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In situ evaluation of cell cultivation on dynamically changed poly(ε-caprolactone) film caused by enzymatic degradation

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Science China Chemistry 2011年第2期54卷 369-374页

作者： ZHANG Yu jiang ni GAN ZhiHua Key Laboratory of Engineering Plastics Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

In situ evaluation of cell cultivation on degrading poly(ε-caprolactone) (PCL) films was *** culture surroundings were constructed for cell growth by using PCL films as substrates and adding Pseudomonas cepacia lipase to accelerate biodegradation of PCL *** experiments for 10 h indicated the low cytotoxicity of lipase solution with concentration up to 0.2 mg/mL for MG-63 cells growth on PCL *** the optimized lipase concentration and degradation time,we studied cell growth behavior on dynamically changed PCL films by adding lipase to the culture ***,fluorescence microscopy and scanning electron microscopy (SEM) were used to evaluate cell viability,proliferation and *** was found that cell viability and proliferation were not affected by the added lipase solution *** contrast,cells cultured on degrading PCL films showed good growth behavior with clear fusiform shape and ***,the enzymatic degradation of PCL films with cells attachment showed distinctive morphology compared to the degradation in lipase solution without *** simultaneous cell growth and PCL film degradation were well discussed in this work,which may better understand the interaction between cell growth and polymer degradation.

关键词： poly(ε-caprolactone) film enzymatic degradation cell growth surface morphology

Identifying influential spreaders in complex networks based on entropy weight method and gravity law

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Chinese Physics B 2020年第4期29卷 582-590页

作者： Xiao-Li Yan Ya-Peng Cui Shun-jiang ni Institute of Public Safety Research Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Beijing Key Laboratory of City Integrated Emergency Response Science Beijing 100084China

In complex networks,identifying influential spreader is of great significance for improving the reliability of networks and ensuring the safe and effective operation of ***,it is widely used in power networks,aviation networks,computer networks,and social networks,and so *** centrality methods mainly include degree centrality,closeness centrality,betweenness centrality,eigenvector centrality,k-shell,***,single centrality method is onesided and inaccurate,and sometimes many nodes have the same centrality value,namely the same ranking result,which makes it difficult to distinguish between *** to several classical methods of identifying influential nodes,in this paper we propose a novel method that is more full-scaled and universally *** into account in this method are several aspects of node’s properties,including local topological characteristics,central location of nodes,propagation characteristics,and properties of neighbor *** view of the idea of the multi-attribute decision-making,we regard the basic centrality method as node’s attribute and use the entropy weight method to weigh different attributes,and obtain node’s combined ***,the combined centrality is applied to the gravity law to comprehensively identify influential nodes in ***,the classical susceptible-infected-recovered(SIR)model is used to simulate the epidemic spreading in six real-society *** proposed method not only considers the four topological properties of nodes,but also emphasizes the influence of neighbor nodes from the aspect of *** is proved that the new method can effectively overcome the disadvantages of single centrality method and increase the accuracy of identifying influential nodes,which is of great significance for monitoring and controlling the complex networks.

关键词： complex networks influential nodes entropy weight method gravity law

NONLINEAR DYNAMICAL ANALYSIS OF BIFURCATION AND CONFLUENCE OF THE PACIFIC WESTERN BOUNDARY CURRENTS

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Journal of Hydrodynamics 2012年第3期24卷 383-390页

作者： ni Guo-xi jiang Song JU Qiang-chang KONG Ling-hai LCP Institute of Applied Physics and Computational Mathematics Beijing 100088 China

In this paper, we analyze the bifurcation and the confluence of the Pacific western boundary currents by an analytical approach. Applying the conservation law, the geostrophic balance relation and the Bernoulli integral to a reduced gravity model, we get a quantitative relation for the outflow and the inflow, and establish the related formulae for the width and the veering angle of offshore currents under the inflow condition. Furthermore, a comparison between the volume transport based on the observation data and the analytical value for the Pacific western boundary currents is presented, which validates the theoretical analysis.

