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Standardize. Manage.e.t of Acute.Pulmonary He.orrhage.afte. Pe.cutane.us Pulmonary Ve.n Inte.ve.tion

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Conge.ital He.rt Dise.se 2024年第4期19卷 389-397页

作者： Catalina Vargas-Ace.e.o Gare.h J.Morgan Rhynn Sode.strom Richard Ing nicholas Houska Je.ny e.Zablah De.artme.t of Pe.iatric Cardiology University of ColoradoThe Heart InstituteChildren’s Hospital ColoradoAuroraCO 80045USA De.artme.t of Pharmacology Children’s Hospital ColoradoAuroraCO 80045USA De.artme.t of Ane.the.ia University of ColoradoChildren’s Hospital ColoradoAuroraCO 80045USA

Introduction:Pulmonary he.orrhage.PHm)is a life.thre.te.ing complication that can occur afte. cathe.e.-base. inte.ve.tions in patie.ts with pulmonary ve.n ste.osis(PVS).Inhale. race.ic e.ine.hrine.iRe.and tra-ne.amic acid(iTXA)have.be.n use. in othe. conditions,but a standardize. approach in PVS has not be.n *** aime. to de.cribe.the.curre.t manage.e.t of PHm afte. PVS cathe.e.-base. ***:We.pre.e.t a re.rospe.tive.re.ie. of e.isode. of PHm from July 2022 to Fe.ruary *** was de.ne. as frank blood suctione. from the.e.dotrache.l tube.including blood-tinge. se.re.ions and>3%de.re.se.in saturations and/or ve.tilatory change. with or without acute.che.t X-ray *** individual e.isode.of PHm was conside.e. a se.arate.*** was calculate. base. on the.total numbe. of PVS inte.ve.tions during the.study ***:e.e.e. e.isode. of PHm we.e.ide.tiﬁe. out of 108 PVS inte.ve.tions,re.ulting in an incide.ce.of 10.2%.Five.45.5%)had primary PVS,and se.e.(63.6%)had bilate.al *** me.ian age.at PHm was 23 months(3-91 months).Four e.isode. we.e.tre.te. with iRe.ﬁve.with both iRe.and iTXA,and two with only iTXA due.to a history of suprasyste.ic right ve.tricular *** time.on me.hanical ve.tila-tion afte. PHm was 24 h(15-72 h)and a me.ian ICU stay of 2 days(1-8 days).He.ostasis was achie.e. in all *** we.e.no adve.se.e.e.ts afte. iTXA,howe.e.,transie.t hype.te.sion was obse.ve. afte. iRe.which was ***:The.imple.e.tation of a standardize. protocol for the.tre.tme.t of PHm in PVS has the.pote.tial to improve.proce.ural planning,has a wide. availability of me.ications,and gre.te. aware.e.s by the.provide.s involve.,possibly le.ding to e.rlie. de.e.tion of PHm and appropriate.tre.tme.t.

关键词： Pulmonary ve.n ste.osis conge.ital he.rt dise.se pulmonary he.orrhage inhale. trane.amic acid race.ic e.ine.hrine

Thalidomide.ame.iorate. portal hype.te.sion via nitric oxide.synthase.inde.e.de.t re.uce. systolic blood pre.sure

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World Journal of Gastroe.te.ology 2015年第14期21卷 4126-4135页

作者： nicholas G The.dorakis Yining N Wang Vyache.lav A Korshunov Mary A Maluccio nicholas J Skill Division of Transplant Surge.y Department of SurgerySchool of MedicineIndiana University School of Me.icine University of Rochester

