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Establishing normal ranges for fetal and neonatal small and large intestinal lengths:results from a prospective postmortem study

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World Journal of Pediatric Surgery 2022年第3期5卷 139-146页

作者： Cameron Bardwell Dina El Demellawy Irina Oltean Michelle Murphy Amisha Agarwal Jemila S Hamid Deepti Reddy nick barrowman Joseph de Nanassy Ahmed Nasr Faculty of Medicine University of OttawaOttawaOntarioCanada Department of Pathology Children's Hospital of Eastern OntarioOttawaOntarioCanada Clinical Research Unit Children's Hospital of Eastern OntarioOttawaOntarioCanada Faculty of Science University of OttawaOttawaOntarioCanada Department of Mathematics and Statistics University of OttawaOttawaOntarioCanada Department of Surgery Children's Hospital of Eastern OntarioOttawaOntarioCanada

Objective To establish reference intervals(RIs)for fetal and neonatal small and large intestinal *** Linear measurements on small and large intestines were made upon postmortem examination of 131 preterm and term infants with gestational ages between 13 and 41 *** cases were referred from the Eastern Ontario and Western Québec regions to a tertiary care *** and sex partitions were considered and RI limits were *** Data consisted of 72 male(54.96%)and 59 female(45.04%)fetuses and neonates with mean gestational age of 25.6 *** showed that small and large intestinal lengths increased linearly with gestational *** for small intestinal length(cm)of fetuses and neonates aged 13-20 weeks were(21.1,122.4);of those aged 21-28 weeks were(57.7,203.8);of those aged 29-36 weeks were(83.6,337.1);and of those aged 37-41 weeks were(132.8,406.4).RIs for large intestinal length(cm)of fetuses and neonates from the same four age groups were(5.1,21.4),(12.7,39.7),(32.4,62.4),and(29.1,82.2).Conclusions Establishing accurate RIs for premature and term infants has clinical relevance for pathologists performing postmortem analysis and for surgeons planning postoperative management of *** results of this study reaffirm that fetal small and large intestinal lengths increase linearly with gestational age irrespective of *** studies should aim to further investigate the role of possible confounders on growth of fetal intestinal length,including maternal factors such as age and substance use during pregnancy.

关键词： fetal postmortem fetus

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