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Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.Reddy Erika orlov PHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of Pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of Public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAP-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun Zhen-ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Electronic structure and bonding interactions in Ba1-xSrxZr0.1Ti0.9O3 ceramics

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Frontiers of Materials Science 2017年第2期11卷 182-189页

作者： Jegannathan MANGAIYARKKARASI Subramanian SASIKUMAR olai Vasu SARAVANAN Ramachandran SARAVANAN PG and Research Department of Physics NMSSVN College Nagamalai Madurai-625 019 Tamil Nadu India Research Centre and PG Department of Physics The Madura College Madurai-625 011 Tamil Nadu India

An investigation on the precise electronic structure and bonding interactions has been carried out on Ba1-xSrxZr0.1Ti0.9O3 （short for BSZT, x = 0, 0.05, 0.07 and 0.14） ceramic systems prepared via high-temperature solid state reaction technique. The influence of Sr doping on the BSZT structure has been examined by characterizing the prepared samples using PXRD, UV-visible spectrophotometry, SEM and EDS. Powder profile refinement of X-ray data confirms that all the synthesized samples have been crystallized in cubic perovskite structure with single phase. Charge density distribution of the BSZT systems has been completely analyzed by the maximum entropy method （MEM）. Co-substitution of Sr at the Ba site and Zr at the Ti site into the BaTiOz structure presents the ionic nature between Ba and O ions and the covalent nature between Ti and O ions, revealed from MEM calculations. Optical band gap values have been evaluated from UV-visible absorption spectra. Particles with irregular shapes and well defined grain boundaries are clearly visualized from SEM images. The phase purity of the prepared samples is further confirmed by EDS qualitative spectral analysis.

关键词： barium titanate X-ray diffraction Rietveld refinement maximum entropy method bonding

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu liang ni-Hui Zhang Zhi-lai Zhan Guang-lu Chang Yan Gao Xia li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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A New Species of Japalura(Agamidae: lacertilia: Reptilia) from Central Highland,Vietnam

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Asian Herpetological Research 2017年第1期18卷 14-21页

作者： Natalia B.ANANJEVA nikolay l.orlov Tao Thien NGUYEN Department of Herpetology Zoological InstituteRussian Academy of Sciences Vietnam National Museum of Nature Vietnam Academy of Science and Technology

A new species of the agamid genus Japalura is described based on three specimens from southern part of Central Vietnam. It is distinguished from remaining congeners by the following combination of characters： adult size （SVl females 68-69 mm）, tail length/SVl ratio 226%-239%, HW/SVl ratio 17%-18%; Fll/SVl ratio 41%43%; Hll/SVl ratio 72%-73%; 7-9 supralabials, 7-9 infralabials, 54-56 middorsal scales, 20-22 lamellae under finger IV, 24-26 lamellae under toe IV, 1 scale between nasal and supralabials; tympanum concealed; absence of transverse gular fold. The geographical distribution of Japalura genus in general and of a new species in particular is discussed.

关键词： Agamidae Japalura taxonomy Vietnam description of a new species distribution

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Spin-glass behavior in the competing CoCrGaO_(4)cubic spinel system

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Nano Research 2025年第1期18卷 501-507页

作者： Jiyu Hu Jiangli ni Zhenfa Zi Chaocheng liu School of Physics and Materials Engineering Hefei Normal UniversityHefei 230009China National Synchrotron Radiation laboratory University of Science and Technology of ChinaHefei 230026China

Spin glasses(SGs),generally defined as disordered systems with randomized competing interactions,are widely investigated complex *** the ground states of spin glasses is crucial for understanding the nature of disordered magnets and many other physical manifestations,while also helping to solve some hard combinatorial optimization problems across multiple ***,the intrinsic cause of SG has always been elusive,especially in spinel oxide ***,we report the SG behavior observed in the cubic spinel oxides CoCrGaO_(4),and provide a comprehensive understanding of its intrinsic *** results indicate a frustrated state under multi-magnetic competition,and the features of SG are confirmed by susceptibility *** fitting parameters ofτ0,T0,and zv of isothermal remanent magnetization further reveal the relaxation behavior and strong spin ***,the varying exchange coupling under different temperatures and magnetic fields is unveiled,which should be responsible for the disordered *** studies unravel the underlying mechanism responsible for doping-induced magnetic frustration and introduce CoCrGaO_(4)as a potential platform for investigating spin glass behavior,thereby advancing fundamental research on frustrated magnetism within the spinel system.

