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ALDH Activity Correlates with Metastatic Potential in Primary Sarcomas of Bone

Journal of Cancer Therapy 2014年第4期5卷 331-338页

作者： nicholas greco Trevor Schott Xiaodong Mu Adam Rothenberg Clifford Voigt Richard L. McGough III Mark Goodman Johnny Huard Kurt R. Weiss Department of Orthopaedic Surgery University of Pittsburgh Medical Center Pittsburgh USA

Osteosarcoma (OS), chondrosarcoma (CSA), and Ewings sarcoma (ES) are the most common primary malignancies of bone, and are rare diseases. As with all sarcomas, the prognosis of these diseases ultimately depends on the presence of metastatic disease. Survival is therefore closely linked with the biology and metastatic potential of a particular bone tumor’s cells. Here we describe a significant correlation of aldehyde dehydrogenase (ALDH) activity and the presence/absence of distant metastases in ten consecutive cases of human bone sarcomas. Additionally, cultured human CSA cells, which are historically chemo- and radio-resistant, may be sensitive to the ALDH inhibitor, disulfiram. While it is premature to draw broad conclusions from such a small series, the importance of ALDH activity and inhibition in the metastatic potential of primary bone sarcomas should be investigated further.

关键词： Osteosarcoma Chondrosarcoma Ewings Sarcoma Aldehyde Dehydrogenase Metastases

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Sugar concentration influences decision making in Apis mellifera *** during early-stage honey storage behaviour

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Open Journal of Animal Sciences 2013年第3期3卷 210-218页

作者： Mark K.greco Johann Lang Peter Gallmann nicholas Priest Edward Feil Karl Crailsheim Department of Biology and Biochemistry University of BathBathUK INVERT Group Department of Electrical and Electronic EngineeringUniversity of BathBathUK Department für Klinische Veterinarmedizin Vetsuisse-FakultatUniversitat BernBernSwitzerland Swiss Bee Research Institute Agroscope Liebefeld-Posieux Research Station(ALP)BernSwitzerland Institute for Zoology at the Karl-Franzens-Universitat Graz Austria

Decision making in honeybees is based on information which is acquired and processed in order to make choices between two or more alternatives. These choices lead to the expression of optimal behaviour strategies such as floral constancy. Optimal foraging strategies such as floral constancy improve a colony’s chances of survival, however to our knowledge, there has been no research on decision making based on optimal storage strategies. Here we show, using diagnostic radioentomology, that decision making in storer bees is influenced by nectar sugar concentrations and that, within 48 hours of collection, honeybees workers store carbohydrates in groups of cells with similar sugar concentrations in a nonrandom way. This behaviour, as evidenced by patchy spatial cell distributions, would help to hasten the ripening process by reducing the distance between cells of similar sugar concentrations. Thus, colonies which exhibit optimal storage strategies such as these would have an evolutionary advantage and im- prove colony survival expectations over less efficient colonies and it should be plausible to select colonies that exhibit these preferred traits.

关键词： Honey Floral Constancy Nectar Foraging Behaviour Decision Making

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