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Extravasated contrast volumetric assessment on computed tomography angiography in gastrointestinal bleeding:A useful predictor of positive angiographic findings

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World Journal of Radiology 2024年第5期16卷 115-127页

作者： Laura Maria Cacioppa Chiara Floridi Alessandra Bruno nicolòRossini Tommaso Valeri Alessandra Borgheresi Riccardo Inchingolo Francesco Cortese Giacomo Novelli Alessandro Felicioli Mario Torresi Pietro Boscarato Letizia Ottaviani Andrea Giovagnoni Division of Interventional Radiology Department of Radiological SciencesUniversity Politecnica Delle MarcheAncona 60126Italy Department of Clinical Special and Dental SciencesUniversity Politecnica Delle MarcheAncona 60126Italy Division of Radiology Department of Radiological SciencesUniversity Hospital"Azienda Ospedaliero Universitaria Delle Marche"Ancona 60126Italy Interventional Radiology Unit "F Miulli"Regional General HospitalAcquaviva delle Fonti 70021Italy Department of Radiology IRCCS INRCAAncona 60126Italy

BACKGROUND Gastrointestinal bleeding(GIB)is a severe and potentially life-threatening condition,especially in cases of delayed *** tomography angiography(CTA)plays a pivotal role in the early identification of upper and lower GIB and in the prompt treatment of the *** To determine whether a volumetric estimation of the extravasated contrast at CTA in GIB may be a predictor of subsequent positive angiographic *** In this retrospective single-centre study,35 patients(22 men;median age 69 years;range 16-92 years)admitted to our institution for active GIB detected at CTA and further submitted to catheter angiography between January 2018 and February 2022 were ***-three(65.7%)patients underwent endoscopy before *** volumetry was evaluated in both arterial and venous phases via a semi-automated dedicated *** rate was obtained from volume change between the two phases and standardised for unit *** were divided into two groups,according to the angiographic signs and their concordance with *** Upper bleeding accounted for 42.9%and lower GIB for 57.1%.Mean haemoglobin value at the admission was 7.7 g/dL.A concordance between positive CTA and direct angiographic bleeding signs was found in 19(54.3%)*** no significant differences in terms of bleeding volume in the arterial phase(0.55 mL vs 0.33 mL,P=0.35),a statistically significant volume increase in the venous phase was identified in the group of patients with positive angiography(2.06 mL vs 0.9 mL,P=0.02).In the latter patient group,a significant increase in bleeding rate was also detected(2.18 mL/min vs 0.19 mL/min,P=0.02).CONCLUSION In GIB of any origin,extravasated contrast volumetric analysis at CTA could be a predictor of positive angiography and may help in avoiding further unnecessary procedures.

关键词： Gastrointestinal haemorrhage Computed tomography angiography Volumetric analysis Computer-assisted image interpretation Therapeutic embolization Transcatheter arterial embolization

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棉棉细语

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现代装饰（家居） 2015年第5期 54-61页

作者： Audrey Benzonana & Piment de Mer AMR Internacional Lda Arpin Anatology Anne Couderc Cline Richard & Guillaume Grimbert Coral & Tusk Dan Duchars ferm LIVING Jan Gustav Sφrensen Lina Rickardsson Mikabarr No More Twist nicolò bottarelli Row Pinto 伏平范嘉苑

布艺软饰在家居空间中独具魅力,包括窗帘、地毯、织物、布艺沙发、靠垫、抱枕、床上用品等。它们柔化了家居空间生硬的线条,以柔软、放松、多变等特性营造家居温馨的格调,给人慰贴的温暖,低调、不动声色地彰显着独特的魅力。柔和的质感... 详细信息

布艺软饰在家居空间中独具魅力,包括窗帘、地毯、织物、布艺沙发、靠垫、抱枕、床上用品等。它们柔化了家居空间生硬的线条,以柔软、放松、多变等特性营造家居温馨的格调,给人慰贴的温暖,低调、不动声色地彰显着独特的魅力。柔和的质感与丰富的色彩赋予布艺沙发极具亲和力与＂表情＂多变的特点。

