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The apple REFPOP—a reference population for genomics-assisted breeding in apple

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Horticulture Research 2020年第1期7卷 364-379页

作者： Michaela Jung Morgane Roth Maria JoséAranzana Annemarie Auwerkerken Marco Bink Caroline Denancé christian Dujak charles-Eric Durel Carolina Font i Forcada Celia M.Cantin Walter Guerra Nicholas P.Howard Beat Keller Mariusz Lewandowski Matthew Ordidge Marijn Rymenants Nadia Sanin Bruno Studer Edward Zurawicz François Laurens Andrea Patocchi Hélène Muranty Molecular Plant Breeding Institute of Agricultural SciencesETH Zurich8092 ZurichSwitzerland Breeding Research group Agroscope 8820 WädenswilSwitzerland IRTA(Institut de Recerca i Tecnologia Agroalimentàries) 08140 Caldes de MontbuiBarcelonaSpain Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UB Campus UAB08193 BellaterraBarcelonaSpain Better3fruit N.V. 3202 RillaarBelgium Biometris Wageningen University and Research6708 PB WageningenThe Netherlands Hendrix Genetics Research Technology and Services B.V.PO Box 1145830AC BoxmeerThe Netherlands IRHS Universitéd’AngersINRAEInstitut AgroSFR 4207 QuaSaV49071 BeaucouzéFrance ARAID(Fundación Aragonesa para la Investigación y el Desarrollo) 50018 ZaragozaSpain Research Centre Laimburg 39040 AuerItaly Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Institute of Biology and Environmental Sciences University of Oldenburg26129 OldenburgGermany Research Institute of Horticulture 96-100 SkierniewicePoland School of Agriculture Policy and DevelopmentUniversity of ReadingWhiteknights RG66AR ReadingUK Laboratory for Plant Genetics and Crop Improvement KU Leuven B-3001 LeuvenBelgium GAFL INRAE84140 MontfavetFrance

Breeding of apple is a long-term and costly process due to the time and space requirements for screening selection ***-assisted breeding utilizes genomic and phenotypic information to increase the selection efficiency in breeding programs,and measurements of phenotypes in different environments can facilitate the application of the approach under various climatic *** we present an apple reference population:the apple REFPOP,a large collection formed of 534 genotypes planted in six European countries,as a unique tool to accelerate apple *** population consisted of 269 accessions and 265 progeny from 27 parental combinations,representing the diversity in cultivated apple and current European breeding material,respectively.A high-density genome-wide dataset of 303,239 SNPs was produced as a combined output of two SNP arrays of different densities using marker imputation with an imputation accuracy of *** on the genotypic data,linkage disequilibrium was low and population structure was *** well-studied phenological traits of horticultural importance were *** found marker–trait associations in several previously identified genomic regions and maximum predictive abilities of 0.57 and 0.75 for floral emergence and harvest date,*** decreasing SNP density,the detection of significant marker–trait associations varied depending on trait *** of the trait,10,000 SNPs sufficed to maximize genomic prediction *** confirm the suitability of the apple REFPOP design for genomics-assisted breeding,especially for breeding programs using related germplasm,and emphasize the advantages of a coordinated and multinational effort for customizing apple breeding methods in the genomics era.

关键词： breeding planted utilize

Determining Environmental Impacts for Sensitive Species: Using Iconic Species as Bioindicators for Management and Policy

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Journal of Environmental Protection 2013年第8期4卷 87-95页

作者： Joanna Burger Michael Gochfeld charles W. Powers James H. Clarke Kevin Brown David Kosson Lawrence Niles Amanda Dey christian Jeitner Taryn Pittfield 1Consortium for Risk Evaluation with Stakeholder Participation Vanderbilt University Nashville USA 2Department of Civil and Environmental Engineering and CRESP Vanderbilt University Nashville USA 1Consortium for Risk Evaluation with Stakeholder Participation Vanderbilt University Nashville USA 2Department of Civil and Environmental Engineering and CRESP Vanderbilt University Nashville USA 1Division of Life Sciences Rutgers University Piscataway USA 2Environmental and Occupational Health Sciences Institute Rutgers University Piscataway USA 3Consortium for Risk Evaluation with Stakeholder Participation Vanderbilt University Nashville USA 1Environmental and Occupational Health Sciences Institute Rutgers University Piscataway USA 2Consortium for Risk Evaluation with Stakeholder Participation Vanderbilt University Nashville USA 3Environmental and Occupational Medicine Rutgers-Robert Wood Johnson Medical School Piscataway USA Conserve Wildlife Foundation of New Jersey Greenwich USA Endangered and Nongame Species Program Department of Environmental Protection Trenton USA.

