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Push forward LC-MS-based therapeutic drug monitoring and pharmacometabolomics for anti-tuberculosis precision dosing and comprehensive clinical management

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Journal of Pharmaceutical Analysis 2024年第1期14卷 16-38页

作者： nguyen Quang Thu nguyen Tran Nam Tien nguyen thi hai yen Thuc-Huy Duong nguyen Phuoc Long Huy Truong nguyen Department of Pharmacology and PharmacoGenomics Research Center Inje University College of MedicineBusan47392Republic of Korea Department of Chemistry University of EducationHo Chi Minh City700000Viet Nam Faculty of Pharmacy Ton Duc Thang UniversityHo Chi Minh City700000Viet Nam

The spread of tuberculosis(TB),especially multidrug-resistant TB and extensively drug-resistant TB,has strongly motivated the research and development of new anti-TB *** strategies to facilitate drug combinations,including pharmacokinetics-guided dose optimization and toxicology studies of first-and second-line anti-TB drugs have also been introduced and *** chromatography-mass spectrometry(LC-MS)has arguably become the gold standard in the analysis of both endo-and exo-genous *** technique has been applied successfully not only for therapeutic drug monitoring(TDM)but also for pharmacometabolomics *** improves the effectiveness of treatment,reduces adverse drug reactions,and the likelihood of drug resistance development in TB patients by determining dosage regimens that produce concentrations within the therapeutic target *** on TDM,the dose would be optimized individually to achieve favorable *** is essential in generating and validating hypotheses regarding the metabolism of anti-TB drugs,aiding in the discovery of potential biomarkers for TB diagnostics,treatment monitoring,and outcome *** article highlighted the current progresses in TDM of anti-TB drugs based on LC-MS bioassay in the last two ***,we discussed the advantages and disadvantages of this technique in practical *** pressing need for non-invasive sampling approaches and stability studies of anti-TB drugs was ***,we provided perspectives on the prospects of combining LC-MS-based TDM and pharmacometabolomics with other advanced strategies(pharmacometrics,drug and vaccine developments,machine learning/artificial intelligence,among others)to encapsulate in an all-inclusive approach to improve treatment outcomes of TB patients.

关键词： Tuberculosis Therapeutic drug monitoring LC-MS MIPD Pharmacometabolomics Precision medicine

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Transient responses of double-curved sandwich two-layer shells resting on Kerr's foundations with laminated three-phase polymer/GNP/fiber surface and auxetic honeycomb core subjected to the blast load

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Defence Technology（防务技术） 2024年第5期35卷 222-247页

作者： nguyen thi hai Van thi Hong nguyen Researcher&Lecturer Faculty of Industrial EducationThe University of Danang-University of Technology and Education48 Cao ThangDanang550000Viet Nam Researcher&Lecturer Faculty of Mechanical EngineeringThuyloi University175 Tay SonDong DaHanoi100000Viet Nam

this work uses refined first-order shear theory to analyze the free vibration and transient responses of double-curved sandwich two-layer shells made of auxetic honeycomb core and laminated three-phase polymer/GNP/fiber surface subjected to the blast *** of the two layers that make up the double-curved shell structure is made up of an auxetic honeycomb core and two laminated sheets of three-phase polymer/GNP/*** exterior is supported by a Kerr elastic foundation with three *** key innovation of the proposed theory is that the transverse shear stresses are zero at two free surfaces of each *** contrast to previous first-order shear deformation theories,no shear correction factor is ***'s exact solution was used to treat the double-curved shell problem with a single title boundary,while the finite element technique and an eight-node quadrilateral were used to address the other boundary *** ensure the accuracy of these results,a thorough comparison technique is employed in conjunction with credible *** problem model's edge cases allow for this kind of *** study's findings may be used in the post-construction evaluation of military and civil works structures for their ability to sustain explosive *** addition,this is also an important basis for the calculation and design of shell structures made of smart materials when subjected to shock waves or explosive loads.

