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Communications in Theoretical Physics 2008年第12期50卷 1375-1380页

作者： YANG Chun-Nuan HE Jin-Chun huang nian-Ning Department of Mathematics Huazhong University of Science and Technology Wuhan 430074 China Department of Physics Wuhan University Wuhan 430072 China

Using the integral representation of the Jost solution,we deduce some conditions as the kernel functionN(x,y,t)if the Jost solution satisfies the two Lax *** we verify the multi-soliton solution of NLS equationwith non-vanishing boundary conditions if we prove that these conditions can be demonstrated by the GLM equation,which determines the kernel function N(x,y,t)in according to the inverse scattering method.

关键词： NLS^+ equation inverse scattering method Gel'fand Levitan Marchenko equation

Relationship between Volatile Anesthetics and Tumor Progression: Unveiling the Mystery

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Current Medical Science 2018年第6期38卷 962-967页

作者： Bo JIAO Chun YANG nian-nian huang Ning YANG Jia WEI Hui XU Department of Anesthesiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Gynaecology and Obstetrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

A series of factors can be involved in the perioperative period to cause an increase in cancer-related ***,volatile anesthesia might aggravate the deleterious effects. In this article,we review the association of diverse volatile anesthetic agents with immune system and cancer cell biology,and examine the effects on angeogenesis and postoperative metastasis or ***,haloflurane and enflurane enhance immunosuppression and upregulate hypoxia-inducible-factor 1and matrix metalloproteinases,leading to the cancer malignant progression,whereas roles of desflurane and sevoflurane are still *** the effects of volatile anesthetics on tumor immunity have been known,it will be beneficial for using selective drugs into anesthesia and operation in cancer patients.

关键词： volatile anesthesia metastasis recurrence immunosuppression hypoxia-induciblcfactor

A mechanistic study of flame retardance of novel copolyester phosphorus containing linked pendant groups by TG/XPS/direct Py-MS

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Chinese Chemical Letters 2008年第3期19卷 350-354页

作者： nian Hua huang Qiang Zhang Chou Fan Jian Qi Wang School of Textile and Materials Wuhan University of Science and Engineering Wuhan 430073 China X-ray Photoelectron Spectroscopy Laboratory South-Central University for Nationalities Wuhan 430074 China National Laboratory of Flame Retardant Materials Beijing Institute of Technology Beijing 100081 China

The flame retardant mechanism of the copolyester phosphorus containing linked pendant groups was investigated by thermogravimetric （TG）, X-ray photoelectron spectroscopy （XPS） and direct insertion probe pyrolysis mass spectrometry （DP-MS） technique. TG results show that the incorporation of phosphorus containing unit linked pendant groups can destabilize the copolyester due to the cleavage of P-CH2 bond, and phosphorus containing units cannot promote the char-formation of the copolyester during the thermal degradation of the copolyester. XPS spectra indicate that with the increase of the temperature, the P-CH2 bonds of the copolyester break down gradually, the concentration of phosphorus in the condensed phase products decrease gradually and the chemical state of phosphorus does not change in the temperature of 250-380 ℃. Direct pyrolysis MS suggests that the P-CH2 bonds cleavage occurs at pendant groups and species containing phosphorus can volatilize into the gas phase. A flame retardant mechanism is proposed for the gas phase mode of action of the halogen-free copolyester phosphorus containing linked pendant groups.

关键词： Phosphorus containing copolyester Thermal degradation Flame rctardant mechanism TGA XPS Direct Py-MS

Demonstration of Inverse Scattering Transform for DNLS Equation

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Communications in Theoretical Physics 2007年第2X期48卷 299-303页

作者： YANG Chun-Nuan YU Jia-Lu WANG Qu-Quan huang nian-Ning Department of Physics Wuhan University Wuhan 430072 China

Since the Jost solutions of the DNLS equation does not tend to the free Jost solutioins as ｜λ｜→∞, the usual inverse scattering transform （IST） must be revised. Beside the Kaup and Newell＇s approach, we propose a simple revision in constructing the equations of IST, where the usual Zakharov-Shabat kern is revised by multiplying λ^-2 or λ^-1. To justify the revision we show that the Jost solutions obtained do satisfy the pair of compatibility equations.

