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Prospective associations between j.int categories of physical activity and insomnia symptoms with onset of poor mental health in a population-based cohort

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j.urnal of Sport and Health Science 2023年第3期12卷 295-303页

作者： Mitch j.Duncan Elizabeth G Holliday Nicola W Burton nicholas Glozier Stina Oftedal School of Medicine and Public Health College of HealthMedicineand WellbeingThe University of NewcastleCallaghanNSW 2308Australia Priority Research Centre for Physical Activity and Nutrition The University of NewcastleCallaghanNSW 2308Australia School of Applied Psychology Griffith UniversityBrisbaneQLD 4122Australia Menzies Health Institute Queensland Griffith UniversityBrisbaneQLD 4122Australia Brain and Mind Centre Central Clinical SchoolThe University of SydneyNSW 2050Australia

Background:Physical inactivity and insomnia symptoms are independently associated with increased risk of depression and anxiety;however,few studies j.intly examine these risk *** study aimed to prospectively examine the j.int association of physical activity(PA)and insomnia symptoms with onset of poor mental health in ***:Participants from the 2013 to 2018 annnual waves of the Household Income and Labour Dynamics in Australia panel study who had good mental health(Mental Health Inventory-5>54)in 2013,and who completed at least 1 follow-up survey(2014-2018),were included(n=10,977).Poor mental health(Mental Health Inventory-5≤54)was assessed ***(2013)PA was classified as high/moderate/low,and insomnia symptoms(i.e.,trouble sleeping)were classified as no insomnia symptoms/insomnia symptoms,with 6 mutually exclusive PAinsomnia symptom groups *** of PA-insomnia symptom groups with onset of poor mental health were examined using discrete-time proportional-hazards logit-hazard ***:There were 2322 new cases of poor mental health(21.2%).Relative to the high PA/no insomnia symptoms group,there were higher odds(odds ratio and 95%confidence interval(95%CI))of poor mental health among the high PA/insomnia symptoms(OR=1.87,95%CI:1.57-2.23),moderate PA/insomnia symptoms(OR=1.93,95%CI:1.61-2.31),low PA/insomnia symptoms(OR=2.33,95%CI:1.96-2.78),and low PA/no insomnia symptoms(OR=1.14,95%CI:1.01-1.29)*** level of PA combined with insomnia symptoms was associated with increased odds of poor mental health,with the odds increasing as PA ***:The se findings highlight the potential benefit of interventions targeting both PA and insomnia symptoms for promoting mental health.

关键词： Depression Physical activity Sleep quality

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Analytical model for predicting folding stable state of bistable deployable composite boom

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Chinese j.urnal of Aeronautics 2024年第8期37卷 460-469页

作者： Tianwei LIU j.angbo BAI nicholas FANTUZZI School of Transportation Science and Engineering Beihang UniversityBeijing 100191China j.ngdezhen Research Institute of Beihang University Jingdezhen 333000China DICAM Department University of BolognaBologna 40136Italy

Bistable Deployable Composite Boom(Bi-DCB)can achieve bistable function by storing and releasing strain energy,which has a good application prospect in space *** example,it serves as the main support section of deployable structures(e.g.,solar arrays and antennas).This paper investigates folding stable state of Bi-DCB through the analytical *** on Archimedes’helix and energy principle,an analytical model for predicting folding stable state of Bi-DCB was *** failure index of Bi-DCB in folding stable state were analyzed using the Tsai-Hill criterion and the maximum stress ***,a 2400 mm long Bi-DCB was fabricated using autoclave *** prediction results of the proposed model were compared with experiments and results of two other analytical *** is shown that the proposed model shows good prediction ***,the effect of geometric parameters on folding stable state of Bi-DCB was further investigated with the aid of the proposed model.