关键词： Blast load Two-layer shell Polymer/GNP/Fiber surface Auxetic honeycomb Shear connectors

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Application of extreme gradient boosting in predicting the viscoelastic characteristics of graphene oxide modified asphalt at medium and high temperatures

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Frontiers of Structural and Civil Engineering 2024年第6期18卷 899-917页

作者： Huong-Giang thi HOANG hai-Van thi MAI Hoang Long nguyen hai-Bang LY University of Transport Technology Hanoi 100000Vietnam

Complex modulus(G^(*))is one of the important criteria for asphalt classification according to AASHTO M320-10,and is often used to predict the linear viscoelastic behavior of asphalt *** addition,phase angle(φ)characterizes the deformation resilience of asphalt and is used to assess the ratio between the viscous and elastic *** is thus important to quickly and accurately estimate these two *** purpose of this investigation is to construct an extreme gradient boosting(XGB)model to predict G^(*)andφof graphene oxide(GO)modified asphaltat medium and high *** data sets are gathered from previously published experiments,consisting of 357 samples for G^(*)and 339 samples forφ,and the se are used to develop the XGB model using nine inputs representing theasphalt binder *** findings show that XGB is an excellent predictor of G^(*)andφof GO-modified asphalt,evaluated by the coefficient of determination R^(2)(R^(2)=0.990 and 0.9903 for G^(*)andφ,respectively)and root mean square error(RMSE=31.499 and 1.08 for G^(*)andφ,respectively).In addition,the model’s performance is compared with experimental results and five other machine learning(ML)models to highlight its *** the final step,the Shapley additive explanations(SHAP)value analysis is conducted to assess the impact of each input and the correlation between pairs of important features on asphalt’s two physical properties.

关键词： complex modulus phase angle graphene oxide asphalt extreme gradient boosting machine learning

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Tungsten-based nanocatalysts with different structures for visible light responsive photocatalytic degradation of bisphenol A

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Journal of Environmental Sciences 2024年第5期139卷 569-588页

作者： hai Bang Truong thi Thu Loan Doan nguyen Tien Hoang nguyen Van Tam Minh Kim nguyen Le Gia Trung Jin Seog Gwag nguyen Tien Tran Optical Materials Research Group Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityViet Nam Faculty of Applied Technology School of TechnologyVan Lang UniversityHo Chi Minh CityViet Nam The University of Da Nang University of Science and Technology54 Nguyen Luong BangDa NangViet Nam The University of Da Nang University of Science and Education459 Ton Duc Thang St.Lien ChieuDa Nang 550000Viet Nam Institute of Veterinary Science and Technology 31ha zoneTrau QuyGia LamHa Noi 12400Viet Nam Department of Physics Yeungnam UniversityGyeongsanGyeongbuk 38541Republic of Korea Center for Advanced Chemistry Institute of Research and DevelopmentDuy Tan University03 Quang TrungDa Nang 550000Viet Nam Faculty of Natural Sciences Duy Tan University03 Quang TrungDa Nang 550000Viet Nam

Environmental pollution,such as water contamination,is a critical issue that must be absolutely ***,three different morphologies of tungsten-based photocatalysts(WO_(3)nanorods,WO_(3)/WS_(2)nanobricks,WO_(3)/WS_(2)nanorods)are made using a simple hydrothermal method by changing the solvents(H_(2)O,DMF,aqueous HCl solution).The as-prepared nanocatalysts have excellent thermal stability,large porosity,and high *** results show all materials have good photocatalytic activity in aqueous media,with WO_(3)/WS_(2)nanorods(NRs)having the best activity in the photodegradation of bisphenol A(BPA)under visible-light *** may originate from increased migration of charge carriers and effective prevention of electron–hole recombination in WO_(3)/WS_(2)NRs,whereby this photocatalyst is able to generate more reactive·OH and·O_(2)^(–)species,leading to greater photocatalytic *** 99.6% of BPA is photodegraded within 60 min when using 1.5 g/L WO_(3)/WS_(2)NRs and 5.0 mg/L BPA at pH ***,the optimal conditions(pH,catalyst dosage,initial BPA concentration)for WO_(3)/WS_(2)NRs are also elaborately *** rod-like heterostructures are expressed as potential catalysts with excellent photostability,efficient reusability,and highly active effectivity in different types of *** particular,the removal efficiency of BPA by WO_(3)/WS_(2)NRs reduces by only 1.5% after five recycling runs and even reaches 89.1%in contaminated lake *** study provides promising insights for the nearly complete removal of BPA from wastewater or different water resources,which is advantageous to various applications in environmental remediation.

