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商业周刊（中文版） 2024年第15期 20-21页

作者： nic Querolo 王非(译) 不详

在美国,超过三分之二的孩子在13岁生日前就拥有了一部智能手机,而智能手机的普及让家长、教育工作者和地方官员对学校的手机管理忧心仲。

关键词：教育工作者智能手机管理

Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy

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Cancer Communications 2024年第4期44卷 508-513页

作者： Andrés Pastor-Fernández Manuel Montero Gómez de las Heras Jose Ignacio Escrig-Larena Marta Barradas Cristina Pantoja Adrian Plaza Jose Luis Lopez-Aceituno Esther Durán Alejo Efeyan Maria Mittelbrunn Lola Martinez Pablo Jose Fernandez-Marcos Metabolic Syndrome Group(BIOPROMET) Madrid Institute for Advanced Studies(IMDEA)FoodE28049MadridSpain Molecular Biology Center Severo Ochoa(CBMSO) Spanish National Research Council(CSIC)Madrid Autonoma University(UAM)MadridSpain Department of Basic Medical Sciences Institute of Applied Molecular MedicineSchool of MedicineUniversity Studies Center(CEU)-San Pablo UniversityMadridSpain Metabolism and Cell Signaling Laboratory Spanish National Cancer Research Centre(CNIO) MadridSpain 5Flow Cytometry UnitBiotechnology ProgrammeSpanish National Cancer Research Centre(CNIO)MadridSpain

Fasting reduces chemotherapy toxicity[1],enhances immunogenic tumor cell death[2,3]and increases CD8^(+)T cell infiltration in tumors,particularly when combined with chemotherapy[2,3]or immunotherapy[4].More-over,fast... 详细信息

关键词： chemotherapy fasting immune

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新中国成立以来党的政治建设的历史经验

攀登（藏文版） 2024年第3期 7-13页

作者：李智中共青海省委党校藏学研究中心

党的政治建设是中国共产党立党、兴党、强党的保证和有力武器,是中国共产党治国理政有效开展的关键环节。新中国成立以来,中国共产党积累了丰富的关于推进自身政治建设的理论和实践经验:坚持和加强党的全面领导,坚决维护党中央权威和集... 详细信息

党的政治建设是中国共产党立党、兴党、强党的保证和有力武器,是中国共产党治国理政有效开展的关键环节。新中国成立以来,中国共产党积累了丰富的关于推进自身政治建设的理论和实践经验:坚持和加强党的全面领导,坚决维护党中央权威和集中统一领导,打造党的政治建设的核心议题;坚持人民至上;完善党的制度建设,为党的政治建设提供纪律保障;提高党员干部政治能力,建构党的政治建设的基础工程。总结和研究新中国成立以来党的政治建设的历史经验,可以促使这些经验转化为新时代推动党的政治建设的有效力量,对新时代推进党的政治建设具有一定的理论价值和实践意义。

关键词：新中国中国共产党政治建设历史经验

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不断夯实铸牢中华民族共同体意识的基础

攀登（藏文版） 2024年第2期 22-27页

作者：烈智中共青海省委党校藏学研究中心

党的十八大以来,以习近平同志为核心的党中央站在实现中华民族伟大复兴的战略高度,谋划和部署新时代党的民族工作,提出“铸牢中华民族共同体意识”这一重大决策部署,并将其确立为新时代党的民族工作和民族地区各项工作的主线。这一重大... 详细信息

党的十八大以来,以习近平同志为核心的党中央站在实现中华民族伟大复兴的战略高度,谋划和部署新时代党的民族工作,提出“铸牢中华民族共同体意识”这一重大决策部署,并将其确立为新时代党的民族工作和民族地区各项工作的主线。这一重大理念,丰富和发展了马克思主义民族理论,巩固和拓展了新时代党的民族工作理论和实践创新。推进新时代坚持走中国特色解决民族问题的正确道路,必须把习近平总书记关于加强和改进民族工作的重要思想不折不扣地贯彻到民族领域各个方面、落实到民族工作各个环节,铸牢中华民族共同体意识,为实现中华民族伟大复兴汇聚磅之力。

关键词：铸牢中华民族共同体意识民族工作夯实

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在新征程上全面推进乡村振兴

攀登（藏文版） 2024年第1期 28-32页

作者：烈智中共青海省委党校藏学研究中心

乡村振兴是建设农业强国的基础性工程,必须落实规划、扎实推进。全面推进乡村振兴,必须通过建立和完善相关制度来推进深化改革,必须以实现农业、农村现代化为根本保障,其关键是激发乡村的内生动力。要确保不发生规模性返贫,抓好防止返... 详细信息

乡村振兴是建设农业强国的基础性工程,必须落实规划、扎实推进。全面推进乡村振兴,必须通过建立和完善相关制度来推进深化改革,必须以实现农业、农村现代化为根本保障,其关键是激发乡村的内生动力。要确保不发生规模性返贫,抓好防止返贫监测,落实帮扶措施,增强内生动力,持续巩固拓展脱贫攻坚成果。要提升乡村产业发展水平、乡村建设水平、乡村治理水平,强化农民增收举措,推进乡村全面振兴不断取得实质性进展、阶段性成果。