关键词：布艺沙发家居空间棉棉有机棉抱枕色彩力几何图 Cotton Basket 寻找自我

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Current and future therapeutic strategies for the treatment of retinal neurodegenerative diseases

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Neural Regeneration Research 2022年第1期17卷 103-104页

作者： Victoria Maneu Pedro Lax nicolás Cuenca Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain Department of Physiology Genetics and MicrobiologyUniversity of AlicanteAlicanteSpain

The complex and mostly multiple and unknown aetiology of neurodegenerative diseases always give way to an intricate scenario of dying tissue that involves multiple cell mediators and cell *** neurodegenerative diseases of the central nervous system(CNS)share common mechanisms,regardless their origin:oxidative stress,neuroinflammation and cell ***,retinal degenerative diseases,with or without a genetic cause,as retinitis pigmentosa(RP),glaucoma,agerelated macular degeneration(AMD)or diabetic retinopathy(DR)do not differ in their basic mechanisms of cell death neither one to another,nor from those observed in other CNS diseases as Parkinson’s or Alzheimer’s(Cuenca et al.,2014).Indeed,the therapeutic findings should be able to be more or less easily extrapolated between these conditions,as far as they are directed to common dartboards.

关键词： diseases degenerative therapeutic

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Chinese Medicine and Culture 2023年第4期6卷 339-348页

作者： nicolás Viotti School of Social Sciences National University of San Martín(UNSAM)San Martín 5570Argentina

Various resources of the so-called traditional Chinese medicine, such as taijiquan, massage, diets, or acupuncture, have become widely available in the everyday therapeutic culture of contemporary Argentina. While these resources can be found in the first half of the 20th century, it is evident that from the 1960s onward their presence is more evident, with a strong emphasis from the 1980s on. This article aims to describe the reception and popularization of body and therapeutic techniques of traditional Chinese medicine in Argentina in the 1980s through the case of Daniel Alegre, a key figure in the dissemination of Chinese therapeutic techniques. To do so, it focuses on certain key mediators in the popularization of techniques such as taijiquan and Chinese massage: teachers, promoters, and specialized magazines. All these mediators are key artifacts in the processes of massification and dissemination of traditional Chinese medicine in a broader emerging horizon associated with two simultaneous processes, the Chinese cultural transnationalization and the boom of new forms of holistic management of personal well-being.

关键词： Argentina Daniel Alegre Taijiquan Traditional Chinese therapy

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MINI-EX:Integrative inference of single-cell gene regulatory networks in plants

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Molecular Plant 2022年第11期15卷 1807-1824页

作者： Camilla Ferrari nicolás Manosalva Pérez Klaas Vandepoele Department of Plant Biotechnology and Bioinformatics Ghent University9052 GhentBelgium Center for Plant Systems Biology VIB9052 GhentBelgium Bioinformatics Institute Ghent Ghent University9052 GhentBelgium

Multicellular organisms,such as plants,are characterized by highly specialized and tightly regulated cell populations,establishing specific morphological structures and executing distinct *** regulatory networks(GRNs)describe condition-specific interactions of transcription factors(TFs)regulating the expression of target genes,underpinning these specific *** efficient and validated methods to identify cell-type-specific GRNs from single-cell data in plants are lacking,limiting our understanding of the organization of specific cell types in both model species and crops,we developed MINI-EX(Motif-Informed Network Inference based on single-cell EXpression data),an integrative approach to infer cell-type-specific networks in ***-EX uses single-cell transcriptomic data to define expression-based networks and integrates TF motif information to filter the inferred regulons,resulting in networks with increased ***,regulons are assigned to different cell types,leveraging cell-specific expression,and candidate regulators are prioritized using network centrality measures,functional annotations,and expression *** embedded prioritization strategy offers a unique and efficient means to unravel signaling cascades in specific cell types controlling a biological process of *** demonstrate the stability of MINI-EX toward input data sets with low number of cells and its robustness toward missing data,and show that it infers state-of-the-art networks with a better performance compared with other related single-cell network ***-EX successfully identifies key regulators controlling root development in Arabidopsis and rice,leaf development in Arabidopsis,and ear development in maize,enhancing our understanding of cell-type-specific regulation and unraveling the roles of different regulators controlling the development of specific cell types in plants.