关键词： Bistable Deployable composite boom Solar arrays Antennas Archimedes’helix Folding Failure analysis

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Classical bovine spongiform encephalopathy and chronic wasting disease:two sides of the prion coin

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Animal Diseases 2024年第1期4卷 1-18页

作者： nicholas j.Haley j.ergen A.Richt Department of Microbiology and Immunology College of Graduate StudiesMidwestern UniversityGlendaleAZUSA Department of Diagnostic Medicine/Pathobiology College of Veterinary MedicineKansas State UniversityManhattanKSUSA

Transmissible spongiform encephalopathies(TSEs)are a group of progressive and ultimately fatal neurologic diseases of man and animals,all resulting from the propagated misfolding of the host's normal cellular prion *** diseases can be spontaneous,heritable,anthropogenic/iatrogenic,or in some cases horizontally transmissible,and include such notable TSEs as bovine spongiform encephalopathy(BSE)of cattle and chronic wasting disease(CWD)of *** they are both unequivocally protein misfolding disorders,they differ markedly in their pathogenesis,transmissibility,and zoonotic *** the BSE epidemic has largely abated over the past three decades following global feed bans on ruminant meat and bone meal,CWD,which is readily transmitted through various forms of excreta,has rapidly expanded from its original endemic zone to encompass much of North America,along with recently identified foci in *** importantly,although the classical form of BSE has proven transmissible to humans consuming contaminated beef or beef products,so far there have been no conclusive reports on the zoonotic transmission of cWD to *** underlying basis for these differences-whether host or agent directed-are not well understood,though may be due to inherent differences in the three-dimensional structure of the misfolded BSE or CWD prion proteins or the expression levels and tissue distribution of respective cellular prion *** the uncontrolled geographic spread of CWD,it is imperative that we improve our understanding of the factors governing prion disease pathogenesis,transmission,and zoonotic potential.

关键词： Prion Bovine Spongiform Encephalopathy Chronic Wasting Disease Transmission Pathogenesis Zoonosis

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Functional integrity of freshwater forested wetlands,hydrologic alteration,and climate change

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Ecosystem Health and Sustainability 2016年第1期2卷 13-30页

作者： Beth A.Middleton nicholas j.Souter U.S.Geological Survey Wetland and Aquatic Research CenterLafayetteLouisiana 70506USA Fauna&Flora International Cambodia ProgrammePhnom Penh12000Cambodia5001

Climate change will challenge managers to balance the freshwater needs of humans and *** Intergovernmental Panel on Climate Change predicts that most regions of the world will be exposed to higher temperatures,CO2,and more erratic precipitation,with some regions likely to have alternating episodes of intense flooding and *** areas will be exposed to more fre-quent saltwater inundation as sea levels *** land managers desperately need intra-regional climate information for site-specific planning,management,and restoration *** will be chal-lenged to deliver freshwater to floodplains during climate change-induced drought,particularly within hydrologically altered and developed *** of forest health,both by field and remote sensing techniques,will be essential to signal the need for hydrologic *** of the util-ity of the release of freshwater to remediate stressed forested floodplains along the Murray and Mis-sissippi Rivers suggest that brief episodes of freshwater remediation for trees can have positive health benefits for these *** challenges of climate change in forests of the developing world will be considered using the Tonle Sap of Cambodia as an *** little ecological knowledge of the im-pacts,managing climate change will add to environmental problems already faced in the developing world with new river engineering *** emerging approaches to remediate stressed trees will be of utmost importance for managing worldwide floodplain forests with predicted climate changes.

关键词： Asia Australia climate change coastal wetlands floodplain forest India North America temperate tropical

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Intrusions of the Panxi region,China,and their magmatic ore deposits

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Geoscience Frontiers 2013年第5期4卷 479-480页

作者： nicholas Arndt ISTerre Universite Joseph Fourier38400 St Martin d'HeresFrance

The intrusions of the Panzhihua-Xichang（Panxi） region in southwest China have become well known in the past decade because they host large and rich magmatic oxide deposits that are mined for Fe,Ti and *** intrusions form part of the Emeishan large igneous province（ELIP）,which is commonly believed to be the product of melting in a mantle *** ELIP was emplaced about 260 Ma ago,at the same time as the end-Guadalupian mass *** investigation of the Panxi intrusions therefore provides information relevant to three broad areas of the earth sciences：（1）the petrogenesis of mafic magmas,

关键词： Intrusions magmatic nicholas

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Fatal Overdoses Involving Carfentanil:A Case Series

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j.urnal of Forensic Science and Medicine 2019年第3期5卷 147-150页

作者： nicholas j.Corsi Lj.bisa j.Dragovic Wayne State University School of Medicine 540 E Canfield StDetroitMichiganUSA Department of Public Services Oakland County Medical Examiners’OfficeOakland CountyPontiacMichiganUSA

