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Biodegradable magnesium alloy with eddy thermal effect for effective and accurate magnetic hyperthermia ablation of tumors

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National Science Review 2021年第1期8卷 98-108页

作者： Nailin Yang Fei Gong Liang Cheng Huali Lei Wei Li Zongbin Sun caifang ni Zhanhui Wang Zhuang Liu Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow University Department of Vascular Surgery and Interventional Radiology First Affiliated Hospital of Soochow University Luoyang Central Hospital affiliated to Zhengzhou University

Magnetic hyperthermia therapy (MHT) is able to ablate tumors using an alternating magnetic field (AMF)to heat up magnetocaloric agents (e.g. magnetic nanoparticles) administered into the tumors. For clinical applications, there is still a demand to find new magnetocaloric agents with strong AMF-induced heating performance and excellent biocompatibility. As a kind of biocompatible and biodegradable material,magnesium (Mg) and its alloys have been extensively used in the clinic as an implant metal. Herein, we discovered that the eddy thermal effect of the magnesium alloy (MgA) could be employed for MHT to effectively ablate tumors. Under low-field-intensity AMFs, Mg A rods could be rapidly heated, resulting in a temperature increase in nearby tissues. Such AMF-induced eddy thermal heating of MgA could not only be used to kill tumor cells in vitro, but also be employed for effective and accurate ablation of tumors in vivo. In addition to killing tumors in mice, we further demonstrated that VXtumors of much larger sizes growing in rabbits after implantation of Mg A rods could also be eliminated after exposure to an AMF, illustrating the ability of MgA-based MHT to kill large-sized tumors. Moreover, the implanted MgA rods showed excellent biocompatibility and～20%of their mass was degraded within three months. Our work thus discovered for the first time that non-magnetic biodegradable Mg A, an extensively used implant metal in clinic, could be used for effective magnetic thermal ablation of tumors under a low-field-intensity AMF. Such a strategy could be readily translated into clinical use.

关键词： magnesium alloy eddy thermal effect alternating magnetic field hyperthermia tumor ablation biodegradation

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Balloon-assisted catheter-directed thrombolysis: A novel approach for acute deep vein thrombosis in the lower extremities

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Journal of Interventional Medicine 2020年第1期3卷 37-40页

作者： Zhi Li Chao Yang Baorui Fan Yonghai Jin caifang ni Department of Interventional Radiology First Affiliated Hospital of Soochow UniversitySuzhouNo.188Shizi StreetJiangsuChina

Background:Deep vein thrombosis(DVT)is a common cardiovascular emergency that may have life-threatening complications,including pulmonary embolism(PE)and post-thrombotic syndrome(PTS).Conventional anticoagulant medication does not completely dissolve the clots and does not decrease the risk of DVT *** catheter-directed thrombolysis(CDT)is an approach that has been reported to reduce the reoccurrence of PTS during acute *** compared balloon-assisted CDT with routine CDT in the treatment of acute DVT and evaluated the clinical efficacy and safety of balloon-assisted ***:This retrospective cohort study included 94 patients diagnosed with a first episode of DVT in the lower extremities and treated from September 2008 to February *** patients underwent routine CDT(group A,n=50)or balloon-assisted CDT(group B,n=44)based on their enrollment *** obtained the circumference difference between the limbs,the degree of clot lysis,and the lysis rate as parameters for evaluating the two *** PE incidence and bleeding amount were *** also compared the total urokinase dose,treatment duration,and retrieval rate of optional ***:Swelling was significantly alleviated in both groups,as indicated by a reduction in the limb *** who underwent balloon-assisted CDT exhibited significantly lower thrombus scores compared with the routine group(S=1403.50,Z=-5.7702,Pnificantly shorter(6 vs.10 days[S=1039.0,Z=-8.0358,Pnificantly higher than that in the routine CDT group(Х~2=4.829,P=0.028).Conclusions:Balloon-assisted CDT is an effective,cost-efficient,and safe method for the treatment of acute *** exhibited advantages

关键词： balloon routine acute

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Stratification of portal vein-invaded hepatocellular carcinoma treated with transarterial chemoembolization monotherapy

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Journal of Interventional Medicine 2020年第4期3卷 201-207页

作者： Lei Zhang BinYan Zhong Bo Hu Wei Li Peng Huang Shen Zhang JinJin Song JianSong Ji caifang ni Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Interventional Radiology Zhejiang University Lishui HospitalThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui Central HospitalLishuiChina

