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Why ecosystem characteristics predicted from remotely sen.ed data are un.iased an. biased at the same time-an. how this affects application.

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Forest Ecosystems 2024年第1期11卷 24-31页

作者： Goran.Ståhl Terje Gobakken.Svetlan. Saarela Hen.ik J.Persson.Magn.s Ekstrom Sean.P.Healey Zhiqian. Yan. Johan.Holmgren.Eva Lin.berg Ken.eth n.strom Eman.ele Papucci Patrik Ulvdal Han. oleØrka Erik n.sset Zhen.yan. Hou Håkan.Olsson.Ron.ld E.McRoberts Departmen. of Forest Resource Man.gemen. Swedish University of Agricultural Sciences90183UmeåSweden Faculty of En.iron.en.al Scien.es an. n.tural Resource Man.gemen. Norwegian University of Life SciencesÅsNorway USDA Forest Service Rocky Mountain Research StationOgdenUTUSA The Key Laboratory for Silviculture an. Con.ervation.of Min.stry of Education Beijing Forestry UniversityBeijing100083China Departmen. of Forest Resources University of MinnesotaSt.PaulMNUSA

Remotely sen.ed data are frequen.ly used for predictin. an. mappin. ecosystem characteristics,an. spatially explicit wall-to-wall in.ormation.is sometimes proposed as the best possible source of in.ormation.for ***,wall-to-wall in.ormation.typically relies on.model-based prediction.an. several features of model-based prediction.should be un.erstood before exten.ively relyin. on.this type of *** such feature is that model-based predictors can.be con.idered both un.iased an. biased at the same time,which has importan. implication. in.several areas of *** this discussion.paper,we first describe the con.en.ion.l model-un.iasedn.ss paradigm that un.erpin. most prediction.techn.ques usin. remotely sen.ed(or other)auxiliary *** this poin. of view,model-based predictors are typically ***,we show that for specific domain.,iden.ified based on.their true values,the same model-based predictors can.be con.idered biased,an. sometimes severely *** suggest distin.uishin. between.con.en.ion.l model-bias,defin.d in.the statistical literature as the differen.e between.the expected value of a predictor an. the expected value of the quan.ity bein. predicted,an. design.bias of model-based estimators,defin.d as the differen.e between.the expected value of a model-based estimator an. the true value of the quan.ity bein. *** show that model-based estimators(or predictors)are typically design.biased,an. that there is a tren. in.the design.bias from overestimatin. small true values to un.erestimatin. large true ***,we give examples of application. where this is importan. to ackn.wledge an. to poten.ially make adjustmen.s to correct for the design.bias *** argue that relyin. en.irely on.con.en.ion.l model-un.iasedn.ss may lead to mistakes in.several areas of application.that use prediction. from remotely sen.ed data.

关键词： Bias Model-based in.eren.e Design.based in.eren.e

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Biomaterial en.in.erin. strategies for modelin. the Bruch's membran. in.age-related macular degen.ration

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n.ural Regen.ration.Research 2024年第12期19卷 2626-2636页

作者： Blan.a Molin. An.rea Rodríguez Víctor Lloren. Alfredo Adán Group of Ocular In.lammation.Clinical an. Experimen.al Studies Institut d’Investigacions Biomèdiques AgustíPi I Sunyer(IDIBAPS)BarcelonaSpain In.titut Clínic d’Oftalmologia(ICOF) Hospital Clínic BarcelonaSpain

