检索结果-南通市图书馆

The impact of urological resection and reconstruction on patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)

引用

Asian Journal of Urology 2018年第3期5卷 194-198页

作者： Grace Hwei Ching Tan nicholas b.shannon Claramae Shulyn Chia Lui Shiong Lee Khee Chee Soo Melissa Ching Ching Teo Division of Surgical Oncology National Cancer Centre SingaporeSingapore Duke-NUS Medical School Singapore Department of Urology Singapore General HospitalSingapore

Objective:Cytoreductive surgery(CRS)and hyperthermic intraperitoneal chemotherapy(HIPEC)are increasingly being used to treat peritoneal *** resections and reconstruction(URR)are occasionally performed during the *** aim to evaluate the impact of these procedures on peri-operative outcomes of CRS and HIPEC ***:A retrospective review of a prospectively maintained database of all patients who underwent CRS-HIPEC from April 2001 to February 2016 was *** between patients who had surgery involving,and not involving URR were *** outcomes were the rate of major complications and the duration of stay in the intensive care unit(ICU)and *** outcomes were that of overall survival(OS)and prognostic factors that would indicate a need for ***:A total of 214 CRS-HIPEC were performed,21 of which involved a *** clinical characteristics did not vary between the groups(URR *** URR).Urological resections comprised of 52%bladder resections,24%ureteric resections,and 24%involving both bladder and ureteric *** bladder defects were closed primarily while ureteric reconstructions consisted of two end-to-end anastomoses,one ureto-uretostomy,five direct implantations into the bladder and three boari *** were more frequently required in patients with colorectal peritoneal disease(p Z 0.029),but was not associated with previous pelvic surgery(76%vs.54%,p Z 0.065).Patients with URR did not suffer more serious complications(14%vs.24%,p Z 0.42).ICU(2.2 days vs.1.4 days,p Z 0.51)and hospital stays(18 days vs.25 days,p Z 0.094)were not significantly *** a URR did not affect OS(p Z 0.99),but was associated with increased operation time(570 min vs.490 min,p Z 0.046).Conclusion:While concomitant URR were associated with an increase in operation time,there were no significant differences in postoperative complications or *** with colorectal peritoneal metastases a

关键词： Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Peritoneal carcinomatosis Urological procedures Urological reconstruction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The pervasive effects of lighting environments on sensory drive in bluefin killifish： an investigation into male/male competition, female choice, and predation

引用

Current Zoology 2018年第4期64卷 499-512页

作者： Lisa D. MITCHEM shannon STANIS nicholas M. SUTTON Zachary TURNER Rebecca C. FULLER School of Integrative biology University of Illinois Urbana IL 61801 USA Department of biology University of Virginia Charlottesville VA 22904 USA Department of Mathematics University of Illinois Urbana IL 61801 USA

Sensory drive predicts that the conditions under which signaling takes place have large effects on signals, sensory systems, and behavior. The coupling of an ecological genetics approach with sen sory drive has been fruitful. An ecological genetics approach compares populations that experi ence different environments and asks whether population differences are adaptive and are the result of genetic and/or environmental variation. The multifaceted effects of signaling environ ments are wellexemplified by the bluefin killifish. In this system, males with blue anal fins are abundant in tanninstained swamps that lack UV/blue light but are absent in clear springs where UV/blue light is abundant. Past work indicates that lighting environments shape genetic and envir onmental variation in color patterns, visual systems, and behavior. Less is known about the select ive forces creating the across population correlations between UV/blue light and the abundance of blue males. Here, we present three new experiments that investigate the roles of lighting environ ments on male competition, female mate choice, and predation. We found strong effects of lighting environments on male competition where blue males were more likely to emerge as dominant in teastained water than in clear water. Our preliminary study on predation indicated that blue males may be less susceptible to predation in teastained water than in clear water. However, there was little evidence for female preferences favoring blue males. The resulting pattern is one where the effects of lighting environments on genetic variation and phenotypic plasticity match the direction of selection and favor the expression of blue males in swamps.