关键词：中国式现代化农业强国乡村振兴

Effect of drug therapies on self-reported chemosensory outcomes after COVID-19

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： Marco A.Fornazieri Bruno M.Cunha Samuel P.nicácio Lucas K.Anzolin JoséL.B.da Silva Aristides Fernandes Neto Deusdedit Brandão Neto Richard L.Voegels Fábio D.R.Pinna Department of Surgery Londrina State UniversityLondrinaBrazil Department of Medicine Pontifical Catholic University of ParanáLondrinaBrazil Department of Otorhinolaryngology University of São PauloSao PauloBrazil Department of Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on self-reported alterations in taste and/or smell ***:Seven hundred and fourteen persons with self-reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personally interviewed regarding specific medications they were administered following the acute phase of the *** dependent measure—self-reported total recovery of chemosensory symptoms—was subjected to stepwise logistic *** predictors included demographic and clinical variables,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibuprofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symptom onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)reported total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of self-reported taste or smell *** who took oral zinc were less likely to ***:No medication employed during the first months after SARS-CoV-2 infection had a clear positive effect on returning self-reported smell or taste function to normal,although nitrazoxide trended in a positive *** zinc had a negative effect on the reported recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therapy SARS-CoV-2 smell loss taste loss

Micro-computed tomography utility for estimation of intraparenchymal spinal cord cystic lesions in small animals

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Neural Regeneration Research 2021年第11期16卷 2293-2298页

作者： Mahmoud Farrag Dipak D.Pukale nic D.Leipzig Integrated Bioscience Program The University of AkronAkronOHUSA Department of Chemical Biomolecularand Corrosion EngineeringThe University of AkronAkronOHUSA Department of Chemical Biomolecularand Corrosion EngineeringIntegrated Bioscience ProgramThe University of AkronAkronOHUSA

Precise assessment of spinal cord cystic lesions is crucial to formulate effective therapeutic strategies,yet histological assessment of the lesion remains the primary method despite numerous studies showing inconsistent results regarding estimation of lesion size via *** the other hand,despite numerous advances in micro-computed tomography(micro-CT)imaging and analysis that have allowed precise measurements of lesion size,there is not enough published data on its application to estimate intraspinal lesion size in laboratory animal *** work attempts to show that micro-CT can be valuable for spinal cord injury research by demonstrating accurate estimation of syrinx size and compares between micro-CT and traditional histological *** used a post-traumatic syringomyelia rat model to compare micro-CT analysis to conventional histological *** study showed that micro-CT can detect lesions within the spinal cord very similar to ***,micro-CT appears to provide more accurate estimates of the lesions with more measures(e.g.,surface area),can detect compounds within the cord,and can be done with the tissue of interest(spinal cord)*** summary,the experimental work presented here provides one of the first investigations of the use of micro-CT for estimating the size of intraparenchymal cysts and detecting materials within the spinal *** animal procedures were approved by the University of Akron Institutional Animal Care and Use Committee(IACUC)(protocol#LRE 16-05-09 approved on May 14,2016).

关键词： cyst size histology intraparenchymal cysts lesion size estimate micro-CT post-traumatic syringomyelia spinal cord imaging spinal cord injury spinal cystic lesion syrinx

CXC family of chemokines as prognostic or predictive biomarkers and possible drug targets in colorectal cancer

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World Journal of Gastroenterology 2018年第42期24卷 4738-4749页

作者： Sara Cabrero-de las Heras Eva Martínez-Balibrea Program Against Cancer Therapeutic Resistance Catalan Institute of OncologyGermans Trias i Pujol health research institute Program of Predictive and Personalized Cancer Medicine Germans Trias i Pujol health research institute

Colorectal cancer(CRC) is the third most common cancer in men and the second most common cancer in women,worldwide. In the early stages of the disease, biomarkers predicting early relapse would improve survival *** metastatic patients, the use of predictive biomarkers could potentially result in more personalized treatments and better outcomes. The CXC family of chemokines(CXCL1 to 17) are small(8 to 10 kDa) secreted proteins that attract neutrophils and lymphocytes. These chemokines signal through chemokine receptors(CXCR) 1 to *** studies have reported that these chemokines and receptors have a role in either the promotion or inhibition of cancer, depending on their capacity to suppress or stimulate the action of the immune system, *** general terms, activation of the CXCR1/CXCR2 pathway or the CXCR4/CXCR7 pathway is associated with tumor aggressiveness and poor prognosis; therefore,the specific inhibition of these receptors is a possible therapeutic strategy. On the other hand, the lesser known CXCR3 and CXCR5 axes are generally considered to be tumor suppressor signaling pathways, and their stimulation has been suggested as a way to fight *** pathways have been studied in tumor tissues(using immunohistochemistry or measuring mRNA levels)or serum [using enzyme-linked immuno sorbent assay(ELISA) or multiplexing techniques], among other sample types. Common variants in genes encoding for the CXC chemokines have also been investigated as possible biomarkers of the disease. This review summarizes themost recent findings on the role of CXC chemokines and their receptors in CRC and discusses their possible value as prognostic or predictive biomarkers as well as the possibility of targeting them as a therapeutic strategy.