Age-related macular degen.ration.a multifactorial in.lammatory degen.rative retin.l disease,ran.s as the leadin. cause of blin.n.ss in.the ***,there is a scarcity of curative therapies,especially for the atrophic advan.ed form of age-related macular degen.ration.likely due to the lack of models able to fully recapitulate the n.tive structure of the outer blood retin.l barrier,the prime to rget tissue of age-related macular *** in.vitro systems rely on.2D mon.cultures un.ble to adequately reproduce the structure an. fun.tion.of the outer blood retin.l barrier,in.egrated by the dyn.mic in.eraction.of the retin.l pigmen. epithelium,the Bruch's membran.,an. the un.erlyin. *** Bruch's membran. provides structu ral an. mechanical support an. regulates the molecular traffickin. in.the outer blood retin.l barrier,an. therefo re adequate Bruch's membran.-mimics are key for the developmen. of physiologically relevan. models of the outer blood retin.l barrie *** the last years,advan.es in.the field of biomaterial en.in.erin. have provided n.vel approaches to mimic the Bruch's membran. from a variety of *** review provides a discussion.of the in.egrated properties an. fun.tion.of outer blood retin.l barrier compon.n.s in.healt hy an. age-related macular degen.ration.status to un.erstan. the requiremen.s to adequately fabricate Bruch's membran. biomimetic ***,we discuss n.vel materials an. techn.ques to fabricate Bruch's membran.-like scaffolds for age-related macular degen.ration.in.vitro modelin.,discussin. their advan.ages an. challen.es with a special focus on.the poten.ial of Bruch's membran.-like mimics based on.decellularized tissue.

关键词： age-related macular degen.ration Bruch's membran. decellularization retin.l pigmen. epithelium scaffold

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Detectin. the presen.e of n.tural forests usin. airborn. laser scan.in. data

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Forest Ecosystems 2023年第6期10卷 668-680页

作者： Marie-Claude Jutras-Perreault Terje Gobakken.Erik n.sset Han. oleØrka Faculty of En.iron.en.al Scien.es an. n.tural Resource Man.gemen. Norwegian University of Life SciencesNMBUP.O.BoxNO-1432ÅsNorway

Cen.uries of forest exploitation.have caused sign.fican. loss of n.tural forests in.Europe,leadin. to a declin. in.population. for man. *** preven. further loss in.biodiversity,the n.rwegian.govern.en. has set a target of protectin. 10%of the forested ***,recen. data from the n.tion.l Forest In.en.ory(n.I)reveals that less than.2%of n.rway's forested area con.ists of n.tural *** iden.ify forests with high con.ervation.value,we used vertical an. horizon.al variables derived from airborn. laser scan.in.(ALS)data,alon. with n.I plot *** study aimed to predict the presen.e of n.tural forests across three coun.ies in.southeastern.n.rway,usin. three differen. defin.tion.:pristin.,n.ar-n.tural,an. semi-n.tural *** forests are scarce,an. their un.errepresen.ation.in.field referen.e data can.compromise the accuracy of the *** address this,we assessed the poten.ial gain.of in.ludin. addition.l field data specifically targetin. n.tural forests to achieve a better balan.e in.the ***,we examin.d the impact of stratifyin. the data by domin.n. tree species on.the performan.e of the *** results revealed that semi-n.tural forests were the most accurately predicted,followed by n.ar-n.tural an. pristin. forests,with Matthews correlation.coefficien. values of 0.32,0.24,an. 0.17,*** addition.l field data did n.t improve the ***,stratification.by species improved the accuracy of prediction. for n.ar-n.tural an. semi-n.tural forests,while reducin. accuracy for pristin. *** use of horizon.al variables did n.t improve the *** study demon.trates the poten.ial of ALS data in.iden.ifyin. forests with high con.ervation.*** provides a basis for further research on.the use of ALS data for the detection.an. con.ervation.of n.tural forests,offerin. valuable in.ights to guide future forest preservation.efforts.

关键词： n.tural forest ALS n.turaln.ss Vertical variables Horizon.al variables Biodiversity Forest con.ition Ecosystem services

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Effects of Topography an. Lan. use on.Woody Plan. Species Composition.an. Beta Diversity in.an.Arid Tran.-Himalayan.Lan.scape, n.pal

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Journ.l of Moun.ain.Scien.e 2014年第5期11卷 1112-1122页

作者： Shishir PAUDEL ole R VETAAS n.tural Resources Ecology an. Man.gemen. Oklahoma State UniversityStillwater OK 74078 USA Departmen. of Geography University of BergenPost Box 7800 N-5020 Bergen Norway

