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Acta Geochimica 2017年第3期36卷 370-373页

作者： Chengfan Yang Shouye Yang ni su State Key Laboratory of Marine Geology Tongji University 1239 Siping Road Shanghai 200092 People's Republic of China

Recent studies suggest that the hydrogen and oxygen isotopic compositions of clay minerals can indicate ***,we report mineralogy and stable isotopic records(d D and δ^(18)O_(OH))of a weathering profile located in the Fujian Province,aiming to validate whether hydroxyl stable isotopes can indicate paleo-precipitation and *** results indicate that the d D and δ^(18)O_(OH)changes in the kaolinite hydroxyl of the weathering profile are basically determined by the isotopic composition of paleo-meteoric water and paleotemperature,***,whether the d D and δ^(18)O_(OH)of kaolinite can quantitatively indicate paleo-precipitation and paleo-temperature needs to be verified further,and especially,the structural oxygen isotopic composition that is the essential element for the kaolinite formation temperature calculation has to be constrained in future work.

关键词： Weathering profile Hydrogen and oxygen isotopes Hydroxyl Kaolinite

Rare earth element chemistry indicates chemical alteration of zircons during the evolution of weathering profile

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Acta Geochimica 2017年第3期36卷 433-436页

作者： ni su Shouye Yang Wei Yue State Key Laboratory of Marine Geology Tongji University Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and Technology

Although rare earth elements(REEs)in magmatic zircons have been widely used to identify the type and compositional evolution of host rocks,REE distribution patterns during the chemical alteration of zircons need *** investigated REE characteristics in zircons with different degrees of chemical weathering through systematic observation of a granodiorite-weathering profile in southeast *** the relatively stable provenance of the studied profile(zircon U–Pb ages are95.2±4.8 Ma),the zircon REEs exhibited systematic differences in abundance and fractionation patterns from the bedrock to upper layers,e.g.∑PREE,(LREE/HREE)_(CN),and Ce/Ce*.This evidence suggests chemical alteration of zircons during intensive chemical weathering and an expected influence on REE variability in the weathered products due to the presence of REE-bearing minerals.

关键词： Weathering profile Rare earth elements Zircon

Model building for Chang-8 low permeability sandstone reservoir in the Yanchang formation of the Xifeng oil field

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Mining Science and Technology 2009年第2期19卷 245-251页

作者： SONG Fan HOU Jia-gen su ni-na School of Resources and Information China University of Petroleum Beijing 102249 China

In order to build a model for the Chang-8 low permeability sandstone reservoir in the Yanchang formation of the Xifeng oil field,we studied sedimentation and diagenesis of sandstone and analyzed major factors controlling this low permeability *** doing so,we have made clear that the spatial distribution of reservoir attribute parameters is controlled by the spatial distribution of various kinds of sandstone *** taking advantage of many coring wells and high quality logging data,we used regression analysis for a single well with geological conditions as constraints,to build the interpretation model for logging data and to calculate attribute parameters for a single well,which ensured accuracy of the 1-D vertical *** this basis,we built a litho-facies model to replace the sedimentary facies *** addition,we also built a porosity model by using a sequential Gaussian simulation with the lithofacies model as the *** the end,we built a permeability model by using Markov-Bayes simula-tion,with the porosity attribute as the *** results show that the permeability model reflects very well the relative differences between low permeability values,which is of great importance for locating high permeability zones and forecasting zones favorable for exploration and exploitation.

关键词： Xifeng oil field low permeability reservoir attribute parameter Markov-Bayes model permeability model

^(226)Ra and ^(228)Ra tracer study on nutrient transport in east coastal waters of Hainan Island,China

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Water Science and Engineering 2011年第2期4卷 157-169页

作者： ni su Jin-zhou DU Tao JI, Jing ZHANG State Key Laboratory of Estuarine and Coastal Research East China Normal University Shanghai 200062 P. R. China

Material fluxes （e.g., nutrients） from coastal waters to offshore areas play an important role in controlling the water quality of the adjacent sea areas not only by increasing nutrient concentration hut also by changing nutrient structures. In this study, naturally occurring isotopes, ^226Ra and ^228Ra, were measured with the alpha spectrometry in the Wenjiao-Wenchang and Wanquan estuaries and adjacent sea areas along the east coast of Hainan Island. The excess ^226Ra and ^228Ra activities were observed by comparison with the values derived from the conservative mixing of freshwater and seawater end-members in both estuaries. Using a one-dimensional diffusion model, the horizontal eddy diffusion coefficient of 3.1 6 × 10^5 cm^2/s, for nutrients diffusing from their sources, was derived from 228Ra activities. Consequently, the corresponding nutrient fluxes flowing into the coastal waters were assessed. The results can provide useful information for the study of the mixing and exchange processes of coastal waters as well as dissoluble pollutant transport in this sea area.

