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Tree growth is more limited by drought in rear-edge forests most of the times

Forest Ecosystems 2021年第2期8卷 330-344页

作者： J.Julio Camarero Antonio Gazol Gabriel sangüesa-Barreda Marta Vergarechea Raquel Alfaro-sánchez nicolás cattaneo sergio M.Vicente-serrano Instituto Pirenaico de Ecología(IPE-CsIC) Avda.Montañana 1005E-50192 ZaragozaSpain Ei FAB-iu FOR University of ValladolidCampus Duques de SoriaE-42004 SoriaSpain NIBIO Norwegian Institute of Bioeconomy ResearchPostboks 155NO-1431ÅsNorway Department of Biology Wilfrid Laurier UniversityN2L 3C575 Univ.Avenue WWaterlooOntarioCanada

Background:Equatorward,rear-edge tree populations are natural monitors to estimate species vulnerability to climate *** to biogeographical theory,exposition to drought events increases with increasing aridity towards the equator and the growth of southern tree populations will be more vulnerable to drought than in central ***,the ecological and biogeographical margins can mismatch due to the impact of ecological factors(topography,soils)or tree-species acclimation that can blur large-scale geographical imprints in trees responses to drought making northern populations more drought ***:We tested these ideas in six tree species,three angiosperms(Fagus sylvatica,Quercus robur,Quercus petraea)and three gymnosperms(Abies alba,Pinus sylvestris and Pinus uncinata)by comparing rear-edge tree populations subjected to different degrees of *** used dendrochronology to compare the radial-growth patterns of these species in northern,intermediate,and southern tree populations at the continental rear *** and conclusions:We found marked variations in growth variability between species with coherent patterns of stronger drought signals in the tree-ring series of the southern populations of ***,***,and *** was also observed in species from cool-wet sites(*** and ***),despite their limited responsiveness to ***,in the case of *** the intermediate population showed the strongest relationship to *** drought-sensitive species as *** and ***,southern populations presented more variable growth which was enhanced by cool-wet conditions from late spring to *** found a trend of enhanced vulnerability to drought in these two *** response of tree growth to drought has a marked biogeographical component characterized by increased drought sensitivity in southern populations even within the species distribution rear ***,the relationship

关键词： Climate change Dendroecology Latitudinal gradient Mediterranean forests standardized evapotranspiration precipitation index(sPEI)

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Role of Helicobacter pylori infection and the risk of cholelithiasis

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World Journal of Gastroenterology 2025年第8期31卷 152-154页

作者： nicolò Fabbri salvatore Greco Antonio Pesce Francesco Virgilio Danila Romeo Carlo V Feo Unit of General surgery Local Health Agency of FerraraFerrara 44100Emilia-RomagnaItaly Unit of Internal Medicine Local Health Agency of FerraraFerrara 44100Emilia-RomagnaItaly Department of Morphology Surgeryand Experimental MedicineUniversity of FerraraFerrara 44100Emilia-RomagnaItaly Unit of Hepato-Biliary surgery IRCCS San Raffaele HospitalMilan 20132LombardyItaly Local Health Agency of Ferrara Ferrara 44100Emilia-RomagnaItaly

This article aims to deepen the understanding of the role of Helicobacter pylori(***)infection in the development of cholelithiasis,initiated by the article by Yao et al,who investigated the potential link between *** infection and the development of cholelithiasis through a multicenter retrospective study on an Asian population of over 70000 *** also performed a compre-hensive analysis of previously published studies on *** and cholelithiasis,finding a positive association therein[odds ratio(OR)=1.103,P=0.049].Patients positive for *** also had lower levels of total and direct bilirubin,but higher levels of total cholesterol and low-density lipoprotein cholesterol compared to uninfected patients(Pstudies have confirmed that *** is a risk factor for cholelithiasis(Pses of case-control and cross-sectional studies have shown a positive association between *** and cholelithiasis in Asia(OR=1.599,P=0.034),but not in Europe(OR=1.277,P=0.246).Moreover,*** appears to be related to a higher ratio of choledocho-lithiasis/cholecystolithiasis(OR=3.321,P=0.033).The authors conclude that *** infection is positively correlated with cholelithiasis,particularly with the choledocholithiasis phenotype,especially in Asia,and it is potentially related to bilirubin and cholesterol metabolism.