Distribution.pattern. of plan. species are believed to be impacted by small-scale habitat heterogen.ity. However, there have been.few comparative studies examin.n. how woody vegetation.composition.an. diversity varies with aspects of differen. orien.ation. in.the Tran.-Himalayan.region.at a local scale. Here, we examin.d the effects of in.omin. solar radiation.on.variation.in.woody species composition.an. compared the diversity between.the n.rtheast- an. southwest-facin. slopes in.a Tran.-Himalayan.valley of n.pal. We also examin.d the implicit in.eraction. between.slope orien.ation.an. lan. use in.determin.n. the composition.l variation. between.the slopes. We selected two pairs of n.rtheast- an. southwest-facin. slopes where the first pair has a similar lan. use an. differs in.exposure on.y(Pisan. site) while the other pair has clear differen.es in.lan. use in.addition.to slope exposure(Braka site). In.each site, we sampled 72 plots(36 on.each slope) in.which the presen.e an. absen.e of woody species, en.iron.en.al variables, an. disturban.e were recorded. Correspon.en.e An.lysis(CA) results suggested that the woody species composition.sign.fican.ly varied between.n.rtheast- an. southwest-facin. slopes at both sites, an. was sign.fican.ly correlated with measured en.iron.en.al variables such as radiation.in.ex, altitude, an. can.py open.ess. In.the Braka site,mean.alpha diversity was sign.fican.ly higher on.southwest-facin. slopes. In.con.rast, beta diversity an. gamma diversity were greater on.n.rtheast-facin. slopes at both sites. Our results suggest that topographic variables(e.g., radiation.in.ex) affect species composition.between.the slopes, likely due to their in.luen.e on.small scale abiotic en.iron.en.al variables. However, the effects of lan. use, such as livestock browsin./grazin. may in.eract with the effects of slope exposure, effectively reducin. differen.es in.species composition.within.slopes but en.an.in. the differen.es in.beta diversity between

关键词： Correspon.en.e an.lysis Diversity En.iron.en.al gradien.s Himalaya Lan. use Topographic aspect Woody vegetation

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A Systems Approach for An.lyzin. Vegetative an. Soil Degradation.in.Arn.gad Micro-watershed of In.ian.Himalayan.Region

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Journ.l of Moun.ain.Scien.e 2010年第4期7卷 315-326页

作者： Mohit Gera Prem L.San.hayan.ole Hofstad Govt. of J&K VanbhavanBelow GumatJammu-180001(J&K) India Departmen. of Ecology an. n.tural Resource Man.gemen. Norwegian University of Life Sciences(UMB)P.O.Box 5003N-1432 sNorway

This study an.lyzes the vegetative an. soil degradation.measured as biomass an. soil loss,for Arn.gad micro-watershed located in.In.ian.Himalayan.state of Uttarakhan.,in.systems framework by usin. dyn.mic lin.ar programmin. bio-econ.mic *** focus is at in.estigatin. the effects of altern.te policy regimes,i.e.,in.roduction.of improved en.rgy sources for cookin. alon. with substitution.of existin. local livestock breeds with improved breed,reduction.in.human.population.growth an. in.roduction.of high yieldin. varieties of main.crops in.ludin. paddy,maize an. *** model horizon.exten.ed over a period of 25 years,i.e.,from 2006 to *** was foun. that the model scen.rio in.orporatin. in.reased use of improved en.rgy sources alon. with substitution.of local cows by improved cows could be the most effective policy option.in.reducin. vegetative an. soil *** vegetative biomass den.ity declin.d to 19.76% compared to 35.24% in.the BASE scen.rio an. soil erosion.loss was also lowered by 29.13%.Also,the reduction.of population.growth rate to half of the BASE scen.rio led to min.r improvemen.s in.*** of high yieldin. varieties of main.crops slightly in.reased vegetative degradation.but reduced soil loss(8.35%) with respect to the BASE *** a phen.men.n.could be explain.d in.terms of chan.ed crop mix resultin. in.reduced amoun. of crop by-products requirin. in.reased loppin. of tree bran.hes for an.mal *** policy option.of the in.reased use of improved en.rgy sources alon. with substitution.of improved breed of cows resulted in.9.58% higher *** of high yieldin. varieties of crops led to 1.92% in.rease in.in.ome,but the in.ome decreased by 1.25 % when.population.growth was reduced to *** usefuln.ss of the model lies in.an.lyzin. the systems behavior in.its en.irety where the results can.predict the possible direction.of chan.e as a result of man.pulation.in.altern.te econ.mic regimes.

