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SWIR FluorescenceImaging In Vivo Monitoring and Evaluating Implanted M2 Macrophages in Skeletal Muscle Regeneration

Engineering 2024年第2期33卷 283-294页

作者： Mo Chen Yuzhou Chen Sijia Feng Shixian Dong Luyi Sun Huizhu Li Fuchun Chen nguyen thi Kim thanh Yunxia Li Shiyi Chen You Wang Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Key Laboratory of Infrared System Detection&Imaging Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK Healthcare Biomagnetic and Nanomaterials Laboratories University College LondonLondon W1S 4BSUK

Skeletal muscle has a robust regeneration ability that is impaired by severe injury,disease,and *** in a decline in skeletal muscle ***,improving skeletal muscle regeneration is a key challenge in treating skeletal muscle-related *** to their significant role in tissue regeneration,implantation of M2 macrophages(M2MФ)has great potential for improving skeletal muscle ***,we present a short-wave infrared(SWIR)fluorescence imaging technique to obtain more in vivo information for an in-depth evaluation of the skeletal muscle regeneration effect after M2MФ*** fluorescence imaging was employed to track implanted M2MФin the injured skeletal muscle of mouse *** is found that the implanted M2MФaccumulated at the injury site for two ***,SWIR fluorescence imaging of blood vessels showed that M2MФimplantation could improve the relative perfusion ratio on day 5(1.09±0.09 vs 0.85±0.05;p=0.01)and day 9(1.38±0.16 vs 0.95±0.03;p=0.01)post-injury,as well as augment the degree of skeletal muscle regencration on day 13 ***,multiple linear regression analyses determined that post-injury time and relative perfusion ratio could be used as predictive indicators to evaluate skeletal muscle *** results provide more in vivo details about M2MФin skeletal muscle regeneration and confirm that M2MФcould promote angiogenesis and improve the degree of skeletal muscle repair,which will guide the research and development of M2MФimplantation to improve skeletal muscle regeneration.

关键词： In vivo Short-wave infrared Skeletal muscle Macrophage Regeneration

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Machine learning based models for predicting compressive strength of geopolymer concrete

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 1028-1049页

作者： Quang-Huy LE Duy-Hung nguyen thanh SANG-TO Samir KHATIR Hoang LE-MINH Amir H.GANDOMI thanh CUONG-LE Center for Engineering Application and Technology Solutions Ho Chi Minh City Open UniversityHo Chi Minh 700000Vietnam Institute of Civil Engineering Ho Chi Minh City University of TransportHo Chi Minh 700000Vietnam Faculty of Engineering&Information Technology University of Technology SydneyUltimoNSW 2007Australia

Recently,great attention has been paid to geopolymer concrete due to its advantageous mechanical and environmentally friendly *** effort has been made in experimental studies to advance the understanding of geopolymer concrete,in which compressive strength is one of the most important *** facilitate engineering work on the material,an efficient predicting model is *** this study,three machine learning(ML)-based models,namely deep neural network(DNN),K-nearest neighbors(KNN),and support vector machines(SVM),are developed for forecasting the compressive strength of the geopolymer concrete.A total of 375 experimental samples are collected from the literature to build a database for the development of the predicting models.A careful procedure for data preprocessing is implemented,by which outliers are examined and removed from the database and input variables are standardized before feeding to the fitting *** standard K-fold cross-validation approach is applied for evaluating the performance of the models so that overfitting status is well managed,thus the generalizability of the models is *** effectiveness of the models is assessed via statistical metrics including root mean squared error(RMSE),mean absolute error(MAE),correlation coefficient(R),and the recently proposed performance index(PI).The basic mean square error(MSE)is used as the loss function to be minimized during the model fitting *** three ML-based models are successfully developed for estimating the compressive strength,for which good correlations between the predicted and the true values are obtained for DNN,KNN,and *** numerical results suggest that the DNN model generally outperforms the other two models.

关键词： geopolymer concrete compressive strength prediction machine-learning based model deep neural network K-nearest neighbor support vector machines

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A comparative study on kinetics and dynamics of two dump truck lifting mechanisms using MATLAB simscape

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Theoretical & Applied Mechanics Letters 2024年第2期14卷 146-156页

作者： Thong Duc Hong Minh Quang Pham Son Cong Tran Lam Quang Tran Truong thanh nguyen Faculty of Transportation Engineering Ho Chi Minh City University of Technology(HCMUT)Ho Chi Minh City 700000Vietnam Vietnam National University Ho Chi Minh City(VNU-HCM) Ho Chi Minh City 700000Vietnam Industrial Maintenance Training Center Ho Chi Minh City University of Technology(HCMUT)Ho Chi Minh City 700000Vietnam

