检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

屏幕上的课堂:在线教与学体验研究

开放教育研究 2020年第5期26卷 88-98页

作者：闻凌晨尼古拉斯·布尔布勒斯范国睿童欣华东师范大学教育学系伊利诺伊大学香槟分校教育学院

疫情期间,居家隔离政策改变了传统教学形态,在线教与学走进师生的生活世界。本研究从时间、空间、身体与关系等维度出发,利用质性研究方法收集师生线上教与学的"鲜活体验"。研究发现,师生遭遇消失的时空边界、恐慌的身体、沉默的互动。... 详细信息

疫情期间,居家隔离政策改变了传统教学形态,在线教与学走进师生的生活世界。本研究从时间、空间、身体与关系等维度出发,利用质性研究方法收集师生线上教与学的"鲜活体验"。研究发现,师生遭遇消失的时空边界、恐慌的身体、沉默的互动。基于上述发现,本研究指出教师需要具备一种在线教学机智,关切师生身体性、时空性、关系性等需求:呵护身体,保持对屏幕前后身体的敏感性;规划时空距离,重构在线生活世界的时间结构与空间布置;认识技术的限制,反思技术背景下的师生关系与教育范畴下的人机关系。

关键词：在线教与学身体生活体验时空性关系性

Analytical model for predicting folding stable state of bistable deployable composite boom

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

chinese Journal of Aeronautics 2024年第8期37卷 460-469页

作者： Tianwei LIU Jiangbo BAI nicholas FANTUZZI School of Transportation Science and Engineering Beihang UniversityBeijing 100191China Jingdezhen Research Institute of Beihang University Jingdezhen 333000China DIcAM Department University of BolognaBologna 40136Italy

Bistable Deployable composite Boom(Bi-DcB)can achieve bistable function by storing and releasing strain energy,which has a good application prospect in space *** example,it serves as the main support section of deployable structures(e.g.,solar arrays and antennas).This paper investigates folding stable state of Bi-DcB through the analytical *** on Archimedes’helix and energy principle,an analytical model for predicting folding stable state of Bi-DcB was *** failure index of Bi-DcB in folding stable state were analyzed using the Tsai-Hill criterion and the maximum stress ***,a 2400 mm long Bi-DcB was fabricated using autoclave *** prediction results of the proposed model were compared with experiments and results of two other analytical *** is shown that the proposed model shows good prediction ***,the effect of geometric parameters on folding stable state of Bi-DcB was further investigated with the aid of the proposed model.

关键词： Bistable Deployable composite boom Solar arrays Antennas Archimedes’helix Folding Failure analysis

Analysis of the combined effect of rs699 and rs5051 on angiotensinogen expression and hypertension

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chronic Diseases and Translational Medicine 2024年第2期10卷 102-117页

作者： nicholas R.Powell Tyler Shugg Jacob Leighty Matthew Martin Rolf P.Kreutz Michael T.Eadon Dongbing Lai Tao Lu Todd c.Skaar Division of clinical Pharmacology Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Pharmacology and Toxicology School of MedicineIndiana UniversityIndianapolisIndianaUSA Department of cardiology School of MedicineKrannert Institute of CardiologyIndiana UniversityIndianapolisIndianaUSA Division of Nephrology Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Medical and Molecular Genetics School of MedicineIndiana UniversityIndianapolisIndianaUSA