关键词： Bio-econ.mic model Dyn.mic lin.arprogrammin. Improved en.rgy sources Vegetativean. soil degradation Soil erosion In.ian.Himalayan.egion

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Microtopography driven.plan. species composition.in.alpin. region. a fin.-scale study from Southern.n.rway

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Journ.l of Moun.ain.Scien.e 2020年第3期17卷 542-555页

作者： BHATTARAI Prakash BHATTA Kuber Prasad ZHAn. Yan.-jian.VETAAS ole Reidar Key Laboratory of Ecosystem n.twork Observation.an. Modellin. Institute of Geographic Sciences and Natural Resources ResearchBeijing 100101China Un.versity of Chin.se Academy of Scien.es Beijing 100049China Departmen. of Biological Scien.es University of BergenBergenN-5020Norway Departmen. of Geography University of BergenBergenN-5020Norway

This study explores the relation.hip between.the species composition.of lichen.an. vascular plan. species with microtopography at fin. scale. We con.ucted our study in.Harden.ervidda n.tion.l Park, n.rway. Specifically, we aim to test whether the species richn.ss of differen. plan. lifeforms peaks at middle of the microtopography gradien., an. then.explain.the observed pattern. with an.aid of sn.w cover gradien. alon. microtopography an. sn.w cover. We sampled 69 species of vascular plan.s an. lichen. in.151 plots of 4 m^2 alon. 23 tran.ects durin. summer on.Tron.bu, San.haug an. Besso. Detren.ed correspon.en.e an.lysis(DCA) was performed to explore how microtopographical gradien. was related to the variation.in.the species composition. On.-way An.VA was performed to test the microtopographic variability in.species ***, gen.ralized lin.ar model(GLM) was used to reveal species richn.ss pattern. alon. the sn.w cover gradien.. The first axis in.DCA represen.s the complex gradien. from sn.w free ridge to wet sn.wbed habitats an. the secon. axis represen.s a gradien. from acidic to calcareous sites. Lichen.s species richn.ss is greater in.ridge than.in.sn.wbeds, while all other life forms follow the opposite tren.. Species richn.ss for total plan. species, vascular plan. species an. herbaceous plan. species in.reased with in.rease in.weighted average sn.w in.icator value(WASI), whilst species richn.ss for lichen.species declin.d substan.ially towards the maximum WASI value. In.con.rast, species richn.ss for dwarf shrub species showed a un.modal relation.hip with WASI. This study shows that liquid water availability provides a good poten.ial explan.tion.for species composition.an. richn.ss in.moun.ain., which is con.rolled by sn.w cover an. prevalen. win. direction.

关键词： Species richn.ss Water en.rgy dyn.mics hypothesis Weighted average sn.w in.icator value Microtopography Ordin.tion

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Surgical treatmen. for rectal can.er:An.in.ern.tion.l perspective on.what the medical gastroen.erologist n.eds to kn.w

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World Journ.l of Gastroen.erology 2008年第21期14卷 3281-3289页

作者： Rolv-ole Lin.setmo Yon.-Geul Joh Con.r P Delan.y Departmen. of Gastroin.estin.l Surgery University Hospital of North Norway and Institute of Clinical MedicineUniversity of TromsTromsN-9036Norway Departmen. of Surgery Hansol HospitalSeoul 138-844South Korea Division.of Colorectal Surgery University Hospital Case Medical CenterClevelandOhio 44106-5047United States

Rectal can.er accoun.s for on. third of all colorectal *** age adjusted death rates from colorectal can.er have declin.d over recen. decades due to a combin.tion.of colorectal can.er screen.n.,improved diagn.stic tests,improved stan.ardized surgical techn.que,improved medical support,n.oadjuvan. chemotherapies an. radiation.treatmen. or combin.tion. of *** of complex treatmen. algorithms,use of multidisciplin.ry teams in.the man.gemen. of rectal can.er patien.s has also been.*** gastroen.erologists performin. colon.scopies are frequen.ly the first health care provider to raise the suspicion.of a rectal *** the diagn.sis depen.s on.histological con.irmation.the en.oscopic presen.ation.is almost diagn.stic in.man. *** order to meet the patien.'s immediate n.eds for in.ormation.it is importan. that the en.oscopist has kn.wledge about the in.estigation. an. treatmen. option. that will be required for their *** aim of this paper is to describe the modern.preoperative in.estigation. an. operative procedures common.y offered to rectal can.er patien.s takin. in.o accoun. perspectives of three colorectal surgeon.,practicin. in.the USA,Europe an. Asia.

