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Risk Factors Recurrence of Spontaneous Ascitic Fluid Infection (Slai) in Cirrhotic Patients

Open Journal of Gastroenterology 2024年第8期14卷 249-260页

作者： Diallo Mamadou Sarifou Ottou Onana Christian Lionel Soro Dramane Youssouf Oumarou Yaogo Abdoulatif Lohoues-Kouacou marie Jeanne Hepato-Gastroenterology Department The Donka National Hospital Conakry Guinea Faculty of Health Sciences and Techniques Gamal Abdel Nasser University Conakry Guinea Hepato Gastroenterology Department Cocody University Hospital Abidjan Ivory Coast Community University Hospital Center of Bangui Internal Medicine Department Bangui African Hepato Gastroenterology Department Angr University Hospital Abidjan Ivory Coast

Introduction: After an episode of spontaneous infection of ascitic fluid (ISLA). The recurrence of ISLA at one year is greater than 70%. We studied the risk factors associated with the occurrence of recurrence. Patients and methods: this was a retrospective, descriptive and analytical study of patient files, hospitalized in the department for 12 months, the choice of the sample was of convenience. Results: We have 1347 patient files collected including 389 cases of cirrhosis. We had 37 files of cirrhotic patients with ISLA including 28 cures without recurrence of ISLA, 08 files of patients with recurrence of ISLA and 03 excluded, i.e. a hospital prevalence of recurrence of 0.6% and a prevalence in cirrhotic patients of 23.5%. The most common antecedents were: hospital contact recent (35.3%), the concept of iterative ascites punctures (32.3%), the presence of HCC (29.4%), hepatic encephalopathy (20.6%) and digestive hemorrhage (14.7%). In univariate analysis, recent digestive bleeding was associated with an increased risk of recurrence (OR 7.2, 95% CI 0.96 - 67.1). HBV (62.5%) is the main etiology of cirrhosis. The PNN rate at 250 - 499 mm3 (62.5%), the protein level 3 (75%). Patients on secondary prophylaxis with NORFLOXACIN were 25%. Recurrence of ISLA was treated with CEFTRIAXONE 2 g/24 hours. Conclusion: Recurrence of ISLA is serious, the predictive factors for recurrence are, hospital contact recent, the concept of iterative ascites punctures, the presence of HCC, the presence of hepatic encephalopathy and digestive bleeding.

关键词： Antibiotic Cirrhosis Risk factors Spontaneous Ascitic Fluid Infection Recurrence

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The Prevalence of Overweight/Obesity and Related Comorbidities among HIV-Positive and HIV-Negative Patients Attending the Same Clinics in Gaborone, Botswana

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Advances in Infectious Diseases 2024年第3期14卷 523-540页

作者： Jose Gaby Tshikuka Matshwenyego Boitshwarelo Shimeles Genna Hamda Roy Tapera ngoyi Kashiba Zacharie Bukonda marie Esako Onokoko Department of Family Medicine and Public Health Faculty of Medicine University of Botswana Gaborone Botswana Department of Nursing Science Faculty of Health Sciences National Pedagogical University Kinshasa I Congo Department of Public Health Faculty of Medicine University of Mbuji-Mayi Mbuji-Mayi Congo School of Public Health Faculty of Health Sciences University of Botswana Gaborone Botswana

Context: Antiretroviral therapy (ART) helps restore the health status of people living with HIV (PLHIV). Likewise, it increases the risk of overweight/obesity and related comorbidities among the recipients. In countries like Botswana where ±84% of PLHIV is on ART, the paucity of data comparing overweight/obesity between HIV-positive on ART and HIV-negative patients may impede clinical and policy decision-making. This study sought to estimate and compare: i) the prevalence of overweight/obesity between HIV-positive on ART and HIV-negative patients;ii) the prevalence of hypertension (HTN), diabetes mellitus (DM)/coronary heart disease (CHD) between HIV-positive patients on ART and HIV-negative patients attending same outpatient departments of general clinics in Gaborone, Botswana. Patients and Methods: Five hundred eighty-one (581) outpatients were recruited in four major clinics of Gaborone, Botswana, between June and July 2019;294 or 51% of them were HIV-negative and 287 or 49% were HIV-positive on ART. The prevalence of overweight/obesity and of HTN and DM/CHD were calculated and examined using stratified analysis. Subgroups were compared using Chi-square analysis with Yates correction or Fisher exact test and t-student test for continuous data. Results: Major findings after stratification of the study population by HIV status were: i) the prevalence of all categories of (BMI), including overweight/obesity, were comparable between HIV-negative-patients and HIV-positive. In fact, there were 24 (8.0%) cases of underweight among HIV-negative-Patients and 15(5%) cases among HIV-positive patients, p = 0.2;145 (49%) HIV-negative-patients and 128 (45%) HIV-positive, p = 0.07 cases of normal weight;72 (25%) HIV-negative-patients and 87 (30%) HIV-positive, p = 0.08, were overweight;53 (18%) HIV-negative-patients and 57 (20%) HIV-positive, p = 0.12, were obese;125 (43%) HIV-negative patients and 144 (50%) HIV-positive, p=0.06 were overweight/obese;ii) the prevalence of HTN a