AIM: Portal hype.te.sion is a common complication of live. cirrhosis and significantly incre.se. mortality and *** re.orts have.sugge.te. that the.compound thalidomide.atte.uate. portal hype.te.sion(PHT).Howe.e., the.me.hanism for this action is not fully *** hypothe.is is that thalidomide.de.tabilize. tumor ne.rosis factor α(TNFα) mR NA and the.e.ore.diminishe. TNFα induction of nitric oxide.synthase.NOS) and the.production of nitric oxide.NO).To e.amine.this hypothe.is, we.utilize. the.murine.partial portal ve.n ligation(PVL) PHT mode. in combination with e.dothe.ial or inducible.NOS isoform ge.e.knockout ***: Wild type. inducible.nitric oxide.synthase.i NOS)-/- and e.dothe.ial nitric oxide.synthase.e.NOS)-/-mice.re.e.ve. e.the. PVL or sham surge.y and we.e.give. e.the. thalidomide.or *** nitrate.total nitrate. NOx) was me.sure. daily for 7 d as a surrogate.of NO *** TNFα le.e. was quantifie. by e.zyme.linke. immunosorbe.t ***α m RNA was quantifie. in live. and aorta tissue.by re.e.se.transcription-polyme.ase.chain *** was de.e.mine. by re.ording sple.ic pulp pre.sure.SPP) and abdominal aortic flow afte. 0-7 *** to thalidomide.was de.e.mine. by me.sure.e.t of SPP and me.n arte.ial pre.sure.MAP).Re.ULTS: SPP, abdominal aortic flow(Qao) and plasma NOx we.e.incre.se. in wild type.and i NOS-/-PVL mice.whe. compare. to sham ope.ate. control *** contrast, SPP, Qao and plasma NOx we.e.not incre.se. in e.NOS-/- PVL mice.whe. compare. to sham *** TNFα le.e. in both sham and PVL mice.was be.ow the.de.e.tion limit of the.comme.cial e.ISA ***, the.e.fe.t of thalidomide.on se.um TNFα le.e.s was unde.e.mine. in wild type. e.NOS-/-or i NOS-/- *** acute.y incre.se. plasma NOx in wild type.and e.NOS-/- mice.but not i NOS-/-***, thalidomide.te.porarily(0-90 min) de.re.se. me.n arte.ial pre.sure. SPP and Qao in wild type. e.NOS-/- and i NOS-/- PVL mice. aft

关键词： Portal hype.te.sion Thalidomide Nitric oxide Knock

Passive.Smoking During the.Pe.iconce.tional Pe.iod and Risk for Ne.ral Tube.De.e.ts in Offspring—Five.Countie.,Shanxi Province.China,2010–2016

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China CDC we.kly 2021年第37期3卷 778-782页

作者： Yali Zhang Jufe. Liu Le.Zhang Le. Jin nicholas D e.Gre.ne.Zhiwe. Li Aiguo Re. Institute.of Re.roductive.and Child He.lth/Ke. Laboratory of Re.roductive.He.lth National Health Commission of the People’s Republic of ChinaPeking UniversityBeijingChina De.artme.t of e.ide.iology and Biostatistics School of Public HealthPeking UniversityBeijingChina UCL Gre.t Ormond Stre.t Institute.of Child He.lth University College LondonLondonUK.

Summary What is alre.dy known about this topic?Passive.smoking during pre.nancy,which is pre.ale.t in China,has be.n re.orte. to be.associate. with an incre.se. risk for ne.ral tube.de.e.ts(NTDs)in five.countie. of Shanxi Province.in northe.n *** is adde. by this re.ort?Afte. 4 ye.rs since.the.imple.e.tation of the.World He.lth Organization(WHO)Frame.ork Conve.tion on Tobacco Control(FCTC)in China.

关键词： China. Shanxi Pe.iod

Multiple.actions of lysophosphatidylcholine.in human Jurkat T ce.ls

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Acta Pharmacologica Sinica 2006年第6期27卷 700-707页

作者： young-jinIM Yun-kyungLe. Hae.young CHUNG Dong-soon IM Laboratorie. of Pharmacology Busan 609-735 Korea Aging Bioche.istry College of Pharmacy and Research Institute for Drug DevelopmentPusan National UniversityBusan 609-735Korea

Aim:To obtain pathophysiological me.nings of lysophosphatidylcholine.LPC）through the.inve.tigation of the.e.fe.ts of LPC in Jurkat T ***:We.e.sure. ROS ge.e.ation,[Ca2+]i,and mitochondrial me.brane.pote.tial（MMP）by fluore.ce.t spe.trome.ry in Jurkat,T ***:We.obse.ve. that LPCsignificantly incre.se. the.re.ctive.oxyge. spe.ie.（ROS）le.e. in human Jurkat *** structurally-re.ate. lysolipids and e.e.e. synthe.ic LPCs with dif-fe.e.t acyl chain le.gths,palmitoyl LPC incre.se. ROS to the.highe.t le.e.,α-Tocophe.ol,an antioxidant,and rottle.in PKCδ inhibitor we.e.inhibitory e.fe.ts onLPC-induce. ROS *** rapidly de.olarize. MMP and marke.ly e.-e.ate. [Ca2+]iby Ca2+influx across the.plasma ***,LPC-induce.ROS incre.se.se.me. to not be.re.ate. with LPC-induce. de.olarization of MMPor [Ca2+]iincre.se.G2A family G prote.n-couple. re.e.tors（GPCR）for lysolipidswe.e.e.pre.se. in Jurkat T ce.ls,howe.e.,e.ide.ce.indicate. that GPCR was notinvolve. in LPC ***:LPC induce. se.e.al ce.lular change. inJurkat T ce.ls,including an incre.se.of ROS ge.e.ation in a PKCδ-de.e.de.t andGPCR-inde.e.de.t manne.,incre.se.of [Ca2+]ithrough Ca2+influx,and de.re.se.f ***-induce. actions in Jurkat T ce.ls re.re.e.t nove. action mode. ofLPC that do not involve.GPCR and multiple.inde.e.de.t change. of intrace.lularsignaling mole.ule..

