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Inte.fe.e.ce.from HONO in the.me.sure.e.t of ambie.t air NO2 via photolytic conve.sion and quantification of NO

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Journal of e.vironme.tal Scie.ce. 2021年第9期33卷 184-193页

作者： nicholas J.Ginge.ysty Charle. A.Odame.Ankrah Nick Jordan Hans d.Osthoff de.artme.t of Che.istry University of CalgaryCalgary AB T2N 1N4Canada Global Analyze. Syste.s Ltd. Calgary AB T2E 7L6Canada

The.re.e.e.ce.me.hod to quantify mixing ratios of the.crite.ia air pollutant nitroge. dioxide.NO_(2)) is NO-O_(3) che.ilumine.ce.ce.CL), in which mixing ratios of nitric oxide.NO) are.me.sure. by sampling ambie.t air dire.tly, and mixing ratios of NO_(x)(= sum of NO and NO_(2))are.me.sure. by conve.ting NO_(2) to NO using, for e.ample. he.te. molybde.um catalyst or,more.se.e.tive.y, photolytic conve.sion(P-CL).In this work, the.nitrous acid(HONO) inte.fe.e.ce.in the.me.sure.e.t of NO_(2) by P-CL was *** with two photolytic NO2 conve.te.s are.*** first use. radiation ce.te.e. at 395 nm, a wave.e.gth re.ion commonly utilize. in *** se.ond use. light at 415 nm, whe.e.the.ove.lap with the.HONO absorption spe.trum and he.ce.its photolysis rate.are.*** ratios of NO_(2),NO_(x) and HONO e.te.ing and e.iting the.conve.te.s we.e.quantifie. by The.mal dissociation Cavity Ring-down Spe.troscopy(Td-CRdS).Both conve.te.s e.hibite. high NO_(2) conve.sion e.ficie.cy(CF_(NO2);> 90%) and partial conve.sion of *** of CF against flow rate.we.e.consiste.t with photolysis fre.ue.cie. of 4.2 s^(-1) and 2.9 s^(-1) for NO_(2) and 0.25 s^(-1) and 0.10 s^(-1) for HONO at 395 nm and 415 nm, *** large. than pre.icte. from the.ove.lap of the.e.ission and HONO absorption *** re.ults imply that me.sure.e.ts of NO2 by P-CL marginally but syste.atically ove.e.timate.true.NO_(2) conce.trations,and that this inte.fe.e.ce.should be.conside.e. in e.vironme.ts with high HONO:NO_(2) ratios such as the.marine.boundary laye. or in biomass burning plume..

关键词： Photolytic conve.sion of NO_(2) HONO inte.fe.e.ce

Nitric oxide.activation of a potassium channe. (BK_(Ca)) in fe.ine.lowe. e.ophage.l sphincte.

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World Journal of Gastroe.te.ology 2010年第46期16卷 5852-5860页

作者： Marie.Claude.L'He.re.x Ahmad Muinuddin He.be.t Y Gaisano nicholas e.diamant de.artme.t of Physiology University of Toronto Ahmad Muinuddin Nicholas E DiamantToronto Western Research InstituteUniversity Health Network de.artme.t of Me.icine University of Toronto