关键词： Ra isotope ^226Ra and 228Ra tracers horizontal eddy diffusion coefficient nutrient flux east coastal waters of Hainan Island

Origin of the springtime South China Sea Warm Current in the southwestern Taiwan Strait: Evidence from seawater oxygen isotope

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Science China Earth Sciences 2020年第10期63卷 1564-1576页

作者： Dongyu CHEN Ergang LIAN Yeqiang SHU Shouye YANG Yalong LI Chao LI Pengfei LIU ni su State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China

Oxygen isotope(δ^18O)of seawater is an excellent proxy for tracing the origins of water masses and their mixing *** with hydrographic observation,hybrid coordinate ocean model(HYCOM)analysis data,and seawater oxygen isotope,we investigated the source of the South China Sea Warm Current(SCSWC)in the southwestern Taiwan Strait and its underlying *** show that the Kuroshio subsurface water(KSSW)can intrude the continental slope in the southwestern Taiwan Strait,and thereby climb up the continental slope coupled with ***δ^18O-salinity relationship further indicates that in spring,the SCSWC in the southwestern Taiwan Strait originates from the upslope deflection of the slope current formed by the KSSW intrusion into the South China Sea,rather than from the west segment of the SCSWC formed to the east of Hainan *** addition,the southward flowing Zhe-Min Coastal Current(ZMCC)can reach as far as the Taiwan Bank(TB)and deflects offshore over the western TB at approximately 23.5°N,to some extent affecting the ***,this study reveals that seawaterδ^18O is exquisitely sensitive to the determination of the origin and transport of water masses as compared with traditional potential temperature-salinity plot(θ-S)and HYCOM analysis *** addition,their coupling can more reliably interpret the mixing processes of shelf water masses.

关键词： Oxygen isotope South China Sea Warm Current Zhe-Min Coastal Current Kuroshio Southwestern Taiwan Strait

Comparative pharmacophore modeling of human adenosine receptor A1 and A3 antagonists

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Science China Chemistry 2012年第11期55卷 2407-2418页

作者： XU ZheJun CHENG FeiXiong LI Jie ZHOU YaDi su ni LI WeiHua LIU GuiXia TANG Yun Department of Pharmaeeutical Sciences School of PharmacyEast China University of Science and TechnologyShanghai 200237China

Adenosine receptors are promising therapeutic targets in drug discovery. In this study, three-dimensional pharmacophore mod- els of human adenosine receptor A1 and A3 antagonists were developed based on 26 and 23 diverse compounds, respectively. The best A1 pharmacophore model （A1-Hopyl） consists of four features： one hydrogen bond donor, one hydrophobic point and two ring aromatics, while the best A3 pharmacophore model （A3_Hopyl） also has four features： one hydrogen bond ac- ceptor, one hydrophobic point and two ring aromatics. The correlation coefficients were 0.840 for A1 test set with 146 diverse compounds and 0.827 for A3 test set with 238 diverse compounds. In the simulated virtual screening experiments, high en- richment factors of 6.51 and 6.90 were obtained for A1_Hopyl and A3_Hopyl models, respectively. Moreover, two models also showed high subtype-selectivity in the simulated virtual screening experiments. These results could be helpful for the dis- covery of novel potent and selective A1 and A3 antagonists.

关键词： pharmacophore modeling adenosine receptors antagonists enrichment factor simulated virtual screening

Complement use of Chinese herbal medicine after percutaneous coronary intervention: a prospective observational study

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Journal of Geriatric Cardiology 2022年第9期19卷 696-704页

作者： Si-Yu YAN Wei-Xian YANG Pei-Pei LU Xuan-Tong GUO Cai-Xia GUO Yan-ni su Li-Hong MA Chinese Academy of Medical Sciences&Peking Union Medical College Fuwai Hospital Xicheng DistrictBeijingChina

