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DRG付费下柳州市某三甲综合医院开展中医优势病种按病种点数法付费的实践探索

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中国卫生标准管理 2024年第10期15卷 50-55页

作者：兰妮廖莉莉朱光炜韦昕烨柳州市工人医院医疗保险办公室广西柳州545005

目的分析广西柳州市某三甲综合医院在疾病诊断相关分组(diagnosisrelatedgroups,DRG)付费下执行中医优势病种按病种点数法付费的实践情况,为优化医院付费管理和完善付费改革提供建议。方法以2022年7月—2023年12月柳州市某三甲综合医... 详细信息

目的分析广西柳州市某三甲综合医院在疾病诊断相关分组(diagnosisrelatedgroups,DRG)付费下执行中医优势病种按病种点数法付费的实践情况,为优化医院付费管理和完善付费改革提供建议。方法以2022年7月—2023年12月柳州市某三甲综合医院实行中医优势病种按病种点数法付费的病例及相同诊断按DRG付费的病例为样本,采用SPSS24.0统计学软件进行分析和描述统计。比较柳州市某三甲综合医院中医优势病种点数法付费申报及通过例数、中医治疗腰椎间盘突出2种付费方式均次费用和住院天数、中医治疗腰椎间盘突出2种付费方式结算盈亏。结果 2022年7月—2023年12月每月中医优势病种付费的申报例数、申报病种、申报科室和成功结算病例数呈递增趋势;筛选中医治疗“腰椎间盘突出”的非手术病例按DRG付费和中医优势病种付费分2组对比分析,2组均次费用比较,差异无统计学意义(P>0.05);而中医优势病种付费组的住院天数为(8.81±2.72)d,结余例数占比为60.42%,高于DRG付费中医治疗组的(6.77±2.86)d、34.62%(P<0.05)。结论某三甲综合医院应充分利用中医药服务支付方式改革的机遇,发展中医科室及中医治疗项目,做好中医人才培养,顺应多元化付费方式改革。建议医保部门完善中医优势病种遴选和准入标准,强化信息建设,及时反馈中医优势病种付费数据,进一步提高中医优势病种付费的精细化管理。

关键词：中医药服务中医优势病种点数付费 DRG 综合医院柳州

The C_2H_2 -type Zinc Finger Protein ZFP182 is Involved in Abscisic Acid-Induced Antioxidant Defense in Rice

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Journal of Integrative Plant Biology 2012年第7期54卷 500-510页

作者： Hong Zhang lan ni Yanpei Liu Yunfei Wang Aying Zhang Mingpu Tan Mingyi Jiang College of Life Sciences Nanjing Agricultural UniversityNanjing 210095China National Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjing 210095China

C2H2-type zinc finger proteins （ZFPs） are thought to play important roles in modulating the responses of plants to drought, salinity and oxidative stress. However, direct evidence is lacking for the involvement of these ZFPs in abscisic acid （ABA）-induced antioxidant defense in plants. In this study, the role of the rice （Oryza sativa L. *** cv. nipponbare） C2H2-type ZFP ZFP182 in ABA-induced antioxidant defense and the relationship between ZFP182 and two rice MAPKs, OsMPK1 and OsMPK5 in ABA signaling were investigated. ABA treatment induced the increases in the expression of ZFP182, OsMPK1 and OsMPK5, and the activities of superoxide dismutase （SOD） and ascorbate peroxidase （APX） in rice leaves. The transient gene expression analysis and the transient RNA interference （RNAi） analysis in protoplasts showed that ZFP182, OsMPK1 and OsMPK5 are involved in ABA-induced up-regulation in the activities of SOD and APX. Besides, OsMPK1 and OsMPK5 were shown to be required for the up-regulation in the expression of ZFP182 in ABA signaling, but ZFP182 did not mediate the ABA-induced up-regulation in the expression of OsMPK1 and OsMPKS. These results indicate that ZFP182 is required for ABA-induced antioxidant defense and the expression of ZFP182 is regulated by rice MAPKs in ABA signaling.

关键词： Zinc finger protein abscisic acid antioxidant defense rice MAPK.

