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Adiponectin restores the obesity-induced impaired immunomodulatory function of mesenchymal stromal cells via glycolytic reprogramming

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Acta Pharmaceutica Sinica B 2024年第1期14卷 273-291页

作者： Duc-Vinh Pham Thi-Kem nguyen Bao-Loc nguyen Jong-Oh Kim Jee-Heon Jeong Inho Choi Pil-Hoon Park Department of Pharmacology Hanoi University of PharmacyHanoi 100000Viet Nam College of Pharmacy Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Medical Biotechnology Yeungnam UniversityGyeongsan 38541Republic of Korea Research Institute of Cell Culture Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Precision Medicine School of MedicineSungkyunkwan UniversitySuwon 16419Republic of Korea

Obesity has been known to negatively modulate the life-span and immunosuppressive potential of mesenchymal stromal cells(MSC).However,it remains unclear what drives the compromised potency of obese *** this study,we examined the involvement of adiponectin,an adipose tissuederived hormone,in obesity-induced impaired therapeutic function of ***-induced obesity leads to a decrease in serum adiponectin,accompanied by impairment of survival and immunomodulatory effects of adipose-derived MSC(ADSC).Interestingly,priming with globular adiponectin(gAcrp)improved the immunomodulatory potential of obese *** effects were also observed in lean *** addition,gAcrp potentiated the therapeutic effectiveness of ADSC in a mouse model of DSS-induced ***,while obesity inhibited the glycolytic capacity of MSC,gAcrp treatment induced a metabolic shift toward glycolysis through activation of adiponectin receptor type 1/p38 MAPK/hypoxia inducible factor-1a *** findings suggest that activation of adiponectin signaling is a promising strategy for enhancing the therapeutic efficacy of MSC against immune-mediated disorders.

关键词： Adiponectin Adipose-derived stromal cells Colitis Glycolytic induction HIF1a Immunomodulation Mesenchymal stromal cells Obesity

An Efficient Adaptive Hierarchical Sliding Mode Control Strategy Using Neural Networks for 3D Overhead Cranes

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International Journal of Automation and computing 2019年第5期16卷 614-627页

作者： viet-Anh Le Hai-Xuan Le linh nguyen Minh-Xuan Phan Department of Automatic Control Hanoi University of Science and TechnologyHanoi 10000Vietnam Centre for Autonomous Systems University of Technology SydneyNew South Wales 2007Australia

In this paper, a new adaptive hierarchical sliding mode control scheme for a 3D overhead crane system is proposed. A controller is first designed by the use of a hierarchical structure of two first-order sliding surfaces represented by two actuated and un-actuated subsystems in the bridge crane. Parameters of the controller are then intelligently estimated, where uncertain parameters due to disturbances in the 3D overhead crane dynamic model are proposed to be represented by radial basis function networks whose weights are derived from a Lyapunov function. The proposed approach allows the crane system to be robust under uncertainty conditions in which some uncertain and unknown parameters are highly difficult to determine. Moreover, stability of the sliding surfaces is proved to be guaranteed. Effectiveness of the proposed approach is then demonstrated by implementing the algorithm in both synthetic and reallife systems, where the results obtained by our method are highly promising.

关键词： 3D overhead crane adaptive control hierarchical sliding mode control neural network radial basis function

STRONG CONVERGENCE OF AN INERTIAL EXTRAGRADIENT METHOD WITH AN ADAPTIVE NONDECREASING STEP SIZE FOR SOLVING VARIATIONAL INEQUALITIES

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Acta Mathematica Scientia 2022年第2期42卷 795-812页

作者： nguyen Xuan linh Duong viet THONG Prasit CHOLAMJIAK Pham Anh TUAN Luong Van LONG Department of Mathematics Mathematics Falcuty of Information TechnologyNational University of Civil Engineering Division of Applied Mathematics Thu Dau Mot UniversityBinh Duong ProvinceVietnam School of Science University of PhayaoPhayao 56000Thailand Paculty of Mathematical Economics National Economics UniversityHanoi CityVietnam

In this work,we investigate a classical pseudomonotone and Lipschitz continuous variational inequality in the setting of Hilbert space,and present a projection-type approximation method for solving this *** method requires only to compute one projection onto the feasible set per iteration and without any linesearch procedure or additional projections as well as does not need to the prior knowledge of the Lipschitz constant and the sequentially weakly continuity of the variational inequality mapping.A strong convergence is established for the proposed method to a solution of a variational inequality problem under certain mild ***,we give some numerical experiments illustrating the performance of the proposed method for variational inequality problems.