关键词： Overweight/Obesity Related Comorbidities HIV-Positive HIV-Negative

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Nano-fried-eggs： Structural, optical, and magnetic characterization of physically prepared iron-silver nanoparticles

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Nano Research 2018年第11期11卷 6074-6085页

作者： Julien Ramade Nicolas Troc Olivier Boisron Michel Pellarin marie-ange Lebault Emmanuel Cottancin Vitor T. A. Oiko Rafael Cabreira Gomes Varlei Rodrigues Matthias Hillenkamp Univ. Lyon Universitd Claude Bernard Lyon I CNRS UMR5306 Institut Lumiee Matiee t=-69622 Villeurbanne France Instituto de F[sica Gleb Wataghin UNICAMP CP 6165 13083-970 Campinas SP Brazil

The prospect of combining both magnetic and plasmonic properties in a single nanoparticle promises both valuable insights on the properties of such systems from a fundamental viewpoint and numerous possibilities for technological applications. However, the combination of two of the most prominent metallic candidates—iron and silver—has presented numerous experimental difficulties because their thermodynamic properties impede miscibility and even coalescence. Herein, we present the thorough characterization of physically prepared Fe50Ag50 nanoparticles embedded in carbon and silica matrices via electron microscopy, optical spectroscopy, magnetometry and synchrotron-based X-ray spectroscopy. Iron and silver segregate completely into structures resembling fried eggs, with a nearly spherical, crystallized silver part surrounded by an amorphous structure of iron carbide or oxide, depending on the environment of the particles. Consequently, the particles exhibit both plasmonic absorption corresponding to the silver nanospheres in an oxide environment and a reduced but measurable magnetic response. The suitability of such nanoparticles for technological applications is discussed from the viewpoint of their high chemical reactivity with their environment.

关键词： nanoalloy bimetallic nanoparticles iron silver FeAg optical spectroscopy magnetometry

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在医疗保健领域开发和使用生物标记物的政策性问题

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中国生物工程杂志 2014年第1期34卷 101-126页

作者： Rachael Ritchie marie-ange Baucher 经济合作与发展组织

描述了发展中的生物标记物所处的科学、产业、监管和医疗保健管理系统背景,指出了可能阻碍生物标记物研究、发现、发展、商业化及最终临床应用的一些障碍,聚焦了医疗保健中基于生物标记物的诊断方法和医学检验的应用,探索了生物标记物... 详细信息

描述了发展中的生物标记物所处的科学、产业、监管和医疗保健管理系统背景,指出了可能阻碍生物标记物研究、发现、发展、商业化及最终临床应用的一些障碍,聚焦了医疗保健中基于生物标记物的诊断方法和医学检验的应用,探索了生物标记物在改良药物开发中的应用。

关键词：生物标记物政策医疗保健经合组织

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A privacy-preserving video subscription scheme with the limitation of expire date

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Science China(Information Sciences) 2017年第9期60卷 271-273页

作者： Liehuang ZHU Mingxin CHEN Zijian ZHANG ange TONG Chen XU School of Computer Science and Technology Beijing Institute of Technology

There are many video service websites(e.g.,iqiyi and youku)providing VIP *** these video services,users can register for VIP by paying fare and then they can enjoy some special services in a certain time *** just define the video subscription as an aforementioned *** and more users enjoy this form of video services and the number of the users is increasing all the ***,it is extremely easy for the video

关键词： exp more time A privacy-preserving video subscription scheme with the limitation of expire date link

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山东省潍坊市农村居民耐碳青霉烯类阴沟肠杆菌耐药基因特征及核心基因组特征分析

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中华预防医学杂志 2024年第1期58卷 48-55页

作者：王安阁王爽刘璐孙高翔陈玉贞齐加新寇增强毕振旺山东第一医科大学(山东省医学科学院)附属省立医院医院感染管理办公室济南250021 山东省疾病预防控制中心传染病防制所济南250014

目的探究山东省潍坊市农村居民耐碳青霉烯类阴沟肠杆菌(CR-ECL)耐药基因特征及核心基因组特征。方法收集2017年山东省潍坊市农村社区居民粪便标本,使用耐碳青霉烯类肠杆菌显色培养基筛选耐药菌株,通过激光解吸/电离飞行时间质谱仪(MALDI... 详细信息