关键词： inverse scattering transform soliton solutions Liouville theorem

Xiaotan Sanjie recipe,a compound Chinese herbal medicine,inhibits gastric cancer metastasis by regulating GnT-V-mediated E-cadherin glycosylation

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Journal of Integrative Medicine 2023年第6期21卷 561-574页

作者： nian huang Hai-wei He Yu-yu He Wei Gu Ming-juan Xu Long Liu Department of Integrative Medicine Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200433China Department of Obstetrics and Gynecology Changhai HospitalNaval Medical UniversityShanghai 200433China School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Department of Traditional Chinese Medicine Tianyou HospitalTongji UniversityShanghai 200333China

Objective:Xiaotan Sanjie recipe(XTSJ),a Chinese herbal compound medicine,exerts a significant inhibitory effect on gastric cancer(GC)*** work investigated the mechanism underlying the XTSJmediated inhibition of GC ***:The effect of XTSJ on GC metastasis and the associated mechanism were investigated in vitro,using GC cell lines,and in vivo,using a GC mouse model,by focusing on the expression of Glc-N-Actransferase V(GnT-V;encoded by MGAT5).Results:The migration and invasion ability of GC cells decreased significantly after XTSJ administration,which confirmed the efficacy of XTSJ in treating GC in *** increased the accumulation of Ecadherin at junctions between GC cells,which was reversed by MGAT5 *** administration and MGAT5 knockdown alleviated the structural abnormality of the cell–cell junctions,while MGAT5 overexpression had the opposite ***5 knockdown and XTSJ treatment also significantly increased the accumulation of proteins associated with the E-cadherin-mediated adherens junction ***,the expression of MGAT5 was significantly lower in the lungs of BGC-823-MGAT5+XTSJ mice than in those of BGC-823-MGAT5+solvent mice,indicating that the ability of gastric tumors to metastasize to the lung was decreased in vivo following XTSJ ***:XTSJ prevented GC metastasis by inhibiting the GnT-V-mediated E-cadherin glycosylation and promoting the E-cadherin accumulation at cell–cell junctions.

关键词： Xiaotan Sanjie Recipe Gastric cancer Traditional Chinese medicine E-cadherin Metastasis Glc-N-Ac-transferase V

Efficient Synthesis,Crystal Structure and Antibacterial Activity of Two Novel Thieno[2,3-d]pyrimidin-4(3H)-one Derivatives

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Chinese Journal of Structural Chemistry 2015年第5期34卷 673-680页

作者： LI Rong-Kun YANG Quan-Li huang nian-Yu CHEN Hong LIU Ming-Guo Hubei Key Laboratory of Natural Products Research and Development College of Biological and Pharmaceutical SciencesChina Three Gorges University

Two new thieno[2,3-d]pyrimidin-4（3H）-one derivatives,C24H22 Cl N3O2S（5a） and C25H25N3O2S（5b）,have been synthesized via a tandem aza-Wittig *** tandem reaction has many attractive aspects such as easily accessible and versatile starting materials,mild conditions and high *** compounds have been characterized by elemental analysis,HR-MS,IR,NMR spectra and X-ray single-crystal *** 5a crystallizes in monoclinic,space group P21/c with a = 9.986（3）,b = 14.263（4）,c = 15.530（5）A,β = 93.806（5）o,V = 2207.1（11） A^3,Mr = 451.96,Z = 4,Dc = 1.360 g/cm3,F（000） = 944,μ = 0.294 mm-1,Mo Kα radiation（λ = 0.71073 A）,the final R = 0.0444 and w R = 0.1219 for 3407 observed reflections with I 〉 2σ（I）.Compound 5bcrystallizes in triclinic,space group P1 with a = 8.974（4）,b = 10.766（5）,c = 12.260（6） A,β = 93.047（7）o,V = 1122.1（9） A^3,Mr = 431.54,Z = 2,Dc = 1.277 g/cm3,F（000） = 456,μ = 0.170 mm-1,Mo Kα radiation（λ = 0.71073 A）,the final R = 0.0378 and w R = 0.1072 for 3806 observed reflections with I 〉 2σ（I）.The preliminary antibacterial activities of 5a and 5b were *** 5a showed 71.3% and 79.2% in vitro inhibition against Fusarium oxysporium and Rhizoctonia solani,*** 5b showed 75.3% in vitro inhibition against Rhizoctonia solani.

关键词： crystal structure thieno[2 3-d]pyrimidinone aza-Wittig reaction synthesis antibacterial activity

Core muscle functional strength training for reducing the risk of low back pain in military recruits:An open-label randomized controlled trial

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Journal of Integrative Medicine 2022年第2期20卷 145-152页

作者： Xin Wang Wen-juan Song Yi Ruan Bing-chu Li Can Lü nian huang Fan-fu Fang Wei Gu School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Department of Rehabilitation Changhai HospitalNaval Medical UniversityShanghai 200433China School of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China

