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鲑鱼变色综合症的生态毒理学测定——与河流污染有关的大西洋鲑鱼病理状况

Energy and Power Engineering（能源与动力工程） 2022年第11期

作者： nicholas n. tasie* friday b. sigalo valentine b. omubo-pepple chigozie israel-cookey

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人类环境杂志 1997年第8期26卷 497-502页

作者： bronwen Croce Ronald M.Stagg nicholas C.Everall David b.Groman Christopher G.Mitchell Roger owen 张国梁 Scottish Office Agriculture Severn Trent water Ltd 大西洋兽医学院苏格兰农业环境与渔业部斯特灵大学

"鲑鱼变色综合症"是一种与大西洋鲑鱼(Salmo salar)的临床黄疸有关的非传染性溶血性贫血症,由多种化学污染物的综合影响而引起。这种病只发生于英国苏格兰阿伯丁郡唐河(River Don,Aberdeenshire)内洄游性成年大西洋鲑鱼种群中,本世纪80... 详细信息

"鲑鱼变色综合症"是一种与大西洋鲑鱼(Salmo salar)的临床黄疸有关的非传染性溶血性贫血症,由多种化学污染物的综合影响而引起。这种病只发生于英国苏格兰阿伯丁郡唐河(River Don,Aberdeenshire)内洄游性成年大西洋鲑鱼种群中,本世纪80年代初曾在那里达到流行病比率。人们认为造纸厂、供油工业区和机场的污流可能是该综合症的诱因。一些实验表明,当受到石油碳氢化合物(如柴油)和树脂酸的连续综合影响时,该综合症的症状能够再现。从1989年起,鲑鱼变色综合症在唐河的野生鲑鱼中再未出现,我们的研究表明这是由于唐河水质的直接改善。该病是多种污染物综合引起生物效应的很好的例证。而在单一污染物质影响下,这种作用并不明显。本文描述了确定病因的方法。

关键词：鲑鱼变色综合症生态毒理学污染毒理学病因

Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms

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bioactive Materials 2023年第8期26卷 52-63页

作者： Nisakorn Yodsanit Takuro Shirasu Yitao Huang Li Yin Zain Husain Islam Alexander Christopher Gregg Alessandra Marie Riccio Runze Tang Eric william Kent Yuyuan wang Ruosen Xie Yi Zhao Mingzhou Ye Jingcheng Zhu Yi Huang nicholas Hoyt Mengxue Zhang John A.Hossack Morgan Salmon K.Craig Kent Lian-wang Guo Shaoqin Gong bowen wang Department of biomedical Engineering Wisconsin Institute for DiscoveryUniversity of Wisconsin-MadisonMadisonWI53715USA Department of Ophthalmology and Visual Sciences University of Wisconsin-MadisonMadisonWI53715USA Department of Surgery School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA The biomedical Sciences Graduate Program(bIMS) School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA Department of biomedical Engineering School of EngineeringUniversity of VirginiaCharlottesvilleVA22908USA School of Medicine and Health Sciences George Washington UniversityWashingtonDC20052USA Department of Cardiac Surgery Michigan MedicineUniversity of MichiganAnn ArborMI48109USA

Abdominal aortic aneurysm(AAA)is a progressive aortic dilatation,causing~80%mortality upon ***,there is no approved drug therapy for *** repairs are invasive and risky and thus not recommended to patients with small AAAs which,however,account for~90%of the newly diagnosed *** is therefore a compelling unmet clinical need to discover effective non-invasive strategies to prevent or slow down AAA *** contend that the first AAA drug therapy will only arise through discoveries of both effective drug targets and innovative delivery *** is substantial evidence that degenerative smooth muscle cells(SMCs)orchestrate AAA pathogenesis and *** this study,we made an exciting finding that PERK,the endoplasmic reticulum(ER)stress Protein Kinase R-like ER Kinase,is a potent driver of SMC degeneration and hence a potential therapeutic ***,local knockdown of PERK in elastase-challenged aorta significantly attenuated AAA lesions in *** parallel,we also conceived a biomimetic nanocluster(NC)design uniquely tailored to AAA-targeting drug *** NC demonstrated excellent AAA homing via a platelet-derived biomembrane coating;and when loaded with a selective PERK inhibitor(PERKi,GSK2656157),the NC therapy conferred remarkable benefits in both preventing aneurysm development and halting the progression of pre-existing aneurysmal lesions in two distinct rodent models of *** summary,our current study not only establishes a new intervention target for mitigating SMC degeneration and aneurysmal pathogenesis,but also provides a powerful tool to facilitate the development of effective drug therapy of AAA.

