检索结果-南通市图书馆

Epstein-Barr virus negative primary hepatic leiomyoma: Case report and literature review

World Journal of Gastroenterology 2013年第25期19卷 4094-4098页

作者： Xian-Zhang Luo Chang-Sheng Ming Xiao-Ping Chen nian-qiao gong Institute of Organ Transplantation Department of Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Key Laboratory of the Ministry of Health and Key Laboratory of the Ministry of Education

Primary hepatic leiomyoma is a neoplasm of mesen-chymal origin and occurs only rarely. Secondary to benign smooth muscle proliferation, it is usually found in adult women and is associated with Epstein-Barr virus (EBV) infection. Here, we report the 29 th case of primary hepatic leiomyoma with its unique features related to diagnosis, treatment and developmental biology. A 48-year-old man, with an immunocompromised status, complained of pain in the upper quadrant of the abdomen. Serological analysis indicated no presence of hepatitis virus, no human immunodeficiency virus, and no EBV infection. The levels of α-fetoproteinand carcinoembryonic antigen were normal. A mass was detected in segment Ⅲ of the hepatic lobe by ultrasonography and an abdominal computed tomography scan. Endoscopy had negative findings. Exploratory laparotomy found no existing extrahepatic tumor and left lateral lobectomy was performed. Pathological examination showed the mass to be a typical leiomyoma. The cells were positive for α-smooth muscle actin and desmin, and negative for the makers of gastrointestinal stromal tumor (GIST), including CD117, CD34 and DOG1 (discovered on GIST1). In situ hybridization revealed negative status for EBV-encoded small RNA. After left lateral lobectomy, the patient was not given chemotherapy or radiotherapy. During a 2-year follow- up, no sign of local recurrence or distant metastasis was observed. In conclusion, we report a rare case of primary hepatic leiomyoma in a male patient without EBV infection. Hepatic resection was curative. This case presents data to expand our knowledge concerning the complex and heterogeneous nature of primary liver leiomyoma, indicating that EBV infection is important but neither necessary nor sufficient for the development of primary liver leiomyoma.

关键词： Epstein-Barr virus Primary hepatic leiomyoma Cancer diagnosis Tumor resection Developmental biology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combined en bloc liver/pancreas transplantation in two different patients

引用

World Journal of Gastroenterology 2009年第20期15卷 2552-2555页

作者： Zhi-Shui Chen Fan-Ying Meng Xiao-Ping Chen Dun-Gui Liu Lai Wei Ji-Pin Jiang Dun-Feng Du Wei-Jie Zhang Chang-Sheng Ming nian-qiao gong Institute of Organ Transplantation Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubci Province China

Combined en bloc liver/pancreas transplantation （CLPT） was used primarily in the treal^nent of otherwise non- resectable upper abdominal malignancy. In fact, a more appropriate indication is in patients with liver disease and insulin-dependent diabetes mellitus （IDDM）. Here, we report on two successful cases of CLPT at our hospital. One was a patient with non-resectable advanced liver cancer. The recipient survived for 23 mo and finally died of recurrent tumor. The other was a patient with severe biliary complication after orthotopic liver transplantation and preoperative IDDM. We performed CLPT with a modified surgical technique of preserving the native pancreas. He is currently liver-disease- and insulin-free more than 27 mo post-transplant. Based on our experience in two cases of abdominal cluster transplantation, we describe the technical details of CLPT and a modification of the surgical procedure.

关键词： Transplantation Liver Pancreas Diabetes mellitus Liver cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immune protection of auxiliary liver to other allograft: report of 3 cases

引用

Hepatobiliary & Pancreatic Diseases International 2003年第3期2卷 351-353页

作者： nian-qiao gong Qi-Fa Ye the Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Institute of Organ Transplantation Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China. nqgong@***

OBJECTIVE: To assess the immune status of auxiliary liver transplantation and to clarify the immune protection of auxiliary liver to other allograft. METHODS: Immunological markers and pathological changes in 3 patients undergoing auxiliary liver transplantation were analysed. RESULTS: The lower the concentration of immunosuppressive agent, the less the rejection and the milder the intensity in the 3 patients. The function of allograft after auxiliary liver transplantation was excellent. CONCLUSIONS: Patients are in a low immune reaction state after auxiliary liver transplantation. Auxiliary liver can protect other allografts by related immunological mechanisms. The side-effects of low-concentration immunosuppressive agents on auxiliary liver and other allografts are mild.