关键词： Photodegradation Bisphenol A Tungsten-based nanocatalyst Structure Nanorod

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Is convenience really king? Comparative evaluation of catastrophic costs due to tuberculosis in the public and private healthcare sectors of Viet Nam: a longitudinal patient cost study

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贫困所致传染病(英文) 2024年第2期13卷 1-12页

作者： nguyen Hoa Binh Quang Vo Luan nguyen Forse Rachel Jeanette Wiemers Anja Maria Christine Huynh Huy Ba Dong Thuy thi Thu Phan yen thi Hoang Creswell Jacob Dang thi Minh Ha nguyen Lan Huu Shedrawy Jad L?nnroth Knut nguyen Tuan Dinh Van Dinh Luong Annerstedt Kristi Sidney Codlin Andrew James National Lung Hospital Ha Noi Viet Nam Friends for International TB Relief Ha Noi Viet Nam Department of Global Public Health WHO Collaboration Centre On Tuberculosis and Social Medicine Karolinska Institute Stockholm Sweden Stop TB Partnership Geneva Switzerland Pham Ngoc Thach Hospital Ho Chi Minh City Viet Nam

Background In Viet Nam, tuberculosis (TB) represents a devastating life-event with an exorbitant price tag, partly due to lost income from daily directly observed therapy in public sector care. Thus, persons with TB may seek care in the private sector for its flexibility, convenience, and privacy. Our study aimed to measure income changes, costs and catastrophic cost incurrence among TB-affected households in the public and private *** Between October 2020 and March 2022, we conducted 110 longitudinal patient cost interviews, among 50 patients privately treated for TB and 60 TB patients treated by the National TB Program (NTP) in Ha Noi, hai Phong and Ho Chi Minh City, Viet Nam. Using a local adaptation of the WHO TB patient cost survey tool, participants were interviewed during the intensive phase, continuation phase and post-treatment. We compared income levels, direct and indirect treatment costs, catastrophic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The pre-treatment median monthly household income was significantly higher in the private sector versus NTP cohort (USD 868 vs USD 578;P=0.010). However, private sector treatment was also significantly costlier (USD 2075 vs USD 1313;P=0.005), driven by direct medical costs which were 4.6 times higher than costs reported by NTP participants (USD 754 vs USD 164;Pthis resulted in no significant difference in catastrophic costs between the two cohorts (Private: 55% vs NTP: 52%;P=0.675). Factors associated with catastrophic cost included being a single-person household [adjusted odds ratio [(aOR=13.71; 95% confidence interval (CI): 1.36–138.14;P=0.026], unemployment during treatment (aOR=10.86; 95%CI: 2.64–44.60;P<0.001) and experiencing TB-related stigma (aOR=37.90; 95%CI: 1.72–831.73;P=0.021).Conclusions Persons with TB in Viet Nam face similarly high risk of catastrophic costs whether treated in the

关键词： Tuberculosis Patient cost Catastrophic cost Private sector Comparative analysis Viet Nam

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汉越社会称谓语对比与教学研究

汉越社会称谓语对比与教学研究

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作者：阮氏海燕（nguyen thi hai yen）苏州大学

学位级别：硕士

本研究旨在探讨汉越社会称谓语的概念、类型以及越南学生在学习汉语社会称谓语时存在的偏误,并提出相应的教学建议与方法。研究采用问卷调查和分析方法,调查了越南留学生学习汉语社会称谓语的情况。在第一章中,介绍了汉越社会称谓语的... 详细信息

本研究旨在探讨汉越社会称谓语的概念、类型以及越南学生在学习汉语社会称谓语时存在的偏误,并提出相应的教学建议与方法。研究采用问卷调查和分析方法,调查了越南留学生学习汉语社会称谓语的情况。在第一章中,介绍了汉越社会称谓语的概念与类型。汉语和越南语社会称谓语的概念被阐述,并总结了它们各自的特点。这为后续章节的比较研究奠定了基础。第二章对汉越社会称谓语进行了对比研究。首先,对现代汉语和越南语的人称代词称谓语进行比较,揭示了它们之间的差异。接着,通过对姓名称谓语、职务称谓语、拟亲属称谓语、通称称谓语和零称谓语的对比分析,我们进一步探讨了两种语言中称谓语的异同之处。第三章重点分析了越南学生在学习汉语社会称谓语时存在的偏误。通过问卷调查和测试,发现了越南学生在运用汉语社会称谓语方面的偏误类型和成因。这有助于了解学生的学习需求,并针对性地提供教学帮助。最后一章提出了越南留学生汉语社会称谓语的学习策略。明确了学习的重点和难点,并给出了相应的教学建议和方法,旨在帮助学生提高汉语社会称谓语的运用能力。这些建议和方法涉及课堂教学、学习资源的利用以及与中国文化的互动等方面。通过本研究,我们可以更深入地了解汉越社会称谓语的特点和差异,为汉语教学提供更具针对性的指导,同时为越南留学生在学习汉语社会称谓语时提供有效的教学支持。这将有助于促进中越语言文化交流,提升留学生的汉语交际能力和跨文化沟通能力。最终,希望本研究通过分析两种语言的社会称谓语相同之处,可以帮助越南留学生更准确地掌握和使用汉语中的社会称谓语。

