检索结果-南通市图书馆

Mathematically modelling and controlling prostate cancer under intermittent hormone therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2012年第2期14卷 270-277页

作者： Yoshito Hirata Gouhei Tanaka nicholas Bruchovsky Kazuyuki Aihara Institute of Industrial Science University of Tokyo Tokyo 153-8505 Japan Vancouver Prostate Centre Vancouver General Hospital Vancouver BC V6H 3Z6 Canada

In this review, we summarize our recently developed mathematical models that predict the effects of intermittent androgen suppression therapy on prostate cancer （PCa）. Although hormone therapy for PCa shows remarkable results at the beginning of treatment, cancer cells frequently acquire the ability to grow without androgens during long-term therapy, resulting in an eventual relapse. To circumvent hormone resistance, intermittent androgen suppression was investigated as an alternative treatment option. However, at the present time, it is not possible to select an optimal schedule of on- and off-treatment cycles for any given patient. In addition, clinical trials have revealed that intermittent androgen suppression is effective for some patients but not for others. To resolve these two problems, we have developed mathematical models for PCa under intermittent androgen suppression. The mathematical models not only explain the mechanisms of intermittent androgen suppression but also provide an optimal treatment schedule for the on- and off-treatment periods.

关键词： diagnosis intermittent androgen suppression mathematical models personalized treatment schedule prognosis prostate cancer

Tracking desertification on the Mongolian steppe through NDVI and field-survey data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Digital Earth 2011年第1期4卷 50-64页

作者： Troy Sternberg Renchin Tsolmon nicholas Middleton David Thomas School of Geography Oxford UniversitySouth Parks RoadOxford OX13QYUK UNESCO Remote Sensing Lab National University of MongoliaMain Building 1Bag Toru AvenueUlaan BaatarMongolia

Changing environmental and socio-economic conditions make land degradation,a major concern in Central and East *** satellite imagery,particularly Normalized Difference Vegetation Index(NDVI)data,has proved an effective tool for monitoring land cover *** study examines 33 grassland water points using vegetation field studies and remote sensing techniques to track desertification on the Mongolian *** established a significant correlation between same-year field observation(line transects)and NDVI data,enabling an historical land cover perspective to be developed from 1998 to *** show variable land cover patterns in Mongolia with a 16%decrease in plant density over the time *** in cover identified by NDVI suggests degradation;however,continued annual fluctuation indicates desertificationirreversible land cover changehas not ***,in situ data documenting greater cover near water points implies livestock overgrazing is not causing degradation at water *** combination of the two research methodsremote sensing and field surveysstrengthen findings and provide an effective way to track desertification in dryland regions.

关键词： desertification NDVI piosphere Mongolia overgrazing digital earth

Effect of microporosity on scaffolds for bone tissue engineering

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2018年第2期5卷 115-124页

作者： Ke Zhang Yubo Fan nicholas Dunne Xiaoming Li Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijing 102402China Centre for Medical Engineering Research School of Mechanical and Manufacturing EngineeringDublin City UniversityStokes BuildingCollins AvenueDublin 9Ireland State Key Laboratory of New Ceramic and Fine Processing Tsinghua UniversityBeijing 100084China

Microporosity has a critical role in improving the osteogenesis of scaffolds for bone tissue *** the exact mechanism,by which it promotes new bone formation,is not well recognized yet,the related hypothesis can be found in many previous *** review presents those possible mechanisms about how the microporosity enhances the osteogenic-related functions of cells in vitro and the osteogenic activity of scaffolds in *** summary,the increased specific surface areas by microporosity can offer more protein adsorption sites and accelerate the release of degradation products,which facilitate the interactions between scaffolds and ***,the unique surface properties of microporous scaffolds have a considerable effect on the protein ***,capillary force generated by the microporosity can improve the attachment of bone-related cells on the scaffolds surface,and even make the cells achieve penetration into the micropores smaller than *** review also pays attention to the relationship between the biological and mechanical properties of microporous *** lots of achievements have been obtained,there is still a lot of work to do,some of which has been proposed in the conclusions and perspectives part.