Carfentanil,an ultrapotent analog of fentanyl,has invaded the street drug market,unbeknownst to many heroin *** 10,000 times more potent than morphine,it was initially suspected that 20μg of the substance was *** this case series,we present 17 confirmed carfentanil overdoses in Michigan,with a primary focus on the concentration *** a retrospective review,each public death reported in Oakland County,Michigan,with a subsequent toxicology report was investigated for suspected carfentanil *** characterize each fatality,the autopsy results were collected,including the postmortem findings at scene and the decedent’s medical and social *** levels were measured through liquid chromatography and tandem mass spectrometry(LC-MS-MS)by National Medical Services(NMS)*** case series found postmortem carfentanil concentrations as low as 10 ng/mL,with a mean concentration of 0.387 ng/***,there are implications on law enforcement,first responders,and health care providers when dealing with this emerging illicit substance,and there is an alarmingly high mortality rate associated with the abuse of carfentanil.

关键词： Autopsy carfentanil death epidemic fentanyl heroin investigation Michigan opioid overdose polysubstance

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An in situ monitoring campaign of a hard rock pillar at great depth within a Canadian mine

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j.urnal of Rock Mechanics and Geotechnical Engineering 2020年第3期12卷 427-448页

作者： Bradley Forbes nicholas Vlachopoulos Mark S.Diederichs Andrew j.Hyett Allan Punkkinen Department of Geological Sciences and Geological Engineering Queen’s UniversityKingstonOntarioK7L 3N6Canada Department of Civil Engineering Royal Military College of CanadaKingstonOntarioK7K 7B4Canada YieldPoint Inc. KingstonOntarioK7M 4W9Canada Normet Canada Ltd. LivelyOntarioP3Y 0B3Canada

A recent research campaign at a Canadian nickel-copper mine involved instrumenting a hard rock sill drift pillar with an array of multi-point rod extensometers,distributed optical fibre strain sensors,and borehole pressure cells(BHPCs).The instrumentation spanned across a 15.24 m lengthwise segment of the relatively massive granitic pillar situated at a depth of 2.44 km within the *** May 2016 and March 2017,the pillar’s displacement and pressure response were measured and correlated with mining activities on the same level as the pillar,including:(1)mine-by of the pillar,(2)footwall drift development,and(3)ore body stoping *** displacements of the pillar,the extensometers provided high temporal resolution(logged hourly)and the optical fibre strain sensors provide high spatial resolution(measured every 0.65 mm along the length of each sensor).The combination of sensing techniques allowed centimetre-scale rock mass bulking near the pillar sidewalls to be distinguished from microstrain-scale fracturing towards the core of the ***,the influence and extent of a mine-scale schistose shear zone transecting the pillar was *** converting measured rock mass displacement to velocity,a process was demonstrated which allowed mining activities inducing displacements to be categorised by time-duration and cumulative *** over half of the analysed mining activities,displacements were determined to prolong for over an hour,predominately resulting in submillimetre cumulative displacements,but in some cases multi-centimetre cumulative displacements were *** time-dependent behaviour was more pronounced within the vicinity of the plumb shear *** measurements were also used to assess selected support member load and elongation mobilisation per mining *** was found that a combined static load and elongation capacity of reinforcing members was essential to maintaining excavation stability,while

关键词： Hard rock pillar Rockburst Rock mass bulking Distributed optical fibre strain sensing Extensometer In situ monitoring High stress Dynamic support

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Synergistic and non-specific nucleic acid production by T7 RNA polymerase and Bsu DNA polymerase catalyzed by single-stranded polynucleotides

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Synthetic and Systems Biotechnology 2018年第2期3卷 130-134页

作者： nicholas j.Emery Sagardip Maj.mder Allen P.Liu Department of Mechanical Engineering University of MichiganAnn ArborMIUnited States Cellular and Molecular Biology Program University of MichiganAnn ArborMIUnited States Department of Biomedical Engineering University of MichiganAnn ArborMIUnited States Biophysics Program University of MichiganAnn ArborMIUnited States Department of Biomedical Engineering Boston UniversityBostonMAUnited States.

