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The role of genotype and diet in shaping gut microbiome in a genetic vitamin A deficient mouse model

Journal of Genetics and Genomics 2022年第2期49卷 155-164页

作者： Jun Xu Jie-ni zhang Bo-Hui Sun Qing Liu Juan Ma Qian zhang Yong-Xin Liu ning Chen Feng Chen Department of Gastroenterology Peking University People’s HospitalBeijing 100044China Clinical Center of Immune-Mediated Digestive Diseases Peking University People’s HospitalBeijing 100044China Institute of Clinical Molecular Biology&Central Laboratory Peking University People’s HospitalBeijing 100044China Department of Orthodontics Peking University School of StomatologyBeijing 100081China Central Laboratory Peking University School of StomatologyBeijing 100081China CAS Center for Excellence in Biotic Interactions Chinese Academy of SciencesBeijing 100049China

Multifactors have been reported to affect the gut microbiome, including genotype, age, diet, and ***, few reports have investigated the relative capacity of different factors to shape the gut microbiome in a single study. Our design used a genetic vitamin A-deficient mouse model, the Rbp4^(-/-)mouse,feeding with the low vitamin A diets at different ages of initiation(4 or 7 weeks) for 28 days. Fecal samples were collected for bacterial profiling at seven time points after diet controlling. With Rbp4 depletion,Akkermansia decreased and Bacteroides increased, whereas Desulfovibrio, Barnesiella, Clostridium_Xl Va,and Lactobacillus fluctuated. The bacterial community swiftly adjusted with the vitamin A-deficient diet administration and gradually changed(e.g., decrease of Barnesiella and increase of Desulfovibrio). Age exerted a relatively weaker but long-last influence. At an earlier age to feed a vitamin A-deficient diet, a higher microbial dysbiosis index will be valued. Of note, the shaping effects of diet and age on the bacterial community varied with the difference of genotype, which might indicate a greater role of genotype than diet and age in shaping the gut microbiome.

关键词： Gut microbiome Host genotype Diet Vitamin A deficient Shaping role

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隧道无砟轨道沉降高聚物注浆整治技术

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交通企业管理 2024年第3期39卷 79-81页

作者：何新辉倪国章赵海粟刘成中铁第四勘察设计院集团有限公司

隧道内无砟轨道因其具有较强的稳定性、较好的耐久性、美观等特点而被广泛应用于国内外的高速铁路上。但随着无砟轨道的使用年限增加,防水措施失效部位受地应力变化或者排水不畅等外部地质因素影响,隧道内无砟轨道结构局部区段易发生路... 详细信息

隧道内无砟轨道因其具有较强的稳定性、较好的耐久性、美观等特点而被广泛应用于国内外的高速铁路上。但随着无砟轨道的使用年限增加,防水措施失效部位受地应力变化或者排水不畅等外部地质因素影响,隧道内无砟轨道结构局部区段易发生路基翻浆病害,甚至逐渐在后期演变为不均匀沉降,从而降低列车行驶的安全、舒适以及平顺性,同时显著加快无砟轨道各零部件的变形失效。

关键词：高铁隧道无砟轨道注浆抬升沉降整治

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Two MADS-box proteins,AGL9 and AGL15,recruit the FIS-PRC2 complex to trigger the phase transition from endosperm proliferation to embryo development in Arabidopsis

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Molecular Plant 2024年第7期17卷 1110-1128页

作者： Shen zhang Devasantosh Mohanty Adnan Muzaffar Min ni Department of Plant and Microbial Biology University of Minnesota at Twin CitiesSaint PaulMinnesota MN 55108United States of AmericaUSA