目的探究山东省潍坊市农村居民耐碳青霉烯类阴沟肠杆菌(CR-ECL)耐药基因特征及核心基因组特征。方法收集2017年山东省潍坊市农村社区居民粪便标本,使用耐碳青霉烯类肠杆菌显色培养基筛选耐药菌株,通过激光解吸/电离飞行时间质谱仪(MALDI-TOFMS)分析获得CR-ECL阳性菌株,针对CR-ECL分离株,采用微量肉汤稀释法进行抗生素敏感性试验获得CR-ECL耐药表型,开展全基因组测序(WGS)和分析、bla_(NDM)基因周围环境及菌株间系统进化分析。结果共获得并检测628份粪便标本,6份为CR-ECL阳性(检出率0.96%),均表现为多重耐药(MDR)表型。6株CR-ECL共有4个MLST分型(ST),均携带多种耐药基因(bla_(NDM-1)、bla_(NDM-5)等)和毒力基因(acrA、acrB、entB、fepC等),且bla_(NDM)基因周围遗传环境中均存在移动遗传元件ISAba125、TN3-IS3000、TN3及IS5。系统发育树显示,核心基因组多位点序列分型(core genome multilocus sequence typing,cgMLST)与单核苷酸多态性(SNPs)结果具有一致性,cgMLST结果显示菌株2BC0101B与2BC0251B,2BG0561B与2BI0221B之间等位基因差异分别为2和1,SNPs结果显示上述2对菌同样各自聚成一簇,并发现美国国立生物技术信息中心数据库(National Center for Biotechnology Information,NCBI)中鸡粪样本的菌株居于进化树中心,且本地序列均可追溯到美国人源序列。结论山东省潍坊市农村社区居民中已检出多重耐药碳青霉烯类阴沟肠杆菌。

关键词：基因组,细菌碳青霉烯类耐药阴沟肠杆菌

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船舶结构碰撞试验及简化数值计算方法

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中国舰船研究 2024年第2期19卷 128-139页

作者：卢安格王子棠孔祥韶李樱陈三桂吴卫国武汉理工大学船海与能源动力工程学院湖北武汉430063 中国舰船研究设计中心湖北武汉430064 武汉理工大学绿色智能江海直达船舶与邮轮游艇研究中心湖北武汉430063

[目的]采用流固耦合计算方法虽能较好地模拟船舶碰撞过程,但计算时间较长,为此,提出一种简化的数值计算方法。[方法]以某船的局部舱段为对象,开展多工况水上碰撞试验。采用力传感器和基于高速摄影技术非接触测量的方法获得到碰撞力及碰... 详细信息

[目的]采用流固耦合计算方法虽能较好地模拟船舶碰撞过程,但计算时间较长,为此,提出一种简化的数值计算方法。[方法]以某船的局部舱段为对象,开展多工况水上碰撞试验。采用力传感器和基于高速摄影技术非接触测量的方法获得到碰撞力及碰撞船的运动时程数据,通过对碰撞接触力和加速度响应等数据进行分析,并针对试验过程开展任意拉格朗日-欧拉(ALE)流固耦合数值计算分析,提出将碰撞过程中水域对撞击船的影响简化为等效质量,将对被撞船的影响简化为等效阻力,以面力的形式作用于被撞船非撞击侧用以阻碍被撞船运动的简化方法,然后基于此简化方法开展不涉及水域与结构耦合过程的数值计算。[结果]结果显示,采用简化计算方法得到的各工况的碰撞力峰值与试验值间的误差均在5%以内,且该方法所需要的计算时长远小于ALE流固耦合算法。[结论]所提简化数值计算方法可为实现船舶结构碰撞响应的高效计算提供一定的参考。

关键词：模型试验数值仿真碰撞响应任意拉格朗日-欧拉流固耦合

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“全球发展倡议”视域下中国与突尼斯的抗疫合作

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阿拉伯世界研究 2024年第2期 3-23,157页

作者：钮松 [突尼斯]梅丽安上海外国语大学中东研究所上海200083 上海外国语大学国际关系与公共事务学院、中东研究所上海200083

“阿拉伯之春”和新冠肺炎疫情的叠加对突尼斯的经济与社会发展造成巨大冲击,打造卫生健康共同体和发展共同体成为中国与突尼斯抗疫合作的逻辑与目标。“全球发展倡议”对于战胜疫情和复苏经济做出了明晰的规划与部署,对于中国与突尼斯... 详细信息

