检索结果-南通市图书馆

Determinants of percutaneous coronary intervention success in repeat chronic total occlusion procedures following an initial failed attempt

引用

World Journal of Cardiology 2017年第4期9卷 355-362页

作者： Cecilia Cuevas nicola ryan Alicia Quirós Juan Gustavo Del Angel Nieves Gonzalo Pablo Salinas Pilar Jiménez-Quevedo Luis Nombela-Franco Ivan Nunez-Gil Antonio Fernandez-Ortiz Carlos Macaya Javier Escaned Cardiovascular Institute Hospital Clinico San Carlos28040 MadridSpain

AIM To investigate the rates and determinants of success of repeat percutaneous coronary intervention(PCI) following an initial failed attempt at recanalising the chronic total occlusions(CTO) *** In 445 consecutive first attempt CTO-PCI procedures in our institution,procedural failure occurred in 149(33.5%). Sixty-four re-PCI procedures were performed in 58 patients(39%) all had a single CTO. Procedural and outcome data in the re-PCI population was entered into the institutional database. A retrospective analysis of clinical,angiographic and procedural data was performed. RESULTS Procedural success was achieved in 41(64%) procedures. Univariate analysis of clinical and angiographic characteristics showed that re-PCI success was associated with intravascular ultrasound(IVUS) guidance(19.5% vs 0%,P = 0.042),while failure was associated with severecalcification(30.4% vs 9.7%,P = 0.047) and a JCTO score > 3(56.5% vs 17.1% P = 0.003). Following multiple regression analysis the degree of lesion complexity(J-CTO score > 3),IVUS use,involvement of an experienced CTO operator and LAD CTO location were significant predictors of successful re-PCI. Overall the complication rate was low,with the only MACCE two periprocedural MI's neither of which required intervention. CONCLUSION Re-PCI substantially increases the overall success rate of CTO revascularization. Predictors of re-PCI success included the use of IVUS,the involvement of an experienced CTO operator in the repeat attempt and the location of the CTO.

关键词： Repeat percutaneous coronary intervention Chronic total occlusion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases

引用

Protein & Cell 2010年第8期1卷 780-790页

作者： Ali ryan Chan-Ju Wang nicola Laurieri Isaac Westwood Edith Sim Department of Pharmacology University of OxfordMansfield RoadOxfordOX13QTUK

Azoreductases are involved in the bioremediation by bacteria of azo dyes found in waste *** the gut flora,they activate azo pro-drugs,which are used for treatment of inflammatory bowel disease,releasing the active component 5-aminosalycilic *** bacterium *** has three azoreductase genes,paAzoR1,paAzoR2 and paAzoR3,which as recombinant enzymes have been shown to have different substrate *** mechanism of azoreduction relies upon tautomerisation of the substrate to the hydrazone *** report here the characterization of the *** azoreductase enzymes,including determining their thermostability,cofactor preference and kinetic constants against a range of their favoured *** expression levels of these enzymes during growth of *** are altered by the presence of azo *** is shown that enzymes that were originally described as azoreductases,are likely to act as NADH quinone *** low sequence identities observed among NAD(P)H quinone oxidoreductase and azoreductase enzymes suggests convergent evolution.

关键词： azoreductase enzyme mechanism NAD(P)H quinone oxidoreductase enzyme characterisation convergent evolution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Plasma lipidomics reveal systemic changes persistent throughout early life following a childhood burn injury

引用

Burns & Trauma 2023年第1期11卷 814-824页

作者： Eva Kierath Monique ryan Elaine Holmes Jeremy K.Nicholson Mark W.Fear Fiona M.Wood Luke Whiley nicola Gray 无 Australian National Phenome Centre Health Futures InstituteMurdoch UniversityHarry Perkins Institute5 Robin Warren DriveMurdochPerthWA 6150Australia Fiona Wood Foundation Fiona Stanley HospitalFiona Wood FoundationFiona Stanley HospitalLevel 411 Robin Warren DriveMurdochWA 6150Australia Burn injury research unit School of Biomedical SciencesUniversity of Western Australia6 Verdun streetNedlandsWA 6009 Australia Department of Metabolism Digestion and ReproductionFaculty of MedicineImperial College LondonSir Alexander Fleming BuildingSouth KensingtonLondon SW72AZUK Centre for Computational Medicine Health Futures InstituteMurdoch University5 Robin Warren DriveMurdochPerthWA 6150Australia Medical School University of Western AustraliaHarry Perkins InstituteMurdochPerthWA 6150Australia Faculty of Medicine Institute of Global Health InnovationImperial College LondonLevel 1Faculty Building South Kensington CampusLondon SW72AZUK Burns Service of Western Australia WA Department of Health11 Robin Warren driveMurdochWA 6150Australia Perron Institute for Neurological and Translational Science NedlandsWAAustralia

Background:Non-severe paediatric burns can result in poor long-term health *** occurs even in cases with good acute burn-related outcomes,including minimal *** mechanisms that underpin the transition from non-severe burn to sustained negative long-term health impacts are currently ***,sustained metabolic and immune changes have been observed in paediatric burn studies,suggesting these changes may be *** plasma lipidome consists of a rich pool of bioactive metabolites that play critical roles in systemic processes including molecular signalling and *** hypothesised that changes in the plasma lipidome may reflect underlying changes in health status and be linked to long-term health after burn ***:This study analysed the lipidome in children who had previously experienced a non-severe burn,compared to non-injured ***-three participants were recruited between the ages of 5 and 8 years who had experienced a non-severe burn between the ages of 1 and 3 *** samples were also collected from a non-injured,healthy,age and gender matched control group(n=21).Plasma lipids were measured using reversed-phase liquid chromatographymass spectrometery(LC-MS).Results:In total 838 reproducible lipid species from 19 sub-classes passed quality control procedures and progressed to statistical *** of individual lipid metabolites showed significantly higher concentrations of lysophosphatidylethanolamines and phosphatidylethanolamines,and significantly lower concentrations in myristic,palmitic and palmitoleic acids in the plasma of those who had experienced burn injury compared to ***:Long-term changes in the lipid profile may give insight into the mechanisms underlying poor long-term health subsequent to non-severe burn *** work to investigate the relationship between long-term pathology and lipidomic changes may lead to a better understanding of the causes of seconda

关键词： Lipidomics Lipids Burns Trauma Paediatric Children Mass spectrometry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：