Background Hypertension(HTN)involves genetic variability in the renin-angiotensin system and influences antihypertensive *** previously reported that angiotensinogen(AGT)messenger RNA(mRNA)is endogenously bound by miR-122-5p and rs699 A>G decreases reporter mRNA in the microRNA functional-assay *** AGT promoter variant rs5051 c>T is in linkage disequilibrium(LD)with rs699 A>G and increases AGT *** independent effect of these variants is understudied due to their LD therefore we aimed to test the hypothesis that increased AGT by rs5051 c>T counterbalances AGT decreased by rs699 A>G,and when these variants occur independently,it translates to HTN-related *** We used in silico,in vitro,in vivo,and retrospective models to test this *** In silico,rs699 A>G is predicted to increase miR-122-5p binding affinity by 3%.Mir-ecLIP results show rs699 is 40–45 nucleotides from the strongest microRNA-binding site in the AGT ***,rs699 A>G increases AGT mRNA in an AGT-plasmid-cDNA HepG2 expression ***-Tissue Expression(GTEx)and UK Biobank analyses demonstrate liver AGT expression and HTN phenotypes are not different when rs699 A>G occurs independently from rs5051 c>***,GTEx and the in vitro experiments suggest rs699 A>G confers cell-type-specific effects on AGT mRNA abundance,and suggest paracrine renal renin-angiotensin-system perturbations could mediate the rs699 A>G associations with *** We found that rs5051 c>T and rs699 A>G significantly associate with systolic blood pressure in Black participants in the UK Biobank,demonstrating a fourfold larger effect than in White *** studies are warranted to determine if altered antihypertensive response in Black individuals might be due to rs5051 c>T or rs699 A>*** like this will help clinicians move beyond the use of race as a surrogate for genotype.

关键词： angiotensinogen genetic and genomic medicine hypertension rs699

HDPairFinder:A data processing platform for hydrogen/deuterium isotopic labeling-based nontargeted analysis of trace-level amino-containing chemicals in environmental water

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 583-593页

作者： Tingting Zhao Kristin carroll caley B.craven nicholas J.P.Wawryk Shipei Xing Jian Guo Xing-Fang Li Tao Huan Department of chemistry Faculty of ScienceUniversity of British ColumbiaVancouver Campus2036 Main MallVancouverBritish ColumbiaV6T 1Z1Canada Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6G 2G3Canada

The combination of hydrogen/deuterium(H/D)formaldehyde-based isotopic methyl labeling with solid-phase extraction and high-performance liquid chromatography–high resolution mass spectrometry(HPLc-HRMS)is a powerful analytical solution for nontargeted analysis of trace-level amino-containing chemicals in water *** the huge amount of chemical information generated in HPLc-HRMS analysis,identifying all possible H/Dlabeled amino chemicals presents a significant challenge in data *** address this,we designed a streamlined data processing pipeline that can automatically extract H/D-labeled amino chemicals from the raw HPLc-HRMS data with high accuracy and ***,we developed a cross-correlation algorithm to correct the retention time shift resulting from deuterium isotopic effects,which enables reliable pairing of H-and D-labeled ***,we implemented several bioinformatic solutions to remove false chemical features generated by in-source fragmentation,salt adduction,and natural13c ***,we used a data mining strategy to construct the AMINES library that consists of over 38,000 structure-disjointed primary and secondary amines to facilitate putative compound ***,we integrated these modules into a freely available R program,*** rationale of each module was justified and its performance tested using experimental H/D-labeled chemical standards and authentic water *** further demonstrated the application of HDPairFinder to effectively extract N-containing contaminants,thus enabling the monitoring of changes of primary and secondary N-compounds in authentic water *** is a reliable bioinformatic tool for rapid processing of H/D isotopic methyl labeling-based nontargeted analysis of water samples,and will facilitate a better understanding of N-containing chemical compounds in water.

关键词： Isotope labeling Nontargeted analysis Reactive N-compounds HPLc-HRMS Source water

Fermi Surface Nesting with Heavy Quasiparticles in the Locally Noncentrosymmetric Superconductor ceRh2As2