关键词： Pacific western boundary currents bifurcation confluence volume transport reduced gravity model

Exploring individuals’ effective preventive measures against epidemics through reinforcement learning

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Chinese Physics B 2021年第4期30卷 640-647页

作者： Ya-Peng Cui Shun-jiang ni Shi-Fei Shen Institute of Public Safety Research Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Beijing Key Laboratory of City Integrated Emergency Response Science Beijing 100084China

Individuals’ preventive measures,as an effective way to suppress epidemic transmission and to protect themselves from infection,have attracted much academic concern,especially during the COVID-19 *** this paper,a reinforcement learning-based model is proposed to explore individuals’ effective preventive measures against *** extensive simulations,we find that the cost of preventive measures influences the epidemic transmission process *** infection scale increases as the cost of preventive measures grows,which means that the government needs to provide preventive measures with low cost to suppress the epidemic *** addition,the effective preventive measures vary from individual to individual according to the social *** who contact with others frequently in daily life are highly recommended to take strict preventive measures to protect themselves from infection,while those who have little social contacts do not need to take any measures considering the inevitable *** research contributes to exploring the effective measures for individuals,which can provide the government and individuals useful suggestions in response to epidemics.

关键词： epidemic simulation complex networks reinforcement learning preventive measures

Arc flash fault detection in wind farm collection feeders based on current waveform analysis

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Journal of Modern Power Systems and Clean Energy 2017年第2期5卷 211-219页

作者： Bin WANG jiang ni Jianzhao GENG Yuanyuan LU Xinzhou DONG State Key Laboratory of Power System Department of Electrical EngineeringTsinghua UniversityBeijing 100084China

High impedance faults(HIFs) are easy to occur in collective feeders in wind farms and may cause the cascading of wind generators tripping. This kind of faults is difficult to be detected by traditional relay or fuse due to the limited fault current values and the situation is worse in wind farms. The mostly adopted HIF detection algorithms are based on the 3rd harmonic characteristic of the fault zero-sequence currents, whereas these 3rd harmonics are very easy to be polluted by wind power back-to-back converters. In response to this problem, the typical harmonic characteristic of HIF arc flash based on Mayr’s arc model is first analyzed, and the typical fault waveforms of HIF in wind farm are presented. Then the performance of the harmonic based HIF detection algorithm is discussed,and a novel detection algorithm is proposed from the viewpoint of time domain, focusing on the convex and concave characteristic of zero-sequence current at zerocrossing points. A HIFs detection(HIFD) prototype implementing the proposed algorithm has been *** sensitivity and security of the algorithm are proved byfield data and RTDS experiments.

关键词： Wind farm High impedance fault Arc flash Zero-sequence current Convex and concave characteristic

Naphthalene decomposition in a DC corona radical shower discharge

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第1期12卷 71-77页

作者： Ming-jiang ni Xu SHEN Xiang GAO Zu-liang WU Hao LU State Key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou 310027 China College of Environmental Science and Engineering Zhejiang Gongshang University Hangzhou 310015 China Division of Combustion Physics Lund University S-22100 Lund Sweden

The naphthalene decomposition in a corona radical shower discharge (CRS) was investigated, with attention paid to the influences of voltage and initial naphthalene density. The OH emission spectra were investigated so as to know the naphthalene decomposing process. The by-products were analyzed and a decomposing theory in discharge was proposed. The results showed that higher voltage and relative humidity were effective on decomposition. The initial concentration affected the decomposing efficiency of naphthalene. When the initial naphthalene density was 17 mg/m3, the decomposition rate was found to be 70% under 14 kV. The main by-products were carbon dioxide and water. However, a small amount of carbonic oxide, 1,2-ethanediol and acetaldehyde were found due to the incomplete oxidization.