Spatiotemporal regulation of gene expression by polycomb repressive complex 2(PRc2)is critical for animal and plant *** Arabidopsis fertilization independent seed(FIS)-PRC2 complex functions specifically during plant reproduction from gametogenesis to seed *** a double fertilization event,triploid endosperm proliferates early,followed by the growth of a diploid embryo,which replaces the endosperm in Arabidopsis and many *** genes critical for endosperm proliferation such as IKkU2 and MIni3 are activated after *** we report that two MADS-box AGAMOUS-LIKE(AGL)proteins associate with the key endosperm proliferation loci and recruit the FIS-PRC2 repressive complex at 4-5 days after pollination(DAP).Interestingly,AGL9 and AGL15 only accumulate toward the end of endosperm proliferation at 4-5 DAP and promote the deposition of H3K27me3 marks at key endosperm proliferation *** of AGL9 and AGL15 or overexpression of AGL9 or AGL15 significantly influence endosperm proliferation and ***-wide analysis with cleavage Under Targets and tagmentation(CUT&Tag)sequencing and RNA sequencing revealed the landscape of endosperm H3K27me3 marks and gene expression profiles in Col-0 and agl9 ***&Tag qPCR also demonstrated the occupancy of the two MADS-box proteins and FIS-PRC2 on a few representative target *** studies suggest that MADS-box proteins could potentially recruit PRc2 to regulate many other developmental processes in plants or even in fungi and animals.

关键词： AGL9 AGL15 embryo endosperm IKU2 MEDEA MIni3

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Discrete state space method and modal extension method based impact sound synthesis model

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Chinese Physics B 2018年第11期27卷 270-277页

作者： Xu-Hua Tian Ke-An Chen Yan-ni zhang Han Li Jian Xu Department of Environmental Engineering School of Marine Science and Technology Northwestern Polytechnical University Xi＇an 710072 China

The efficient and accurate synthesis of physical parameter-controllable impact sounds is essential for sound source identification. In this study, an impact sound synthesis model of a cylinder is proposed based on discrete state space（DSS） method and modal extension method（MEM）. This model is comprised of the whole three processes of the physical interaction, i.e., the Hertz contact process, the transient structural response process, and the sound radiation process. Firstly,the modal expanded DSS equations of the contact system are constructed and the transient structural response of the cylinder is obtained. Then the impact sound of the cylinder is acquired using improved discrete Raleigh integral. Finally, the proposed model is verified by comparing with existing models. The results show that the proposed impact sound synthesis model is more accurate and efficient than the existing methods and easy to be extended to the impact sound synthesis of other structures.

关键词： impact sound synthesis discrete state space contact force

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Autonomy Evaluation of Unmanned Systems Based on Task Models

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Machine Intelligence Research 2024年第5期21卷 815-830页

作者： Yi Zou Zehao ni Xun Lei Chi zhang Key Laboratory of Complex Aviation Simulation System Beijing100076China State Key Laboratory of Multimodal Artificial Intelligence Systems(MAIS) Institute of AutomationChinese Academy of Sciences(CASIA)Beijing100190China Hong Kong Institute of Science&Innovation Chinese Academy of Sciences(HKISI CAS)Hong Kong999077China

In this study,relevant work on autonomy evaluation(AE)in recent years was comprehensively reviewed and classified from the perspective of task models,and a closed-loop task models based theoretical framework for AE was *** main contributions of this study are as follows.1)A taxonomy for AE based on task models was introduced to classify current theories,methods and standards.2)The limitations of the current autonomous evaluation methods were addressed to provide a theoretical framework for quantitative evaluation based on task models,and evaluation metrics for each stage were proposed based on the AE theoretical framework.3)Qualitative analyses of the superiority of the proposed AE framework based on the closed-loop task models were *** study attempts to provide a reference for researchers and engineers in the autonomous unmanned systems field and inspire future development of AE.