关键词： Abdominal aortic aneurysm ER stress PERK biomimetic nanomedicine Targeted delivery

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透视信息高速公路革命第1版

Kaldis, nicholas A. The Chinese Prose Poem： A Study of Lu Xun＇s wild Grass （Yecao）

1998年

作者：（美）尼古拉斯·巴任（nicholas baran）于丹李振译

本书讨论了信息高速公路对社会生活的影响，涉及商业、教育和娱乐，向读者展示了如何充分利用迅猛发展的信息通讯技术。

ISBN: (纸本)7806451269

本书讨论了信息高速公路对社会生活的影响，涉及商业、教育和娱乐，向读者展示了如何充分利用迅猛发展的信息通讯技术。

关键词：工业技术无线电电子学、电信技术通信

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2016年第3期10卷 495-497页

作者： Paul b. Foster Georgia Institute of Technology

The Chinese Prose Poem is a well-crafted, critical, and interpretive analysis of Lu Xun＇s wild Grass （ Yecaa5. In addition to standing as its own critical interpretation, The Chinese Prose Poem is also a well annotated bibliographical reference for interpretations of Lu Xun＇s prose poem collection. nicholas A. Kaldis draws convincingly on the literary interpretive strategy of walter A. Davis and is informed by Freudian psychology and Nietzschean symbolism （an interest of Lu Xun＇s）, which the author weaves into his close readings of Lu Xun＇s prose poems themselves.

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The apple REFPOP—a reference population for genomics-assisted breeding in apple

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Horticulture Research 2020年第1期7卷 364-379页

作者： Michaela Jung Morgane Roth Maria JoséAranzana Annemarie Auwerkerken Marco bink Caroline Denancé Christian Dujak Charles-Eric Durel Carolina Font i Forcada Celia M.Cantin walter Guerra nicholas P.Howard beat Keller Mariusz Lewandowski Matthew Ordidge Marijn Rymenants Nadia Sanin bruno Studer Edward Zurawicz François Laurens Andrea Patocchi Hélène Muranty Molecular Plant breeding Institute of Agricultural SciencesETH Zurich8092 ZurichSwitzerland breeding Research group Agroscope 8820 WädenswilSwitzerland IRTA(Institut de Recerca i Tecnologia Agroalimentàries) 08140 Caldes de MontbuiBarcelonaSpain Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAb-Ub Campus UAB08193 BellaterraBarcelonaSpain better3fruit N.V. 3202 RillaarBelgium biometris Wageningen University and Research6708 PB WageningenThe Netherlands Hendrix Genetics Research Technology and Services B.V.PO Box 1145830AC BoxmeerThe Netherlands IRHS Universitéd’AngersINRAEInstitut AgroSFR 4207 QuaSaV49071 BeaucouzéFrance ARAID(Fundación Aragonesa para la Investigación y el Desarrollo) 50018 ZaragozaSpain Research Centre Laimburg 39040 AuerItaly Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Institute of biology and Environmental Sciences University of Oldenburg26129 OldenburgGermany Research Institute of Horticulture 96-100 SkierniewicePoland School of Agriculture Policy and DevelopmentUniversity of ReadingWhiteknights RG66AR ReadingUK Laboratory for Plant Genetics and Crop Improvement KU Leuven B-3001 LeuvenBelgium GAFL INRAE84140 MontfavetFrance

breeding of apple is a long-term and costly process due to the time and space requirements for screening selection ***-assisted breeding utilizes genomic and phenotypic information to increase the selection efficiency in breeding programs,and measurements of phenotypes in different environments can facilitate the application of the approach under various climatic *** we present an apple reference population:the apple REFPOP,a large collection formed of 534 genotypes planted in six European countries,as a unique tool to accelerate apple *** population consisted of 269 accessions and 265 progeny from 27 parental combinations,representing the diversity in cultivated apple and current European breeding material,respectively.A high-density genome-wide dataset of 303,239 SNPs was produced as a combined output of two SNP arrays of different densities using marker imputation with an imputation accuracy of *** on the genotypic data,linkage disequilibrium was low and population structure was *** well-studied phenological traits of horticultural importance were *** found marker–trait associations in several previously identified genomic regions and maximum predictive abilities of 0.57 and 0.75 for floral emergence and harvest date,*** decreasing SNP density,the detection of significant marker–trait associations varied depending on trait *** of the trait,10,000 SNPs sufficed to maximize genomic prediction *** confirm the suitability of the apple REFPOP design for genomics-assisted breeding,especially for breeding programs using related germplasm,and emphasize the advantages of a coordinated and multinational effort for customizing apple breeding methods in the genomics era.