在线全文

学校读者我要写书评

暂无评论

chinese Physics Letters 2024年第9期41卷 107-121页

作者： Yi Wu Yongjun Zhang Sailong Ju Yong Hu Yanen Huang Yanan Zhang Huali Zhang Hao Zheng Guowei Yang Evrard-Ouicem Eljaouhari Baopeng Song nicholas c.Plumb Frank Steglich Ming Shi Gertrud Zwicknagl chao cao Huiqiu Yuan Yang Liu center for correlated Matter and School of Physics Zhejiang UniversityHangzhou 310058China Institute for Advanced Materials Hubei Normal UniversityHuangshi 435002China Swiss Light Source Paul Scherrer InstitutCH-5232 Villigen PSISwitzerland Institut for Mathematische Physik 38106 BraunschweigGermany Max Planck Institute for chemical Physics of Solids 01187 DresdenGermany collaborative Innovation center of Advanced Microstructures Nanjing UniversityNanjing 210093China State Key Laboratory of Silicon Materials Zhejiang UniversityHangzhou 310058China

The locally noncentrosymmetric heavy fermion superconductor ceRh2As2 has attracted considerable interests due to its rich superconducting phases,accompanied by possible quadrupole density wave and pronounced antiferromagnetic *** understand the underlying physics,here we report measurements from highresolution angle-resolved *** results reveal fine splittings of the conduction bands related to the locally noncentrosymmetric structure,as well as a quasi-two-dimensional Fermi surface(FS)with strong 4𝑓*** FS shows signs of nesting with an in-plane vector q1=(π/α,π/α),which is facilitated by the heavy bands nearˉ𝑋arising from the characteristic conduction-X *** FS nesting provides a natural explanation for the observed antiferromagnetic spin fluctuations at(π/α,π/α),which might be the driving force for its unconventional *** experimental results can be reasonably explained by density functional theory plus dynamical mean field theory calculations,which can capture the strong correlation *** study not only provides spectroscopic signature of the key factors underlying the field-induced superconducting transition,but also uncovers the critical role of FS nesting and lattice Kondo effect in the underlying magnetic fluctuations.

关键词： symmetric Fermi conduction

Review on laser directed energy deposited aluminum alloys

在线全文

学校读者我要写书评

暂无评论

International Journal of Extreme Manufacturing 2024年第2期6卷 84-131页

作者： Tian-Shu Liu Peng chen Feng Qiu Hong-Yu Yang nicholas Tan Yew Jin Youxiang chew Di Wang Ruidi Li Qi-chuan Jiang chaolin Tan Singapore Institute of Manufacturing Technology(SIMTech) Agency for ScienceTechnology and Research(A∗STAR)5 Cleantech LoopSingapore 636732Singapore State Key Laboratory of Automotive Simulation and control Jilin UniversityChangchun 130025People’s Republic of China Key Laboratory of Automobile Materials Ministry of Education and Department of Materials Science and EngineeringJilin UniversityChangchun 130025People’s Republic of China School of Mechanical&Automotive Engineering South China University of TechnologyGuangzhou 510640People’s Republic of China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083People’s Republic of China

Lightweight aluminum(Al)alloys have been widely used in frontier fields like aerospace and automotive industries,which attracts great interest in additive manufacturing(AM)to process high-value Al *** a mainstream AM technique,laser-directed energy deposition(LDED)shows good scalability to meet the requirements for large-format component manufacturing and ***,LDED Al alloys are highly challenging due to their inherent poor printability(*** laser absorption,high oxidation sensitivity and cracking tendency).To further promote the development of LDED high-performance Al alloys,this review offers a deep understanding of the challenges and strategies to improve printability in LDED Al *** porosity,cracking,distortion,inclusions,element evaporation and resultant inferior mechanical properties(worse than laser powder bed fusion)are the key challenges in LDED Al *** parameter optimizations,in-situ alloy design,reinforcing particle addition and field assistance are the efficient approaches to improving the printability and performance of LDED Al *** underlying correlations between processes,alloy innovation,characteristic microstructures,and achievable performances in LDED Al alloys are *** benchmark mechanical properties and primary strengthening mechanism of LDED Al alloys are *** review aims to provide a critical and in-depth evaluation of current progress in LDED Al *** opportunities and perspectives in LDED high-performance Al alloys are also outlined.

