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Beta-lactam antibiotic resistance among Escherichia coli isolates from patients with urinary tract infections in Vietnam:A systematic review and meta-analysis

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Asian Pacific Journal of Tropical Medicine 2024年第6期17卷 243-255,I0001-I0003页

作者： dat T nguyen Princess Margaret Cancer Centre University Health NetworkTorontoOntarioCanada

Objective:To investigate the evolving patterns of antimicrobial resistance against beta-lactam antibiotics in Escherichia coli isolates from urinary tract infection patients in Vietnam,covering the period from 2005 to ***:29 Descriptive studies published between 2010 and 2022 in English and Vietnamese were included in the *** on resistance rates to beta-lactam antibiotics,including cephalosporins and carbapenems,were extracted and *** pooled resistance rates were calculated using random-effects *** trends in resistance were assessed using linear regression ***:Among the beta-lactam antibiotics studied,Escherichia coli exhibited varying levels of resistance,with cephalosporins showing higher resistance rates compared to *** pooled resistance rates were 66%for cefotaxime,65%for ceftriaxone,54%for ceftazidime,and 56%for *** contrast,carbapenems demonstrated lower resistance rates,with weighted pooled resistance rates ranging from 3%to 4%for meropenem,ertapenem,and *** rates were also observed for amoxicillin/clavulanate(35%),ticarcillin/clavulanate(26%),and piperacillin/tazobactam(12%).Significant annual increases in resistance were noted for imipenem(0.56%,P<0.001).Conclusions:This study highlights the critical issue of antimicrobial resistance in urinary tract infections in Vietnam and emphasizes the importance of prudent antibiotic use and the regular monitoring of resistance *** insights are useful for guiding healthcare professionals in optimizing treatment strategies and for policymakers in formulating evidence-based clinical guidelines to combat antibiotic resistance effectively.

关键词： Antimicrobial resistance Urinary tract infection Vietnam

Anti-inflammatory effects of alkaloid enriched extract from roots of Eurycoma longifolia Jack

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Asian Pacific Journal of Tropical Biomedicine 2019年第1期9卷 18-23页

作者： Dao Thi Thanh Hien Tran Phi Long Tran Phuong Thao Jeong-Hyung Lee Duong Thu Trang nguyen Thi Thu Minh Pham Van Cuong Do Thi Ngoc Lan nguyen Hai Dang nguyen tien dat Deparment of Traditional Pharmacy Hanoi University of Pharmacy Department of Biochemistry College of Natural Sciences Kangwon National University Advanced Center for Bio-organic Chemistry Institute of Marine Biochemistry Vietnam Academy of Science and Technology National Institute of Drug Quality Control Center for Research and Technology Transfers

Objective: To examine the in vitro and in vivo anti-inflammatory effects of the alkaloid enriched extract(ELA) from the roots of Eurycoma longifolia. Methods: The in vitro antiinflammatory effects of ELA were evaluated by examining its inhibitory activities against nitric oxide(NO) production and inducible nitric oxide synthase(iN OS) and cyclooxygenase2(COX-2) expressions in lipopolysaccharide(LPS)-stimulated RAW264.7 cells. The level of NO produced in the culture media was determined by Griess method. The i NOS and COX-2 protein expressions were analyzed by Western blot. The in vivo effect of ELA was evaluated on LPS-induced septic shock in mice model. Mice mortality was monitored for5 days after injection of LPS. The chemical contents of the ELA were determined by using various chromatographic and spectroscopic techniques. Results: The ELA was found to exhibit a significant anti-inflammatory effect in both in vitro and in vivo models. The results demonstrated that ELA dose-dependently inhibited LPS-induced NO production as well as the protein iN OS and COX-2 expressions. In the septic shock model, ELA dose-dependently protected mice from LPS-induced mortality. Further study on the isolated components of ELA indicated that 9,10-dimethoxycanthin-6-one may contribute significantly to the antiinflammatory effects of the extract. Conclusions: These results suggest that ELA exhibits the anti-inflammatory activity via suppression of pro-inflammatory mediators such as NO, iN OS,and COX-2 and protects mice from LPS-induced mortality in septic shock model.