Background:Core muscle functional strength training(CMFST)has been reported to reduce injuries to the lower ***,no study has confirmed whether CMFST can reduce the risk of low back pain(LBP).Objective:This study identified the effects of CMFST on the incidence of LBP in military ***,setting,participants and intervention:We performed a prospective,open-label,randomized,controlled study in a population of young healthy male naval recruits from a Chinese basic combat training *** were randomly assigned to either the core group or the control *** additional to normal basic combat training,recruits in the core group underwent a CMFST program for 12 weeks,while recruits in the control group received no extra *** outcome measures:At the beginning of the study and at the 12 th week,the number of participants with LBP was counted,and lumbar muscle endurance was *** addition,when participants complained of LBP,they were assessed using the visual analog scale(VAS)and Roland Morris Disability Questionnaire(RMDQ).Results:A total of 588 participants were included in the final analysis(295 in the core group and 293 in the control group).The incidence of LBP in the control group was about twice that of the core group over the 12-week study(20.8%vs 10.8%,odds ratio:2.161–2.159,P<0.001).The core group had better lumbar muscle endurance at 12 weeks than the control group([200.80±92.98]s vs[147.00±84.51]s,P<0.01).There was no significant difference in VAS score between groups,but the core group had a significantly lower RMDQ score at week 12 than the control group(3.33±0.58 vs 5.47±4.41,P<0.05).Conclusion:This study demonstrated that the CMFST effectively reduced the incidence of LBP,improved lumbar muscle endurance,and relieved the dysfunction of LBP during basic military training.

关键词： Low back pain Core exercise Recruits Randomized controlled trial

Integrative medicine is an evolving field and the future of healthcare:a summary of the 2017 Integrative Medicine Shanghai Forum

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Journal of Integrative Medicine 2018年第2期16卷 71-71页

作者： nian huang Changhai Hospital of Traditional Chinese Medicine Second Military Medical UniversityShanghai 200433China Office of Shanghai Association of Chinese Integrative Medicine Shanghai 200040China

The first Integrative Medicine Shanghai Forum （IMSF）, with the theme ＂Integrative medicine is an evolving field and the future of healthcare,＂ sponsored by the Shanghai Association of Chinese Integrative Medicine （SACIM）, was successfully held at the Lake Meilan International Convention Center, Shanghai, on December 3, 2017. Prof. Ke-ji Chen, honorary president of the Chinese Asso- ciation of Integrative Medicine and member of the Chinese Acad- emy of Sciences. Prof. Wei-kang Zhao.

关键词： Integrative Medicine Shanghai Forum Integrative medicine Shanghai Association of Chinese Integrative Medicine

A novel and green synthesis of indolone-N-amino acid derivatives via the Passerini three-component reactions in water

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Chinese Chemical Letters 2016年第3期27卷 345-348页

作者： Rong-Kun Li Quan-Li Yang Yi Liu Dong-Wei Li nian-Yu huang Ming-Guo Liu Hubei Key Laboratory of Natural Products Research and Development College of Biological and Pharmaceutical SciencesChina Three Gorges University

A green Passerini three-component reaction of 2-（4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl）acetic acid with alkyl or aryl isocyanides and aldehydes was reported under aqueous conditions at 35 ℃ for 1 h, and21 indolone-N-amino acid derivatives were prepared in high yields of 42%–99%. Their structures were characterized by IR, ESI–MS, NMR and elemental analysis, and the possible mechanisms have been also proposed. The highly efficient and eco-friendly method provides a facile access to a library of indoloneN-amino acid derivatives for future research on bioactivity screening.

关键词： Passerini three-component reaction Indolone-N-amino acid Green synthesis Heterocycles Isocyanide

Demonstration of Dark Soliton Solutions Found by Inverse Scattering Transform

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Communications in Theoretical Physics 2006年第8期46卷 244-248页

作者： LI Cun, YANG Bai-Feng,t CAI Hao, and huang nian-Ning Deparment of Physics, Wuhan University, Wuhan 430072, China Deparment of Physics Wuhan University Wuhan 430072 China

One of the basic problems about the inverse scattering transform for solving a completely integrable nonlinear evolutions equation is to demonstrate that the Jost solutions obtained from the inverse scattering equations of Cauchy integral satisfy the Lax equations. Such a basic problem still exists in the procedure of deriving the dark soliton solutions of the NLS equation in normal dispersion with non-vanishing boundary conditions through the inverse scattering transform. In this paper, a pair of Jost solutions with same analytic properties are composed to be a 2×2 matrix and then another pair are introduced to be its right inverse confirmed by the Liouville theorem. As they are both 2×2 matrices, the right inverse should be the left inverse too, based upon which it is not difficult to show that these Jost solutions satisfy both the first and second Lax equations. As a result of compatibility condition, the dark soliton solutions definitely satisfy the NLS equation in normal dispersion with non-vanishing boundary conditions.

关键词： inverse scattering transform dark soliton solultions Liouville theorem