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Alternative Exposure Parameters and Post Process Noise Reduction Expect Considerable Dose Reduction in Single Mammography Views—Initial Experience on Mastectomy Specimens

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Advances in Breast Cancer Research 2013年第3期2卷 91-96页

作者： Adriana M. J. Bluekens Ruben Evan Engen nico karssemeijer Klaas H. Schuur Mireille J. M. Broeders Gerard J. den Heeten Gerard J. den Heeten Department of Radiology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands National Expert and Training Centre for Breast Cancer Screening Nijmegen The Netherlands St. Elisabeth Hospital Department of Radiology Tilburg The Netherlands

Objective: To experimentally indicate a lower limit of dose in mammographic imaging yielding adequate image quality for complementary diagnostic views, by evaluation of image series with different exposure parameters and additional image processing on mastectomy specimens with diverse pathology. Methods: Image series were obtained on seven specimens with different target-filter combinations at different exposure values. Three experienced radiologists assessed the lowest acceptable dose level per specimen using a relative grading technique. With the standard image as reference, fibroglandular tissue and pathological structures, including microcalcifications, were evaluated. Subsequently, a series of pixel binning processes was tested and subjectively assessed on the selected images. Results: The lowest dose level at which image quality was acceptable, and achieved with a W/Ag target-filter combination at 32 kV and 4 mAs. These images can be acquired with 10.4% to 22.4% of the average glandular dose in standard images. Post process pixel binning added to the interpretability of such low dose images. Conclusion: This specimen study suggests that dose level of mammography images might be reduced substantially by general application of a W/Ag spectrum, particularly when combined with post process noise reduction. Future studies should focus on the feasibility of this technique in clinical mammography.

关键词： Digital Mammography Dose Reduction

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