“阿拉伯之春”和新冠肺炎疫情的叠加对突尼斯的经济与社会发展造成巨大冲击,打造卫生健康共同体和发展共同体成为中国与突尼斯抗疫合作的逻辑与目标。“全球发展倡议”对于战胜疫情和复苏经济做出了明晰的规划与部署,对于中国与突尼斯以南南合作为实质的抗疫合作形成了新的助力作用。中国对突尼斯的医疗援助已走过50余年历程。就中突抗疫合作的路径而言,中国一方面将常规援突医疗队的职能扩大到兼顾对突应急抗疫合作,并实现多批援突医疗队的正常轮换,做到了常规合作与应急合作的结合;另一方面基于疫苗多边主义,向突尼斯适时应急提供新冠疫苗。中突抗疫合作不仅对于突尼斯疫情缓解和疫苗接种率的提升起到了重要作用,提升了中突政治互信,而且也助力中突关系朝着更深广的领域发展,如数字经济、文化合作和绿色发展合作等。中突抗疫合作事实上促进了两国卫生健康共同体与发展共同体建设,并助力推进双边关系取得更大发展。

关键词：中国突尼斯抗疫合作全球发展倡议南南合作

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Amniotic Band Syndrome at the Van Norman Clinic in Burundi: A Case Series

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Surgical Science 2024年第3期15卷 118-124页

作者： Alice Ndayishimiye Hélène Bukuru Déogratias Niyungeko Anne marie Nikuze Sylvestre Bazikamwe Jean Claude Mbonicura Gilbert Ndayizeye Department of Pediatrics Kamenge University Hospital Center Bujumbura Burundi Department of Obstetrics and Gynecology Kamenge University Hospital Center Bujumbura Burundi General Surgery Department Kamenge University Hospital Center Bujumbura Burundi Orthopaedy Department Kamenge University Hospital Center Bujumbura Burundi

Amniotic band syndrome is an acquired embryo-fetopathy. It is rare and is characterized by malformations mainly affecting the limbs but also the skull, face and thoraco-abdominal axis. Its etiopathogenesis remains poorly understood. Its diagnosis is essentially clinical and is classically based on the existence of signs such as furrows, amputations and pseudosyndactyly. To show the importance of antenatal diagnosis in resource-limited countries, we report the case of two newborns, one premature at 31 weeks and the other at term, in whom amniotic band syndrome was discovered incidentally at birth. It involved an amputation of the right leg for both cases. The premature baby was born in a context of neonatal sepsis and will succumb to the latter while the 2nd case was released from the hospital alive. Imaging examinations to search for probable congenital malformations could only be carried out for the 2nd case and no accessible congenital malformation had been identified. And as management of the disease, only psychological support to the parents was provided for the 2 cases. The antenatal discovery of a case of amniotic band syndrome in countries with low technical capacity such as Burundi should push clinicians to think in time about treatment options.

关键词： Amniotic Band Syndrome Embryo-Fetopathies Antenatal Diagnosis Limbs

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Immunovirological Profile of HIV1 Infection in Children and Adolescents Followed at the Bangui Pediatric University Hospital

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Open Journal of Pediatrics 2024年第3期14卷 585-597页

作者： Simplice Cyriaque Kango Synthia Ningatoloum Nazita marie Colette Nganda-Bangue Michaël Dan-Houron Alexandre Manirakiza Jean Chrysostome Gody Department of The Clinique Mé dicale Infantile Raymond Max Siopathis University Children&#8217s Hospital Bangui CAR Faculty of Health Sciences (FACSS) Bangui CAR National Laboratory of Clinical Biology and Public Health Bangui CAR Pasteur Institute Bangui CAR

History: Pediatric management of HIV infection in children in the Central African Republic began in 2004 with the use of fractionated adult antiretrovirals and Cotrimoxazole. It has evolved over the years with the use of pediatric forms, oral suspensions and dispersible tablets. The transition to Dolutegravir took place in 2020. The active file of our patients will grow from 78 to over 1900 today. Follow-up examinations are carried out to assess adherence to treatment. Objective: To determine the immunovirological profile and factors associated with treatment failure during follow-up of children on ART at the Bangui pediatric university hospital. Patients and Method: This was a cross-sectional, analytical study from May 30 to December 02, 2022. The study sample was drawn from a cohort of HIV-1-infected children followed up at the Bangui pediatric university hospital and on ART for three semesters who met the selection criteria. Results: The prevalence of treatment failure varied from one semester to the next. Thus, the prevalence of therapeutic failure was 20% in the first semester, 10% in the second semester and 7% in the third semester. The prevalence of virological failure was 10.28% in the first half of the year, 6.91% in the second half and 4.98% in the third. Secondly, immunological failure was 0.48% in the first half of the year, 0.32% in the second 0.64% in the third half. Finally, clinical failure was 8.82% in the first half, 4.82% in the second half, 1.92% in the third half. Socio-demographic and clinical factors associated with treatment failure were male gender (p 1000 copies/ml (p Conclusion: The occurrence of treatment failures in children is a major problem, especially in our resource-limited countries, given the challenges facing antiretroviral therapy. It is therefore necessary to carry out a study on resistance genotyping in order to propose correct management protocols, as the future of treatment programs depends on it.

关键词： Profile Immunovirological HIV/AIDS Children Bangui

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