个月的复发情况。结果:观察组临床总有效率为92.86%高于对照组的76.19%(P0.05)。观察组复发率明显低于对照组(P<0.05)。结论:逍遥散加味联合曲安奈德可有效提高OLP肝郁血瘀证患者的治疗效果,进一步缓解患者的临床症状,降低复发率及唾液炎症因子表达水平,提高机体免疫功能,安全性较好。

关键词：口腔扁平苔藓肝郁血瘀逍遥散加味曲安奈德唾液炎症因子免疫功能不良反应

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万物皆AI?那自行车运动呢?

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中国自行车 2024年第4期 96-99页

作者：尼古拉·史密斯不详

在万物皆可AI(人工智能)的当下,能利用AI的力量来改善自行车运动吗?AI可以快速处理大量数据来探寻变化趋势,能在一定程度上预测未来,并且它正在渗透到我们生活的各个领域,自行车运动也避免不了它的进入。自行车运动员或者爱好者可以利... 详细信息

在万物皆可AI(人工智能)的当下,能利用AI的力量来改善自行车运动吗?AI可以快速处理大量数据来探寻变化趋势,能在一定程度上预测未来,并且它正在渗透到我们生活的各个领域,自行车运动也避免不了它的进入。自行车运动员或者爱好者可以利用这一新兴技术来提高他们的表现,享受更加舒适的骑行,或者只是为了让骑行更安全,你已经在不知不觉中应用到了AI技术。

关键词：自行车运动人工智能 AI技术快速处理新兴技术骑行预测未来万物

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福田中学校园设计

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建筑实践 2024年第4期 100-103页

作者：陈忱 nicola Saladino 吕守拓 Federico Ruberto reMIX临界工作室

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紧迫感增强欧洲车企加强合作

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商业周刊（中文版） 2024年第3期 54-55页

作者： Albertina Torsoli Stefan nicola Monica Raymunt 孟洁冰(译) 不详

大众汽车公司(Volkswagen)、雷诺公司(Renault)和斯泰54兰蒂斯集团(Stellantis)正在考虑采取不可思议的举措,不惜与势不两立的竞争对手结盟,以生产更便宜的电动汽车,抵御事关生存的威胁。

关键词：大众汽车公司电动汽车 Volkswagen 竞争对手紧迫感不可思议

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Empirical assessment of the role of the Sun in climate change using balanced multi-proxy solar records

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Geoscience Frontiers 2023年第6期14卷 191-209页

作者： nicola Scafetta Department of Earth Sciences Environment and GeoresourcesUniversity of Naples Federico IIComplesso Universitario di Monte S.Angelovia Cinthia21Naples 80126Italy

The role of the Sun in climate change is hotly *** studies suggest its impact is significant,while others suggest it is *** Intergovernmental Panel on Climate Change(IPCC)supports the latter view and suggests that nearly 100%of the observed surface warming from 1850–1900 to 2020 is due to anthropogenic ***,the IPCC’s conclusions are based solely on computer simulations made with global climate models(GCMs)forced with a total solar irradiance(TSI)record showing a low multi-decadal and secular *** same models also assume that the Sun affects the climate system only through radiative forcing–such as TSI–even though the climate could also be affected by other solar *** this paper I propose three“balanced”multi-proxy models of total solar activity(TSA)that consider all main solar proxies proposed in scientific *** optimal signature on global and sea surface temperature records is assessed together with those produced by the anthropogenic and volcanic radiative forcing functions adopted by the CMIP6 *** is done by using a basic energy balance model calibrated with a differential multi-linear regression methodology,which allows the climate system to respond to the solar input differently than to radiative forcings alone,and to evaluate the climate’s characteristic time-response as *** proposed methodology reproduces the results of the CMIP6 GCMs when their original forcing functions are applied under similar physical conditions,indicating that,in such a scenario,the likely range of the equilibrium climate sensitivity(ECS)could be 1.4℃to 2.8℃,with a mean of 2.1℃(using the HadCRUT5 temperature record),which is compatible with the low-ECS CMIP6 GCM ***,if the proposed solar records are used as TSA proxies and the climatic sensitivity to them is allowed to differ from the climatic sensitivity to radiative forcings,a much greater solar impact on climate change is found,along with a significant

关键词： Solar activity changes Solar variability climatic impact Global climate change and modeling Equilibrium climate sensitivity

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Effect of template shape on metal nanoimprinting:a dislocation dynamics study

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第10期11卷 722-726页

作者： Lucia nicola Department of Materials Science and Engineering Delft University of Technology

Dislocation dynamics simulations are performed to investigate the effect of template shape on the nanoimprinting of metal layers. To this end, metal thin films are imprinted by a rigid template made of an array of equispaced indenters of various shapes, i.e., rectangular, wedge, and circular. The geometry of the indenters is chosen such that the contact area is approximately the same at the final imprinting depth. Results show that, for all template shapes, the final patterns strongly depend on the dislocation activity, and that each imprint differs from the neighboring ones. Large material pile ups appear between the imprints, such that polishing of the metal layer is suggested for application of the patterns in electronics. Rectangular indenters require the lowest imprinting force and achieve the deepest retained imprints.

关键词： Nanoimprinting Dislocation dynamics Simulations

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