关键词： Inertial method Tseng’s extragradient viscosity method variational inequality problem pseudomonotone mapping strong convergence

Modeling bending behavior of shape memory alloy wire-reinforced composites: Semi-analytical model and finite element analysis

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Chinese Journal of Aeronautics 2021年第8期34卷 176-191页

作者： nguyen Van viet Wael ZAKI Department of Mechanical Engineering Khalifa University of Science and TechnologyAbu DhabiUnited Arab Emirates

In this study,we propose a novel and simple exact semi-analytical model for superelastic Shape Memory Alloy(SMA)wire reinforced composites subjected to bending *** order to study the mechanical response of the composite during loading/unloading,a Representative Volume Element(RVE)is extracted to examine the bending response of the *** moment–curvature,and shear force-shear strain relations are derived based on a 3-Dimensional(3 D)thermomechanical SMA model and Timoshenko beam *** composite Simpson’s rule is adopted to numerically solve the exact analytical moment–curvature and shear force-shear strain *** including the moment–curvature response,axial stress distribution along the vertical and longitudinal directions,martensite volume fraction,and the tip deflection are reported and validated against 3 D finite element *** influence of temperature,martensite volume fraction distribution,and matrix stiffness on the mechanical performance of the composite is also *** particular,the composite is found to behave superelastically under certain conditions of temperature,SMA volume fraction,and elastic stiffness of the *** behavior is advantageous in applications requiring large recoverable strains or high energy dissipation density.

关键词： Bending Finite element analysis Modelling Phase transformation Shape memory alloy reinforced composite Superelasticity

The impact of green finance,eco-innovation,renewable energy and carbon taxes on CO_(2) emissions in BRICS countries:Evidence from CS ARDL estimation

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Geoscience Frontiers 2024年第4期15卷 449-458页

作者： Muhammad Sadiq Ka Yin Chau nguyen Tran Thai Ha Thi Thu Hien Phan Thanh Quang Ngo Pham Quang Huy Carbon Economy Research Center Fuzhou University of International Studies and TradeFuzhou 350202China School of Accounting and Finance Faculty of Business and LawTaylor’s UniversityMalaysia Faculty of Business City University of MacaoTaipaMacaoChina Faculty of Finance and Banking Van Lang UniversityHo Chi Minh CityVietnam Zhejiang Shuren University No.8 Shuren streetHangzhou 310015China School of Government University of Economics Ho Chi Minh City(UEH)Ho Chi Minh City 72407Viet Nam Research Group Public Governance and Developmental Issues University of Economics Ho Chi Minh City(UEH)Ho Chi Minh City 72407Viet Nam Ho Chi Minh City University of Economics and Finance(UEF) Ho Chi Minh CityVietnam University of Economics and Human Sciences in Warsaw WarsawPoland

A sharp increase in economic and human development has multiplied the carbon intensity due to which there is a significant need of effective strategies in order to curb carbon ***,the present study aims to examine the effective of green finance,eco-innovation,renewable energy output(REO),renewable energy consumption(REC),and carbon taxes on carbon dioxide(CO_(2))emissions in BRICS countries in the time of ***-sectional autoregressive distributed lag(CS ARDL)is used to test the connection among the *** estimations of CS-ARDL approach validates the effectiveness of green finance,eco-innovation,REO,REC,carbon taxes,and industrialization as the relationship of these factors with carbon emissions is negative in nature in BRICS *** on the evidences,the study recommends the formulation of environmentally friendly practices and advancement in green finances to mitigate carbon emissions.

关键词： Green finance Eco-innovation Renewable energyoutput Carbon taxes Environmental degradation CO_(2)emissions

Design and Demonstration of a Locust-Like Jumping Mechanism for Small-Scale Robots

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Journal of Bionic Engineering 2012年第3期9卷 271-281页

作者： Quoc-viet nguyen Hoon Cheol Park Department of Advanced Technology Fusion Konkuk University Seoul 143-701 Republic of Korea

A jumping mechanism can be an efficient mode of motion for small robots to overcome large obstacles on the ground and rough terrain. In this paper, we present a 7 g prototype of locust-inspired jumping mechanism that uses springs, wire, reduction gears, and a motor as the actuation components. The leg structure and muscles of a locust or grasshopper were mimicked using springs and wire, springs for passive extensor muscles, and a wire as a flexor muscle. A small motor was used to slowly charge the spring through a lever and gear system, and a cam with a special profile was used as a clicking mechanism for quick release of elastic energy stored in the springs to create a sudden kick for a quick jump. Performance analysis and experiments were conducted for comparison and performance estimation of the jumping mechanism prototype. Our prototype could produce standing jumps over obstacles that were about 14 times its own size （approximate to 71 cm） and a jumping distance of 20 times its own size （approximate to 100 cm）.