关键词： Unmanned system(UMS) autonomy evaluation task models closed-loop task models kill chain

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Solitary hyoid plasmacytoma with unicentric Castleman disease:A case report and review of literature

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World Journal of Clinical Cases 2022年第36期10卷 13364-13372页

作者： Yan-Hui zhang Yi-Feng He Hao Yue Yue-ni zhang Lei Shi Bin Jin Pin Dong Department of Otolaryngology-Head and Neck Surgery Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China Department of Radiology Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China Department of Pathology Shanghai Cancer CenterFudan UniversityShanghai 200032China NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy The Fourth Affiliated Hospital of Harbin Medical UniversityHarbin 150028Heilongjiang ProvinceChina

BACKGROUND Solitary plasmacytoma and unicentric Castleman disease(UCD)are rare lymphoproliferative disorders characterized by monoclonal plasma cells and a single set of locally enlarged lymph nodes,*** SUMMARY A 48-year-old Han Chinese man presented to our department with a neck mass and progressive foreign body sensation in his throat.18F-FDG positron emission tomography revealed focally increased radioactivity centered around the hyoid,and computed tomography(CT)revealed osteolytic *** revealed Castleman-like features and CD138/CD38-positive mature plasma *** work-up ruled out the possibility of POEMS syndrome,lymphoma,and multiple myeloma,leading to a final diagnosis of solitary hyoid plasmacytoma with *** patient underwent partial hyoid resection and selective neck dissection,followed by intensity-modulated radiotherapy.99mTc-MDP singlephoton emission computed tomography/CT reevaluation showed neither local recurrence nor distant bone metastasis at the 40-mo *** The diagnostic process and differential diagnosis of this rare case provided valuable educational information to clinicians.

关键词： 18F-FDG Positron emission tomography/computed tomography Plasmacytoma Hyoid bone Castleman disease Case report

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Adsorption Site and State of nitrogen Atom on Ru(0001),(1010) Low-index and (1120),(1121) Stepped Surfaces

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Chemical Research in Chinese Universities 2009年第5期25卷 705-710页

作者： DIAO Zhao-yu YU Hai-yan WANG Zhong-ni zhang Xue-na WANG Ze-xin Department of Chemistry Shandong Normal University Jinan 250014 P. R. China

The adsorptions of nitrogen atoms on Ru（0001）, （1010） low index surfaces and （1120）, （1121） stepped surfaces were investigated by the five-parameter Morse potential（5-MP） method in details, Calculated results demonstrate that N atoms show a tendency to be adsorbed at threefold sites. No subsurface state was found for N atoms on Ru（1010） surface. There exist 6 stable adsorption sites for N atoms on Ru（1121） stepped surface which can be classified into 3 types： the on-surface adsorption state, the facet adsorption state and the subsurface state. Moreover, two new perpendicular vibrations at 97 and 98 meV are predicted. All calculated results are in good accord with HR-EELS experiments.

关键词： N-Ru system 5-MP Surface adsorption

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Clinical and oncologic findings of extraprostatic extension on needle biopsy in de novo metastatic prostate cancer

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Asian Journal of Andrology 2020年第4期22卷 427-431页

作者： Jun-Ru Chen Jin-Ge Zhao Sha Zhu Meng-ni zhang ni Chen Jian-Dong Liu Guang-Xi Sun Peng-Fei Shen Hao Zeng Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Department of Pathology West China HospitalSichuan UniversityChengdu 610041China

This study aimed to explore the clinical and oncologic findings in patients with de novo metastatic prostate cancer(mPCa)and extraprostatic extension(EPE)on *** retrospectively evaluated data on 630 patients with de novo mPCa between January 2009 and December 2017 in the West China Hospital(Chengdu,China),including evaluating the relationships between EPE and other variables and the association of EPE with survival outcomes by the Chi-square test,Kaplan–Meier curves,and the Cox proportional-hazards *** was found in 70/630 patients,making a prevalence of 11.1%.The presence of EPE on biopsy was associated with higher Gleason scores and higher incidence of neuroendocrine differentiation(NED),intraductal carcinoma of the prostate(IDC-P),and perineural invasion(Pni).Compared with those without EPE,patients with EPE had shorter castration-resistant prostate cancer-free survival(CFS;median:14.1 vs 17.1 months,P=0.015)and overall survival(OS;median:43.7 vs 68.3 months,P=0.032).According to multivariate analysis,EPE was not an independent predictor for *** analyses demonstrated that patients with favorable characteristics,including negative NED or IDC-P status,Eastern Cooperative Oncology Group(ECOG)scorenicopathological features and poorer CFS and *** data suggest that EPE may be an indicator of poor prognosis,particularly in patients,otherwise considered likely to have favorable survival outcomes.