关键词： single-cell RNA-seq gene regulatory network transcription factors systems biology

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Conservative management of an early abdominal complication during a Tullio percutaneous endoscopic excision of renal pelvis urothelial carcinoma:A case report

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World Journal of Clinical Urology 2024年第1期13卷 1-6页

作者： Massimiliano Bernabei nicolòFabbri Danila Romeo Elisa Paiolo Martina Bandi Maurizio Simone Department of Urology Azienda USL di FerraraFerrara 44100Italy Department of Surgery University of FerraraAzienda USL of FerraraAzienda USL of FerraraFerrara 44100FerraraItaly Local Health Agency of Ferrara Ferrara 44100Italy

BACKGROUND Upper tract urothelial carcinoma(UTUC)representing only a small fraction of all urothelial *** predominantly affects the renal pelvis in men,often coexisting with bladder *** displays a more aggressive genetic profile compared to bladder neoplasms,with the majority of patients presenting with advanced ***,about a quarter of UTUC cases exhibit high-grade subtypes,associated with a worse *** use and past exposure to aromatic amines are significant risk factors for *** modalities such as Uro-computed tomography and magnetic resonance imaging play crucial roles in *** is vital for direct visualization and biopsy sampling,but its limited sampling capacity presents challenges in determining tumor depth and ***,nephroureterectomy with bladder cuff excision has been the gold-standard treatment for *** conservative treatment has recently emerged as a viable option for selected patients,offering comparable oncological outcomes to radical *** access is also feasible for larger intrarenal *** SUMMARY We present a case of an 84-year-old woman who underwent percutaneous endoscopic excision of a renal pelvis neoplasm using the Tullio *** successful tumor removal,the patient experienced a postoperative complication with abdominal fluid *** management effectively resolved the *** the patient's age and refusal for radical surgery,the conservative approach proved to be a valid therapeutic *** Overall,UTUC remains a diagnostic and therapeutic challenge due to its ***,advances in endoscopic and percutaneous techniques provide valuable alternatives for selected patients,warranting further exploration in this evolving field.

关键词： Upper tract urothelial carcinoma Endoscopic treatment Damage management Case report

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From unstructured texts to semantic story maps

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International Journal of Digital Earth 2023年第1期16卷 234-250页

作者： Valentina Bartalesi Gianpaolo Coro Emanuele Lenzi Pasquale Pagano nicolòPratelli Istituto di Scienza e Tecnologie dell’Informazione‘A.Faedo’del Consiglio Nazionale delle Ricerche PisaItaly

Digital maps greatly support storytelling about territories,especially when enriched with data describing cultural,societal,and ecological aspects,conveying emotional messages that describe the territory as a *** maps are interactive online digital narratives that can describe a territory beyond its map by enriching the map with text,pictures,videos,and other multimedia *** paper presents a semi-automatic workflow to produce story maps from textual documents containing territory *** expertfirst assembles one territory-contextual document containing text and ***,automatic processes use natural language processing and Wikidata services to(i)extract key concepts(entities)and geospatial coordinates associated with the territory,(ii)assemble a logically-ordered sequence of enriched story-map events,and(iii)openly publish online story maps and an interoperable Linked Open Data semantic knowledge base for event exploration and inter-story correlation *** workflow uses an Open Science-oriented methodology to publish all processes and *** our workflow,we produced story maps for the value chains and territories of 23 rural European areas of 16 *** numerical evaluation,we demonstrated that territory experts considered the story maps effective in describing their territories,and appropriate for communicating with citizens and stakeholders.

