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Linking land and sea： Towards global reconstructions of the Jurassic world

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Episodes 2008年第4期31卷 420-422页

作者： nicol.Morton Le Chardon Quartier Brugere 07200 Vogtie France

The Jurassic is traditionally famous for shallow marine sediments that are often very fossiliferous, notably in Europe, where the standard chronostratigraphic subdivisions were established and defined. However, widespread marginal and non-marine Jurassic sediments are also known, and are of great importance for the wellpreserved terrestrial biotas they contain, as well as for their hydrocarbon and coal reserves. IGCP Project 506 is directed towards finding means of correlation between marine and non-marine Jurassic rocks, as a foundation for a better understanding of the evolution of the Earth during the Jurassic Period.

关键词：侏罗纪陆地海洋整体重建

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斜地震剖面

石油参考资料 1989年第1期 30-37,14页

作者： nicol.,S 王宏

Liver Lesions at Risk of Transformation into Hepatocellular Carcinoma in Cirrhotic Patients:Hepatobiliary Phase Hypointense Nodules without Arterial Phase Hyperenhancement

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 100-112页

作者： nicol.Brandi Matteo Renzulli Department of Radiology IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly

Recent technical advances in liver imaging and surveillance for patients at high risk for developing hepatocellular carcinoma(HCC)have led to an increase in the detection of borderline hepatic nodules in the gray area of multistep carcinogenesis,particularly in those that are hypointense at the hepatobiliary phase(HBP)and do not show arterial phase *** their potential to transform and advance into hypervascular HCC,these nodules have progressively attracted the interest of the scientific *** date,however,no shared guidelines have been established for the decision management of these borderline hepatic *** is therefore extremely important to identify features that indicate the malignant potential of these nodules and the likelihood of *** fact,a more complete knowledge of their history and evolution would allow outlining shared guidelines for their clinical-surgical management,to implement early treatment programs and decide between a preventive curative treatment or a watchful *** review aims to summarize the current knowledge on hepatic borderline nodules,particularly focusing on those imaging features which are hypothetically correlated with their malignant evolution,and to discuss current guidelines and ongoing management in clinical practice.

关键词： Nonhypervascular hypointense nodule Hepatocellular carcinoma Magnetic resonance imaging Gd-EOB Liver

Comparison of three-dimensional fluorescence analysis methods for predicting formation of trihalomethanes and haloacetic acids

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Journal of Environmental Sciences 2015年第1期27卷 159-167页

作者： nicol.s M.Peleato Robert C.Andrews Department of Civil Engineering University of Toronto

This work investigated the application of several fluorescence excitation–emission matrix analysis methods as natural organic matter（NOM） indicators for use in predicting the formation of trihalomethanes（THMs） and haloacetic acids（HAAs）. Waters from four different sources（two rivers and two lakes） were subjected to jar testing followed by 24 hr disinfection by-product formation tests using chlorine. NOM was quantified using three common measures： dissolved organic carbon, ultraviolet absorbance at 254 nm, and specific ultraviolet absorbance as well as by principal component analysis, peak picking,and parallel factor analysis of fluorescence spectra. Based on multi-linear modeling of THMs and HAAs, principle component（PC） scores resulted in the lowest mean squared prediction error of cross-folded test sets（THMs： 43.7（μg/L）^2, HAAs： 233.3（μg/L）^2）. Inclusion of principle components representative of protein-like material significantly decreased prediction error for both THMs and HAAs. Parallel factor analysis did not identify a protein-like component and resulted in prediction errors similar to traditional NOM surrogates as well as fluorescence peak picking. These results support the value of fluorescence excitation–emission matrix–principal component analysis as a suitable NOM indicator in predicting the formation of THMs and HAAs for the water sources studied.

关键词： Natural organic matter Fluorescence Principal component analysis PARAFAC Disinfection byproducts Drinking water

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Chinese Medicine and Culture 2023年第4期6卷 339-348页

作者： nicol.s Viotti School of Social Sciences National University of San Martín(UNSAM)San Martín 5570Argentina

Various resources of the so-called traditional Chinese medicine, such as taijiquan, massage, diets, or acupuncture, have become widely available in the everyday therapeutic culture of contemporary Argentina. While these resources can be found in the first half of the 20th century, it is evident that from the 1960s onward their presence is more evident, with a strong emphasis from the 1980s on. This article aims to describe the reception and popularization of body and therapeutic techniques of traditional Chinese medicine in Argentina in the 1980s through the case of Daniel Alegre, a key figure in the dissemination of Chinese therapeutic techniques. To do so, it focuses on certain key mediators in the popularization of techniques such as taijiquan and Chinese massage: teachers, promoters, and specialized magazines. All these mediators are key artifacts in the processes of massification and dissemination of traditional Chinese medicine in a broader emerging horizon associated with two simultaneous processes, the Chinese cultural transnationalization and the boom of new forms of holistic management of personal well-being.