关键词： biomimetics locust jumping mechanism passive tibia extensor muscle

Shilian Dashan With the Propagation of the Caodong Sect in Cochinchina in the Seventeenth Century

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Philosophy Study 2024年第4期14卷 194-203页

作者： Ngoc Phuong nguyen Guangxi University for Nationalities NanningChina

The prosperous development of the“Maritime Silk Road”in the 17th century not only brought convenience in sea transportation and promoted trade between countries,but also acted as a bridge connecting *** bridge has the function of cultural exchange between peoples,especially in introducing and promoting China’s cultural and ideological quintessence with neighboring *** this period,Linji and Caodong sects of Chinese Zen Buddhism were spread directly into Cochinchina of Dai viet through Chinese senior monks who followed merchant ships to this *** them was the Most Venarable Shilian Dashan,a senior monk at Changshou Temple,Guangzhou,who accepted Lord nguyen Phuc Chu’s invitation to teach the Soto Dharma in Cochinchina for nearly two years(1695-1696).Based on the study of relevant historical documents and autobiographical works on this trip byMost ***,the article presents his biography and ***,this article analyzes the method of spreading Dharma,Chan ideology,as well as the significance of his Dharma propagation activities for Buddhism in Cochinchina at that time.

关键词： Shilian Dashan Buddhism in Cochinchina Caodong Chan

Stand dynamics of old-growth hemlock forests in central Bhutan are shaped by natural disturbances

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Forest Ecosystems 2024年第4期11卷 434-447页

作者： Karma Tenzin Craig R.Nitschke Kathryn J.Allen Raphael Trouve Thiet V.nguyen Patrick J.Baker School of Agriculture Foodand Ecosystem SciencesUniversity of Melbourne500 Yarra BlvdRichmondVictoriaAustralia School of Geography Planningand Spatial SciencesUniversity of TasmaniaSandy BayTasmaniaAustralia Forest Science Institute of South vietnam 1 Pham Van Hai StreetTan Binh DistrictHo Chi Minh CityViet Nam

Understanding how past disturbances have influenced the development of forests is critical for deciphering their current structure and composition and forecasting future *** this study,dendrochronological methods were applied to uncover the disturbance history of old-growth hemlock-dominated forests in central *** of tree-ring samples from two old-growth hemlock stands,located in two different topographic settings,identified the importance of gap-phase dynamics in facilitating recruitment and growth releases and producing complex,multi-aged structure s over *** site showed evidence of a near stand-replacing disturbance in the late 1700s,while the other showed no evide nce of high-severity disturbance at any time over the last 400 *** both sites low-to medium-severity disturbances,some of which appear to be associated with cyclones originating in the Bay of Bengal,dominated the disturbance *** hemlock stands exhibited a significant positive association between cyclone occurrence and growth release events and between recruitment pulses and growth release *** 1800 to 1970 there was an increase in recruitment of angiosperm tree species at most sites and a corresponding decline in conifer *** the past 50 years there has been little new recruitment;this may be due to light limitation in the understory from shade-tolerant angiosperms and bamboo in the lower strata of these *** variations in disturbance dynamics and recruitment were observed across the study sites,suggesting that other factors,such as topography and climate,may be influencing long-term stand development *** study highlights the complex interplay between historical disturbance regimes and tree recruitment in shaping the age and size structures of old-growth hemlock forests in central *** also provides new insights into the dynamics of these forests that can be used to support effective forest conservation and management i

关键词： Forest structure Hemlock forest Himalaya Natural disturbance

Scouring of a granular bed by dam break: Experimental study and numerical simulation by a VOF-LPT coupling

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International Journal of Sediment Research 2023年第3期38卷 432-445页

作者： Quyen Thi Le nguyen viet Dung nguyen Patrice Coorevits EPROAD Research Unit University of Picardie Jules Verne IUT of Aisne Hanoi University of Civil Engineering

The first part of the research reported here consists of an experimental campaign to study the scouring of a granular bed(glass beads, sand) induced by a dam break in an open channel. Two configurations are considered: with and without cylinders. In the second part of this study, the volume of fluid method coupled with the shear stress transport turbulent model and the lagrangian particle tracking method is used to simulate the local scour processes. The four-way coupling is realized by considering the drag force and collisions between particles. Using a vortex map and velocity profiles, the flow dynamics and scour pattern can be studied. The current research also focuses on the profiles of the erodible particle bed and the sediment transport rate to study the effects of a cylinder on local scour. The presence of the cylinder increases the experimental erosion depth by up to 42%. It was found that for relatively close particle diameters(2 and 3 mm), a granular bed with larger porosity(larger diameter) erodes the *** and numerically it was found that the center of the granular bed experiences more erosion compared to the channel sides. In the last part of the research, comparisons between the numerical results and the experimental data allowed risk areas to be identified and the roles of porosity,sediment density, and flow dynamics on erosion to be identified.

关键词： Volume of fluid Lagrangian particle tracking Scour Granular bed Cylinder Dam break