In this paper,two lifting mechanism models with opposing placements,which use the same hydraulic hoist model and have the same angle of 50°,have been *** mechanical and hydraulic simulation models are established using MATLAB Simscape to analyze their kinetics and dynamics in the lifting and holding *** simulation findings are compared to the analytical calculation results in the steady state,and both methods show good *** the early lifting stage,Model 1 produces greater force and discharges goods in the container faster than Model ***,Model 2 reaches a higher force and ejects goods from the container cleaner than its counterpart at the end lifting *** established simulation models can consider the effects of dynamic loads due to inertial moments and forces generated during the system *** is crucial in studying,designing,and optimizing the structure of hydraulic-mechanical systems.

关键词： Dump truck Lifting mechanism Hydraulic MATLAB Simscape Kinetic dynamic analysis

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Development of an experimental method for well-controlled blast induced traumatic limb fracture in rats

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Defence Technology（防务技术） 2024年第4期34卷 168-176页

作者： Luyang Xu Xiancheng Yu Clement DFavier Ibidumo Igah thuy-Tien nguyen Warren Macdonald Anthony MJ.Bull Centre for Blast Injury Studies Imperial College LondonLondonUnited Kingdom Department of Bioengineering Imperial College LondonLondonUnited Kingdom Dyson School of Design Engineering Imperial College LondonLondonUnited Kingdom Department of Trauma and Orthopaedics Royal Free London National Health Service Foundation TrustLondonUnited Kingdom

Heterotopic ossification(HO)is a consequence of traumatic bone and tissue damage,which occurs in 65%of military casualties with blast-associated ***,the mechanisms behind blast-induced HO remain *** models are used to study blast-induced HO,but developing such models is challenging,particularly in how to use a pure blast wave(primary blast)to induce limb fracture that then requires an *** studies,including our recent study,have developed platforms to induce limb fractures in rats with blast loading or a mixture of blast and impact ***,these models are limited by the survivability of the animal and repeatability of the *** this study,we developed an improved platform,aiming to improve the animal's survivability and injury repeatability as well as focusing on primary blast *** platform exposed only one limb of the rat to a blast wave while providing proper protection to the rest of the rat's *** obtained very consistent fracture outcome in the tibia(location and pattern)in cadaveric rats with a large range of size and ***,the rats did not obviously move during the test,where movement is a potential cause of uncontrolled *** further conducted parametric studies by varying the features of the design of the *** factors,such as how the limb is fixed and how the cavity through which the limb is placed is sealed,significantly affect the resulting *** platform and test setups enable well-controlled limb fracture induced directly by pure blast wave,which is the fundamental step towards a complete in vivo animal model for blast-induced HO induced by primary blast alone,excluding secondary and tertiary blast *** addition,the platform design and the findings presented here,particularly regarding the proper protection of the animal,have implications for future studies investigating localized blast injuries,such as blast induced brain and lung injuries.

关键词： Blast injury Biomechanics Heterotopic ossification Limb fracture Blast wave Animal model

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One-loop contributions for h→ℓℓγ and e−e+→hγ in the U(1)_(B−L) extension of the standard model

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Chinese Physics C 2024年第5期48卷 23-49页

作者： Tran Dzung Tri thanh Huy nguyen Khiem Hong Phan Institute of Fundamental and Applied Sciences Duy Tan UniversityHo Chi Minh City 700000Vietnam Faculty of Natural Sciences Duy Tan UniversityDa Nang City 550000Vietnam VNUHCM-University of Science 227 Nguyen Van CuDistrict 5Ho Chi Minh CityVietnam

We present one-loop contributions for h→ℓℓγ with ℓ=νe,μ,τ,e,μ and e−e+→hγ in the U(1)_(B−L) extension of the standard model. In the phenomenological results, the signal strengths for h→ℓℓγ at the Large Hadron Collider and for e−e+→hγ at future lepton colliders are analyzed in the physical parameter space for both the vector and chiral B−L models. We found that the contributions from the neutral gauge boson Z′ to the signal strengths are rather small. Consequently, the effects will be difficult to probe at future colliders. However, the impacts of charged Higgs and CP-odd Higgs in the chiral B−L model on the signal strengths are significant and can be measured with the help of the initial polarization beams at future lepton colliders.