关键词： Eurycoma longifolia Anti-inflammation Alkaloid 9,10-dimethoxycanthin-6-one

Tungsten-based nanocatalysts with different structures for visible light responsive photocatalytic degradation of bisphenol A

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Journal of Environmental Sciences 2024年第5期139卷 569-588页

作者： Hai Bang Truong Thi Thu Loan Doan nguyen tien Hoang nguyen Van Tam Minh Kim nguyen Le Gia Trung Jin Seog Gwag nguyen tien Tran Optical Materials Research Group Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityViet Nam Faculty of Applied Technology School of TechnologyVan Lang UniversityHo Chi Minh CityViet Nam The University of Da Nang University of Science and Technology54 Nguyen Luong BangDa NangViet Nam The University of Da Nang University of Science and Education459 Ton Duc Thang St.Lien ChieuDa Nang 550000Viet Nam Institute of Veterinary Science and Technology 31ha zoneTrau QuyGia LamHa Noi 12400Viet Nam Department of Physics Yeungnam UniversityGyeongsanGyeongbuk 38541Republic of Korea Center for Advanced Chemistry Institute of Research and DevelopmentDuy Tan University03 Quang TrungDa Nang 550000Viet Nam Faculty of Natural Sciences Duy Tan University03 Quang TrungDa Nang 550000Viet Nam

Environmental pollution,such as water contamination,is a critical issue that must be absolutely ***,three different morphologies of tungsten-based photocatalysts(WO_(3)nanorods,WO_(3)/WS_(2)nanobricks,WO_(3)/WS_(2)nanorods)are made using a simple hydrothermal method by changing the solvents(H_(2)O,DMF,aqueous HCl solution).The as-prepared nanocatalysts have excellent thermal stability,large porosity,and high *** results show all materials have good photocatalytic activity in aqueous media,with WO_(3)/WS_(2)nanorods(NRs)having the best activity in the photodegradation of bisphenol A(BPA)under visible-light *** may originate from increased migration of charge carriers and effective prevention of electron–hole recombination in WO_(3)/WS_(2)NRs,whereby this photocatalyst is able to generate more reactive·OH and·O_(2)^(–)species,leading to greater photocatalytic *** 99.6% of BPA is photodegraded within 60 min when using 1.5 g/L WO_(3)/WS_(2)NRs and 5.0 mg/L BPA at pH ***,the optimal conditions(pH,catalyst dosage,initial BPA concentration)for WO_(3)/WS_(2)NRs are also elaborately *** rod-like heterostructures are expressed as potential catalysts with excellent photostability,efficient reusability,and highly active effectivity in different types of *** particular,the removal efficiency of BPA by WO_(3)/WS_(2)NRs reduces by only 1.5% after five recycling runs and even reaches 89.1%in contaminated lake *** study provides promising insights for the nearly complete removal of BPA from wastewater or different water resources,which is advantageous to various applications in environmental remediation.

关键词： Photodegradation Bisphenol A Tungsten-based nanocatalyst Structure Nanorod

Push forward LC-MS-based therapeutic drug monitoring and pharmacometabolomics for anti-tuberculosis precision dosing and comprehensive clinical management

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Journal of Pharmaceutical Analysis 2024年第1期14卷 16-38页

作者： nguyen Quang Thu nguyen Tran Nam tien nguyen Thi Hai Yen Thuc-Huy Duong nguyen Phuoc Long Huy Truong nguyen Department of Pharmacology and PharmacoGenomics Research Center Inje University College of MedicineBusan47392Republic of Korea Department of Chemistry University of EducationHo Chi Minh City700000Viet Nam Faculty of Pharmacy Ton Duc Thang UniversityHo Chi Minh City700000Viet Nam