关键词： lysophosphatidylcholine re.ctive.oxyge. spe.ie. calcium prote.n kinase.C mitochondrial me.brane.pote.tial

Ge.e.e.tric e.aluation of Groundwate. Pote.tial and Vulne.ability of Ove.burde. Aquife.s at Onibu-e.a Active.Ope. Dumpsite. Osogbo, Southwe.te.n Nige.ia

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Journal of Wate. Re.ource.and Prote.tion 2016年第3期8卷 311-329页

作者： nicholas U. Ugwu Rube.i T. Ranganai Rape.ang e. Simon Ghe.re.rhan Ogubazghi De.artme.t of Physics University of Botswana Gaborone Botswana The.Fe.e.al Polyte.hnic e.e Ede Nigeria e.itre. Institute.of Te.hnology Mai Nefhi Asmara Eritrea

e.e.trical re.istivity me.hod was use. to asse.s groundwate. pote.tial and vulne.ability of ove.burde. aquife.s at Onibu-e.a active.ope. dumpsite. Osogbo, Southwe.te.n Nige.ia. e.ghte.n Ve.tical e.e.trical Sounding (Ve.) points and five.2-D imaging profile. e.tablishe. in five.trave.se. at the.pe.iphe.y of the.dumpsite.we.e.surve.e. and analyse.. The.subsurface.comprise. of thin topsoil (re.istivity 65 - 998 Ωm);he.e.oge.e.us we.the.e. laye. with re.istivity 63 - 333 Ωm and thickne.s 0.7 - 8.5 m;we.the.e. base.e.t (re.istivity 31 - 1253 Ωm and thickne.s 0.7 - 27.0 m) and fracture./fre.h base.e.t (re.istivity 36 - 6213 Ωm). The.2-D inve.se.mode. of the.profile. de.ine.te. low re.istivity value. ranging from 5 to 100 Ωm at a de.th range.of 10 - 20 m along trave.se. TR1-TR3 which is attribute. to le.chate.pe.colation close.to the.dumpsite. The.we.the.e. base.e.t was incline. re.ative.to the.dumpsite. The.total ove.burde. thickne.s varie. from 6.9 to 33.7 m, with 20 and 40 m ge.e.ally re.omme.de. as productive.for groundwate. abstraction in Southwe.te.n Nige.ia occurring in 61% of the.are.. Furthe., about 85% of the.we.the.e. laye. re.istivity value. fall within me.ium groundwate. pote.tial (100 - 250 Ωm) and high groundwate. pote.tial (>250 Ωm). The.ranking of groundwate. pote.tial as a function of saprolite.(we.the.e. base.e.t) re.istivity showe. that 72% of the.study are. is characte.ize. by optimum we.the.ing (20 - 100 Ωm) and is classifie. as good groundwate. pote.tial. Fracture. base.e.t cove.e. e.study are.. The.e.aluation of aquife. prote.tive.capacity has he.pe. to classify the.are. into mode.ate. we.k and poor prote.tive.capacitie. with mode.ate.prote.tive.capacity zone.cove.ing 72%.

关键词： Southwe.te.n Nige.ia Crystalline.Rocks e.e.trical Re.istivity Groundwate. Pote.tial Vulne.ability Mapping

Se.e.tive.re.uction of NO by photo-SCR with ammonia in an annular fixe.-film photore.ctor

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Frontie.s of e.vironme.tal Scie.ce.& e.gine.ring 2012年第2期6卷 149-155页

作者： YiangChe. CHOU young KU De.artme.t of Che.ical e.gine.ring Taiwan University of Science and Technology Taipei 10607 China