Purpose:The study aimed to establish a prognostic prediction model and an artificial neural network(ANN)model to determine who will benefit from transarterial chemoembolization(TACE)monotherapy for patients with hepatocellular carcinoma(HCC)invading portal ***:Treatment-naive patients with HCC and portal vein invasion who were treated with TACE monotherapy at hospital A as training cohort and hospital B as validation cohort were *** primary endpoint was overall survival(OS).In training cohort,independent risk factors associated with OS were identified by univariate and multivariate *** prognostic prediction(PP)and ANN models based on the independent risk factors were established to find out who will benefit most from TACE *** type of portal vein tumor thrombosis was classified based on the Cheng’s *** accuracy of the models was validated in validation ***:Totally,242 patients(training cohort:n=159;validation cohort:n=83)were *** median OS was 7.1 and 8.5 months in training and validation cohort,*** training cohort,the PP model was established based on the following five independent risk factors:Cheng’s Classification,Eastern Cooperative Oncology Group score,maximum tumor size,number of HCC nodules,and Child-Pugh *** score of 17.5 was identified as cut-off point and patients were divided into two groups by PP score17.5 in survival benefit and prognostication(8.8 vs.5.5 months;P<0.001).These five factors were included and ranked based on the importance associated with OS in the ANN *** of the two models received high accuracy after ***:Portal vein invaded HCC patients with PP score<17.5 may benefit most from TACE *** these patients,TACE monotherapy should be considered.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Portal vein tumor thrombosis Prognostic Artificial neural network

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Kyphoplasty versus vertebroplasty for the treatment of malignant vertebral compression fractures caused by metastases： a retrospective study

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Chinese Medical Journal 2014年第8期127卷 1493-1496页

作者： Li Zhi ni caifang Chen Long Sun Zhiyong Yang Chao Zhao Xin Wang Yanwei Department of Interventional Radiology the First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Department of Orthopaedic Surgery the First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Department of General Surgery the First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China

Background There are few comparative studies regarding kyphoplasty （KP） and vertebroplasty （VP） for the treatment of painful vertebral compression fractures （VCF） in patients with cancer. The purpose of this study is to retrospectively compare KP with VP in pain improvement, cement leakage incidence, and the cost of treatment of malignant VCE Methods We performed a retrospective study of clinical data for 80 patients with multiple spinal metastases, treated with KP in 42 cases and VP in 38. Visual analog scale （VAS） scores were collected pre-operatively, post-operatively, at 1 month, 6 months, and 1 year after treatment. Cement leakage was identified using fluoroscopy and CT scan. Total cost per patient was also collected. Results There was a significant difference between the pre- and post-operative VAS scores （7.4＋2.0 to 3.8＋1.6, P 〈0.001 in the KP group; 6.7＋2.4 to 3.7＋1.4, P 〈0.001 in the VP group）, and was maintained at 1-year follow-up （3.2＋1.4 in the KP group, 3.1＋1.3 in the VP group）. However, the difference in VAS score between these two groups was insignificant at baseline and every follow-up assessment post-operatively （P 〉0.05）. The incidence of cement leakage in the KP group was lower than that of the VP group （16.9% （14/83） vs 30.3% （23/76）, P 〈0.05）. However, none of the patients developed any symptoms. The length of postoperative hospital stay in the VP group was shorter than that of the KP group （（2.4＋1.3） vs （5.3＋1.9） days, P 〈0.05）. Total hospital cost in the KP group was much higher than that of the VP group （RMB Yuan 8 492_＋3 332 vs RMB Yuan 3 173~1 341, P〈0.01）. Conclusions VP and KP are both effective in providing pain relief for patients with cancer-related VCF. KP provides no greater degree of pain improvement. KP is associated with a lower rate of cement leakage compared with VP. VP is associated with lower cost and shorter postoperative hospital stay in China.