关键词： auxiliary liver transplantation immune protection allograft

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Values of Donor Serum Lipids and Calcium in Predicting Graft Function after Kidney Transplantation:A Retrospective Study

引用

Current Medical Science 2023年第3期43卷 514-519页

作者： Hui-bo SHI Yuan-yuan ZHAO Yu LI Yi LI Bin LIU nian-qiao gong Sheng CHANG Dun-feng DU Lan ZHU Jing XU Xiao-qin LI Meng-jun ZENG Shang-xin DONG Zhi-shui CHEN Ji-pin JIANG Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyKey Laboratory of Organ TransplantationMinistry of EducationMinistry of Public HealthChinese Academy of Medical SciencesWuhan430030China The Organ Procurement Organizations Ofice Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective Delayed graft function(DGF)and early graft loss of renal grafts are determined by the quality of the kidneys from the deceased ***“non-traditional”risk factors,serum biomarkers of donors,such as lipids and electrolytes,have drawn increasing attention due to their effects on the postoperative outcomes of renal *** study aimed to examine the value of these serum biomarkers for prediction of renal graft *** The present study consecutively collected 306 patients who underwent their first single kidney transplantation(KT)from adult deceased donors in our center from January 1,2018 to December 31,*** correlation between postoperative outcomes[DGF and abnormal serum creatinine(SCr)after 6 and 12 months]and risk factors of donors,including gender,age,body mass index(BMI),past histories,serum lipid biomarkers[cholesterol,triglyceride,high-density lipoprotein(HDL)and low-density lipoprotein(DL)],and serum electrolytes(calcium and sodium)were analyzed and ***(1)Donor age and pre-existing hypertension were significantly correlated with the incidence rate of DGF and high SCr level(≥2 mg/dL)at 6 and 12 months after KT(P<0.05);(2)The donor’s BMI was significantly correlated with the incidence rate of DGF after KT(P<0.05);(3)For serum lipids,merely the low level of serum HDL of the donor was correlated with the reduced incidence rate of high SCr level at 12 months after KT[P<0.05,OR(95%CI):0.425(0.202–0.97)];(4)The serum calcium of the donor was associated with the reduced incidence rate of high SCr level at 6 and 12 months after KT[P<0.05,OR(95%CI):0.184(0.045–0.747)and P<0.05,OR(95%CI):0.114(0.014–0.948),respectively].Conclusion The serum HDL and calcium of the donor may serve as predictive factors for the postoperative outcomes of renal grafts after KT,in addition to the donor’s age,BMI and pre-existing hypertension.

关键词： delayed graft function serum creatinine serum high-density lipoprotein serum calcium kidney transplantation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acute respiratory distress syndrome after liver transplantation: etiology, prevention and management

引用

Hepatobiliary & Pancreatic Diseases International 2002年第3期1卷 330-334页

作者： Gang-Shan Li Qi-Fa Ye Sui-Sheng Xia Zhi-Shui Chen Fan-Jun Zeng Zheng-Bing Lin nian-qiao gong Wei-Jie Zhang Zhi-Xiang Wen Po Sha Ji-Pin Jiang Tongji Organ Transplantation Institute Tongji Hospital Tongji Medical School of Huazhong Science and Technology University Wuhan 430030 China. gene1_cn@***

Objective: To study the etiology, prevention andmanagement of acute respiratory distress syndrome(ARDS) after liver ***: The clinical data of 104 patients with end-stage liver diseases who had had liver transplanta-tions were retrospectively ***: Seventeen patients (16.3%, 17/104) alto-gether were diagnosed as having ARDS after livertransplantation. Ten of them developed ARDS within24 hours, of whom 1 died during the operation, and7 developed ARDS 3 or 4 days after they were extu-bated and when methylprednisolone was *** of the 17 ARDS patients (14/17) werefound to have overloaded crystalloid infusion, mas-sive transfusion of blood or blood products such asplasma, platelets, in addition to a prolonged surgicaltime secondary to serious bleeding during the dis-eased liver removal without evidence of active infec-tion. One was found to have serious systemic infec-tion and operatively disseminated intravascular coag-ulation. Four of the recipients developed ARDS sud-denly when intravenous cyclosporine was given on the3rd day after operation. One patient of the 4 had allof the aforementioned conditions. Two patients suf-fered from gastric aspiration. Five (30%, 5/17) ofthem survived ARDS with the combined treatmentconsisting of positive end-expiratory pressure me-chanicai ventilation suctioning as much edema fluidor sputum as possible, administration of diuretics,bolus of corticosteroids, and culture-based antibiot-ics. Hemeodialysis was indicated for patients with ol-iguric renal ***: ARDS is a serious multifactoral compli-cation after liver transplantation with a high mortali-ty and fatality. The most likely cause is fluid over-load from crystalloid liquid infusion or massive trans-fusion. The other predisposing or contributing fac-tors include sepsis, Ⅳ use of cyclosporine, fast ta-pering of corticosteroids, and gastric *** factors such as transfusion-related acute lunginjury (TRALI), and reper