关键词： breeding planted utilize

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10分钟会诊探查癌症患者的低落情绪

英国医学杂志中文版 2019年第3期22卷 175-177页

作者： Alexandra Pitman Sahil Suleman nicholas Hyde Andrew Hodgkiss 王雷(译) St George's University Hospitals NHS Foundation Trust London UK UCL Division of Psychiatry London UK Central & North west London NHS Foundation Trust London UK The Royal Marsden NHS Foundation Trust London UK Institute of Psychiatry Psychology & Neuroscience Kings College London London UK 药物不良反应杂志社编辑部

一名54岁的男性患者问医生要一片安眠药。他最近被诊断为直肠Ducke b型腺癌,情绪低落:虽然他预后良好,已完成新辅助化疗,并很快就会进行择期根治手术,但他怀疑自己能否获得较长的生存期。他的医生想知道他是否存在抑郁或焦虑,以及如何... 详细信息

一名54岁的男性患者问医生要一片安眠药。他最近被诊断为直肠Ducke b型腺癌,情绪低落:虽然他预后良好,已完成新辅助化疗,并很快就会进行择期根治手术,但他怀疑自己能否获得较长的生存期。他的医生想知道他是否存在抑郁或焦虑,以及如何最好地解决这个问题.抑郁症和焦虑症在癌症患者中更为常见,并且它们与较差的生活质量和癌症生存相关1-2.本文就如何认识这些疾病以及何时转诊提供了专家建议。

关键词：癌症患者情绪低落会诊新辅助化疗男性患者根治手术生活质量焦虑症

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皮肤癌

国际内科双语杂志（中英文） 2005年第8期5卷 5-8,36-38页

作者： Caroline M owen nicholas R Telfer 渠涛（译）王宝玺（校）英国伯恩利blackburn皇家医院和伯恩利综合医院的皮肤科顾问医师英国曼彻斯特Hope医院皮肤科中心的皮肤顾问外科医师不详

皮肤癌可来源于任何皮肤结构。比如从来源于表皮成分（基底细胞癌和鳞状细胞癌）及黑素细胞（恶性黑素瘤），到少见情况下来源于血管（血管肉瘤），结缔组织（如隆突皮肤纤维肉瘤）和其他皮肤附属结构（如微囊性附属器癌）。皮肤也可被... 详细信息

皮肤癌可来源于任何皮肤结构。比如从来源于表皮成分（基底细胞癌和鳞状细胞癌）及黑素细胞（恶性黑素瘤），到少见情况下来源于血管（血管肉瘤），结缔组织（如隆突皮肤纤维肉瘤）和其他皮肤附属结构（如微囊性附属器癌）。皮肤也可被淋巴瘤细胞浸润（T细胞性和b细胞性）以及其他系统恶性疾病也可侵犯到皮肤。

关键词：皮肤癌皮肤纤维肉瘤皮肤结构血管肉瘤恶性黑素瘤鳞状细胞癌基底细胞癌黑素细胞结缔组织

Operations management for competitive advantage: 10th ed.

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Human Systems Therapy:Use of Interpersonal Relations in Promoting Therapeutic Change

丛书名： The McGraw-Hill/Irwin series Operations and decision sciences

2004年

作者： Chase Richard b.

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Psychology Research 2020年第10期10卷 383-394页

作者： nicholas C.Paritsis Society for Human Systems Therapy and Intervention in Individuals Families and Larger SystemsAthensGreece University of CreteCreteGreece

The aim of this work is to present the central role of interpersonal relations in Human Systems Therapy(HST).Psychotherapies can be classified as(a)down-top therapies,such as individual therapies following reductionism,namely influencing the whole(behavior)through the intra-psychic parts,(b)top-down or holistic therapies,such as family therapies influencing the parts(individuals)through the whole family,and(c)the combination of down-top and *** Focused Therapy(EFT)and Multisystemic Therapy(MST)act on two levels that influence each other,namely the individuals and their *** is also applied,more or less,on relational and interpersonal *** there is an intervention in two interacting parts or levels,then the result of the intervention is more than additive and more *** the levels are more than two,then the effectiveness is expected to be even *** is the case of Human Systems Therapy(HST),which is applied intrapsychically,on interpersonal relations and on family and/or larger systems,with interpersonal relations having a central *** is based on general systems principles and it constitutes a multilevel approach:(a)a definition of a human system,(b)epistemology,(c)a model of human systems personality/intelligence,(d)an increase in order and ***,HST includes a large number of *** support of HST effectiveness shows that(a)after seven sessions with schizophrenics,39%of psychotic symptoms are reduced,(b)after eight sessions with hashish adolescent users,all users stop the use completely,and(c)9 out of 11 psychiatric non-psychotic cases(81%),after four sessions,become non-psychiatric ones(treated).

关键词： human relations multilevel intervention Human Systems Therapy