关键词： Rectal can.er man.gemen. Evaluation Stagin. n.oadjuvan. Adjuvan. Surgical treatmen. Surveillan.e

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Efficien. n.n.n.asive FHB Estimation.usin. RGB Images from a n.vel Multiyear,Multirater Dataset

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Plan. Phen.mics 2023年第3期5卷 533-545页

作者： Domin.kRößle LukasPrey LudwigRamgraber An.aHan.man. Dan.elCremers Patrick olen.ack Torsten.chön AImotion.Bavaria Technische Hochschule IngolstadtIngolstadtGermany Hochschule Weihen.tephan.Triesdorf WeidenbachGermany Saatzucht Josef Breun.GmbH an. Co.KG HerzogenaurachGermany Technical Un.versity of Munich MunichGermany

Fusarium head blight(FHB)is on. of the most prevalen. wheat diseases,causin. substan.ial yield losses an. health *** phen.typin. of FHB is crucial for acceleratin. resistan.e breedin.,but curren.ly used methods are time-con.umin. an. *** presen. article suggests a n.n.n.asive classification.model for FHB severity estimation.usin. red–green.blue(RGB)images,without requirin. exten.ive *** model accepts images taken.from con.umer-grade,low-cost RGB cameras an. classifies the FHB severity in.o 6 ordin.l *** addition.we in.roduce a n.vel dataset con.istin. of aroun. 3,000 images from 3 differen. years(2020,2021,an. 2022)an. 2 FHB severity assessmen.s per image from in.epen.en. *** used a pretrain.d Efficien.n.t(size b0),redesign.d as a regression.*** results demon.trate that the in.errater reliability(Cohen.s kappa,κ)is substan.ially lower than.the achieved in.ividual n.twork-to-rater results,e.g.,0.68 an. 0.76 for the data captured in.2020,*** model shows a gen.ralization.effect when.train.d with data from multiple years an. tested on.data from an.in.epen.en. ***,usin. the images from 2020 an. 2021 for train.n. an. 2022 for testin.,we improved the F_(1)^(w) score by 0.14,the accuracy by 0.11,κ by 0.12,an. reduced the root mean.squared error by 0.5 compared to the best n.twork train.d on.y on.a sin.le year’s *** proposed lightweight model an. methods could be deployed on.mobile devices to automatically an. objectively assess FHB severity with images from low-cost RGB *** source code an. the dataset are available at https://***/cvims/FHB_classification.

关键词： n.twork con.umin. breedin.

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MicroRn.s in.in.lammatory bowel disease-pathogen.sis,diagn.stics an. therapeutics

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World Journ.l of Gastroen.erology 2012年第34期18卷 4629-4634页

作者： Mehmet Coskun.Jacob Tveiten.Bjerrum Jakob Ben.dict Seidelin.ole Haagen.n.elsen Departmen. of Gastroen.erology Medical Section 54 O3University of CopenhagenHerlev HospitalDK-2730 HerlevDenmark Departmen. of Cellular an. Molecular Medicin. the Panum InstituteUniversity of CopenhagenDK-2200 Copenhagen NDenmark Departmen. of In.ern.l Medicin. I University of CopenhagenBispebjerg HospitalDK-2400 Copenhagen NVDenmark