关键词： ARDS liver transplantation factors prevention management

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Role of mitogen activated protein kinase cascade pathway and anti-stress response in liver transplantation

引用

Hepatobiliary & Pancreatic Diseases International 2003年第2期2卷 507-511页

作者： nian-qiao gong Jian-Sheng Xiao Jin-Sheng Zeng Guo-Xun Li Hui Guo Wei-Jie Zhang Qi-Fa Ye the Institute of Organ Transplantation, Tongji Hospital. Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Institute of Organ Transplantation Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China. nqgong@***

OBJECTIVE: To explore the changes of mitogen activated protein kinase (MAPK) cascade pathway and anti-stress response of hepatocytes after liver transplantation. METHODS: Ten normal liver specimens and 18 punctured donor liver specimens were divided into 3 groups: A (control: 10), B (no rejection: 10) and C (acute rejection:8). MAPK, Ras, Jun and heat shock protein 70 (HSP70) were tested immunohistochemically while Ras and HSP70 were tested by in situ hybridization. All sections were subjected to image analysis. RESULTS: Protein expressions of MAPK, Ras and Jun were increased by an ascending order of groups A, B and C. The protein expression of HSP70 was the highest in group B but lower in group C. Expressions of Ras and HSP7O mRNA were consistent with those of protein. CONCLUSIONS: The changes of the MAPK cascade pathway and anti-stress response of hepatocytes after liver transplantation are one of regulation mechanisms for protecting the hepatocytes from damage after liver transplantation. This mechanism is active to support individual survival.

关键词： liver transplantation MAPK caseade pathway anti-stress response Ras Jun HSP70

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

药物和缺血预处理对供肝细胞增殖周期的影响

引用

世界华人消化杂志 2000年第7期8卷 759-762页

作者：宫念樵叶启发姜汉英郭辉朱彤杨军龚建平同济医科大学附属同济医院器官移植研究所湖北省武汉市430030 同济医科大学附属同济医院外科/分子医学中心湖北省武汉市430030

目的了解供肝复流后细胞增殖周期的变化,明确药物预处理和缺血预处理对其的影响.方法建立大鼠三袖套法原位肝移植模型,观察移植肝细胞复流前后不同时间增殖细胞核抗原的表达情况;对供肝分别作药物预处理和缺血预处理,比较正常肝、预处... 详细信息

目的了解供肝复流后细胞增殖周期的变化,明确药物预处理和缺血预处理对其的影响.方法建立大鼠三袖套法原位肝移植模型,观察移植肝细胞复流前后不同时间增殖细胞核抗原的表达情况;对供肝分别作药物预处理和缺血预处理,比较正常肝、预处理供肝和未预处理供肝复流2 h 后的增殖细胞核抗原、肝酶谱及肝细胞凋亡状况.结果移植肝细胞复流2 h 后增殖细胞核抗原表达显著增高,12 h 后恢复正常水平;正常肝、药物预处理供肝、缺血预处理供肝、未预处理供肝复流2 h 后的增殖细胞核抗原表达和肝酶谱依次升高,PCNA(%):2.1±0.1,4.3±0.2,7.0±0.4,9.4±0.4,AST(nKat·L^(-1)):3.5±1.6,28.1±11.9,53.8±12.3,75.2±24.1,ALT(nKat·L^(-1)):2.8±2.7,46.1±17.6,61.7±22.9,90.5±30.1,LDH(nKat·L^(-1)):49.6±7.6,61.4±15.3,95.4±23.2,148.3±30.1.结论供肝复流后肝细胞 G_1期缩短至2 h 以内,整个细胞周期时间缩短至20 h 左右.正常肝、药物预处理供肝、缺血预处理供肝、未预处理供肝肝损害程度依次加重,整个细胞周期时间依次缩短.