关键词： Lucania goodei adaptive plasticity intrasexual selection male competition private communication predation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pesticides and trace elements in cannabis:Analytical and environmental challenges and opportunities

引用

Journal of Environmental Sciences 2019年第11期31卷 82-93页

作者： Caley b.Craven nicholas Wawryk Ping Jiang Zhongshan Liu Xing-Fang Li Department of Chemistry Faculty of Science University of Alberta Edmonton AB T6G 2G2 Canada Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and Pathology Faculty of Medicine and DentistryUniversity of Alberta Edmonton AB T6G 2G3 Canada

Cannabis is increasingly used for both medicinal and recreational purposes with an estimate of over 180 million users *** has recently legalized cannabis use in October 2018,joining several states,in the United States of America (e.g.,Colorado,California,and Oregon) and a few other countries.A variety of cannabis products including dry flowers,edibles,and oil products are widely *** high demand for cannabis products worldwide,the quality of cannabis and its related products has become a major concern for consumer *** guidelines have been set by different countries to ensure the quality,safety,and efficacy of cannabis *** general,these guidelines require control of contaminants including pesticides,toxic elements,mycotoxins,and pathogens,as well as residual solvents in regard to cannabis ***,appropriate analytical methods are required to determine these contaminants in cannabis products for quality *** this review,we focus on the current analytical challenges and method development for detection of pesticides and toxic elements in cannabis to meet various guidelines.

关键词： Cannabis QA/QC Contaminants Analytical testing Pesticides Heavy metals Regulations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Combined risk modelling approach to identify the optimal carotid revascularisation approach

引用

Stroke & Vascular Neurology 2021年第3期6卷 476-482,I0080-I0084页

作者： James Francis burke Lewis b Morgenstern nicholas H Osborne Rodney A Hayward Neurology University of Michigan Michigan MedicineAnn ArborMichiganUSA Vascular Surgery Univerity of Michigan MedicineAnn ArborMichiganUSA Internal Medicine University of Michigan Michigan MedicineAnn ArborMichiganUSA

background Carotid endarterectomy(CEA)results in fewer perioperative strokes,but more myocardial infarctions(MI)than carotid artery stenting(CAS).We explored a combined modelling approach that stratifies patients by baseline stroke and *** baseline registry-based risk models for perioperative stroke and MI were identified via literature *** then selected treatment risk models in the Carotid Revascularisation Stenting versus Endarterectomy(CREST)trial by serially adding covariates(baseline risk,treatment(CEA vs CAS),treatment-risk interaction and age-treatment interaction terms).Treatment risk models were externally validated using data from the Society for Vascular Surgery(SVS)Vascular Quality Initiative(VQI)CEA and carotid stenting registries and treatment models were recalibrated to the SVS-VQI *** net benefit was estimated by summing the predicted stroke and MI risk differences with CEA versus *** Perioperative treatment models had moderate predictiveness(c-statistic 0.69 for stroke and 0.68 for MI)and reasonable calibration across the risk spectrum for both stroke and MI within *** external validation in SVS-VQI,predictiveness was substantially reduced(c-statistic 0.61 for stroke and 0.54 for MI)and models substantially overpredicted *** patients(86.7%)were predicted to have net benefit from CEA in CREST(97.0%of symptomatic patients vs 75%of asymptomatic patients).Discussion A combined modelling approach that separates risk elements has potential to inform optimal ***,our current approach is not ready for clinical *** data support guidelines that suggest that CEA should be the preferred revascularisation modality in most patients with symptomatic carotid stenosis.