The spread of tuberculosis(TB),especially multidrug-resistant TB and extensively drug-resistant TB,has strongly motivated the research and development of new anti-TB *** strategies to facilitate drug combinations,including pharmacokinetics-guided dose optimization and toxicology studies of first-and second-line anti-TB drugs have also been introduced and *** chromatography-mass spectrometry(LC-MS)has arguably become the gold standard in the analysis of both endo-and exo-genous *** technique has been applied successfully not only for therapeutic drug monitoring(TDM)but also for pharmacometabolomics *** improves the effectiveness of treatment,reduces adverse drug reactions,and the likelihood of drug resistance development in TB patients by determining dosage regimens that produce concentrations within the therapeutic target *** on TDM,the dose would be optimized individually to achieve favorable *** is essential in generating and validating hypotheses regarding the metabolism of anti-TB drugs,aiding in the discovery of potential biomarkers for TB diagnostics,treatment monitoring,and outcome *** article highlighted the current progresses in TDM of anti-TB drugs based on LC-MS bioassay in the last two ***,we discussed the advantages and disadvantages of this technique in practical *** pressing need for non-invasive sampling approaches and stability studies of anti-TB drugs was ***,we provided perspectives on the prospects of combining LC-MS-based TDM and pharmacometabolomics with other advanced strategies(pharmacometrics,drug and vaccine developments,machine learning/artificial intelligence,among others)to encapsulate in an all-inclusive approach to improve treatment outcomes of TB patients.

关键词： Tuberculosis Therapeutic drug monitoring LC-MS MIPD Pharmacometabolomics Precision medicine

Development of an experimental method for well-controlled blast induced traumatic limb fracture in rats

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Defence Technology（防务技术） 2024年第4期34卷 168-176页

作者： Luyang Xu Xiancheng Yu Clement DFavier Ibidumo Igah Thuy-tien nguyen Warren Macdonald Anthony MJ.Bull Centre for Blast Injury Studies Imperial College LondonLondonUnited Kingdom Department of Bioengineering Imperial College LondonLondonUnited Kingdom Dyson School of Design Engineering Imperial College LondonLondonUnited Kingdom Department of Trauma and Orthopaedics Royal Free London National Health Service Foundation TrustLondonUnited Kingdom

Heterotopic ossification(HO)is a consequence of traumatic bone and tissue damage,which occurs in 65%of military casualties with blast-associated ***,the mechanisms behind blast-induced HO remain *** models are used to study blast-induced HO,but developing such models is challenging,particularly in how to use a pure blast wave(primary blast)to induce limb fracture that then requires an *** studies,including our recent study,have developed platforms to induce limb fractures in rats with blast loading or a mixture of blast and impact ***,these models are limited by the survivability of the animal and repeatability of the *** this study,we developed an improved platform,aiming to improve the animal's survivability and injury repeatability as well as focusing on primary blast *** platform exposed only one limb of the rat to a blast wave while providing proper protection to the rest of the rat's *** obtained very consistent fracture outcome in the tibia(location and pattern)in cadaveric rats with a large range of size and ***,the rats did not obviously move during the test,where movement is a potential cause of uncontrolled *** further conducted parametric studies by varying the features of the design of the *** factors,such as how the limb is fixed and how the cavity through which the limb is placed is sealed,significantly affect the resulting *** platform and test setups enable well-controlled limb fracture induced directly by pure blast wave,which is the fundamental step towards a complete in vivo animal model for blast-induced HO induced by primary blast alone,excluding secondary and tertiary blast *** addition,the platform design and the findings presented here,particularly regarding the proper protection of the animal,have implications for future studies investigating localized blast injuries,such as blast induced brain and lung injuries.

关键词： Blast injury Biomechanics Heterotopic ossification Limb fracture Blast wave Animal model

Generating highly active oxide-phosphide heterostructure through interfacial engineering to break the energy scaling relation toward urea-assisted natural seawater electrolysis

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Journal of Energy Chemistry 2024年第10期97卷 687-699,I0014页

作者： Ngoc Quang Tran Nam Hoang Vu Jianmin Yu Khanh Vy Pham nguyen Thuy tien nguyen Tran Thuy-Kieu Truong Lishan Peng Thi Anh Le Yoshiyuki Kawazoe Center for Innovative Materials and Architectures Ho Chi Minh City 700000Vietnam Vietnam National University Ho Chi Minh City 700000Vietnam Faculty of Materials Science and Technology University of ScienceHo Chi Minh City 700000Vietnam Department of Mechanical Engineering Hanbat National University(HBNU)Daejeon 34158Republic of Korea Key Laboratory of Rare Earths Ganjiang Innovation AcademyChinese Academy of SciencesGanzhou 341119JiangxiChina School of Chemical Engineering-Hanoi University of Science and Technology Hanoi 10000Vietnam New Industry Creation Hatchery Center Tohoku UniversitySendai 980-8579Japan