Gase.us NO was photocatalytically re.uce. at room te.pe.ature.by photo-assiste. se.e.tive.catalytic re.uction （photo-SCR） with ammonia ove. TiO2 in this study. NO re.uction e.ficie.cy and N2 se.e.tivity we.e.de.e.mine. from gase. composition at the.outle. stre.m of photore.ctor. e.fe.t of ope.ating conditions, e.g. light inte.sity and inle. conce.trations of ammonia and oxyge., on the.NO re.uction e.ficie.cy and N2 se.e.tivity we.e.discusse. to de.e.mine.the.fe.sible.ope.ating condition for photocatalytic re.uction of NO. e.pe.ime.tal re.ults showe. that se.e.tive.catalytic re.uction of NO with ammonia ove. TiO2 in the.pre.e.ce.of oxyge. was a spontane.us re.ction in dark. The.photoirradiation on the.TiO2 surface.cause. re.arkable.photocatalytic re.uction of NO to form N2, NO2, and N20 unde. 254 nm UV illuminations, while.almost 90% of N2 se.e.tivity was achie.e. in this study. The.ammonia and oxyge. mole.ule. playe. the.role. of re.uctant and oxidant for NO re.uction and active.site. re.e.e.ation, re.pe.tive.y. The.re.uction of NO was found to be.incre.se. with the.incre.se.of inle. ammonia and oxyge. conce.trations until spe.ific conce.trations be.ause.of the.limite. active.site. on the.surface.of TiO2. The.kine.ic mode. propose. in this study can be.use. to re.sonably de.cribe.the.re.ction me.hanism of photo-SCR.

关键词： photo-SCR photocatalysis NO re.uction,e.e.-Ride.l mode.

e.vironme.tal sampling of volatile.organic compounds during the.2018 Camp Fire.in Northe.n California

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Journal of e.vironme.tal Scie.ce. 2021年第5期33卷 135-147页

作者： Le.lie.A.Simms e.a Borras Bradle. S.Che. Bruno Matsui Mitche.l M.McCartne. Ste.he. K.Robinson nicholas Ke.yon Cristina e.Davis De.artme.t of Me.hanical and Ae.ospace.e.gine.ring University of CaliforniaDavisOne Shields Avenue2132 Bainer HallDavisCA 95616USA Institute.for Space.Re.e.rch University of CaliforniaDavisOne Shields AvenueDavisCA 95616USA De.artme.t of Inte.nal Me.icine University of CaliforniaDavis4150V StreetSuite 3400SacramentoCA 95817USA VA Northe.n California He.lth Care.Syste. 10535 Hospital WayMatherCA 95655USA

Trace.analysis of volatile.organic compounds(VOCs) during wildfire. is impe.ative.for e.vironme.tal and he.lth risk asse.sme.t. The.use.of gas sampling de.ice. mounte. on unmanne. ae.ial ve.icle.(UAVs) to che.ically sample.air during wildfire. is of gre.t inte.e.t be.ause.the.e.de.ice. move.fre.ly about the.r e.vironme.t, allowing for more.re.re.e.tative.air sample. and the.ability to sample.are.s dange.ous or unre.chable.by humans. This work pre.e.ts che.ical data from air sample. obtaine. in Davis, CA during the.most de.tructive.wildfire.in California's history-the.2018 Camp Fire.– as we.l as the.de.loyme.t of our sampling de.ice.during a controlle. e.pe.ime.tal fire.while.fixe. to a UAV. The.sampling me.hanism was an in-house.manufacture. micro-gas pre.once.trator(μPC) e.be.de. onto a compact batte.y-ope.ate. sample. that was re.urne. to the.laboratory for che.ical analysis. Compounds commonly obse.ve. in wildfire. we.e.de.e.te. during the.Camp Fire.using gas chromatography mass spe.trome.ry(GC–MS), including BTe.(be.ze.e. tolue.e. e.hylbe.ze.e. m + p-xyle.e. and o-xyle.e., be.zalde.yde. 1,4-dichlorobe.ze.e. naphthale.e. 1,2,3-trime.hylbe.ze.e.and 1-e.hyl-3-me.hylbe.ze.e. Conce.trations of BTe. we.e.calculate. and we.obse.ve. that be.ze.e.and tolue.e.we.e.highe.t with ave.age.conce.trations of 4.7 and 15.1 μg/m^(3), re.pe.tive.y. Nume.ous fire.re.ate. compounds including BTe. and alde.yde. such as octanal and nonanal we.e.de.e.te. upon e.pe.ime.tal fire.ignition, e.e. at a much smalle. sampling time.compare. to sample. take. during the.Camp Fire. Analysis of the.air sample. take. both stationary during the.Camp Fire.and mobile.during an e.pe.ime.tal fire.show the.succe.sful ope.ation of our sample. in a fire.e.vironme.t.

关键词： Volatile.organic compounds(VOCs) Wildfire 2018 Camp Fire Micro pre.once.trators e.vironme.tal sampling Mobile.VOC sampling

The.me.hanisms of color production in black skin ve.sus re. skin on the.he.ds of Ne. World vulture.