Environmental assessment of impacts, management, and policy are important aspects of protection of human health and the environment. Assessing the impacts of human activities requires selection of bioindicator species that can be used to assess, manage, and develop public policies that ensure ecosystem integrity, and therefore sustainability of social, cultural, and economic systems. With the use of Chinook Salmon (Oncorhynchus tshawytscha), Pacific Cod (Gadusmacrocephalus), Mallard (Anas platyrhynchos), and Red Knot (Calidris canutus rufa), we explore assessment and measurement endpoints, and their relationship to management and development of public policy. This combination of fish and birds provides a diversity of life histories, ecosystem roles, human values, and resource use to explore their use as bioindicators and endpoints. It also allows examination of 1) conservation and protection of species and biodiversity, 2) protection of ecosystems, 3) provision of goods and services, and 4) societal well-being.

关键词： Assessment Bioindicators Contaminants Endpoints Management Public Policy Fish Birds

Confronting Religious Extremism in the New Silk Web

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Asian Journal of Middle Eastern and Islamic Studies 2015年第4期9卷 59-84,I0004页

作者： charles Magee RAMSEY Department of Religious Studies Forman Christian College

The rise in religious extremism is highly documented,but not well *** most frequently cited explanations are economic and ***,the specific role of religion has received far less attention and is often glossed within social-scientific *** aim of this paper is to elucidate the rise of religious ideology in pre-modern Indian Muslim thought and to draw attention to the importance of religious narratives in causing and possibly resolving violent religious extremism in Southwest *** historic setting,more than any other,informs the trajectory of competing religious expressions of *** positions are considered because of their polar responses to similar *** proceed from the same school of thought,and overlap considerably in the use of interpretative methodologies,yet they articulate radically different visions for fidelity to *** has been used to legitimize and mobilize extremist violence in order to establish a righteous society,the other to advocate for a pluralistic participation with the secular *** shared roots allow for a juxtaposition that allows for a cursory description of the challenges faced within the Muslim community to retain fidelity to some most cherished *** is argued that within the Muslim religious intellectual tradition there are ample resources to support a dynamic and pluralistic *** identification and promotion of these values is essential to halting the spread of violent *** need to promote proponents of this narrative and avoid practices that further alienate and limit the natural outworking of this dialogue within Muslim communities.

关键词： Islam Shanghai Cooperation Organization Pakistan Extremism Governance The New Silk Web

高频DC-DC功率变换器的平面电感器的微制造

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磁性元件与电源 2018年第2期 142-150页

作者： Elias Haddad christian Martin Bruno Allard Maher Soueidan charles Joubert 冯文飞法国里昂大学

1介绍电感器是射频（RF）集成电路的基本元件。大量的RF功能通信设备（如移动电话或无线以太网）需要收发器、滤波器和功率放大器，其中电感器是关键组件。近来，随着电子元件小型化的推进，催生了越来越多的便携式设备和高能耗配件。

关键词： DC-DC功率变换器电感器微制造平面高频无线以太网功率放大器基本元件

Trauma and Narrative Wreckage in the Biblical Story of Hagar

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Cultural and Religious Studies 2015年第3期3卷 167-176页

作者： charles M. Rix Oklahoma christian University Oklahoma City USA

The story of Hagar （Genesis 16 and 12） figures prominently in Bible＇s patriarchal narratives of both the elected and rejected with respect to divine promise. As the story of an abused foreign woman cast out into an inhospitable wilderness along with her son, the story raises troubling questions about the portrayal of domestic violence perpetuated by those otherwise celebrated as “faithful” within biblical narratives： Abraham and his wife Sarah. In response to the relative silence on the topic of domestic violence among clergy and leaders of churches, synagogues, and other “sacred spaces”, this paper explores a reading of Hagar＇s story that reclaims her value as a human being. With the help of post-Shoah reading sensitivities that expose strategies of dehumanization, this reading makes visible the way in which the ancient writer/reactor of Genesis performs as an advocate for Hagar in the face of the abuse heaped upon her. In so doing, Hagar＇s story is transformed from a narrative about a rejected “other” into one that exposes abuse by the so-called“elected.” Thus read, the story provides support and encouragement for victims in contemporary religious cultures to step forward and tell their stories.