关键词： bone tissue engineering mechanism microporosity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Echoes of fluid spin

National Science Review 2020年第1期7卷 2-3页

作者： Huifeng Du Chu Ma nicholas X.Fang Department of Mechanical Engineering Massachusetts Institute of Technology

Spin—an intrinsic angular momentum carried by elementary particles—has long been thought to be exclusive to quantum mechanical systems. The spin of photons, for example, is associated with the vectorial nature of electromagnetic waves [1]. In classical systems,however, the concept of a spinning degree of freedom is not as well *** instance, sound is often considered to be spinless due to the longitudinal

关键词： Echoes of fluid spin

Potential of organic waste to energy and bio-fertilizer production in Sub-Saharan Africa:a review

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Waste Disposal and Sustainable Energy 2023年第3期5卷 259-267页

作者： Isaac Rubagumya Allan John Komakech Isa Kabenge nicholas Kiggundu Department of Agricultural and Biosystems Engineering Makerere UniversityP.O.Box 7062KampalaUganda

Many growing cities of Sub-Saharan Africa(SSA)are marred by the inefficient collection,management,disposal and reuse of organic *** purpose of this study was to review and compare the energy recovery potential as well as bio-fertilizer perspective,from the organic waste volumes generated in SSA *** on computations made with a literature review,we find that the amount of organic wastes varies across countries translating to differences in the energy and bio-fertilizer production potentials across *** wastes generated in SSA can potentially generate about 133 million GWh of energy per *** organic waste to bio-fertilizer production potentials range from 11.08 million tons to 306.26 million tons *** has the highest energy and bio-fertilizer potential among the SSA countries with a total per capita of 630 MWh/year and 306.26 million tons,*** challenges and technical considerations for energy and bio-fertilizer approaches in the management of organic waste in SSA have also been *** study is of help to the readers and strategic decision makers in understanding the contribution of bioenergy and bio-fertilizer to achieving sustainable development goals,namely,7(Affordable and Clean Energy)and 13(Climate Action)in SSA.

关键词： Sub-Saharan Africa Organic waste Energy production Bio-fertilizer production Challenges

Machine learning for the discovery of molecular recognition based on single-walled carbon nanotube corona-phases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2022年第1期8卷 1265-1277页

作者： Xun Gong nicholas Renegar Retsef Levi Michael S.Strano Massachusetts Institute of Technology Department of Chemical EngineeringCambridgeMAUSA Massachusetts Institute of Technology Operations Research CenterCambridgeMAUSA Massachusetts Institute of Technology Sloan School of ManagementCambridgeMAUSA

Nanoparticle corona phase(CP)design offers a unique approach toward molecular recognition(MR)for sensing ***-walled carbon nanotube(SWCNT)CPs can additionally transduce MR through its band-gap photoluminescence(PL).While DNA oligonucleotides have been used as SWCNT CPs,no generalized scheme exists for MR prediction de novo due to their sequence-dependent three-dimensional *** work generated the largest DNA-SWCNT PL response library of 1408 elements and leveraged machine learning(ML)techniques to understand MR and DNA sequence dependence through local(LFs)and high-level features(HLFs).Out-of-sample analysis of our ML model showed significant correlations between model predictions and actual sensor responses for 6 out of 8 experimental *** HLF combinations were found to be uniquely correlated with different ***,models utilizing both LFs and HLFs show improvement over that with HLFs alone,demonstrating that DNA-SWCNT CP engineering is more complex than simply specifying molecular properties.