AIM:To asse.s the.e.fe.t of nitric oxide.(NO) on the.large.conductance.potassium channe. (BKCa) in isolate. circular (CM) and sling (SM) muscle.ce.ls and muscle.strips from the.cat lowe. e.ophage.l sphincte. (Le.) to de.e.mine.its re.ulation of re.ting tone.and ***:Fre.hly e.zymatically-dige.te. and isolate. circular smooth muscle.ce.ls we.e.pre.are. from e.ch Le. *** study outward K + curre.ts,the.pe.forate. patch clamp te.hnique.was *** asse.s Le. re.ting tone.and re.axation,muscle.strips we.e.mounte. in pe.fuse. organ ***:(1) e.e.trophysiological re.ordings from isolate. ce.ls:(a) CM was more.de.olarize. than SM (-39.7 ± 0.8mV vs-48.1 ± 1.6 mV,P d maximal outward curre.t was similar (27.1 ± 1.5 pA/pF vs 25.7 ± 2.0 pA/pF,P > 0.05);(b) The.NO donor sodium nitroprusside.(SNP) incre.se. outward curre.ts only in CM (25.9 ± 1.9 to 46.7 ± 4.2 pA/pF,P 0.05);(c) SNP adde. in the.pre.e.ce.of the.BK Ca antagonist ibe.iotoxin (IbTX) produce. no incre.se.in the.outward curre.t in CM (17.0 ± 2.8 vs 13.7 ± 2.2,P > 0.05);and (d) L-NNA cause. a small insignificant inhibition of outward K + curre.ts in both muscle.;and (2) Muscle.strip studie.:(a) Blockade.of the.ne.ve. with te.rodotoxin (TTX),or BK Ca with IbTX had no significant e.fe.t on re.ting tone.of e.the. muscle.and (b) SNP re.uce. tone.in both muscle.,and was unaffe.te. by the.pre.e.ce.of TTX or ***:e.oge.ous NO activate. BK Ca only in CM of the.***,as oppose. to othe. spe.ie.,e.oge.ous NO-induce. re.axation is pre.ominantly by a non-BK Ca me.hanism,and e.doge.ous NO has minimal e.fe.t on re.ting tone.

关键词： Circular smooth muscle Fe.ine K+ channe. Lowe. e.ophage.l sphincte. Nitric oxide Sling Tone

Re.e.aluating the.importance.of carbohydrate. as re.e.e.ative.biomate.ials

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Re.e.e.ative.Biomate.ials 2019年第1期6卷 1-12页

作者： He.di F.Olde.kamp Julia e.Ve.a Ramire. nicholas A.Pe.pas Institute.for Biomate.ials Drug Deliveryand Regenerative Medicine McKe.ta de.artme.t of Che.ical e.gine.ring de.artme.t of Biome.ical e.gine.ring de.artme.t of Pe.iatrics Dell Medical School de.artme.t of Surge.y and Pe.iope.ative.Care Dell Medical School division of Mole.ular Pharmace.tics and drug de.ive.y College of PharmacyThe University of Texas at AustinAustinTX 78712USA

Introduction Carbohydrate. are.the.most abundant natural biomate.ials in the.*** inte.acting with ce.ls of a varie.y of le.e.s,the. take.part in e.se.tial functions of organisms including ce.lular communication,inflammation,infe.tion de.e.opme.t and *** carbohydrate.ce.l inte.actions occur on a varie.y of le.e.s through glycoconjugate. such as glycolipids,glycosaminoglycans(GAGs),glycoprote.ns and prote.glycans[1–4].The.role. of carbohydrate. in biological syste.s pose.the. as some.of the.most sought-afte. *** use.of the.e.multiface.e. mole.ule. provide. the.opportunity to tailor de.ire. re.ponse. de.e.ding on the.targe. application[1–5].

关键词： carbohydrate re.e.e.ative.biomate.ials polysaccharide tissue.e.gine.ring

Orofacial Cle.ts in High Pre.ale.ce.Are. of Birth de.e.ts—Five.Countie.,Shanxi Province.China,2000–2020

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China CdC we.kly 2021年第37期3卷 773-777页

作者： Jufe. Liu Yali Zhang Le.Zhang Linlin Wang Le. Jin nicholas d e.Gre.ne.Zhiwe. Li Aiguo Re. Institute.of Re.roductive.and Child He.lth/Ke. Laboratory of Re.roductive.He.lth National Health Commission of the People’s Republic of ChinaPeking UniversityBeijingChina de.artme.t of e.ide.iology and Biostatistics School of Public HealthPeking UniversityBeijingChina UCL Gre.t Ormond Stre.t Institute.of Child He.lth University College LondonLondonUK.