关键词： domestic violence, church leaders, Hagar, patriarch, clergy, narrative, post-Shoah, Holocaust narrative

Epidemiological and Diagnostic Features of Non-Traumatic Gonalgia in Adults in Bouake (Ivory Coast): About 140 Patients

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Open Journal of Rheumatology and Autoimmune Diseases 2023年第4期13卷 78-87页

作者： Kouakou Ehaulier Soh christian Louis Sougué charles Yao Konan Joe Clauvis Traore Aissata Koffi Joseph Kan Enock Goua Jean Jacques Same Bebey Francine Goupille Phillipe Daboiko Jean Claude Felix Rheumatology Department University Hospital Center Bouaké Bouaké C&#244te d’Ivoire Internal Medicine Department University Hospital Center Sour&#244 Sanou Bobo Dioulasso Burkina Faso Rheumatology Department Laquintinie Hospital Douala Cameroon Rheumatology Department University Hospital Center Tours France

Background: Non traumatic gonalgia is the second most common reason for rheumatology consultations and accounted for 15.6% of rheumatological disorders in Abidjan. Objective: The aim of this work was to study the epidemiological and diagnostic features of non-traumatic gonalgia (NTG) in a black adult population from sub-Saharan Africa. Patients and Methods: This was a five-year retrospective descriptive study (January 2014 to December 2018) of black sub-Saharan African adult patients with non traumatic gonalgia seen in the rheumatology department of the Bouake University Hospital in Côte d’Ivoire. Results: Of 2198 patients seen for rheumatological conditions, 140 had non traumatic gonalgia (6.4%). The mean age of patients was 56.13 ± 13.3 years (extremes 20 and 87 years), and the sex ratio was 0.43 (42 men and 98 women). Gonalgia without swelling was observed in 33.6% of cases. Symptoms were predominantly progressive (97.1%), chronic (82.1%) and bilateral (50%). The causes of TNM were gonarthrosis (85%), septic arthritis (7.1%), reactive arthritis (2.9%), gout (2.9%), rheumatoid arthritis (1.4%) and chondrocalcinosis (0.7%). Gonarthrosis (119/140) was bilateral in 65 patients, bi- or tri-compartmental in 83, radiographic stage (Kellgren and Lawrence) III in 80 and IV in 15. A germ was isolated in two cases of septic arthritis (methicillin-sensitive Staphylococcus aureus and Streptococcus pneumoniae). Conclusion: GNT is common in rheumatology practice in Bouake, and mainly affects women in their fifties. It is most often a chronic bilateral gonalgia, with gonarthrosis as the main etiology.

关键词： Non-Traumatic Gonalgia Gonarthrosis Bouake

Epidemiological and Clinical Aspects of Hospitalized Patients with Chronic Rheumatic Disease at Cocody University Hospital in Abidjan

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Open Journal of Rheumatology and Autoimmune Diseases 2023年第3期13卷 65-70页

作者： Ehaulier Soh christian Louis Kouakou charles Sougué Konan Joe Clauvis Yao Aissata Traore Joseph Kan Enock Koffi Jean Jacques Goua Francine Same Bebey Phillipe Goupille Jean Claude Felix Daboiko Rheumatology Department Bouake University Hospital Bouake C&#244te d’Ivoire Rheumatology Department Cocody University Hospital Abidjan C&#244te d’Ivoire Department of Internal Medicine Sour&#244 Sanou University Hospital Bobo Dioulasso Burkina Faso Rheumatology Department Laquintinie Hospital Douala Cameroon Rheumatology Department Tours University Hospital Tours France

Objective: To study the epidemiological and diagnostic features of chronic rheumatic disease (CRD) in a black population in sub-Saharan Africa. Patients and Methods: Retrospective descriptive study over eight years (January 2005 to December 2012) of patients seen for CRD in rheumatology hospitalization at the CHU de Cocody in Abidjan, Côte d’Ivoire. Results: Of 3147 hospitalized patients, 92 had CRD, a frequency of 2.9%. The mean age of patients was 43.50 ± 15.6 years (extremes: 10 to 79 years). The sex ratio was 0.08 (7 men and 85 women). The socio-economic level was low in 44 patients (47.8%), medium in 44 patients (47.8%), and high in 4 patients (4.4%). The reasons for consultation were polyarthritis (64.1%), polyarthralgia (30.4%), and oligoarthritis (5.4%). The mean duration of symptomatology was 19 months (range: 3 to 20 years). The mean length of hospital stay was 14.2 ± 7.7 days (range: 2 to 36 days). The CRD observed were: rheumatoid arthritis (59.8%), systemic lupus erythematosus (23.9%), mixed connective tissue disease (6.5%), undifferentiated connective tissue disease (3.3%), polymyositis (3.3%), systemic scleroderma (2.2%), and systemic vasculitis (1%). Conclusion: CRD is not uncommon in rheumatology hospitals in Abidjan. Diagnostic delays are long, and rheumatoid arthritis and systemic lupus erythematosus are the most frequently encountered conditions.