关键词： Higgs phenomenology one-loop Feynman integrals analytic methods for quantum field theory dimensional regularization future lepton colliders

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Effects of Serum Concentration, Synchronization Time and Confluence on the Cell-Cycle Synchronization Efficiency of Goat Fibroblasts

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Open Journal of Animal Sciences 2024年第3期14卷 194-203页

作者： Van Khanh nguyen Huong Thu thi Vu Au thi Hoang Yen Kim thi Pham Giang thi thanh Nhan Hung Phu Lai Lan Doan Pham Key Laboratory of Animal Cell Biotechnology National Institute of Animal Science Hanoi Vietnam

this study aims to evaluate the effect of serum concentration, synchronization time, and confluence degree on the synchronisation efficiency of goat fibroblast cycle. The results indicated that there was no difference in the percentage of nucleated fibroblasts in the G0/G1 stage between serum concentrations of 0.3% and 0.4% (83.89% and 82.69%, respectively, P > 0.05) as well as between serum concentrations of 0.2% and 0.5% (76.95% and 75.46%, respectively, P > 0.05). The percentage of nucleated fibroblasts in the G0/G1 stage was highest at the concentration of 0.3% and lowest in the control group (83.89% vs. 62.67%, P 0.05). The beneficial effect of high confluence was confirmed by the large percentage of nucleated fibroblasts at the G0/G1 stage. The 60% confluency was significantly lower than the 80% and 100% confluency (73.44%, 86.63%, and 87.17%, respectively, P < 0.05). The results indicate that the goat fibroblast cycle synchronization is the most effective at the serum concentration of 0.3%, 72 hours of synchronization and 100% confluency.

关键词： Goat Fibroblast Cycle Synchronisation Serum Concentration Synchronization Time Confluence

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Mobilization of Arsenic in Groundwater in the Southern Hanoi City (Vietnam) as Studied by Isotopic and Related Techniques

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Journal of Environmental Protection 2013年第7期4卷 68-74页

作者： Dang Duc Nhan Doan Van Canh Pham Quy Nhan nguyen thi thanh thuy Dinh thi Bich Lieu Vo thi Anh Dang Anh Minh Center for Water Resources Management Hanoi Vietnam Hanoi University of Mining and Geology Hanoi Vietnam Institute for Nuclear Science and Technology Hanoi Vietnam Vietnam Association of Hydrogeology Hanoi Vietnam Vietnam Atomic Energy Institute Hanoi Vietnam

Sixteen samples of surface and groundwater from the most southern part of the Hanoi city (Vietnam) has been taken and analyzed for the soluble major ions, namely Na+, K+, , Ca2+, Mg2+, Cl-, , and arsenic as well as molybdenum content along with isotopic composition of deuterium and oxygen (δ2H and δ18O), tritium activity, and δ13C in DIC. The stable isotopic composition of groundwater indicates the water in that area is recharged from the local meteoric and theRed River’s water sources. The mean residence time of the groundwater should be before 60-ies of the past century as its 3H activity ranged from LOD of the analytical technique (0.4 TU) to 2.1 TU only implying that As would not be related to its recent application. The concentrations of As in the water samples is weakly correlated with those of Fe2+ (R2 = 0.08) but it strongly did with the concentrations of bicarbonate (R2 = 0.80). Thus, bicarbonate seems to liberate As adsorbed on hydrous ferric oxides (Hfo) into water through the displacement mechanism. The surface adsorption-desorption of As could be proven by a strong correlation between As and Mo concentrations (R2 = 0.77). The bicarbonate formation in groundwater was thought to be, partly, due to the bio-mineralization of natural organic matter (NOM) by bacteria followed by the dissolution of calcite and/or dolomite present in the sediments. Evidence for the NOM bio-mineralization was found in the close relationship between δ13C and the concentration of bicarbonate in water. Therefore, the mobilization of As in groundwater of bicarbonate type in the southern part of Hanoi city seems to be not only due to the reductive dissolution of the Hfo but the bicarbonate displacement also should be considered.

关键词： Arsenic Mobilization Isotopic Technique Groundwater Nom Bio-Mineralization As-Bicarbonate Displacement

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One-loop contributions for h→?■γ and e-e+→hγ in the U（1）B-L extension of the standard model

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Chinese Physics C 2024年第5期 27-53页

作者： Tran Dzung Tri thanh Huy nguyen Khiem Hong Phan Institute of Fundamental and Applied Sciences Duy Tan University Faculty of Natural Sciences Duy Tan University VNUHCM-University of Science

We present one-loop contributions for h→?■γ with l=ve,μ,τ,e,μ and e-e+→ hγ in the U（1）B-Lextension of the standard *** the phenomenological results,the signal strengths for h→?■γ at the Large Hadron Collider and for e-e+→hγ at future lepton colliders are analyzed in the physical parameter space for both the vector and chiral B-L *** found that the contributions from the neutral gauge boson Z' to the signal strengths are rather ***,the effects will be difficult to probe at future ***,the impacts of charged Higgs and CP-odd Higgs in the chiral B-L model on the signal strengths are significant and can be measured with the help of the initial polarization beams at future lepton colliders.