关键词： Biomarkers Treatment Chemotherapy Oxaliplatin Irinotecan Immunotherapy Colorectal cancer CXC chemokines Immune system Bevacizumab

Grazing effects on vegetation dynamics in the savannah ecosystems of the Sahel

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Ecological Processes 2023年第1期12卷 752-763页

作者： Haftay Hailu Gebremedhn Ousmane Ndiaye Sylvanus Mensah Cofélas Fassinou Simon Taugourdeau Torbern Tagesson Paulo Salgado African Center of Excellence for Climate-Smart Agriculture and Biodiversity Conservation Haramaya UniversityP.O.Box 138Dire DawaEthiopia Dispositif en Partenariat«Pôle Pastoralisme Et Zones Sèches» Route du Front de Terre BP 2057Pôle de Recherche de HannISRADakarSenegal Centre de Recherches Zootechniques de Dahra Institut Sénégalais de Recherches AgricolesDakarSenegal Laboratoire de Biomathématiques et d’Estimations Forestières Facultédes Sciences AgronomiquesUniversitéd’Abomey-CalaviCotonouBenin Chair of Forest Growth and Dendroecology Albert-Ludwigs-Universität FreiburgFreiburg Im BreisgauGermany Facultédes Sciences et Techniques Département BVUniversitéCheikh-Anta-DiopDakarSenegal UMR SELMET CIRADINRAEInstitut Agro Univ MontpellierMontpellierFrance Department of Physical Geography and Ecosystem Science Lund UniversitySölvegatan 1222362 LundSweden Department of Geosciences and Natural Resource Management University of CopenhagenØster Voldgade 101350 CopenhagenDenmark

Background The savannah ecosystems of Sahel have experienced continuous and heavy grazing of livestock for centuries but still,their vegetation response to grazing pressure remains poorly *** this study,we analysed the herbaceous plant dynamics,measured by species diversity,composition,cover,and biomass in response to grazing pressure in the savannah ecosystems of *** Senegal,we selected four savannah sites represented with high,moderate,light and no grazing intensity *** survey methods were used for sampling the vegetation data within each of the *** richness and composition were analysed using species accumulation curve and multivariate ***,we used General Linear Models and a piecewise Structural Equation Model(pSEM)to examine the relationships between grazing intensity,vegetation cover,diversity and *** The herbaceous species diversity and composition varied significantly among the different grazing intensity levels(p<0.001).The plant species composition shifted from the dominance of grass cover to the dominance of forb cover with increasing grazing ***,the attributes of species diversity,herbaceous biomass,and ground cover were higher on sites with low grazing than sites with high and moderate grazing *** all sites,species diversity was positively related to total *** pSEM explained 37%of the variance in total biomass and revealed that grazing intensity negatively influenced total biomass both directly and indirectly through its negative influence on species *** Managing grazing intensity may lead to higher plant production and higher mixed forage establishment in the dryland savannah *** information can be used to support land management strategies and promote sustainable grazing practices that balance the needs of livestock with the conservation of ecosystem health and biodiversity.

关键词： Biomass Biodiversity Diodella sarmentosa Forb Grazing intensity Invasive species Pastoral ecosystem Senegal West Africa

Lessons from a Marine Spatial Planning data management process for Ireland

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International Journal of Digital Earth 2021年第2期14卷 139-157页

作者： Sarah Flynn Will Meaney Adam M.Leadbetter Jeffrey P.Fisher Caitriona nic Aonghusa Marine Institute RinvilleOranmoreCounty GalwayH91 R673Ireland

This paper presents a framework containing ten components to deliver a data management process for the storage and management of data used for Marine Spatial Planning(MSP)in *** work includes a data process flow and a recommended solution *** architecture includes a central data catalogue and a spatial storage *** components of the process are presented to maximise the reuse potential of any dataset within an MSP *** terms‘Suitability’and‘Readiness’in the MSP context are offered as both formal and considered assessments of data,as is the applicability of a data stewardship maturity *** data contained in such a storage system can be published externally to potential consumers of these data is also *** process presents a means of managing data and metadata to ensure data lineage is optimised by carrying information about the origin of and the processing applied to the data;to evaluate the quality and relevance of geospatial datasets for use in MSP decisions in *** process was piloted in the National Marine Planning Framework for Ireland in the development of draft map products;feedback from the public consultation is ongoing and not presented.

关键词： Marine Spatial Planning MSP marine data storage&management data governance reuse&integration