关键词：肝脏移植细胞周期增殖细胞核抗原缺血预处理

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tyrosine Hydroxylase as a Target for Deltamethrin in the Nigrostriatal Dopaminergic Pathway

引用

Biomedical and Environmental Sciences 2006年第1期19卷 27-34页

作者： gong-PING LIU QIANG MA nian SHI Department of Toxicology MOE key Laboratory of Environmental and Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei China Receptor Biology Laboratory Toxicology and Molecular Biology Branch Health Effects Laboratory Division National Institute for Occupational Safety and Health Centers for Disease Control and Prevention Morgantown WV 26505 USA

Objective To study the effects of deltamethrin on tyrosine hydroxylase in nigrostriatum of male rats. Methods Sprague-Dawley rats were daily treated with deltamethrin at 6.25 or 12.5 mg/kg body weight by gavage for 10 days. Then HPLC-fluorescence detection was used to analyze the contents of dopamine （DA）, 3,4-dihydmxyphenylacetic acid （DOPAC） and homoranillic acid （HVA） in substantial nigra and striatum. The activities of tyrosine hydroxylase （TH） were also detected by HPLC-fluorescence detection. TH mRNA or TH protein levels were measured by RT-PCR and immunohistochemistry method. Results The content of DA in stfiatum was significantly decreased by the treatments, suggesting an inhibition of DA synthesis by deltamethrin. The contents of DA metabolites DOPAC and HVA increased, indicating increased dopamine turnover. Furthermore, deltamethrin significantly decreased the activity, as well as the mRNA and protein levels of TH. Conclusions These findings reveal a novel aspect of deltamethfin neurotoxicity and suggest tyrosine hydroxylase as a molecular target of deltamethin on dopamine metabolism in the nigrostriatal pathway.

关键词： Deltamethrin Nigrostriatum Dopamine Tyrosine hydroxylase Parkinson's disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A non-myopic scheduling method of radar sensors for maneuvering target tracking and radiation control

引用

Defence Technology（防务技术） 2020年第1期16卷 242-250页

作者： Gan-lin Shan gong-guo Xu Cheng-lin qiao Department of Electronic and Optical Engineering Army Engineering UniversityShijiazhuang 050003China

In decades,the battlefield environment is becoming more and more complex with plenty of electronic ***,in order to improve the survivability of radar sensors and satisfy the requirement of maneuvering target tracking with a low probability of intercept,a non-myopic scheduling is proposed to minimize the radiation cost with tracking accuracy *** first,the scheduling problem is formulated as a partially observable Markov decision process(POMDP).Then the tracking accuracy and radiation cost over the future finite time horizon are predicted by the posterior carmer-rao lower bound(PCRLB) and the hidden Markov model filter,***,the proposed scheduling is implemented efficiently by utilizing the branch and bound(B&B) pruning *** results show that the performance of maneuvering target tracking was improved by the improved interacting multiple model(IMM),and the scheduler time and maximum memory consumption were significant reduced by the present B&B pruning algorithm without losing the optimal solution.

关键词： Non-myopic scheduling Radiation control PCRLB POMDP Branch and bound

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

催化剂排布状态对催化裂解反应影响的可视化研究

引用

石油炼制与化工 2025年第1期56卷 92-98页

作者：李泽坤王惠琳龚剑洪乔瑞琪中石化石油化工科学研究院有限公司北京100083 中国石化集团经济技术研究院有限公司

针对催化裂解提升管反应器内出现的催化剂颗粒团聚现象,建立了一套催化裂解原位微反应可视化研究系统,采用高温热台显微镜研究了不同反应温度、进料速率和催化剂粒径下,催化剂排布状态对异丁烯催化裂解反应产物分布的影响。研究结果表明... 详细信息

针对催化裂解提升管反应器内出现的催化剂颗粒团聚现象,建立了一套催化裂解原位微反应可视化研究系统,采用高温热台显微镜研究了不同反应温度、进料速率和催化剂粒径下,催化剂排布状态对异丁烯催化裂解反应产物分布的影响。研究结果表明:提高反应温度和进料速率可以削弱催化剂团聚对转化率的影响;催化剂粒径对催化裂解反应的影响与催化剂排布状态和分子筛类型有关,催化剂团聚会影响原料与催化剂的接触以及产物的扩散,从而对反应转化率和产物选择性产生影响。

关键词：催化裂解催化剂团聚反应转化率

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：