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Essential Oil from Citrus aurantium Alleviates Anxiety of Patients Undergoing Coronary Angiography: A Single-Blind, Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2021年第3期27卷 177-182页

作者： Khalil Moradi Hossein Ashtarian nicholas yakubu danzima Hamid Saeedi Behrouz Bijan Farzaneh Akbari Mohammad Mehdi Mohammadi Intensive Care Unit Imam Reza HospitalKermanshah University of Medical SciencesKermanshahIran Health Education Department Health SchooKermanshah University of Medical SciencesKerm anshahIran School of Nursing and Micwilery Tehran University of Medical SciencesTehranIran Student Research Comite School of NursingTabriz University of Medical SciencesTabrizIran

Objective To determine the effectiveness and safety of essential oil from Citrus aurantium on anxiety in patients undergoing coronary angiography.Methods A single-blind,randomized controlled trial was conducted in 80 patients experiencing coronary angiography in Imam Ali Hospital in Kermanshah,Iran from April to November in 2016.All patients were randomly divided into intervention and control groups by a random number table,40 cases in each group.The patients in the intervention group inhaled Citrus aurantium essential oil for 15–20 min about 60 min before angiography.Following the same procedure,distilled water was used instead of Citrus aurantium in the control group.Spielbergers State-Trait Anxiety Inventory(STAI)was filled in and vital signs including systolic blood pressure(SBP),diastolic blood pressure(DBP),respiratory and pulse rate were recorded before and 20 min after the intervention.Adverse reactions after intervention were observed.Results In the intervention group,the mean scores of STAI,SBP,DBP,respiratory and pulse rate were 53.30±10.13,134.82±11.75 mm Hg,84.49±6.99 mm Hg,17.87±1.73 times/min,and 76.48±12.55 beats/min at baseline and significantly decreased to 42.37±10.15,124.49±10.48 mm Hg,79.23±6.62 mm Hg,14.54±1.43 times/min,and 70.03±13.66 beats/min respectively 20 min after intervention(all P0.05).All subjects reported no adverse reactions.Conclusion Inhalation of the essential oil from Citrus aurantium was effective in reducing anxiety and stress levels in patients undergoing coronary angiography.

关键词： single-blind randomized controlled trial essential oil Citrus aurantium anxiety coronary angiography non-drug treatment aromatherapy

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GC-MS and NMR analysis of the bioactive compounds from the crude extracts of Waltheria indica and the histopathological changes induced in albino rats challenged with Naja nigricollis venom

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Journal of Coastal Life Medicine 2016年第5期4卷 395-402页

作者： Philip Ilani nicholas Ajodo Folashade Adewusi Samirat yakubu Victor yakubu Cosmos Ache Eunice Atonila Kayode Ezekiel Oshiedu Sarah Emmanuel Amlabu Department of Biochemistry Kogi State UniversityAnyigbaNigeria

Objective:To develop a characteristic fingerprint of the different chemical compounds of plant by gas chromatography-mass spectrometer(GC-MS)and nuclear magnetic resonance(NMR)analysis and assess the effect of the crude extract on histological changes induced in Naja nigricollis(N.nigricollis)envenomed albino rats.Methods:The coarsely powdered Waltheria indica(W.indica)whole plant material was extracted using 70%methanol.GC-MS analysis was carried out using a Shimadzu GC-MS QP 2010 plus system of gas chromatography interfaced to a mass spectrometer.The identification of components was based on National Institute of Standard and Technology-08 and Willey-8 libraries.Hydrogen-NMR spectra of the extracts was performed using Bruker Biospin Avance 400-MHz NMR spectrophotometer with a 5 mm broad inverse probe head,equipped with shielded z-gradient accessories and C-13 NMR hetero-nuclear single quantum correction was carried out using the Brucker’s standard pulse library.The efficacy of the crude extract of W.indica whole plant was tested and the lesions induced in the liver,brain and kidney of albino rats challenged with N.nigricollis were analyzed by light microscopy.Results:The identification of the bioactive compounds from W.indica by GC-MS analysis revealed 41 peaks.A total of 38 compounds were identified with majority having important pharmacological activities that included anti-microbial,anti-cancer,anti-oxidant antiinflammatory,anti-allergenic,anti-ageing,anti-arthritic,larvicidal,anti-convulsant and herbicidal activities.C-13 and hydrogen-NMR analysis of W.indica elucidated key bioactive compounds in the whole plant that were consistent with the classes of bioactive compounds detected by GC-MS analysis.The efficacy of the crude extract of W.indica whole plant in ameliorating histopathological lesions induced in the liver,brain and kidney of albino rats challenged with N.nigricollis venom revealed the abrogation of tissue degeneration when compared with the experimental control group.Conclusions:The present stud

关键词： Waltheria indica Gas chromatography-mass spectrometer Nuclear magnetic resonance Bioactive compounds Pharmacological activities Web-based analysis Naja nigricollis venom Histopathology

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