关键词： Argentina Daniel Alegre Taijiquan Traditional Chinese therapy

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洋脊岩浆房到底有多大？

国外地质与勘测 1993年第4期 5-8页

作者： nicol.,A 王晓霞

Current and future therapeutic strategies for the treatment of retinal neurodegenerative diseases

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Neural Regeneration Research 2022年第1期17卷 103-104页

作者： Victoria Maneu Pedro Lax nicol.s Cuenca Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain Department of Physiology Genetics and MicrobiologyUniversity of AlicanteAlicanteSpain

The complex and mostly multiple and unknown aetiology of neurodegenerative diseases always give way to an intricate scenario of dying tissue that involves multiple cell mediators and cell *** neurodegenerative diseases of the central nervous system(CNS)share common mechanisms,regardless their origin:oxidative stress,neuroinflammation and cell ***,retinal degenerative diseases,with or without a genetic cause,as retinitis pigmentosa(RP),glaucoma,agerelated macular degeneration(AMD)or diabetic retinopathy(DR)do not differ in their basic mechanisms of cell death neither one to another,nor from those observed in other CNS diseases as Parkinson’s or Alzheimer’s(Cuenca et al.,2014).Indeed,the therapeutic findings should be able to be more or less easily extrapolated between these conditions,as far as they are directed to common dartboards.

关键词： diseases degenerative therapeutic

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MINI-EX:Integrative inference of single-cell gene regulatory networks in plants

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Molecular Plant 2022年第11期15卷 1807-1824页

作者： Camilla Ferrari nicol.s Manosalva Pérez Klaas Vandepoele Department of Plant Biotechnology and Bioinformatics Ghent University9052 GhentBelgium Center for Plant Systems Biology VIB9052 GhentBelgium Bioinformatics Institute Ghent Ghent University9052 GhentBelgium

Multicellular organisms,such as plants,are characterized by highly specialized and tightly regulated cell populations,establishing specific morphological structures and executing distinct *** regulatory networks(GRNs)describe condition-specific interactions of transcription factors(TFs)regulating the expression of target genes,underpinning these specific *** efficient and validated methods to identify cell-type-specific GRNs from single-cell data in plants are lacking,limiting our understanding of the organization of specific cell types in both model species and crops,we developed MINI-EX(Motif-Informed Network Inference based on single-cell EXpression data),an integrative approach to infer cell-type-specific networks in ***-EX uses single-cell transcriptomic data to define expression-based networks and integrates TF motif information to filter the inferred regulons,resulting in networks with increased ***,regulons are assigned to different cell types,leveraging cell-specific expression,and candidate regulators are prioritized using network centrality measures,functional annotations,and expression *** embedded prioritization strategy offers a unique and efficient means to unravel signaling cascades in specific cell types controlling a biological process of *** demonstrate the stability of MINI-EX toward input data sets with low number of cells and its robustness toward missing data,and show that it infers state-of-the-art networks with a better performance compared with other related single-cell network ***-EX successfully identifies key regulators controlling root development in Arabidopsis and rice,leaf development in Arabidopsis,and ear development in maize,enhancing our understanding of cell-type-specific regulation and unraveling the roles of different regulators controlling the development of specific cell types in plants.

关键词： single-cell RNA-seq gene regulatory network transcription factors systems biology

Isoxazolone Reactivity Explained by Computed Electronic Structure Analysis

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Chinese Journal of Chemistry 2020年第2期38卷 163-168页

作者： Giovanni Bella Antonio Santoro Massimiliano Cordaro Francesco nicol. Giuseppe Bruno Department of Chemical BiologicalPharmaceutical and Environmental SciencesUniversity of MessinaViale F.Stagno d'Alcontres 3198166 MessinaItaly

Summary of main observation and conclusion lsoxazol(2H)-5-one was chosen as a model molecule to study the structural features(a,p angles and carbonyl bond length)regarding lactone moiety in the isoxazolone species by computational *** method with B3LYP 6-311++G(2df,2p)basis set was used to carry out the optimization on a series(A and B families)of isoxazolones suitably substituted on double bond.

关键词： calculation. moiety substituted