关键词： carotid Surgery optimal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thermal hypersensitivity in a subset of irritable bowel syndrome patients

引用

World Journal of Gastroenterology 2009年第26期15卷 3254-3260页

作者： QiQi Zhou Roger b Fillingim Joseph L Riley Ⅲ G nicholas Verne Department of Medicine OhioState University Columbus Ohio 43210 United States College of Dentistry University of Florida Gainesville Florida 32610 United States North Florida/South Georgia Veteran Health System Gainesville Florida 32610 United States Research Service Cincinnati VAMCCincinnati Ohio 45220 United States

AIM： To characterize thermal hypersensitivity in patients with constipation- and diarrhea-predominant irritable bowel syndrome （IbS）. METHODS： Thermal pain sensitivity was tested among patients with diarrhea-predominant IbS （D-IbS） and constipation-predominant IbS （C-IbS） compared to healthy subjects. A total of 42 patients （29 female and 13 male; mean age 27.0 ＋ 6.4 years） with D-IbS; 24 patients （16 female and eight male; mean age 32.5 ：1：8.8 years） with C-IbS; and 52 control subjects （34 female and 18 male; mean age 27.3 ± 8.0 years） participated in the study. Thermal stimuli were delivered using a Medoc Thermal Sensory Analyzer with a 3 cm × 3 cm surface area. Heat pain threshold （HPTh） and heat pain tolerance （HPTo） were assessed on the left ventral forearm and left calf using an ascending method of limits. The Functional bowel Disease Severity Index （FbDSI） was also obtained for all subjects. RESULTS： Controls were less sensitive than C-IbS and D-IbS （both at P 〈 0.001） with no differences between C-IbS and D-IbS for HPTh and HPTo. Thermal hyperalgesia was present in both groups of IbS patients relative to controls, with IbS patients reporting significantly lower pain threshold and pain tolerance at both test sites. Cluster analysis revealed the presence of subgroups of IbS patients based on thermal hyperalgesia. One cluster （17% of the sample） showed a profile of heat pain sensitivity very similar to that of healthy controls; a second cluster （47% of the sample） showed moderate heat pain sensitivity; and a third cluster （36% of the sample） showed a very high degree of thermal hyperalgesia. CONCLUSION： A subset of IbS patients had thermal hypersensitivity compared to controls, who reported significantly lower HPTh and HPTo. All IbS patients had a higher score on the FbDSI than controls. Interestingly, the subset of IbS patients with high thermal sensitivity （36%） had the highest FbDSI score compared to the other two groups of IbS patients.

关键词： Irritable bowel syndrome Visceral pain thermal hypersensitivity Heat pain threshold Heat pain tolerance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural grafting for Parkinson's disease:challenges and prospects

引用

Neural Regeneration Research 2017年第3期12卷 389-392页

作者： Thomas b.Stoker nicholas F.blair Roger A.barker John van Geest Center for brain Repair Department of Clinical NeurosciencesUniversity of CambridgeCambridgeUK Wellcome Trust-Medical Research Council Stem Cell Institute University of CambridgeCambridgeUK

Parkinson＇s disease（PD） is a neurodegenerative condition which causes a characteristic movement disorder secondary to loss of dopaminergic neurons in the substanitia *** motor disorder responds well to dopamine-replacement therapies,though these result in significant adverse effects due to non-physiological release of dopamine in the striatum,and off-target ***-based regenerative treatments offer a potential means for targeted replacement of dopamine,in a physiological *** neurons for cell-based therapies can be obtained from several *** ventral mesencephalon tissue contains dopaminergic neuron progenitors,and has been transplanted into the striatum of PD patients with good results in a number of ***,the ethical implications and logistical challenges of using fetal tissue mean that fetal ventral mesencephalon is unlikely to be used in a widespread clinical *** pluripotent stem cells can be used to generate dopaminergic neurons for transplantation,providing a source of autologous tissue for *** approach means that challenges associated with allografts,such as the potential for immune rejection,can be ***,the associated cost and difficulty in producing a standardized product from different cell lines means that,at present,this approach is not commercially viable as a cell-based *** neurons derived from embryonic stem cells offer the most promising basis for a cell-based therapy for Parkinson＇s disease,with trials due to commence in the next few *** there are ethical considerations to take into account when using embryonic tissue,the possibility of producing a standardized,optimized cell product means that this approach can be both effective,and commercially viable.