关键词： Helicobacter pylori Helicobacter pylori infection Cholelithiasis Proton pump inhibitors Choledocholithiasis

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Mechanical Properties of Copper with Dendritic silver Inclusions:Insights from Molecular Dynamics simulations

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Computers, Materials & Continua 2024年第12期81卷 3665-3678页

作者： nicolás Amigo Departamento de Física Facultad de Ciencias NaturalesMatemática y del Medio AmbienteUniversidad Tecnológica MetropolitanaLas Palmeras 3360NunoaSantiago7800003Chile

This study explores the mechanical behavior of single-crystal copper with silver inclusions,focusing on the effects of dendritic and spherical geometries using molecular dynamics *** tensile tests reveal that dendritic inclusions lead to an earlier onset of plasticity due to the presence of high-strain regions at the complex inclusion/matrix interfaces,whereas spherical inclusions exhibit delayed plasticity associated with their symmetric geometry and homogeneous strain *** the plastic regime,the dislocation density is primarily influenced by the volume fraction of silver inclusions rather than their shape,with spherical inclusions showing the highest densities due to their larger volume and higher silver *** faults,quantified via hexagonal closed-packed atom populations,are strongly correlated with dislocation activity but exhibit transient behavior,indicating that many faults are swept out or transformed during *** transfient effect is observed in all cases,independently of the inclusion *** findings highlight the complex interplay between inclusion geometry,dislocation activity,and stacking fault evolution in shaping the mechanical properties of *** study underscores the need to account for inclusion morphology and defect dynamics when designing advanced copper-based materials and suggests further investigations into the role of dendrite orientation and distribution to enhance material performance in engineering applications.

关键词： Dendrites inclusions mechanical properties molecular dynamics

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La3+ substitution-adjusted magnetic and optical properties with enhanced photocatalytic activity and stability of copper zinc nickel ferrites for wastewater treatment applications

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Journal of Rare Earths 2025年第2期43卷 319-328页

作者： N.s.Al-Bassami General studies Department Jubail Industrial College

Copper-zinc-nickel（Cu-Zn-Ni） ferrite nanoparticles are used for wastewater treatment ***,low degradation efficiency and stability are two main issues that make them unsuitable for actual production *** this paper,the citrate-nitrate auto-combustion method was applied for the formation of Cu0.5Zn0.25Ni0.25LaxFe2-xO4;（0≤x≤0.1;step 0.02）(CZNL) *** the substitution process entails the replacement of a small ion with a larger one,the lattice constant and crystallite size does not exhibit a consistent incremental *** behavior is justified and *** size of all the CZNL ferrite nanoparticles is in the range of 8-12 nm,and the lattice constant is in the range of 8.6230 to 8.4865 *** morphological analysis conducted using field emission-scanning electron microscopy（FE-sEM） reveals that the CZNL exhibits agglomerated spherical *** energy dispersive X-ray spectrameter（EDAX） analysis was employed to confirm the elemental composition of CZNL *** the process entails the substitution of Fe3+magnetic ions with nonmagnetic ions La3+,the magnetic parameters of CZNL nanoferrites show a general decreasing trend as *** 20 K,saturation magnetization Ms shows an overall drop in its values from 59.302 emu/g at x=0.0-41.295 emu/g at x=0.1,the smallest value of 37.87 emu/g is recorded at x=*** highest coercivity（Hc=125.9 Oe） and remanence（Mr=13.32 emu/g） are recorded for x=0.08 and x=0.04 nanoferrite,*** band gap of all the CZNL nanoferrites was determined using the Kubelka-Munk function and Tauc plot for direct permitted *** doping modifies the band gap（within 1.86-1.75 eV）,increases light absorption,induces efficient e/h separation and charge migration to *** nanoferrite Cu0.5Zn0.25Ni0.25La0.06Fe1.94O4achieves a degradation efficiency of 97.3% for methylene blue（MB） dye removal after just 60 *** five recycling processes,the nanoc

关键词： Copper-zinc-nickel Ferrite Photocatalytic properties Rare earths Wastewater treatment

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A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： s.sAURABH R.KIRAN D.sINGH R.VAIsH V.s.CHAUHAN school of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHsDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(Hs), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

关键词： bio-inspired composite plate finite element method (FEM) Green-Lagrange helicoidal inverse hyperbolic shear deformation theory (IHsDT) nonlinear O322

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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Multi-component decompositions, linear superpositions, and new nonlinear integrable coupled KdV-type systems

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Communications in Theoretical Physics 2025年第2期77卷 3-14页

作者： Xiazhi Hao s Y Lou school of Mathematical science Zhejiang University of Technology school of Physical science and Technology Ningbo University

In the realm of nonlinear integrable systems, the presence of decompositions facilitates the establishment of linear superposition solutions and the derivation of novel coupled systems exhibiting nonlinear integrability. By focusing on single-component decompositions within the potential BKP hierarchy, it has been observed that specific linear superpositions of decomposition solutions remain consistent with the underlying equations. Moreover, through the implementation of multi-component decompositions within the potential BKP hierarchy,successful endeavors have been undertaken to formulate linear superposition solutions and novel coupled Kd V-type systems that resist decoupling via alterations in dependent variables.

关键词： integrable system single-component decomposition multi-component decomposition linear superposition integrable coupled KdV-type system

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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