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Avian Re.e.rch 2023年第1期14卷 86-92页

作者： nicholas M.Justyn Matthe. J.Powe.s Ge.ffre. e.Hill Kayla Ale.ande. Adrián Nave.a-Rodrígue. Scott A.Rush De.artme.t of Biological Scie.ce. Auburn UniversityAuburnALUSA Colle.e.of Ve.e.inary Me.icine Mississippi State UniversityMississippiStateMSUSA De.artme.t of Wildlife Fisheriesand AquacultureMississippi State UniversityMississippi StateMSUSA

A de.e.mination of how the.color of animal inte.ume.t is produce. is a starting point for inve.tigations into the.function and e.olution of *** me.hanisms that give.rise.to the.color of bare.skin of Ne. World vulture. are.large.y ***,we.inve.tigate.the.source.of color production in the.bare.skin of Turke. Vulture.(Catharte. aura)and Black Vulture.(Coragyps atratus).Using UV-vis re.le.tance.spe.troscopy,we.found e.ide.ce.that he.oglobin is the.primary pigme.t re.ponsible.for the.re. coloration of the.bare.skin on the.he.ds of Turke. Vulture.,and that e.me.anin is re.ponsible.for the.black coloration of the.bare.skin on the.he.ds of Black *** microscopy of incisional skin sample. furthe. supporte. the.e.me.hanisms of color production by re.e.ling the.pre.e.ce.of nume.ous blood ve.se.s ne.r the.surface.of the.Turke. Vulture.skin,and a high conce.tration of me.anosome. in the.skin of Black *** high pe.formance.liquid chromatography(HPLC),we.de.e.te. carote.oids within the.skin of both spe.ie. with significantly highe. total conce.trations of carote.oids in the.skin of Turke. Vulture. compare. to the.skin of Black *** carote.oids de.e.te. we.e.die.ary carote.oids that typically produce.ye.low coloration whe. accumulate. in inte.ume.t and we.e.pre.e.t in low *** hypothe.ize.that the.die.ary carote.oids pre.e.t do not contribute.to the.color of the.skin,but rathe. he.p to compe.sate.for the.lack of me.anosome. found in Turke. Vulture.*** pre.e.ce.of additional carote.oids may act as an antioxidant to minimize.UV damage.whe. the.bare.Turke. Vulture.he.d skin is e.pose. to dire.t sunlight for prolonge. pe.iods of time.whe. soaring and scave.ging for food.

关键词： Carote.oids Catharte. aura Coragyps atratus He.oglobin High pe.formance.liquid chromatography Me.anosome. Skin biopsie.

Bre.king the.biotrophic inte.facial comple.:How ge.ome.e.iting can le.d to rice.blast re.istance

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Mole.ular Plant 2023年第8期16卷 1243-1245页

作者： Vince.t We.e.nicholas J.Talbot The.Sainsbury Laboratory University of East AngliaNorwich Research ParkNorwich NR47UHUK

Ge.ome.e.iting is a transformational te.hnology—by pre.ise.y alte.ing the.coding or re.ulatory se.ue.ce.of a spe.ific ge.e.it is now possible.to change.spe.ific traits within a wide.varie.y of *** a conse.ue.ce.plant bre.ding can be.take. to a ne. le.e. of pre.ision,and many countrie. are.moving rapidly to adopt ne. le.islation to pe.mit ge.ome.e.iting(Gre.nwood e. al.,2023).Howe.e.,ge.ome.e.iting has so far se.dom be.n use. to de.e.op dise.se.re.istant *** is be.ause.plant immunity ofte. de.e.ds on single.dominant re.istance.ge.e.,which e.code.immune.re.e.tors that re.ognize.se.re.e. e.fe.tors de.loye. by plant pathoge.s(Jone. and Dangl,2006).In this conte.t,ge.e.ic modification has prove. to be.a much more.powe.ful te.hnology so far to introduce.the.e.ge.e. from distinct varie.ie.,or e.e. diffe.e.t spe.ie.,to de.e.op dise.se.re.istant crop spe.ie.(Gre.nwood e. al.,2023),e.pe.ially whe. multiple.dise.se.re.istance.loci can be.introduce. toge.he. to provide.more.durable.re.istance.Luo e. al.,2021).Ge.ome.e.iting can be.use. in an innovative.way to re.urre.t pre.iously e.fe.tive.re.istance.ge.e.(Contre.as e. al.,2023),but it has be.n le.s e.fe.tive.at introducing ne. forms of dise.se.re.istance.to crops.

关键词： bre.ding re.istance e.iting