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Trabecular Plate Loss and Deteriorating Elastic Modulus of Femoral Trabecular Bone in Intertrochanteric Hip Fractures

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Bone Research 2013年第4期1卷 346-354页

作者： Ji Wang Bin Zhou Ian Parkinson C.David L.Thomas John G.Clement nick fazzalari X.Edward Guo Bone Bioengineering Laboratory Department of Biomedical EngineeringColumbia UniversityNew YorkNew York 10027USA Bone and Joint Research Lab SA Pathology and Discipline of Anatomy and PathologyUniversity of AdelaideAdelaideAustralia Section of Oral Anatomy and Surgery The Melbourne Dental SchoolUniversity of MelbourneVictoria 3010Australia

Osteoporotic hip fracture is associated with significant trabecular bone loss, which is typically characterized as low bone density by dual-energy X-ray absorptiometry （DXA） and altered microstructure by micro-computed tomography （pCT）. Emerging morphological analysis techniques, e.g. individual trabecula segmentation （ITS）, can provide additional insights into changes in plate-like and rod-like trabeculae, two major micro- structural types serving different roles in determining bone strength. Using ITS, we evaluated trabecular microstructure of intertrochanteric bone cores obtained from 23 patients undergoing hip replacement surgery for intertrochanteric fracture and 22 cadaveric controls. Micro-finite element （~FE） analyses were performed to further understand how the abnormalities seen by ITS might translate into effects on bone strength. ITS analyses revealed that, near fracture site, plate-like trabeculae were seriously depleted in fracture patients, but trabecular rod volume was maintained. Besides, decreased plate area and rod length were observed in fracture patients. Fracture patients also showed decreased elastic moduli and shear moduli of trabecular bone. These results provided evidence that in intertrochanteric hip fracture, preferential loss of plate-like trabeculae led to more rod-like microstructure and deteriorated mechanical competence adjacent to the fracture site, which increased our understanding of the biomechanical pathogenesis of hip fracture in osteoporosis.

关键词： hip fracture intertrochanteric microstructure individual trabecula segmentation finite element

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