BACKGROUND Chinese herbal medicine is widely used as a complement or alternative treatment in coronary artery disease(CAD)patients after percutaneous coronary intervention(PCI)in *** compared the incidence of the major adverse cardi-ovascular event(MACE)of CAD patients with or without the complement use of Chinese herbal medicine after *** In this prospective,observational study that was conducted from September 2016 to August 2019 in Fuwai Hospital(China),we followed up consecutive patients who received PCI treatment for two *** was defined as the composite all-cause mortality,revascularization,and myocardial infarction(MI)and was compared between those using(integrative medicine group)or those not using Chinese herbal medicine as an additional treatment to standard Western medicine,with unadjusted(Kaplan-Meier curves)and risk-adjusted(multivariable Cox regression)*** A total of 5942 patients after PCI were enrolled in this study,and 5453 patients were included in the final analysis(4189[76.8%]male;mean age:61.9±9.9%years).During the follow-ups,2932(53.8%)patients used only Western medicine while 2521(46.2%)patients had used Chinese herbal medicine as an additional treatment to standard Western *** in the integrative medicine group(IM group)were older than the Western medicine group(WM group),had more females and less pre-vious *** incidence of MACE was 15.3%(449/2932)in WM group and 11.54%(291/2521)in IM *** regression ana-lysis showed that cumulative incidence of MACE was 27%lower in patients of the IM group than those in WM group(hazard ra-tio=0.73;95%CI:0.63-0.85;P<0.0001).CONCLUSIONS For CAD patients after PCI treatment,complement use of Chinese herbal medicine is associated with a lower 2-year MACE *** prospective studies are warranted to provide higher levels of benefit evidence in these pa-tients.

关键词： herbal prospective coronary

Qishen capsule safely boosts cardiac function and angiogenesis via the MEK/ERK pathway in a rat myocardial infarction model

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Journal of Geriatric Cardiology 2019年第10期16卷 764-774页

作者： Cai-Xia GUO Zhi-Yuan LI Jin-Bang niU Shuan-Cheng FAN Si-Yu YAN Pei-Pei LU Yan-ni su Li-Hong MA State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Shanghai Kai Bao Pharmaceutical Co. LtdShanghaiChina

Background Qishen(QS) capsules, a Traditional Chinese Medicine, has been widely used to treat coronary heart disease in China. However, evidence of its effectiveness remains unclear. Methods To explore whether QS has cardioprotective efficacy and/or promotes angiogenesis after myocardial infarction (MI), we performed experiments in a preclinical rat MI model. One month after left anterior descending coronary artery ligation, the rats received either QS solution (0.4 g/kg/day) or the same volume of saline by intragastric injection for four weeks. Results Echocardiographic and hemodynamic analyses demonstrated relatively preserved cardiac function in MI rats administered QS. Indeed, QS treatment was associated with reduced infarct scar size and heart weight index, and these beneficial effects were responsible for enhancing angiogenesis. Mechanistically, QS treatment increased phosphorylation of protein kinase B (Akt) and downregulated phosphorylation of mitogen-activated protein kinase/extracellular-regulated kinase (MEK/ERK). Conclusions QS therapy can improve the cardiac function of rats after MI by an underlying mechanism involving increased angiogenesis, at least partially via activation of the Akt signaling pathway and inhibition of MEK/ERK phosphorylation.

关键词： Angiogenesis Cardioprotective efficacy Qishen capsule

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论制度的民主与法治

福建论坛（人文社会科学版） 2007年第1期 122-125页

作者：倪愫襄武汉大学政治与公共管理学院湖北武汉430072

民主与法治作为现代社会的管理形式和手段,不仅是社会政治文明的标志,也是制度建设和完善的有效途径。在现代社会制度的建构中,民主作为有效的管理形式和体制,是法治的基础和条件;法治作为强制性的管理方式则是民主的前提和保障。

关键词：制度民主法治

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MPLS网络多路径动态流量分配的研究

电子学报 2005年第4期33卷 718-720页

作者：倪甦华唐宝民南京邮电学院通信工程系江苏南京210003

本文描述了MPLS(多协议标记交换)流量工程性能最优化方面的一种分析途径,首先对多路径系统模型进行了描述,然后在引入流量分配颗粒度g的概念的基础上,提出一种改进的多路径上的动态流量分配算法,利用此算法,可以实现LSPs(标记交换路径)... 详细信息

本文描述了MPLS(多协议标记交换)流量工程性能最优化方面的一种分析途径,首先对多路径系统模型进行了描述,然后在引入流量分配颗粒度g的概念的基础上,提出一种改进的多路径上的动态流量分配算法,利用此算法,可以实现LSPs(标记交换路径)上流量的动态调整,并降低运算量,本文通过数值分析验证了算法的性能和稳定性.

关键词： MPLS 流量工程 ISP 流量分配