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循环三轴试验加载频率和压实度对重塑砂土液化行为的影响

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岩土力学 2024年第6期45卷 1813-1823页

作者： thuy Do Van TIEP Pham Duc HIEU nguyen Van THANG Pham Cao 勒奎东技术大学特殊工程技术研究所越南河内越南航空科技协会越南河内

通过对各向同性固结不排水试样进行循环三轴试验,研究了饱和重塑砂土的液化行为。试验采用恒幅正弦载荷,通过测量剪切模量、阻尼比、轴向应变和超孔隙水压力比的变化,评估了加载频率(分别为0.1、0.5、1.0 Hz)和压实度(分别为0.95、0.90... 详细信息

通过对各向同性固结不排水试样进行循环三轴试验,研究了饱和重塑砂土的液化行为。试验采用恒幅正弦载荷,通过测量剪切模量、阻尼比、轴向应变和超孔隙水压力比的变化,评估了加载频率(分别为0.1、0.5、1.0 Hz)和压实度(分别为0.95、0.90和0.80)对砂土液化行为的影响。试验结果表明,对于压实度为0.95的砂样,在5000次加载循环中,0.1 Hz的加载频率对液化过程影响甚微;而对于压实度为0.90和0.80的砂样,此频率的影响显著。对于压实度为0.80的砂样,当频率增加到0.5 Hz时几乎一加载就直接发生液化。这表明增加加载频率会加快液化速度,而增加压实度则会减慢液化速度。因此,通过一系列的试验可以模拟现场砂土在不同频率下的动荷载条件。试验结果表明,饱和砂土的液化行为由以下因素决定:(1)试样的压实度越低,液化越容易发生;(2)加载频率越高,液化越容易发生;(3)循环轴向应变越大,发生液化所需的循环次数越少;(4)超孔隙水压力随加载循环次数增加,直至试样完全液化。

关键词：液化行为加载频率循环三轴试验饱和固结不排水条件重塑砂土压实度

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Intra-arterial tenecteplase during thrombectomy for acute stroke(BRETIS-TNK II):rationale and design

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Stroke & Vascular Neurology 2024年第1期9卷 59-65页

作者： Zi-Ai Zhao Jing Qiu Wei Li thanh nguyen Shouchun Wang Huaizhang Shi Ming Wei Feng Wang Di Li Hui-Sheng Chen Department of Neurology General Hospital of Northern Theater CommandShenyangLiaoning ProvinceChina Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Department of Neurology First Affiliated Hospital of Jilin UniversityChangchunJilinChina Department of Neurosurgery First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurosurgery Tianjin Huanhu HospitalTianjinTianjinChina Department of Interventional Therapy First Affiliated Hospital of Dalian Medical UniversityDalianChina Neurological Intervention Department Dalian Municipal Central HospitalDalianLiaoningChina

Background Our recent pilot study suggests intra-arterial tenecteplase(TNK)during the first pass of endovascular treatment(EVT)seems safe,may increase first-pass reperfusion and good outcome in acute ischaemic stroke(AIS)patients with large-vessel occlusion(LVO).Aims To determine the efficacy and safety of intra-arterial TNK administration during EVT in AIS-LVO patients presenting up to 24 hours from symptom *** size estimates A maximum of 380 patients are required to test the superiority hypothesis with 80%power according to a two-side 0.05 level of significance,stratified by age,gender,baseline systolic blood pressure,prestroke modified Rankin Scale(mRS),baseline National Institute of Health stroke scale,baseline ASPECTS,time from onset to groin puncture,intravenous thrombolysis before EVT,stroke territory and stroke *** Intra-arterial TNK during thrombectomy for acute stroke(BRETIS-TNK II)study is a prospective,randomised,adaptive enrichment,open-label,blinded end point,multicentre *** AIS-LVO patients are randomly assigned into the experimental group and control group with a ratio of 1:*** experimental group will be treated with intra-arterial infusion of TNK during *** control group will be treated with standard *** The primary end point is a favourable outcome,defined as an mRS score of 0–2 at 90 *** primary safety end point is symptomatic intracranial haemorrhage within 48 hours,which is defined as an increase in the National Institutes of Health Stroke Scale score of≥4 points as a result of the intracranial *** The results of BRETIS-TNK II will provide evidence for the efficacy and safety of intra-arterial TNK administration during EVT in AIS patients with LVO.

关键词： rational stratified TNK

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