关键词： Story maps semantic web ontology natural language processing narratives e-infrastructures virtual research environments

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Vascular injury during laparoscopic cholecystectomy:An oftenoverlooked complication

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World Journal of Gastrointestinal Surgery 2023年第3期15卷 338-345页

作者： Antonio Pesce nicolò Fabbri Carlo Vittorio Feo Department of Surgery University of FerraraAzienda USL of FerraraAzienda USL of FerraraLagosanto 44023FerraraItaly

Laparoscopic cholecystectomy is one of the most frequently performed procedures in gastrointestinal surgery *** complications due to vascular injuries represent an important cause of morbidity and mortality,especially when facing major bleeding during laparoscopy,where bleeding control can be technically challenging in inexperienced ***,the reported incidence rate of conversion to open surgery due to vascular lesions is approximately 0%-1.9%,with a mortality rate of approximately 0.02%.The primary aim of this article was to perform an up-to-date overview regarding the incidence and surgical management of vascular injuries during laparoscopic cholecystectomy according to the available scientific evidence.

关键词： Laparoscopic cholecystectomy Vascular injury Vascular anomalies Surgical management Specialized hepatobiliary centers

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Macrophage phagocytosis of SARS-CoV-2-infected cells mediates potent plasmacytoid dendritic cell activation

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Cellular & Molecular Immunology 2023年第7期20卷 835-849页

作者： O.García-nicolás A.Godel G.Zimmer A.Summerfield Institute of Virology and Immunology(IVI) Sensemattstrasse 2933147 MittelhäusernSwitzerland Department of Infectious Diseases and Pathobiology Vetsuisse FacultyUniversity of BernBernSwitzerland Multidisciplinary Center for Infectious Diseases University of BernBernSwitzerland.

Early and strong interferon type I (IFN-I) responses are usually associated with mild COVID-19 disease, whereas persistent orunregulated proinflammatory cytokine responses are associated with severe disease outcomes. Previous work suggested thatmonocyte-derived macrophages (MDMs) are resistant and unresponsive to SARS-CoV-2 infection. Here, we demonstrate that uponphagocytosis of SARS-CoV-2-infected cells, MDMs are activated and secrete IL-6 and TNF. Importantly, activated MDMs in turnmediate strong activation of plasmacytoid dendritic cells (pDCs), leading to the secretion of high levels of IFN-α and ***, pDC activation promoted IL-6 production by MDMs. This kind of pDC activation was dependent on direct integrinmediated cell‒cell contacts and involved stimulation of the TLR7 and STING signaling pathways. Overall, the present studydescribes a novel and potent pathway of pDC activation that is linked to the macrophage-mediated clearance of infected *** findings suggest that a high infection rate by SARS-CoV-2 may lead to exaggerated cytokine responses, which maycontribute to tissue damage and severe disease.

关键词： SARS-CoV-2 COVID-19 Monocyte-derived macrophages Plasmacytoid dendritic cell Interferon-α Inflammatory cytokines

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In search for the “idyllic” animal model to evaluate ocular pathologies and translate new therapies to improve human health

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Neural Regeneration Research 2022年第12期17卷 2697-2699页

作者： Francisco M.Nadal-nicolás Kiyoharu J.Miyagishima Wei Li Retinal Neurophysiology Section National Eye InstituteNational Institutes of HealthBethesdaMDUSA

The retina is a highly specialized neural tissue that encodes information of vision,a vital sensory modality for most *** the retina also contributes to other non‐image‐forming signals(*** of circadian clocks),vision chiefly enables animals to interpret and navigate their environment(despite the diverse variety of species and lifestyles;Baden et al.,2020)and also to interact with other ***,features such as high visual resolution and color discrimination are important for interactive behaviors like prey capture and also for social animals,including primates,that establish a dominance *** vertebrates,the laminar structure of the retina is notably *** photoreceptor layer(rods and cones)initiates the process of converting light energy into nerve impulses by absorbing photons and transferring the signals to interneurons.

关键词： laminar enable absorbing

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