关键词：汉越对比社会称谓语教学

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Stable operation of highly loaded pure Si-Fe anode under ambient pressure via carboxy silane-directed robust solid electrolyte interphase

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Journal of Energy Chemistry 2024年第7期94卷 568-576页

作者： Guntae Lim Dong Guk Kang Hyeon Gyu Lee yen hai thi Tran Kihun An Junghyun Choi Kwang Chul Roh Do Youb Kim Seung-Wan Song Department of Chemical Engineering&Applied Chemistry Chungnam National University Daejeon 34134Republic of Korea Energy Storage Materials Center Korea Institute of Ceramic Engineering&TechnologyJinju 52851Republic of Korea Advanced Energy Materials Research Center Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea

Incorporation of higher content Si anode material beyond 5 wt% to Li-ion batteries(LIBs)is challenging,owing to large volume change,swelling,and solid electrolyte interphase(SEI)instability ***,a strategy of diacetoxydimethylsilane(DAMS)additive-directed SEI stabilization is proposed for a stable operation of Si-0.33FeSi_(2)(named as Si-Fe)anode without graphite,which provides siloxane inorganics and organics enrichment that compensate insufficient passivation of fluoroethylene carbonate(FEC)additive and reduce a dependence on *** stable cycling performance of highly loaded(3.5 mA h cm^(-2))pure Si-Fe anode is achieved with 2 wt%DAMS combined with 9 wt%FEC additives under ambient pressure,yielding high capacity 1270 mA h g^(-1)at 0.5 C and significantly improved capacity retention of 81% after 100 cycles,whereas short circuit and rapid capacity fade occur with FEC only ***-directed robust SEI layer dramatically suppresses swelling and particles crossover through separator,and therefore prevents short circuit,demonstrating a possible operation of pure Si or Sidominant anodes in the next-generation high-energy-density and safe LIBs.

关键词： High-energy Li-ion battery Pure Si-Fe anode without graphite Silane additive SEI layer Suppressed swelling

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Wedelolactone from Eclipta prostrata(L)*** inflammation and improves insulin resistance

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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 253-258页

作者： Trinh Tat Cuong Duong Duc thien Hoang hai yen nguyen Anh Duc Trinh Quang Nam Do Viet Khanh Key Laboratory for Enzyme and Protein Technology Vietnam National University University of ScienceHanoiVietnam Faculty of Biology Vietnam National University University of ScienceHanoiVietnam Hanoi University of Pharmacy HanoiVietnam Vinschool HanoiVietnam

Objective:To evaluate the effects of wedelolactone,a major flavonoid from Vietnamese Eclipta prostrata(L)L.,on inflammation and insulin ***:Wedelolactone was extracted from the leaves of Vietnamese Eclipta prostrata(L.)*** methanol by *** effects of wedelolactone on lipopolysaccharide(LPS)-induced cytokine production,reactive oxygen species(ROS)generation,and nicotinamide adenine dinucleotide phosphate(NADPH)oxidase activities in Raw 264.7 cells were measured by enzyme-linked immunosorbent assay(ELISA),specific immunofluorescent dyes and luminometric analysis,*** addition,its effects on glucose uptake and the protein expression of insulin receptor substrate 1(IRS1)and glucose transporter 4(GLUT4)were examined in 3T3-L1 cells by immunofluorescent dyes and Western ***:Wedelolactone at 30μg/mL significantly inhibited LPS-induced production of tumor necrosis factor-α,interleukin(IL)-6,and IL-8(P<0.01)with no noticeable effects on IL-10 *** also reduced ROS generation and NADPH oxidase activities in LPS-stimulated Raw 264.7 cells(P<0.01).Furthermore,wedelolactone showed anti-insulin resistance activity,as evidenced by improved glucose uptake and the upregulated expression of IRS1 and GLUT4 in 3T3-L1 cells(P<0.01).Conclusions:Wedelolactone exhibits anti-inflammation and anti-insulin resistance effects,which may be used for the treatment of diabetes and inflammation-associated diseases.