Hierarchical porous carbon derived from animal bone as matric to encapsulated selenium for high performance Li-Se battery

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Rare Metals 2017年第5期36卷 434-441页

作者： Li-Sheng Xie Sheng-Xue Yu Hui-Jun Yang Jun Yang Jian-lan ni Jiu-Lin Wang Shanghai Electrochemical Energy Devices Research Center Department of Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China College of Environment and Chemistry Engineering Yanshan UniversityQinhuangdao 066004China Shanghai Using Yuan Environmental Engineering Co. LtdShanghai 201801China

Animal bone was employed as raw material to prepare hierarchical porous carbon by KOH activation. Rare metal selenium（Se） was encapsulated into hierarchical porous carbon successfully for the cathode material of Li–Se battery, achieving the transformation of waste into energy,protecting environment and reducing the spread of the disease. Animal bone porous carbon（ABPC） acquires a specific surface area of 1244.7903 m^2·g^-1 and a pore volume of 0.594184 cm^3·g^-1. The composite Se/ABPC with 51 wt%Se was tested as a novel cathode for Li–Se batteries. The results show that Se/ABPC exhibits high specific capacity,good cycling stability and current-rate performance; at 0.1C,the composite Se/ABPC delivers a high reversible capacity of 705 mAh·g^-1 in the second cycle and 591 mAh·g^-1 after 98 cycles. Even at the current density of 2.0C, it can still maintain at a reversible capacity of 485 mAh·g^-1. The excellent electrochemical properties benefit from the high electron conductivity and the carbon with unique hierarchical porous structure. ABPC can be a promising carbon matrix for Li–Se batteries.

关键词： Se/ABPC Animal bones High rate capability Li–Se battery Hierarchical porous structure

Losartan reduced connexin43 expression in left ventricular myocardium of spontaneously hypertensive rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 448-454页

作者： Li-li ZHAO Hong-juan CHEN Jun-zhu CHEN Min YU Yun-lan ni Wei-fang ZHANG Department of Cardiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective:To assess the effect of angiotensin II type 1(AT1)receptor antagonist losartan on myocardium con- nexin43(Cx43)gap junction(GJ)expression in spontaneously hypertensive rats(SHRs)and investigate possible mechanisms. Methods:Sixteen 9-week-old male SHRs and 8 age-matched male Wistar-Kyoto(WKY)rats were included in this *** were randomly divided into two groups to receive losartan at 30 mg/(kg·d)by oral gavage once daily for 8 weeks(SHR-L)or vehicle(0.9%saline)to act as controls(SHR-V);WKY rats receiving vehicle for 8 weeks served as normotensive *** the end of the experiment,rats were sacrificed and the hearts were *** of Cx43 and nuclear factor-kappaB p65 (NF-κB p65)proteins in all three groups were observed and further investigations on the effect of angiotensin II type 1 receptor antagonist losartan(30 mg/(kg·d),8 weeks)on Cx43 expression were conducted with Western blot and immunohistochemistry. NF-κB p65 protein in nuclear extracts was determined by Western ***:Left ventricular(LV)hypertrophy was prominent in SHRs,Cx43 and NF-κB p65 protein expressions were obviously upregulated and Cx43 distribution was dispersed over the cell *** with losarton reduced the over-expressions of Cx43 and NF-κB p65 in LV *** distribution of Cx43 gap junction also became much regular and confined to intercalated disk after losartan ***- sion:Cx43 level was upregulated in LV myocardium of SHR during early stage of *** II type 1 receptor antagonist losartan prevented Cx43 gap junction remodeling in hypertrophied left ventricles,possibly through the NF-κB pathway.

关键词： Connexin43 (Cx43) Left ventricular (LV) hypertrophy Angiotensin II Nuclear factor-kappaB p65 (NF-κB p65) Gap junction (GJ)

基于CiteSpace的公共图书馆弱势群体服务可视化研究

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江苏科技信息 2024年第2期41卷 46-49页

作者：兰妮湘潭大学公共管理学院湖南湘潭411105

文章运用CiteSpace软件对近20年公共图书馆弱势群服务领域的相关文献进行科学的梳理并从发文量、发文趋势、关键词分析、关键词聚类4个方面分析该领的研究态势与发展趋势。结果表明,弱势群体服务研究工作较为深入,未来研究方向将集中在... 详细信息