关键词： spin glass(SG) magnetic frustration magnetic competition spinel ferrites

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Reproductive Biology of Boiga guangxiensis Wen,1998(Serpentes:Colubridae)

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Asian Herpetological Research 2010年第1期1卷 44-47页

作者： Sergei A.Ryabov ni.olai.l.orlov Tula Exotarium Oktyabrskaya26Tula 300002Russia Zoological Institute Russian Academy of SciencesUniversitetskaya Nab. 1St. Petersburg 199034Russia

Up to now, the reproductive biology of most species of the genus Boiga is investigated very little. Important data on the reproductive biology of Boiga guangxiensis were received by us for the first time. The investigations were carried out in Viet Nam during expeditions and in the laboratories of Tula Exotarium in the period between 1998-2000. The data on the feeding, egg size, incubation, size of hatchings, and juvenile colouration of this species are provided for the first time. In addition, the data on size and ratio of snout-vent length/tail length of this snake are provided based on the Vietnamese samples. Our researches demonstrated that B. guangxiensis is distinguished from most other species of the genus by a number of peculiarities of its reproductive biology. Also, morphological differences between Chinese and Vietnamese individuals of this species were noted.

关键词： Boiga guangxiensis reproduction juvenile colouration Viet Nam

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Exploring the mechanical behavior and microstructure of compacted loess subjected to dry-wet cycles and chemical contamination

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3673-3695页

作者： Yongpeng nie Wankui ni Xiangfei lü Wenxin Tuo College of Geological Engineering and Geomatics Chang'an UniversityXi'an710054China Department of Civil Engineering Nagoya Institute of TechnologyNagoya466-8555Japan School of Water and Environment Chang'an UniversityXi'an710054China

Due to climatic factors and rapid urbanization,the soil in the loess Plateau,China,experiences the coupled effects of dry-wet cycles and chemical *** the mechanical behavior and corresponding microstructural evolution of contaminated loess subjected to dry-wet cycles is essential to elucidate the soil degradation ***,direct shear and consolidation tests were performed to investigate the variations in mechanical properties of compacted loess contaminated with acetic acid,sodium hydroxide,and sodium sulfate during dry-wet *** mechanical response mechanisms were investigated using zeta potential,mineral chemical composition,and scanning electron microscopy(SEM)*** results indicate that the mechanical deterioration of sodium hydroxidecontaminated loess during dry-wet cycles decreases with increasing contaminant concentration,which is mainly attributed to the thickening of the electrical double layer(EDl)by Nat and the precipitation of calcite,as well as the formation of colloidal flocs induced by OH,thus inhibiting the development of large pores during the dry-wet *** contrast,the attenuation of mechanical properties of both acetic acid-and sodium sulfate-contaminated loess becomes more severe with increasing contaminant concentration,with the latter being more particularly *** is primarily due to the reduction of the EDl thickness and the erosion of cement in the acidic environment,which facilitates the connectivity of pores during dry-wet ***,the salt expansion generated by the drying process of saline loess further intensifies the structural ***,the mechanical performance of compacted loess is sensitive to both pollutant type and concentration,exhibiting different response patterns in the dry-wet cycling condition.

关键词： Contaminated loess Dry-wet cycles Compressibility Shear strength Microstructural evolution

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

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Mathematical modeling of building structures and nonlinear differential equations

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International Journal of Modeling, Simulation, and Scientific Computing 2020年第3期11卷 154-160页

作者： Victor orlov Yulia Zheglova Moscow State University of Civil Engineering Yaroslavskoye Shosse 26 Moscow 129337Russia

Nonlinear differential equations with moving singular points require emergence and development of new approximate methods of *** this paper,we give a solution to one of the problems of the analytical approximate method for solving nonlinear differential equations with moving singular points,and study the influence of the perturbation of the initial conditions on the analytical approximate solution in the analytic *** material was tested using a numerical experiment confirming its *** theoretical material presented in this paper allows researchers to use nonlinear differential equations with moving singular points when designing mathematical models of building structures.

关键词： Mathematical modeling moving singular points a priori estimate approximate solution a posteriori error estimate

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