关键词： Wedelolactone Eclipta prostrata Inflammatory responses Anti-insulin resistance Diabetes IRS1 GLUT4

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越南民众与媒介接触情况调查研究

越南民众与媒介接触情况调查研究

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作者： nguyen thi hai yen 重庆大学

学位级别：硕士

进入二十一世纪以来,随着科学技术的飞速发展,传统媒体以及新媒体的出现给受众的选择越来越多。大众与媒介之间有密切关系,不仅影响媒体发展的趋势,而会影响国家的政治、经济、社会的问题。本文从传播学的视角切入,通过选取越南河内市... 详细信息

进入二十一世纪以来,随着科学技术的飞速发展,传统媒体以及新媒体的出现给受众的选择越来越多。大众与媒介之间有密切关系,不仅影响媒体发展的趋势,而会影响国家的政治、经济、社会的问题。本文从传播学的视角切入,通过选取越南河内市纸桥区的奕望后坊、观花坊与福寿县的福寿小镇、寿禄社为调查对象,采用定量与定性结合的研究方法,结合文献分析、数据统计分析等研究方法。根据越南民众与媒介接触情况、特点以及影响因素,进行探讨民众与报纸、广播、电视、网络等四大媒体接触的类型、内容、习惯等方面的异同点。本文采用SPSS 21.0统计分析软件对283个样本数据分为性别、年龄、职业、婚姻情况、受教育程度的变量进行描述分析和相关性分析。研究发现:(1)电视是越南民众最依赖的媒介渠道,此外,网络、报纸在提供信息方面仍然发挥着重要的作用,相比之下,广播的受众较小;(2)民众对电视传播的内容也是最可靠,其次是报纸,再次是广播,最后是网络;(3)男性人群比女性人群更倾向于媒介接触,年龄越大与媒介接触的需求越少,文职人员、大学生比农民、工人与媒介接触的程度更高,未婚人群与媒介接触多于已婚人群,受教育程度高人群比受教育程度低人群接触媒体更有选择;(4)在越南媒体背景下,民众与媒介接触有所变化。趋势和预测如下:男性人口增多是越南媒体发展的潜力,年轻人更倾向于新媒体,电视、报纸、广播都需要数字化才能生存下去,媒介受众逐渐转为网络媒体以及新媒体,受众与媒介接触的需求越来越高。

关键词：媒介接触越南媒体业大众媒介

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中国电视剧在越南的传播及其影响

中国电视剧在越南的传播及其影响

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作者： nguyen thi hai yen（阮氏海燕）华南理工大学

学位级别：硕士

中国电视剧自20世纪80年代开始发轫,伴随着传播技术的飞速发展、电视受众群体的不断壮大,30多年后的今天,电视剧作为当今电视节目的重要形态,已成为大众文化的一种载体。中国电视剧不仅在国内获得比较大的发展和进步,还不断进入海外市场... 详细信息

中国电视剧自20世纪80年代开始发轫,伴随着传播技术的飞速发展、电视受众群体的不断壮大,30多年后的今天,电视剧作为当今电视节目的重要形态,已成为大众文化的一种载体。中国电视剧不仅在国内获得比较大的发展和进步,还不断进入海外市场,包括东南亚、欧美、非洲等区域。就影响所及以及文化传播的角度来看,中国电视剧对东南亚,特别是对越南的影响力尤为巨大。从上个世纪90年代中越邦交正常化以来,中越两国在政治、经济、教育、科技等领域的合作与交流更为广泛和密切。中国电视剧也是伴随着中越邦交正常化进入越南市场,并在越南吸引了大量各阶层的观众。从中越文化交流的角度看,中国电视剧实际上为越南观众提供了一个了解中国社会和文化的窗口。本文研究的题目是“中国电视剧在越南的传播及其影响”,牵涉到中国和越南两国文化。因此本文将从跨文化传播的视角考察中国电视剧在越南的传播历程、影响因素等,并借此进一步研究越南观众对中国电视剧的接受心理。而在这方面,越南国内几乎没有现存的文献,作为一个留学生,希望能在这个方面填补越南跨文化传播研究的空白。本文通过问卷调查法对越南观众进行研究。研究内容主要有四个方面：第一,中国电视剧在越南的传播途径及手段;第二,中国电视剧在越南的传播效果;第三,中国电视剧输入越南的主要类型及受欢迎情况;第四,中国电视剧对越南社会文化的影响。整个调查围绕这四个部分进行,通过调查资料的归类,并结合跨文化传播的系列理论,分析得出中国电视剧在越南传播过程中跨文化传播的内容,影响因素等。最后根据研究结果提出相应的跨文化传播传播建议,以深入探讨越南观众借助中国电视剧完成的文化融合,从而为两国民众在历史和文化层面的沟通和交流提供学识上的贡献。

关键词：中国电视剧跨文化传播越南观众

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