Urea-assisted natural seawater electrolysis is an emerging technology that is effective for grid-scale carbon-neutral hydrogen mass production yet *** scaling relations is an effective strategy to break through the bottleneck of natural seawater ***,by DFT calculation,we demonstrated that the interface boundaries between Ni_(2)P and MoO_(2) play an essential role in the selfrelaxation of the Ni-O interfacial bond,effectively modulating a coordination number of intermediates to control independently their adsorption-free energy,thus circumventing the adsorption-energy scaling *** this conceptual model,a well-defined 3D F-doped Ni_(2)P-MoO_(2) heterostructure microrod array was rationally designed via an interfacial engineering strategy toward urea-assisted natural seawater *** a result,the F-Ni_(2)P-MoO_(2) exhibits eminently active and durable bifunctional catalysts for both HER and OER in acid,alkaline,and alkaline sea water-based *** in-situ analysis,we found that a thin amorphous layer of NiOOH,which is evolved from the Ni_(2)P during anodic reaction,is real catalytic active sites for the OER and UOR ***,such electrode-assembled urea-assisted natural seawater electrolyzer requires low voltages of 1.29 and 1.75 V to drive 10 and600 mA cm^(-2)and demonstrates superior durability by operating continuously for 100 h at 100 mA cm^(-2),beyond commercial Pt/C||RuO_(2) and most previous reports.

关键词： Interfacial engineering Break scaling relationships Doping Natural seawater splitting Urea electrolysis

Liouvillian Solutions of Algebraic Ordinary Differential Equations of Order One of Genus Zero

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Journal of Systems Science & Complexity 2023年第2期36卷 884-893页

作者： nguyen Tri dat NGO Lam Xuan Chau Faculty of Basic Science Ho Chi Minh City University of TransportHo Chi Minh CityVietnam Department of Mathematics and Statistics Quy Nhon UniversityQuy Nhon CityVietnam

This paper considers the class of autonomous algebraic ordinary differential equations(AODEs)of order one,and studies their Liouvillian general *** particular,let F(y,w)=0 be a rational algebraic curve over *** authors give necessary and sufficient conditions for the autonomous first-order AODE F(y,y′)=0 to have a Liouvillian solution over ***,the authors show that a Liouvillian solutionαof this equation is either an algebraic function over C(x)or an algebraic function over C(exp(ax)).As a byproduct,these results lead to an algorithm for determining a Liouvillian general solution of an autonomous AODE of order one of genus *** parametrizations of rational algebraic curves play an important role on this method.

关键词： Algebraic ordinary differential equation autonomous differential equation Liouvillian solution rational algebraic curve rational parametrizations

On the Multiplicity and the Cohen-Macaulayness of Fiber Cones of Graded Modules

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Algebra Colloquium 2021年第1期28卷 13-32页

作者： nguyen tien Manh Department of Mathematics Hung Vuong University Nguyen Tat Thanh StreetViet Tri CityPhu ThoVietnam

Let(A,m)be a Noetherian local ring with maximal ideal m,I an ideal of A,J an m-primary ideal of A,N a finitely generated A-module,S=■n≥0 Sn a finitely generated standard graded algebra over A and M=■n≥0 Mn a finitely generated graded *** characterize the multiplicity and the Cohen-Macaulayness of the fiber cone F(M)=■n≥0 Mn/JM_(n).As an application,we obtain some results on the multiplicity and the Cohen--Macaulayness of the fiber cone■n≥0 I^(n)N/JI^(n)N.

关键词： (FC)-sequence filter-regular sequence multiplicity Cohen-Macaulay fiber cone

ITÔDIFFERENTIAL REPRESENTATION OF SINGULAR STOCHASTIC VOLTERRA INTEGRAL EQUATIONS

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Acta Mathematica Scientia 2020年第6期40卷 1989-2000页

作者： nguyen tien DUNG Division of Computational Mathematics and Engineering Institute for Computational ScienceTon Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Mathematics and Statistics Ton Duc Thang UniversityHo Chi Minh CityVietnam

In this paper we obtain an Itôdifferential representation for a class of singular stochastic Volterra integral *** an application,we investigate the rate of convergence in the small time central limit theorem for the ... 详细信息

关键词： stochastic integral equation Itôformula central limit theorem