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HeALTHCARe: A COMPLeX seRVICe sYsTeM

Journal of systems science and systems engineering 2009年第3期18卷 257-282页

作者： James M. TIeN pascal J. GOLDsCHMIDT-CLeRMONT Dean College of Engineering University of Miami Coral GablesFlorida USA Dean Miller School of Medicine University of Miami Coral GablesFlorida USA

Healthcare.is indeed a complex service system, one requiring the technobiology approach of systems engineering to underpin its development as an integrated and adaptive system. In general, healthcare services are carried out with knowledge-intensive agents or components which work together as providers and consumers to create or co-produce value. Indeed, the engineering design of a healthcare system must recognize the fact that it is actually a complex integration of human-centered activities that is increasingly dependent on information technology and knowledge. Like any service system, healthcare can be considered to be a combination or recombination of three essential components - people （characterized by behaviors, values, knowledge, etc.）, processes （characterized by collaboration, customization, etc.） and products （characterized by software, hardware, infrastructures, etc.）. Thus, a healthcare system is an integrated and adaptive set of people, processes and products. It is, in essence, a system of systems which objectives are to enhance its efficiency （leading to greater interdependency） and effectiveness （leading to improved health）. Integration occurs over the physical, temporal, organizational and functional dimensions, while adaptation occurs over the monitoring, feedback, cybernetic and learning dimensions. In sum, such service systems as healthcare are indeed complex, especially due to the uncertainties associated with the human-centered aspects of these systems. Moreover, the system complexities can only be dealt with methods that enhance system integration and adaptation.

关键词： services healthcare system integration system adaptation system complexity system of systems customization co-production de.ision informatics real-time de.ision making

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Association between Placental Malaria and severe Pre-eclampsia in Two University Hospitals of Yaounde City

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Open Journal of Obstetrics and Gynecology 2024年第9期14卷 1488-1511页

作者： Ayissi Gregory Astrid Ruth Ndolo Kondo Ndoumba Afouba Alice Noa Ndoua Claude Cyrille essiben Félix Meka esther Belinga etienne Metogo Junie engo engo samuel Désiré Bodo edmond Lemaire Tchente Nguefack Charlotte Foumane pascal Mboudou emile Télésphore Department of Obstetrics and Gynecology Faculty of Medicine and Biomedicals Sciences University of Yaound I Yaounde Cameroon Department of Obstetrics and Gynecology Faculty of Medicine and Pharmaceuticals Sciences University of Douala Douala Cameroon Department of Morphological and Anatomo-Pathological sciences Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon. Department of Morphological and Anatomo-Pathological sciences Faculty of Medicine and Biomedicals Sciences University of Yaound I Yaounde Cameroon

Context: Pre-eclampsia and placental malaria, are two diseases that share pathophysiological similarities, such as placental ischemia, endothelial dysfunction and production of pro-inflammatory cytokines. Objective: The objective of our study was to investigate the association between placental malaria lesions and severe pre-eclampsia. Methodology: We conducted a prospective analytical cross-sectional study in two University Hospitals in the city of Yaounde (Yaounde Central Hospital and the Gynaecological Obstetrics and Paediatrics Hospital), and in the laboratory of the Centre Pasteur in Yaounde over an eight-month period (1st January 2021 – 1st september 2021). All patients with pre-eclampsia diagnosed according to the criteria of the International society for the study of Hypertension (IssHP) and free of chronic metabolic or infectious pathology were included in this study. The patients were divided into two groups: group 1 (mild pre-eclampsia) and group 2: severe pre-eclampsia. socio-demographic, clinical and histopathological characte.istics specific to pre-eclampsia and placental malaria were investigated. statistical analysis was performed with sPss 23.0 software, Chi 2 was used to compare categorical variables, student t-test was used to compare means, and logistic regression was used to assess the association between placental malaria lesions and Pes. Results: The mean age of our study population was 29.93 ± 7.36 years versus 28.28 ± 7.18 years in patients with mild and severe pre-eclampsia respectively. Pre-eclampsia placental lesions (accelerated villous maturation, infarction) were significantly greater in patients with severe pre-eclampsia (p Conclusion: Placental malaria lesions were significantly associated with severe pre-eclampsia and increased the risk of developing severe pre-eclampsia placental lesions by a factor of 10.

关键词： Mild Pre-eclampsia severe Pre-eclampsia Malaria Placental Lesions Association

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AsYMPTOTIC LIMITs OF ONe-DIMeNsIONAL HYDRODYNAMIC MODeLs FOR PLAsMAs AND seMICONDUCTORs

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Chinese Annals of Mathematics,series B 2002年第1期23卷 25-36页

作者： PeNG YUeJUN Laboratoire de Mathematiques Appliquees, CNRs UMR 6620, Universite Blaise pascal (Clermont-Ferrand 2), F-63177 Aubiere cedex, France. e-mail: peng@math.univ-bpclermont.fr Laboratoire de Mathématiques Appliquées CNRS UMR 6620 Université Blaise Pascal (Clermont-Ferrand 2) F-63177 Aubière cedex France

This paper studies the zero-electron-mass limit, the quasi-neutral limit and the zero-relaxation-time limit in one-dimensional hydrodynamic models of euler-Poisson system for plasmas and semiconductors. For each limit in the steady-state models, the author proves the strong convergence of the sequence of solutions and gives the corresponding convergence rate. In the time-dependent models, the author shows some useful estimates for the quasi-neutral limit and the zero-electron-mass limit. This study completes the analysis made in [11,12,13,14,19].