关键词： walled carbon utilizing

Advances in functional limb reconstruction in the irradiated setting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plastic and Aesthetic Research 2019年第11期6卷 1-11页

作者： nicholas Marsden Damien Grinsell Department of Plastic Surgery St Vincent's HospitalMelbourne 3065Australia

The management of extremity soft tissue sarcoma is constantly evolving, and, in recent decades, limb salvage has been the main goal. More commonly, this is being achieved with a combination of neo-adjuvant radiotherapy,followed by wide excision and soft tissue reconstruction in the form of vascularised soft tissue transfer. Although limb salvage is now readily achievable, the resultant functional disabilities following excision of major musculotendinous and neurovascular structures can be life changing. In recent years, there has been a move towards functional limb reconstruction in the form of free functioning muscle transfer. This paper reviews the advances in functional limb reconstruction in the setting of preoperative radiation and reports our experience in this challenging reconstructive field.

关键词： Sarcoma radiation functional limb reconstruction free functioning muscle transfer nerve transfer

Integration of solid phase extraction with HILIC-MS/MS for analysis of free amino acids in source water

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2022年第7期34卷 190-196页

作者： Junlang Qiu Caley Craven nicholas Wawryk Kristin Carroll Xing-Fang Li Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyUniversity of AlbertaEdmontonT6G 2G3Canada School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China

Amino acids(AAs) are prevalent in source water, particularly during spring run-off. Monitoring of amino acids in source water is desirable for water treatment plants(WTP) to indicate changes in source water quality. The objective of this study was to establish analytical procedures for reliable monitoring of amino acids in source water. Therefore, we examined two different methods, large volume inject(LVI) and solid phase extraction(SPE), for sample preparation prior to HILIC-MS/MS. The LVI-HILIC-MS/MS method can provide fast and sensitive detection for clean samples, but suffers from matrix effects, resulting in irreproducible separation and shortening column lifetime. We have demonstrated that SPE was necessary prior to HILIC-MS/MS to achieve reproducible and reliable quantification of AAs in source water. A natural heterocyclic amine 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid(MTCCA) was also included in the method to indicate changes in other natural nitrogenous compounds in source water. The SPE-HILIC-MS/MS method was able to achieve limits of detection from 2.6-3400 ng/L for the amino acids and MTCCA with RSDs( n = 3) of 1.1%-4.8%. As well, retention times(RT) of the analytes were reproducible with variation less than 0.01 min( n = 3) through the entire project. We further applied the SPE-HILICMS/MS method to determine AAs in authentic source water samples collected from two drinking water treatment plants(WTPs) during the 2021 spring run-off season. The results support that the SPE-HILIC-MS/MS method does not require derivatization and can provide reliable, accurate, and robust analysis of AAs and MTCCA in source water, supporting future monitoring of source water quality.

关键词： Water analysis Disinfection byproducts Amino acids HPLC MS HILIC

Distributed fiber optic monitoring of a CFA pile with a central reinforcement bar bundle

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2021年第1期15卷 167-176页

作者： Yi RUI nicholas de BATTISTA Cedric KECHAVARZI Xiaomin XU Mei YIN Centre for Smart Infrastructure and Construction Department of EngineeringUniversity of CambridgeCambridge CB21TNUK Department of Engineering University of CambridgeCambridge CB21TNUK

In this paper,we present an application of distributed fiber optic sensor(DFOS)technology to measure the strain of a continuous flight auger(CFA)test pile with a central reinforcement bar bundle,during a static load test carried out in *** distributed in nature,DFOS gives much more information about the pile performance as compared to traditional point sensors,such as identifying cross-sectional irregularities or other *** strain profiles recorded along the depth of the piles from the DFOS were used to calculate pile deformation(contraction),shaft friction,and tip resistance under various *** on this pile load test,a finite element(FE)analysis was performed using a one-dimensional nonlinear load-transfer *** by the shaft friction and tip resistance derived from the monitored data,the FE model was able to simulate the pile and soil performance during the load testing with good *** effect of the reinforcement cage and central reinforcement bar bundle were investigated,and it was found that the addition of a reinforcement cage would reduce the pile settlement by up to 20%.

关键词： continuous flight auger pile static load test central reinforcement bar bundle distributed fiber optic sensor finite element load transfer