关键词： Naphthalene decomposition Corona Discharge OH radical

Safer solid-state lithium metal batteries:Mechanisms and strategies

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InfoMat 2024年第2期6卷 1-27页

作者： Shi-Jie Yang jiang-Kui Hu Feng-ni jiang Hong Yuan Ho Seok Park Jia-Qi Huang School of Materials Science&Engineering Beijing Institute of TechnologyBeijingthe People's Republic of China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijingthe People's Republic of China College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuanShanxithe People's Republic of China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijingthe People's Republic of China Center for Next-Generation Energy Materials and School of Chemical Engineering Sungkyunkwan UniversitySuwonRepublic of Korea

Solid-state batteries that employ solid-state electrolytes(SSEs)to replace routine liquid electrolytes are considered to be one of the most promising solutions for achieving high-safety lithium metal *** with high mechanical modulus,thermal stability,and non-flammability can not only inhibit the growth of lithium dendrites but also enhance the safety of lithium metal ***,several internal materials/electrodes-related thermal hazards demonstrated by recent works show that solid-state lithium metal batteries(SSLMBs)are not ***,understanding the potential thermal hazards of SSLMBs is critical for their more secure and widespread *** this contribution,we provide a comprehensive overview of the thermal failure mechanism of SSLMBs from materials to ***,strategies to improve the thermal safety performance of SSLMBs are included from the view of material enhancement,battery design,and external ***,the future directions are further *** hope that this work can shed bright insights into the path of constructing energy storage devices with high energy density and safety.

关键词： lithium metal batteries safety improvements solid-state batteries thermal failures thermal runaway

Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1341-1354页

作者： Naveed Ullah Khan jiang ni Xiufeng Ju Tongtong Miao Haiyan Chen Liang Han jiangsu Key Laboratory of Neuropsychiatric Diseases Research and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Department of Pharmacy Affiliated Hospital of Jiangnan UniversityWuxi 214000China

Breast cancer brain metastases(BCBMs)are one of the most difficult malignancies to treat due to the intracranial location and multifocal *** and molecular targeted therapy are extremely ineffective for BCBMs due to the inept brain accumulation because of the formidable bloodbrain barrier(BBB).Accumulation studies prove that low density lipoprotein receptor-related protein 1(LRP1)is promising target for BBB ***,as the primary clearance receptor for amyloid beta and tissue plasminogen activator,LRP1 at abluminal side of BBB can clear LRP1-targeting *** metalloproteinase-1(MMP1)is highly enriched in metastatic niche to promote growth of ***,it is reported that nanoparticles(NPs-K-s-A)tethered with MMP1-sensitive fusion peptide containing HER2-targeting K and LRP1-targeting angiopep-2(A),can surmount the BBB and escape LRP1-mediated clearance in metastatic ***-K-s-A revealed infinitely superior brain accumulation to angiopep-2-decorated NPs-A in BCBMs bearing mice,while comparable brain accumulation in normal *** delivered doxorubicin and lapatinib synergistically inhibit BCBMs growth and prolongs survival of mice bearing *** to the efficient BBB penetration,special and remarkable clearance escape,and facilitated therapeutic outcome,the fusion peptide-based drug delivery strategy may serve as a potential approach for clinical management of BCBMs.

关键词： Breast cancer brain metastases Blood-brain barrier Amyloid beta Abluminal LRP1 Brain clearance Fusion peptide MMP Nanoparticles

Development of non-premixed porous inserted regenerative thermal oxidizer

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第9期14卷 671-678页

作者： Jun-chun ZHANG Le-ming CHENG Cheng-hang ZHENG Zhong-yang LUO Ming-jiang ni State Key Laboratory of Clean Energy Utilization Zhejiang University

In this study, a porous inserted regenerative thermal oxidizer （PRTO） system was developed for a 125 kW industrial copper-melting furnace, due to its advantages of low NOr emissions and high radiant efficiency. Zirconium dioxide （ZrOz） ce- ramic foams were placed into the combustion zone of a regenerative thermal oxidizer （RTO）. Different performance characteris- tics of the RTO and PRTO systems, including pressure drop, temperature distribution, emissions, and energy efficiency, were evaluated to study the effects of the porous inserts on non-premixed CH4 combustion. It was found that the PRTO system achieved a significant reduction in the NOx emission level and a fuel saving of approximately 30% compared to the RTO system. It is most suitable for a lean combustion process at an equivalence ratio 〈0.4 with NOx and CO emission levels within 0.002%~）.003% and 0.001%q3.002%, respectively.

关键词： Porous media Regenerative thermal oxidizer (RTO) Non-premixed CH4 combustion