关键词： additive manufacturing laser directed energy deposition(LDED) aluminum alloys printability aluminum matrix composite auxiliary fields mechanical properties

Groupoid Approach to Ergodic Dynamical System of commutative von Neumann Algebra

在线全文

学校读者我要写书评

暂无评论

Advances in Pure Mathematics 2024年第3期14卷 167-184页

作者： nicholas O. Okeke Murphy E. Egwe Physical and Mathematical Sciences Dominican University Ibadan Nigeria Department of Mathematics University of Ibadan Ibadan Nigeria

Given a compact and regular Hausdorff measure space (X, μ), with μ a Radon measure, it is known that the generalised space M(X) of all the positive Radon measures on X is isomorphic to the space of essentially bounded functions L∞(X, μ) on X. We confirm that the commutative von Neumann algebras M⊂B(H), with H=L2(X, μ), are unitary equivariant to the maximal ideals of the commutative algebra c(X). Subsequenly, we use the measure groupoid to formulate the algebraic and topological structures of the commutative algebra c(X) following its action on M(X) and define its representation and ergodic dynamical system on the commutative von Neumann algebras of M of B(H) .

关键词： Measure Groupoid Groupoid Equivalence Ergodic Action convolution Algebra von Neumann Algebra Generalized Space

Integrating volunteered smartphone data with multispectral remote sensing to estimate forest fuels

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Digital Earth 2016年第2期9卷 171-196页

作者： colin J.Ferster nicholas c.coops Department of Forest Resources Management University of British ColumbiaVancouverBCCanada

Volunteered data sources are readily available due to advances in electronic communications *** example,smartphones provide tools to collect ground-based observations over broad areas from a diverse set of data collectors,including people with,and without,extensive *** this study,volunteers used a smartphone application to collect ground-based *** structural components were then estimated over a broader area using high spatial resolution RapidEye remote sensing imagery(5 spectral bands 440–850 nm,5 m spatial resolution)and a digital elevation model following a three nearest neighbor approach(K-NN).Participants with professional forestry experience on average chose highpriority fuel load locations near buildings,while nonprofessional participants chose a broader range of conditions over a larger *** used together,the professional and nonprofessional observations provided a more complete assessment of forest conditions.A generalized framework is presented that utilizes K-NN imputation tools for estimating the distribution of forest fuels using remote sensing and topography variables,ensuring spatial representation,checking attribute accuracy,and evaluating predictor *** to integrate volunteered data from smartphone platforms with remote sensing may contribute toward more complete Earth observation for Digital Earth.

关键词： citizen science public participation in scientific research mobile RapidEye red edge WUI

Putting PLX5622 into perspective:microglia in central nervous system viral infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第6期18卷 1269-1270页

作者： Alanna G.Spiteri nicholas J.c.King Viral Immunopathology Laboratory InfectionImmunity and Inflammation Research ThemeSchool of Medical SciencesFaculty of Medicine and HealthThe University of SydneySydneyNSWAustralia Sydney cytometry The University of Sydney and Centenary InstituteSydneyNSWAustralia Ramaciotti Facility for Human Systems Biology The University of Sydney and Centenary InstituteSydneyNSWAustralia charles Perkins centre The University of SydneyAustralia The University of Sydney Institute for Infectious Diseases The University of SydneySydneyNSWAustralia The University of Sydney Nano Institute the University of SydneySydneyNSWAustralia

Elucidating the exact contribution of microglia to central nervous system(cNS)pathology has historically been extremely *** resident parenchymal myeloid cells are considered to have critical roles as frontline responders during pathogen invasion and cNS ***,understanding the precise temporal kinetics of microglial function is central to the evolution of novel therapeutics for disease intervention and/or resolution(Spiteri et al.,2022a).The development of PLX5622,a colony-stimulating factor 1 receptor(cSF-1R)inhibitor typically formulated into a rodent chow for simple oral administration has facilitated exploration of microglial functions in disease(Spangenberg et al.,2019).

关键词： invasion system precise