Summary What is alre.dy known on this topic?The.pre.ale.ce.of structural birth de.e.ts,e.pe.ially ne.ral tube.de.e.ts,de.re.se. afte. national folic acid(FA)supple.e.tation *** is adde. by this re.ort?The.pre.ale.ce.of orofacial cle.ts(OFCs)in five.countie. of Shanxi Province.in northe.n China,including most subtype. e.ce.t cle.t palate.showe. a downward tre.d in the.past two *** this study,pre.pe.inatal pre.ale.ce.incre.se. due.to e.rlie. de.e.tion.

关键词： Shanxi de.e.ts downward

Groupoid Approach to e.godic dynamical Syste. of Commutative.von Ne.mann Alge.ra

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Advance. in Pure.Mathe.atics 2024年第3期14卷 167-184页

作者： nicholas O. Oke.e.Murphy e. e.we Physical and Mathe.atical Scie.ce. Dominican University Ibadan Nigeria de.artme.t of Mathe.atics University of Ibadan Ibadan Nigeria

Give. a compact and re.ular Hausdorff me.sure.space.(X, μ), with μ a Radon me.sure. it is known that the.ge.e.alise. space.M(X) of all the.positive.Radon me.sure. on X is isomorphic to the.space.of e.se.tially bounde. functions L∞(X, μ) on X. We.confirm that the.commutative.von Ne.mann alge.ras M⊂B(H), with H=L2(X, μ), are.unitary e.uivariant to the.maximal ide.ls of the.commutative.alge.ra C(X). Subse.ue.ly, we.use.the.me.sure.groupoid to formulate.the.alge.raic and topological structure. of the.commutative.alge.ra C(X) following its action on M(X) and de.ine.its re.re.e.tation and e.godic dynamical syste. on the.commutative.von Ne.mann alge.ras of M of B(H) .

关键词： Me.sure.Groupoid Groupoid e.uivale.ce e.godic Action Convolution Alge.ra von Ne.mann Alge.ra Ge.e.alize. Space

Murine.study of portal hype.te.sion associate. e.dothe.in-1 hypo-re.ponse

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World Journal of Gastroe.te.ology 2015年第16期21卷 4817-4828页

作者： nicholas The.dorakis Mary Maluccio nicholas Skill de.artme.t of Surge.y Division of Transplant SurgeryIndiana School of MedicineIndiana University

AIM:To inve.tigate.e.dothe.in-1 hypo-re.ponsive.associate. with portal hype.te.sion in orde. to improve.patie.t tre.tme.t ***:Wild type.e.NOS-/-and i NOS-/-mice.re.e.ve.partial portal ve.n ligation surge.y to induce.portal hype.te.sion or sham *** of portal hype.te.sion was de.e.mine. by me.suring the.sple.ic pulp pre.sure.abdominal aortic flow and portal syste.ic *** me.sure.sple.ic pulp pre.sure.a microtip pre.sure.transduce. was inse.te. into the.sple.n *** aortic flow was me.sure. by placing an ultrasonic dopple. flow probe.around the.abdominal aorta be.we.n the.diaphragm and ce.iac *** syste.ic shunting was calculate. by inje.tion of fluore.ce.t microsphe.e. in to the.sple.ic ve.n and de.e.mining the.pe.ce.tage.accumulation of sphe.e. in live. and pulmonary ***-1 hypo-re.ponse.was e.aluate. by me.suring the.change.in abdominal aortic flow in re.ponse.to e.dothe.in-1 intrave.ous *** addition,thoracic aorta e.dothe.in-1contraction was me.sure. in 5 mm isolate. thoracic aorta rings e.-vivo using an AdI small ve.se. ***:In wild type.and i NOS-/-mice.sple.ic pulp pre.sure.incre.se. from 7.5±1.1 mm Hg and 7.2±1 mm Hg to 25.4±3.1 mm Hg and 22±4 mm Hg *** e.NOS-/-mice.sple.ic pulp pre.sure.was incre.se. afte. 1 d(P=NS),afte. which it de.re.se. and by 7 d was not significantly e.e.ate. whe. compare. to 7 d sham ope.ate. controls(6.9±0.6 mm Hg and 7.3±0.8 mm Hg re.pe.tive.y,P=0.3).Abdominal aortic flow was incre.se. by 80%and 73%in 7 d portal ve.n ligate. wild type.and i NOS whe. compare. to shams,whe.e.s the.e.was no significant diffe.e.ce.in 7 d portal ve.n ligate. e.NOS-/-mice.whe. compare. to ***-1 induce. a rapid re.uction in abdominal aortic blood flow in wild type.e.NOS-/-and i NOS-/-sham mice.50%±8%,73%±9%and 47%±9%re.pe.tive.y).Following portal ve.n ligation e.dothe.in-1 re.uction in blood flow was significantly diminishe. in e.ch mouse.group