Point-of-care molecular diagnostic tests show great promise for providing accurate,timely results in lowinfrastructure healthcare settings and at *** design space for these tests is limited by a variety of possible background reactions,which often originate from relatively weak promiscuous activities of the enzymes used for nucleic acid *** this background signal is amplified alongside the signal of the intended biomarker,the dynamic range of the test can be severely ***,a detailed knowledge of potential side reactions arising from enzyme promiscuity can improve rational design of point-of-care molecular diagnostic *** this end,we report a previously unknown synergistic reaction between T7 RNA polymerase and Bsu DNA polymerase that produces nucleic acid in the presence of single-stranded DNA or *** reaction occurs in the absence of any previously reported substrates for either polymerases and compromises a theoretical microRNA amplification scheme utilizing these polymerases.

关键词： catalyzed utilizing rational

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Risk of bias and reporting practices in studies comparing VO2max responses to sprint interval *** training:A systematic review and meta-analysis

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j.urnal of Sport and Health Science 2022年第5期11卷 552-566页

作者： j.cob T.Bonafiglia Hashim Islam nicholas Preobrazenski Brendon j.Gurd School of Kinesiology and Health Studies Queen’s UniversityKingstonOntarioK7L 3N6Canada

Background:It remains unclear whether studies comparing _(max)imal oxygen uptake(VO_(2max))response to sprint interval training(SIT)***-intensity continuous training(MICT)are associated with a high risk of bias and poor reporting *** purpose of this study was to evaluate the risk of bias and quality of reporting in studies comparing changes in VO_(2max) between SIT and ***:We conducted a comprehensive literature search of 4 maj.r databases:AMED,CINAHL,EMBASE,and *** were excluded if participants were not healthy adult humans or if training protocols were unsupervised,lasted less than 2 weeks,or utilized mixed exercise *** used the Cochrane Collaboration tool and the CONSORT checklist for non-pharmacological trials to evaluate the risk of bias and reporting quality,***:Twenty-eight studies with 30 comparisons(3 studies included 2 SIT groups)were included in our meta-analysis(n=360 SIT participants:body mass index(BMI)=25.9±3.7 kg/m^(2),baseline VO_(2max)=37.9±8.0 mL/kg/min;n=359 MICT participants:BMI=25.5±3.8 kg/m^(2),baseline VO_(2max)=38.3±8.0 mL/kg/min;all mean±SD).All studies had an unclear risk of bias and poor reporting ***:Although we observed a lack of superiority between SIT and MICT for improving VO_(2max)(weighted Hedge’s g=0.004,95%con-fidence interval(95%CI):-0.08 to 0.07),the overall unclear risk of bias calls the validity of this conclusion into *** studies using robust study designs are needed to interrogate the possibility that SIT and MICT result in similar changes in VO_(2max).

关键词： Bias Cardiorespiratory fitness CONSORT Moderate-intensity continuous training Sprint interval training

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New methods for identification of disinfection byproducts of toxicological relevance: Progress and future directions

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j.urnal of Environmental Sciences 2021年第1期33卷 151-159页

作者： nicholas j.P.Wawryk Caley B.Craven Lindsay K.j.aiff Blackstock Xing-Fang Li Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of AlbertaEdmontonABT6G 2G3Canada

Disinfection byproducts(DBPs)represent a ubiquitous source of chemical exposure in disinfected *** over 700 DBPs have been identified,the drivers of toxicity remain poorly ***,ever evolving water treatment practices have led to a continually growing list of *** of analytical technologies have enabled the identification of new classes of DBPs and the quantification of these chemically diverse sets of *** we summarize advances in new workflows for DBP analysis,including sample preparation,chromatographic separation with mass spectrometry(MS)detection,and data *** aid in the selection of techniques for future studies,we discuss necessary considerations for each step in the *** review focuses on how each step of a workflow can be optimized to capture diverse classes of DBPs within a single ***,we highlight new MS-based approaches that can be powerful for identifying novel DBPs of toxicological *** discuss current challenges and provide perspectives on future research directions with respect to studying new DBPs of toxicological *** analytical technologies continue to advance,new strategies will be increasingly used to analyze complex DBPs produced in different treatment processes with the aim to identify potential drivers of toxicity.

关键词： Water disinfection byproducts(DBPs) Emerging contaminants Mass spectrometry Chromatography Nontargeted analysis Toxicity drivers

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