关键词： Chronic Rheumatic Disease Rheumatoid Arthritis Lupus Abidjan

Diagnostics for a troubled backbone:testing topological hypotheses of trapelioid lichenized fungi in a large-scale phylogeny of Ostropomycetidae(Lecanoromycetes)

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Fungal Diversity 2015年第4期73卷 239-258页

作者： Philipp Resl Kevin Schneider Martin Westberg christian Printzen Zdeněk Palice Göran Thor Alan Fryday Helmut Mayrhofer Toby Spribille Institute of Plant Sciences NAWI GrazUniversity of GrazHolteigasse 6A-8010 GrazAustria Department of Botany Swedish Museum of Natural HistoryP.O.Box 50007SE-10405 StockholmSweden Senckenberg Forschungsinstitut und Naturmuseum Senckenberganlage 25D-60325 Frankfurt am MainGermany Institute of Botany Academy of Sciences of the Czech RepublicZámek 125243 PrůhoniceCzech Republic Department of Botany Faculty of SciencesCharles University in PragueBenátská212801 Praha 2Czech Republic Department of Ecology Swedish University of Agricultural SciencesP.O.Box 7044SE-75007 UppsalaSweden Herbarium Department of Plant BiologyMichigan State UniversityEast LansingMI 48824USA Division of Biological Sciences University of Montana32 Campus DriveMissoulaMT 59812USA

Trapelioid fungi constitute a widespread group of mostly crust-forming lichen mycobionts that are key to understanding the early evolutionary splits in the Ostropomycetidae,the second-most species-rich subclass of lichenized *** uncertain phylogenetic resolution of the approximately 170 species referred to this group contributes to a poorly resolved backbone for the entire *** on a data set including 657 newly generated sequences from four ribosomal and four protein-coding gene loci,we tested a series of a priori and new evolutionary hypotheses regarding the relationships of trapelioid clades within *** found strong support for a monophyletic group of nine core trapelioid genera but no statistical support to reject the long-standing hypothesis that trapelioid genera are sister to Baeomycetaceae or ***,we can reject a sister group relationship to Ostropales with high *** data also shed light on several longstanding questions,recovering Anamylopsoraceae nested within Baeomycetaceae,elucidating two major monophyletic groups within trapelioids(recognized here as Trapeliaceae and Xylographaceae),and rejecting the monophyly of the genus *** transfer eleven species of the latter genus to Lambiella and describe the genus Parainoa to accommodate a previously misunderstood species of *** phylogenetic studies in Ostropomycetidae have invoked Bdivergence order^for drawing taxonomic conclusions on higher level *** data show that if backbone support is lacking,contrasting solutions may be recovered with different or added *** accordingly urge caution in concluding evolutionary relationships from unresolved phylogenies.

关键词： Ascomycota Fungi Lambiella Lecanoromycetes Ostropomycetidae Parainoa Paraphyly SOWH test Taxon sampling

Tumor microenvironment-dependent epigenetic imprinting in the vasculature predicts colon cancer outcome

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Cancer Communications 2023年第11期43卷 1280-1285页

作者： Elisabeth Naschberger Maximilian Fuchs Nicholas Dickel Meik Kunz Bernt Popp charles Gwellem Anchang Richard Demmler Yanmin Lyu Steffen Uebe Arif Bülent Ekici Carol Immanuel Geppert Arndt Hartmann christian Flierl Katja Petter Tobias Gass Simon Völkl Michael Scharl Andreas Ramming Claudia Günther Susanne Merkel Vera Simone Schellerer Michael Stürzl Division of Molecular and Experimental Surgery Translational Research CenterUniversitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN) ErlangenBavariaGermany Chair of Medical Informatics Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Fraunhofer Institute of Toxicology and Experimental Medicine Lower saxonyHannoverGermany Institute of Human Genetics Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Medicine 3 Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Institute of Pathology Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Internal Medicine 5 – Hematology and Oncology Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Gastroenterology and Hepatology University Hospital ZurichUniversity of ZurichCanton ZurichZurichSwitzerland Department of Medicine 1 Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Surgery Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany

Dear Editor,Tumor microenvironment(TME)-dependent stromal cell plasticity governs tumor development and therapy *** endothelial cells(TECs)are a major cellular component in this context[1].In colorectal carcinoma(CRC),the stromal cell-dependent impact of the TME is illustrated by an improved survival depending on an interferon(IFN)-γ-dominated Th1-like TME associated with high T-cell density[2]and suppressed angiogenesis[3,4].Cellular transcriptional memory is reported in cell lines after repeated exposure to IFN-γin vitro[5],suggesting that a Th1-like TME may also exert stable imprinting effects in ***,we investigated whether TME-dependent transcriptional imprinting in TECs from CRC patients can be exploited to retrieve clinically relevant signatures predicting outcomes.

关键词： imprinting colon interferon