关键词： Live. dise.se Portal hype.te.sion Hype.dynamiccirculation e.dothe.in-1 Nitric oxide synthase.soforms

Longitudinal bicyclist,drive.,and pe.e.trian pe.ce.tions of autonomous ve.icle.communication strate.ie.

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Journal of Traffic and Transportation e.gine.ring(e.glish e.ition) 2023年第1期10卷 31-44页

作者： nicholas N.Fe.e.chak de.artme.t of Civil Construction&Environmental EngineeringUniversity of New MexicoAlbuquerqueNM 87131USA

We.sought to be.te. unde.stand how autonomous ve.icle.AV)communication strate.ie. impact human road use.s’*** spe.ifically,we.e.plore. the.impact of diffe.e.t e.te.nal human-machine.inte.face.e.MI)de.igns on task load,comfort,trust,and *** accomplish this,we.cre.te. virtual re.lity(VR)sce.arios whe.e.human participants inte.acte. with AVs in biking,driving,and pe.e.trian *** we.e.brought back afte. initial te.ting to e.plore.acclimation and le.rning *** de.igns include. a te.t-base. grille.e.MI,a te.t-base. roof e.MI,a te.t-base. drive.-side.door e.MI,anon-te.tual Le. windshie.d strip e.MI,and a non-te.tual side.mirror arrow *** pre.e.ce.of an e.MI was the.stronge.t positive.pre.ictor of comfort,trust,and acce.tance.outcome. in the.statistical mode.s whe. controlling for all othe. *** was a cle.r divide.be.we.n te.t-base. e.MIs and non-te.t e.MIs with te.t-base. e.MIs e.pe.ie.cing be.te. pe.ce.tion *** Le. Windshie.d e.pe.ie.ce. the.worst pe.ce.tion *** we.e.pe.ce.tion acclimation e.fe.ts de.e.te. which we.e.most notable.for task load(which de.re.se. ove. time.and comfort(which incre.se. ove. time..Pe.ce.tion score. for the.diffe.e.t e.MI de.igns te.de. to cluste. ove. ***,the.acclimation e.fe.ts had le.s of an impact than the.pre.e.ce.of an *** outcome. had we.ke. re.ationships with participant characte.istics than with AV *** sugge.t that e.MI pre.e.ce.and de.ign,AV be.avior,and acclimation are.most impactful in te.ms of pe.ce.tions.

关键词： Ve.icle.automation Communication Human-automation inte.action Te.hnology acce.tance Virtual re.lity

An Algorithm for the.Re.onstruction of e.trance.Be.m Flue.ce.from Virtual Patie.t e.it e.e.tronic Portal Image.

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Inte.national Journal of Me.ical Physics, Clinical e.gine.ring and Radiation Oncology 2015年第2期4卷 177-183页

作者： nicholas N. Spe.ling e. Ishmae. Parsai de.artme.t of Radiation Oncology University of Toledo Medical Center Toledo USA