关键词： Parkinson's disease neural grafting embryonic stem cells induced pluripotent stem cells induced neurons cell-based therapies

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fundamentals of operations management / Mark M. Davis, nicholas J. Aquilano, Richard b. Chase. 4th ed.

引用

丛书名： McGraw-Hill/Irwin series operations and decision sciences

2003年

作者： Mark M. Davis nicholas J. Aquilano Richard b. Chase.

First ed. published under: Aquilano, nicholas J.

ISBN: (数字)0072402857

ISBN: (纸本)007119469X

First ed. published under: Aquilano, nicholas J.

关键词： Production management.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Operations management for competitive advantage / Richard b. Chase, nicholas J. Aquilano, F. Robert Jacobs. 9th ed.

引用

丛书名： The Irwin/McGraw-Hill series. Operations and decision sciences.

2001年

作者： Richard b. Chase nicholas J. Aquilano F. Robert Jacobs.

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

在线全文

学校读者我要写书评

暂无评论

New methods for identification of disinfection byproducts of toxicological relevance: Progress and future directions

引用

Journal of Environmental Sciences 2021年第1期33卷 151-159页

作者： nicholas J.P.Wawryk Caley b.Craven Lindsay K.Jmaiff blackstock Xing-Fang Li Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of AlbertaEdmontonABT6G 2G3Canada

Disinfection byproducts(DbPs)represent a ubiquitous source of chemical exposure in disinfected *** over 700 DbPs have been identified,the drivers of toxicity remain poorly ***,ever evolving water treatment practices have led to a continually growing list of *** of analytical technologies have enabled the identification of new classes of DbPs and the quantification of these chemically diverse sets of *** we summarize advances in new workflows for DbP analysis,including sample preparation,chromatographic separation with mass spectrometry(MS)detection,and data *** aid in the selection of techniques for future studies,we discuss necessary considerations for each step in the *** review focuses on how each step of a workflow can be optimized to capture diverse classes of DbPs within a single ***,we highlight new MS-based approaches that can be powerful for identifying novel DbPs of toxicological *** discuss current challenges and provide perspectives on future research directions with respect to studying new DbPs of toxicological *** analytical technologies continue to advance,new strategies will be increasingly used to analyze complex DbPs produced in different treatment processes with the aim to identify potential drivers of toxicity.

关键词： Water disinfection byproducts(DbPs) Emerging contaminants Mass spectrometry Chromatography Nontargeted analysis Toxicity drivers

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ultrafast imaging of terahertz electric waveforms using quantum dots

引用

Light(Science & Applications) 2022年第1期11卷 63-68页

作者： Moritz b.Heindl nicholas Kirkwood Tobias Lauster Julia A.Lang Markus Retsch Paul Mulvaney Georg Herink Experimental Physics VIII-Ultrafast Dynamics University of BayreuthBayreuthGermany ARC Centre of Excellence in Exciton Science School of ChemistryUniversity of MelbourneMelbourneAustralia Physical Chemistry I University of BayreuthBayreuthGermany

Microscopic electric fields govern the majority of elementary excitations in condensed matter and drive electronics at frequencies approaching the Terahertz(THz)***,only few imaging schemes are able to resolve sub-wavelength fields in the THz range,such as scanning-probe techniques,electro-optic sampling,and ultrafast electron ***,intrinsic constraints on sample geometry,acquisition speed and field strength limit their ***,we harness the quantum-confined Stark-effect to encode ultrafast electric near-fields into colloidal quantum dot *** approach,termed Quantum-probe Field Microscopy(QFIM),combines far-field imaging of visible photons with phase-resolved sampling of electric *** capturing ultrafast movies,we spatio-temporally resolve a Terahertz resonance inside a bowtie antenna and unveil the propagation of a Terahertz waveguide excitation deeply in the sub-wavelength *** demonstrated QFIM approach is compatible with strong-field excitation and sub-micrometer resolution—introducing a direct route towards ultrafast field imaging of complex nanodevices inoperando.

关键词： antenna waveguide quantum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：