文章运用CiteSpace软件对近20年公共图书馆弱势群服务领域的相关文献进行科学的梳理并从发文量、发文趋势、关键词分析、关键词聚类4个方面分析该领的研究态势与发展趋势。结果表明,弱势群体服务研究工作较为深入,未来研究方向将集中在未成年、老年人、视障读者等群体以及美国、日本等国家,还需加强各方合作,把握研究新动向和学习国外分析经验,为该领域后续研究提供参考借鉴。

关键词：弱势群体服务公共图书馆 CiteSpace

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OsDMI3 Is a Novel Component of Abscisic Acid Signaling in the Induction of Antioxidant Defense in Leaves of Rice

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Molecular Plant 2012年第6期5卷 1359-1374页

作者： Ben Shi lan ni Aying Zhang Jianmei Cao Hong Zhang Tingting Qin Mingpu Tan Jianhua Zhang Mingyi-Jiang College of Life Sciences Nanjing Agricultural UniversityNanjing 210095China National Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjing 210095China Department of Biology Hong Kong Baptist UniversityHong KongChina

Ca^2＋ and calmodulin （CAM） have been shown to play an important role in abscisic acid （ABA）-induced anti- oxidant defense. However, it is unknown whether Ca^2＋/CaM-dependent protein kinase （CCaMK） is involved in the pro- cess. In the present study, the role of rice CCaMK, OsDMI3, in ABA-induced antioxidant defense was investigated in leaves of rice （Oryza sativa） plants. Treatments with ABA, H2O2, and polyethylene glycol （PEG） induced the expression of OsDMI3 and the activity of OsDMI3, and H2O2 is required for the ABA-induced increases in the expression and the activity of OsDMI3 under water stress. Subcellular localization analysis showed that OsDMI3 is located in the nucleus, the cytoplasm, and the plasma membrane. The analysis of the transient expression of OsDMI3 in rice protoplasts and the RNA interference （RNAi） silencing of OsDMI3 in rice protoplasts showed that OsDMI3 is required for ABA-induced increases in the expression and the activities of superoxide dismutase （SOD） and catalase （CAT）. Further, the oxidative damage induced by higher concentrations of PEG and H202 was aggravated in the mutant of OsDMI3. Moreover, the analysis of the RNAi silencing of OsDMI3 in protoplasts and the mutant of OsDMI3 showed that higher levels of H2O2 accumulation require OsDMI3 activation in ABA signaling, but the initial H2O2 production induced by ABA is not depend- ent on the activation of OsDMI3 in leaves of rice plants. Our data reveal that OsDMI3 is an important component in ABA-induced antioxidant defense in rice.

关键词： OsDMI3 abscisic acid antioxidant defense H202 oxidative stress signal transduction.

OsDMI3-mediated OsUXS3 phosphorylation improves oxidative stress tolerance by modulating OsCATB protein abundance in rice

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Journal of Integrative Plant Biology 2022年第5期64卷 1087-1101页

作者： lan ni Qingwen Wang Chao Chen Shuang Wang Tao Shen Jingjing Jiang Zhenzhen Cui Kaiyue Li Qiqing Yang Mingyi Jiang College of Life Sciences National Key Laboratory of Crop Genetics and Germplasm EnhancementKey Laboratory of Crop Physiology Ecology and Production ManagementMinistry of AgricultureNanjing Agricultural UniversityNanjing 210095China Southern Regional Collaborative Innovation Center for Grain and Oil Crops in China Hunan Agricultural UniversityChangsha 410128China

Calcium(Ca^(2+))/calmodulin(CaM)-dependent protein kinase(CCaMK)is an important positive regulator of antioxidant defenses and tolerance against oxidative ***,the underlying molecular mechanisms are largely ***,we report that the rice(Oryza sativa)CCa MK(OsDMI3)physically interacts with and phosphorylates OsUXS3,a cytosol-localized UDP-xylose *** and biochemical evidence demonstrated that OsUXS3 acts downstream of OsDMI3 to enhance the oxidative stress tolerance conferred by higher catalase(CAT)***,OsUXS3 interacted with CAT isozyme B(OsCATB),and this interaction was required to increase OsCATB protein abundance under oxidative stress ***,we showed that OsDMI3 phosphorylates OsUXS3 on residue Ser-245,thereby further promoting the interaction between OsUXS3 and *** results indicate that OsDMI3 promotes the association of OsUXS3 with OsCATB to enhance CAT activity under oxidative *** findings reveal OsUXS3 as a direct target of OsDMI3 and demonstrate its involvement in antioxidant defense.