The.proble. of de.e.mining the.in vivo dosime.ry for patie.ts unde.going radiation tre.tme.t has be.n an are. of inte.e.t since.the.de.e.opme.t of the.fie.d. More.re.e.t me.hods of me.sure.e.t e.ploy e.e.tronic Portal Image.de.ice. (e.Id), or dosime.e. arrays, for e.trance.or e.it flue.ce.de.e.mination. The.more.re.e.t me.hods of in vivo dosime.ry make.use.of de.e.tor arrays and re.onstruction te.hnique. to de.e.mine.dose.throughout the.patie.t volume. One.me.hod use. an array of ion chambe.s locate. upstre.m of the.patie.t. This re.uire. a spe.ial hardware.de.ice.and place. an additional atte.uator in the.be.m path, which may not be.de.irable. An alte.native.to this approach is to use.the.e.isting e.Id, which is part of most mode.n line.r acce.e.ators, to image.the.patie.t using the.tre.tme.t be.m. Me.hods e.ist to de.onvolve.the.de.e.tor function of the.e.Id using a se.ie. of we.ghte. e.pone.tials [1]. Additionally, this me.hod has be.n e.te.de. to the.de.onvolution of the.patie.t scatte. in orde. to de.e.mine.in vivo dosime.ry. The.me.hod de.e.ope. he.e.inte.ds to use.e.Id image. and an ite.ative.de.onvolution algorithm to re.onstruct the.impinging primary flue.ce.on the.patie.t. This primary flue.ce.may the. be.e.ploye., using tre.tme.t time.volume.ric imaging, to de.e.mine.dose.through the.e.tire.patie.t volume. Pre.e.te. in this pape. is the.initial discussion of the.algorithm, and a the.re.ical e.aluation of its e.ficacy using monte.arlo de.ive. virtual flue.ce.me.sure.e.ts. The.re.ults pre.e.te. he.e.indicate.an agre.me.t of 1% dose.diffe.e.ce.within 95% the.fie.d are. re.e.ving 10% of the.e.trance.flue.ce.for a se. of sample.highly modulate. fie.ds. The.e.re.ults warrant continue. inve.tigation in applying this algorithm to clinical patie.t tre.tme.ts.

关键词： Be.m Flue.ce e.Id Image. In-Vivo dosime.ry Monte Carlo Algorithm dose Re.onstruction

dise.se.spe.trum and use.of chole.ystolithotomy in gallstone.ile.s

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He.atobiliary & Pancre.tic dise.se. Inte.national 2012年第5期11卷 553-557页

作者： nicholas e.Williams Justin S Gundara Sophia Rose. Jaswinde. S Samra Uppe. Gastrointe.tinal Surgical Unit Royal North Shore HospitalUniversity of SydneySt.LeonardsSydneyNSW 2065Australia

BACKGROUNd: Gallstone.ile.s is a he.e.oge.e.us and highly morbid condition that suffe.s from a lack of conse.sus re.arding the.timing and approach to manage.e.t of the.biliary tre. and associate. fistula. Me.HOdS: We.re.ort thre. case. that de.onstrate.the.spe.trum of gallstone.ile.s with classical e.ample. of both Barnard’s and Bouve.e.’s syndrome.. Clinical pre.e.tation diagnostic imaging, surgical te.hnique.and outcome.are.discusse.. Re.ULTS: One.patie.t with Barnard’s syndrome.pre.e.te. with re.urre.t gallstone.ile.s. To minimize.the.risks of comple., de.initive.biliary surge.y and avoid furthe. re.urre.t e.isode., a chole.ystolithotomy was pe.forme. with e.fe.t Two case. of Bouve.e.’s syndrome.we.e.succe.sfully manage. with e.te.olithotomy/chole.yste.tomy and multivisce.al re.e.tion re.pe.tive.y, thus highlighting the.dive.se.nature.of this dise.se.and manage.e.t options. CONCLUSIONS: Following e.te.olithotomy, pote.tially morbid de.initive.one.stage.surge.y in typically compromise., e.de.ly patie.ts ne.ds to be.we.ghe. against the.risk of re.urre.ce.and ongoing biliary pathology. We.sugge.t the.use.of ope. chole.ystolithotomy for the.re.oval of re.idual gallstone. whe. the.patie.t is not suitable.for de.initive.biliary surge.y.

关键词： chole.yste.tomy biliary tract dise.se gallstone.ile.s biliary tract surge.y