关键词： spinal metastases vertebral compression fractures kyphoplasty vertebroplasty

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Transarterial chemoembolization refractoriness in hepatocellular carcinoma:Chinese College of Interventionalists definition and consensus statement

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Chinese Medical Journal 2024年第17期137卷 2040-2042页

作者： Binyan Zhong Shen Zhang Haidong Zhu Wansheng Wang caifang ni Clinical Guidelines Committee of Chinese College of Interventionalists Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215006China Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjingJiangsu 210009China 不详

Transarterial chemoembolization(TACE)is recommended as the first-line approach for intermediate hepatocellular carcinoma(HCC),and it is the most widely applied method for advanced HCC in real-world clinical practice.[1,2]According to the China Liver Cancer(CNLC)staging system,TACE is recommended as the first-line therapy for stages IIb and IIIa,while it is also recommended as a major approach for stages Ib,IIa,and IIIb.[3]Despite its confirmed treatment efficacy and safety,repeated TACE is sometimes unbeneficial for some patients due to the high heterogenicity of HCC,manifesting as liver function deterioration and occupying the optimal occasion of other ***,the concept of“TACE refractoriness”has been introduced by various societies around the world to avoid ineffective repeated TACE.[4]Nevertheless,there is no widely accepted consensus on the definitions of“TACE refractoriness”and some controversies have yet to be *** addition,whether the existing definitions of“TACE refractoriness”are suitable for Chinese HCC patients is still doubtful.

关键词： hepatocellular arterial Cancer

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Uterine artery embolization in association with methotrexate infusion for the treatment of tubal ectopic pregnancy

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Journal of Interventional Medicine 2018年第3期1卷 182-187页

作者： Zhi Li Wenjian Xu Bo Hu Mingming Li Jianwei Zhou caifang ni Department of Interventional Radiology First Affiliated Hospital of Soochow University Department of Obstetrics and Gynecology Nanjing Maternity and Child Health Care Hospital

Objective To investigate the safety, feasibility, and effectiveness of uterine artery embolization in association with methotrexate(MTX) infusion for the treatment of tubal ectopic pregnancy. Methods Fifty-one patients with tubal ectopic pregnancy were referred for interventional management. All patients received super-selective arteriography of the uterine artery, were infused with 50–100 mg methotrexate(MTX) through a catheter, and underwent embolization of the uterine artery with a gel-foam pledge. Clinical presentation, findings of physical examination, β-HCG values, and the size of the ectopic mass were documented for comparison. The concentration of MTX in blood was evaluated at 0.5, 6, 12, 24, 36, and 48 hours after the procedure. Results Forty-seven out of the 51 patients had clinical resolution of their tubal pregnancy(92.2%). The average time for the β-HCG value to decrease and come back to normal was 9.16 ± 2.54 days(mean +/-SD). MTX levels in peripheral blood could not be detected for patients who received 50 or 75 mg MTX at 36 hours after the procedure, while the MTX level was 0.01 μmol/L at 48 hours after the procedure for patients who received 100 mg. Out of the 4 cases whose ectopic mass size was ≥5 cm, 3 failed to respond to the treatment; however, those whose ectopic mass size was ≤5 cm responded positively to the treatment, regardless of the β-HCG concentration and abdominal bleeding, except for 1 patient who had to undergo laparoscopy for severe abdominal pain and who showed a reduction in her β-HCG level. Conclusion Uterine artery embolization in association with methotrexate infusion is safe and effective in the treatment of tubal ectopic pregnancy, especially for those women with mild to moderate bleeding, or for those at risk of a major hemorrhage. The selection criterion of mass size >5 cm should, therefore, be carefully considered.

关键词： radiology,interventional tubal,pregnancy embolization,therapeutic

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影像基因组学及其在肝细胞癌中的应用

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介入放射学杂志 2020年第1期29卷 104-108页

作者：李炜倪才方苏州大学附属第一医院介入科江苏215006

精准医疗是医学发展的必然趋势,其本质是个性化医疗。肝细胞癌(HCC)具有高度异质性,是制约HCC精准治疗发展的重要原因之一。影像基因组学旨在通过关联肿瘤影像学特征与基因数据建立预测模型,有助于HCC患者分层管理。目前影像基因组学已... 详细信息

精准医疗是医学发展的必然趋势,其本质是个性化医疗。肝细胞癌(HCC)具有高度异质性,是制约HCC精准治疗发展的重要原因之一。影像基因组学旨在通过关联肿瘤影像学特征与基因数据建立预测模型,有助于HCC患者分层管理。目前影像基因组学已应用于治疗胶质瘤、乳腺癌、肺癌等多种恶性肿瘤。影像基因组学有望在HCC诊疗中发挥重要作用,如指导穿刺活检、制订个体化治疗方案、预测药物反应和预测介入治疗效果。该文旨在通过阐述HCC异质性与影像基因组学研究,探讨影像基因组学在HCC中的应用。