The pathogen.sis of in.lammatory bowel disease (IBD) is complex an. largely un.n.wn. Un.il recen.ly, research has focused on.the study of protein.regulators in.in.lammation.to reveal the cellular an. molecular n.tworks in.the pathogen.sis of IBD. However, in.the last few years, n.w an. promisin. in.ights have been.gen.rated from studies describin. an.association.between.an.altered expression.of a specific class of n.n.codin. Rn.s, called microRn.s (miRs or miRn.s) an. IBD. The short (approximately 22 n.cleotides), en.ogen.us, sin.le-stran.ed Rn.s are evolution.ry con.erved in.n.mals an. plan.s, an. regulate specific target mRn.s at the post-tran.cription.l level. MiRn.s are in.olved in.several biological processes, in.ludin. developmen., cell differen.iation. proliferation.an. apoptosis. Furthermore, it is estimated that miRn.s may be respon.ible for regulatin. the expression.of n.arly on.-third of the gen.s in.the human.gen.me. Thus, miRn. deregulation.often.results in.an.impaired cellular fun.tion. an. a disturban.e of down.tream gen. regulation.an. sign.lin. cascades, suggestin. their implication.in.disease etiology. Despite the iden.ification.of more than.1900 mature human.miRn.s, very little is kn.wn.about their biological fun.tion. an. fun.tion.l targets. Recen. studies have iden.ified dysregulated miRn.s in.tissue samples of IBD patien.s an. have demon.trated similar differen.es in.circulatin. miRn.s in.the serum of IBD patien.s. Thus, there is great promise that miRn.s will aid in.the early diagn.sis of IBD, an. in.the developmen. of person.lized therapies. Here, we provide a short review of the curren. state-of-the-art of miRn.s in.IBD pathogen.sis, diagn.stics an. therapeutics.

关键词： Biomarker Crohn.s disease Diagn.stics In.flammatory bowel disease MicroRn. Therapeutics Ulcer-ative colitis

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A min.-review on.the microbial con.in.um:con.ideration.of a lin. between.judicious con.umption.of a varied diet of macroalgae an. human.health an. n.trition

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Journ.l of Ocean.logy an. Limn.logy 2019年第3期37卷 790-805页

作者： CORn.SH M. Lyn. MOURITSEn.ole G. CRITCHLEY Alan.T. Acadian.Seaplan.s Limited James S.Craigie Research CenterCornwallis B0S 1A0N.S.Canada Un.versity of Copen.agen Department of Food Science and Taste for LifeDesign and Consumer BehaviorNordic Food LabRolighedsvej 26Frederiksberg DK-1958Denmark Verschuren.Cen.re for Sustain.bility in.En.rgy an. the En.iron.en. Cape Breton UniversitySydneyNova Scotia B1P 6L2Canada

As the primordial,prokaryotic in.abitan.s on.Earth,microbial en.ities were respon.ible for sign.fican. in.luen.es on.the pathways taken.in.the developmen. of life as we kn.w *** man.festation.of n.merous pathologies in.human. is con.idered to be in.rin.ically associated with microbial dysbiosis in.the gut(i.e.a poorly balan.ed microbiota).Such adverse health con.ition. in.lude obesity,chronic fatigue syn.rome,can.er,cardiovascular issues,n.urological disorders,colitis,irritable bowel syn.rome(IBS),an. rheumatoid *** even.s at the sin.le cell level took place billion. of years ago,even.ually leadin. to eukaryotes,photosyn.hesis,an. ***(seaweeds)were amon.st the first organ.sms to develop these *** an. macroalgae in.eracted in.a pattern.of co-evolution.a process that applies to most,if n.t all livin. *** is recogn.zed that the n.rmal human.microbiome con.ists of over a trillion.microorgan.sms,in.ludin. about 2000 commen.al bacterial species typically station.d in.the *** of these live in.the colon.where they fun.tion.in.the digestion.of foods,releasin. bio-available n.trien.s,bioactive molecules,an. various *** mediate communication.sign.ls between.the gut an. the brain.an. promote the n.rmal developmen. of immun. fun.tion.metabolic activities,behaviour,an. n.urological *** very early human. foraged for food,some would have ben.fi tted from coastal diets,rich in.seaweeds an. associated *** diets would have con.isten.ly provided all the n.trien.s essen.ial for survival an. growth,an. as such,could have con.eyed competitive advan.ages an. con.ributed to en.an.ed cogn.tive *** min.-review article highlights studies regardin. the health ben.fits of dietary fibres an. the production.of short chain.fatty acids(SCFA).In.ights are off ered regardin. the positive effects the in.lusion.of macroalgae in.o the stan.ard,Western.diet can.deliver in.terms

关键词： microbiota macroalgae fibre short chain fatty acids(SCFA) n.trition

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