关键词： Ca2+/calmodulin-dependent protein kinase catalase oxidative stress rice UDP-xylose synthase

Phosphorylation of OsRbohB by the protein kinase OsDMI3 promotes H_(2)O_(2) production to potentiate ABA responses in rice

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Molecular Plant 2023年第5期16卷 882-902页

作者： Qingwen Wang Tao Shen lan ni Chao Chen Jingjing Jiang Zhenzhen Cui Shuang Wang Fengjuan Xu Runjiao Yan Mingyi Jiang College of Life Sciences State Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationKey Laboratory of Crop Physiology Ecology and Production ManagementMinistry of AgricultureNanjing Agricultural UniversityNanjing 210095China

In rice, the Ca^(2+)/calmodulin-dependent protein kinase OsDMI3 is an important positive regulator of abscisic acid (ABA) signaling. In ABA signaling, H_(2)O_(2) is required for ABA-induced activation of OsDMI3, which in turn increase H_(2)O_(2) production. However, how OsDMI3 regulates H_(2)O_(2) production in ABA signaling remains unknown. Here we show that OsRbohB is the main NADPH oxidase involved in ABA-induced H_(2)O_(2) production and ABA-mediated physiological responses. OsDMI3 directly interacts with and phosphorylates OsRbohB at Ser-191, which is OsDMI3-mediated site-specific phosphorylation in ABA signaling. Further analyses revealed that OsDMI3-mediated OsRbohB Ser-191 phosphorylation positively regulates the activity of NADPH oxidase and the production of H_(2)O_(2) in ABA signaling, thereby enhancing the sensitivity of seed germination and root growth to ABA and plant tolerance to water stress and oxidative stress. Moreover, we discovered that the OsDMI3-mediated OsRbohB phosphorylation and H_(2)O_(2) production is dependent on the sucrose non-fermenting 1-related protein kinases SAPK8/9/10, which phosphorylate OsRbohB at Ser-140 in ABA signaling. Taken together, these results not only reveal an important regulatory mechanism that directly activates Rboh for ABA-induced H_(2)O_(2) production but also uncover the importance of this regulatory mechanism in ABA signaling.

关键词： abscisic acid Ca^(2+)/calmodulin-dependent protein kinase NADPH oxidases protein phosphorylation rice

Identification and Function of Acid-sensing Ion Channels in RAW 264.7 Macrophage Cells

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Current Medical Science 2018年第3期38卷 436-442页

作者： lan ni Peng FANG Zhuang-li HU Hai-yun ZHOU Jian-guo CHEN Fang WANG You JIN Department of Pharmacology School of Basic Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Key Laboratory of Neurological Diseases (HUST) Ministry of Education of China Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province Institute of Brain Research School of Basic Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Activation of acid-sensing ion channels （ASICs） plays an important role in neuroinflammation. Macrophage recruitment to the sites of inflammation is an essential step in host defense. ASIC1 and ASIC3 have been reported to mediate the endocytosis and maturation of bone marrow derived macrophages. However, the expression and inflammation-related functions of ASICs in RAW 264.7 cells, another common macrophage, are still elusive. In the present study, we first demonstrated the presence of ASIC 1, ASIC2a and ASIC3 in RAW 264.7 macrophage cell line by using reverse transcriptase polymerase chain reaction （RT-PCR）, Western blotting and immunofluorescence experiments. The non-specific ASICs inhibitor amiloride and specific homomeric ASICla blocker PcTxl reduced the production of iNOS and COX-2 by LPS-induced activating RAW 264.7 cells. Furthermore, not only amiloride but also PcTxl inhibited the migration and LPS-induced apoptosis of RAW 264.7 cells. Taken together, our findings suggest that ASICs promote the inflammatory response and apoptosis of RAW 264.7 cells, and ASICs may serve as a potential novel target for immunological disease therapy.

关键词： acid-sensing ion channels (ASICs) RAW 264.7 cells inflammation apoptosis migration