关键词：影像基因组学肝细胞癌介入放射学

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TACE治疗肝癌后总生存期的替代终点研究进展

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介入放射学杂志 2022年第7期31卷 728-732页

作者：史逸恺倪才方苏州大学附属第一医院介入科江苏215006

在临床研究中,总生存期(OS)已作为评价肝癌疗效的指标。但OS的观察时间长,且受到后续治疗的影响,一些相关替代终点应运而生。经导管动脉化疗栓塞(TACE)与靶免药物在治疗肝细胞癌(HCC)患者时,其适用人群、治疗周期及疗效方面都存在较大差... 详细信息

在临床研究中,总生存期(OS)已作为评价肝癌疗效的指标。但OS的观察时间长,且受到后续治疗的影响,一些相关替代终点应运而生。经导管动脉化疗栓塞(TACE)与靶免药物在治疗肝细胞癌(HCC)患者时,其适用人群、治疗周期及疗效方面都存在较大差异,因此有必要针对TACE相关研究选择合适的替代终点。本文对TACE治疗肝癌后各替代终点进行归纳和分析,为替代终点的选择提供参考。

关键词：经导管动脉化疗栓塞替代终点肝细胞癌

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经导管动脉栓塞术治疗非肿瘤性骨关节疾病研究进展

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介入放射学杂志 2022年第4期31卷 408-412页

作者：侯忠衡倪才方苏州大学附属第一医院介入放射科江苏215006

经导管动脉栓塞术(TAE)是介入放射学最重要的技术之一,近年来开始应用于非肿瘤性骨关节疾病如反复性关节积血、慢性肌肉骨骼疼痛等治疗,并取得良好的临床效果。本文综述TAE治疗反复性关节积血和慢性肌肉骨骼疼痛研究进展,涉及相关治疗... 详细信息

经导管动脉栓塞术(TAE)是介入放射学最重要的技术之一,近年来开始应用于非肿瘤性骨关节疾病如反复性关节积血、慢性肌肉骨骼疼痛等治疗,并取得良好的临床效果。本文综述TAE治疗反复性关节积血和慢性肌肉骨骼疼痛研究进展,涉及相关治疗机制、操作要点、适应证和禁忌证、安全性和有效性,为临床实践提供帮助。

关键词：经导管动脉栓塞术非肿瘤性骨关节疾病介入放射学

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下肢深静脉血栓形成伴髂静脉狭窄支架植入与否近中期临床疗效比较

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介入放射学杂志 2018年第12期27卷 1140-1143页

作者：王孝运段鹏飞倪才方苏州大学附属第一医院介入科江苏215000

目的比较分析急性下肢深静脉血栓形成(DVT)血栓清除后发现髂静脉狭窄/闭塞是否植入支架的近中期疗效。方法回顾性分析2013年6月至2016年6月收治的60例下肢DVT患者临床资料。所有患者均经导管接触溶栓(CDT)和/或AngioJet机械吸栓清除血... 详细信息

目的比较分析急性下肢深静脉血栓形成(DVT)血栓清除后发现髂静脉狭窄/闭塞是否植入支架的近中期疗效。方法回顾性分析2013年6月至2016年6月收治的60例下肢DVT患者临床资料。所有患者均经导管接触溶栓(CDT)和/或AngioJet机械吸栓清除血栓后造影发现髂静脉狭窄/闭塞,其中32例行髂静脉球囊扩张支架植入术(支架组),28例未予髂静脉球囊扩张支架植入(对照组)。比较两组近期溶栓率、出血并发症发生率、出院前下肢消肿率,中期深静脉通畅率、DVT复发率、髂静脉闭塞率、慢性静脉功能不全调查量表(CIVIQ)评分^([3])及临床表现、病因、解剖和病理生理学(CEAP)分级。结果 60例患者手术均获成功。支架组与对照组溶栓时间、出血并发症发生率差异均无统计学意义(P>0.05),溶栓率、出院前下肢消肿率差异均有统计学意义(P<0.05)。平均随访(20.4±7.8)个月,支架组中期深静脉通畅率、DVT复发率、髂静脉闭塞率、CIVIQ评分、CEAP分级等指标均优于对照组(P<0.05)。结论血栓清除后同期髂静脉球囊扩张支架植入,对提高急性下肢DVT伴髂静脉狭窄/闭塞患者近中期疗效具有重要价值。

关键词：深静脉血栓形成导管接触溶栓机械吸栓髂静脉狭窄支架植入深静脉通畅率

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