关键词： extraprostatic extension metastatic prostate cancer prevalence prognosis

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Recent Research Progress of Paper-Based Supercapacitors Based on Cellulose

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Energy & Environmental Materials 2024年第3期7卷 345-373页

作者： Chuanyin Xiong Tianxu Wang Jing Han zhao zhang Yonghao ni College of Bioresources Chemical&Materials Engineering Shaanxi University of Science and TechnologyXi'an 710021China School of Materials Science and Engineering Tianjin Polytechnic UniversityTianjin 300387China Department of Chemical and Biomedical Engineering The University of MaineOronoMaine 04469USA University of New Brunswick Limerick Pulp&Paper CtrFredericton New Brunswick E3B 5A3Canada

In recent years,paper-based functional materials have received extensive attention in the field of energy storage due to their advantages of rich and adjustable porous network structure and good *** an important energy storage device,paper-based supercapacitors have important application prospects in many fields and have also received extensive attention from researchers in recent *** present,researchers have modified and regulated paper-based materials by different means such as structural design and material composition to enhance their electrochemical storage *** development of paper-based supercapacitors provides an important direction for the development of green and sustainable ***,it is of great significance to summarize the relevant work of paper-based supercapacitors for their rapid development and *** this review,the recent research progress of paper-based supercapacitors based on cellulose was summarized in terms of various cellulose-based composites,preparation skills,and electrochemical ***,some opinions on the problems in the development of this field and the future development trend were *** is hoped that this review can provide valuable references and ideas for the rapid development of paper-based energy storage devices.

关键词： cellulose electrochemical performance flexibility paper-based supercapacitor porous

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不同自发气调袋对玛瑙红樱桃贮藏品质的影响分析

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包装工程 2024年第15期45卷 106-115页

作者：李昱昕吉宁王瑞刘仁婵聂华丽张妮刘梦琦陶秋运贵阳学院食品科学与工程学院贵阳550005 贵州多彩田园农业开发有限公司贵州开阳550300

目的探究不同自发气调袋(WK、PE20、PE30和PE40)对玛瑙红樱桃在贮藏期间外观品质和生理生化指标的影响。方法以玛瑙红樱桃为材料,采用不同自发气调袋对其进行包装,贮藏至(1±0.3)℃环境中21 d,每隔7 d测定一次玛瑙红樱桃相关指标,研究... 详细信息

目的探究不同自发气调袋(WK、PE20、PE30和PE40)对玛瑙红樱桃在贮藏期间外观品质和生理生化指标的影响。方法以玛瑙红樱桃为材料,采用不同自发气调袋对其进行包装,贮藏至(1±0.3)℃环境中21 d,每隔7 d测定一次玛瑙红樱桃相关指标,研究贮藏期间自发气调袋内玛瑙红樱桃的品质变化,以探寻其最佳贮藏包装条件。结果随着贮藏时间的延长,PE包装贮藏能有效降低果实的腐烂率,抑制呼吸强度和可溶性固形物(Soluble Solids,TSS)含量的增加,维持了较高的果实硬度,提高果实品质和营养价值。其中,PE20包装贮藏显著延缓了果实维生素C和多酚含量的下降,抑制了丙二醛(Malondialdehyde,MDA)的积累,并保持了较高的过氧化物酶(Peroxidase,POD)活性。此外,主成分分析(PCA)综合得分表明,在玛瑙红樱桃贮藏过程中,PE20包装具有最佳的综合效果。结论玛瑙红樱桃的低温贮藏过程中,PE20包装最为有助维持果实的贮藏品质。

关键词：玛瑙红樱桃自发气调袋贮藏品质主成分分析相关性分析

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