关键词： Zero-electron-mass limit Quasi-neutral limit Zero-relaxation-time limit Hydrodynamic models Plasmas semiconductors

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Totally laparoscopic trans-hiatal gastroesophagectomy for benign diseases of the esophago-gastric junction

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World Journal of Gastroenterology 2007年第2期13卷 285-288页

作者： Jean-Louis Dulucq pascal Wintringer Ahmad Mahajna Department of Abdominal surgery Institute of Laparoscopic Surgery Maison de Santé Protestante Bagatelle Hospital Route de Toulouse 203 Talence-Bordeaux 33401 France

AIM： To prospectively present our initial experience with totally laparoscopic transhiatal esophagogastrectomies for benign diseases of the cardia and distal esophagus. MeTHODs： Laparoscopic gastric mobilization and tubularization combined with transhiatal esophageal dissection and intrathoradc esophagogastric anastomosis accomplished by a circular stapler was done in 3 patients. There were 2 females and 1 male patient with a mean age of 73 ± 5 years. ResULTs： Two patients were operated on due to benign stromal tumor of the cardia and one patient had severe oesophageal peptic stenosis. Mean blood loss was 47 ± 15 mL and mean operating time was 130 ± 10 rain. There were no cases that required conversion to laparotomy. All patients were extubated immediately after surgery. soft diet intake and ambulation times were 5.1 ± 0.4 d and 2.6 ±0.6 d, respectively. There were no intraoperative and postoperative complications and there were no perioperative deaths. The average length of hospital stay was 9.3 ± 3 d. All procedures were curative and all resected margins were tumor free. The mean number of retrieved lymph nodes was 18 ±8. CONCLUsION： Laparoscopic transhiatal esophagogastrectomy for benign lesions has good effects and proves feasible and safe.

关键词： esophagogastrectomy Transhiatal resection Cardial tumor Laparoscopy stromal tumor

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Regulation of shoot and Root Development through Mutual signaling

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Molecular Plant 2012年第5期5卷 974-983页

作者： Jerome Puig Germain Pauluzzi emmanuel Guiderdoni pascal Gantet Universite Montpellier 2 UMR DAP Bat 15 CC 002 Place Eugene Bataillon 34095 Montpellier Cedex 5 France CIRAD UMR DAP Avenue Agropolis TA A-96/03 34398 Montpellier Cedex 5 France University of science and Technology of Hanoi LMI RICE Agricultural Genetics Institute Ha Noi Viet Nam IRD UMR DIADE Avenue Agropolis 34398 Montpellier Cedex 5 France

Plants adjust their development in relation to the availability of nutrient sources. This necessitates signal- ing between root and shoot. Aside from the well-known systemic signaling processes mediated by auxin, cytokinin, and sugars, new pathways involving carotenoid-derived hormones have recently been identified. The auxin-responsive MAX pathway controls shoot branching through the biosynthe.is of strigolactone in the roots. The BYPAssI gene affects the production of an as-yet unknown carotenoid-derived substance in roots that promotes shoot development. Novel local and systemic mechanisms that control adaptive root development in response to nitrogen and phosphorus starvation were recently discovered. Notably, the ability of the NITRATe TRANsPORTeR 1.1 to transport auxin drew for the first time a functional link between auxin, root development, and nitrate availability in soil. The study of plant response to phos- phorus starvation allowed the identification of a systemic mobile miRNA. Deciphering and integrating these signaling pathways at the whole-plant level provide a new perspective for understanding how plants regulate their development in response to environmental cues.

关键词： plant development systemic signaling strigolactone BYPAss1 nitrate phosphate miRNA.

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A decomposition approach to job-shop scheduling problem with discretely controllable processing times

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science China(Technological sciences) 2011年第5期54卷 1240-1248页

作者： NIU GangGang sUN shuDong LAFON pascal YANG HongAn Institute of system Integration and engineering Management Key Lab of Contemporary Design and Integrated Manufacturing Technology MOE Xi'an 710072 China Institut Charles Delaunay-LAsMIs FRe CNRs 28 48 Universite de Technologie de Troyes Troyes 10010 France

Job-shop scheduling problem with discretely controllable processing times (JsP-DCPT) is modeled based on the disjunctive graph, and the formulation of JsP-DCPT is presented. A three-step decomposition approach is proposed so that JsP-DCPT can be handled by solving a job-shop scheduling problem (JsP) and a series of discrete time-cost tradeoff problems. To simplify the decomposition approach, the time-cost phase plane.is introduced to describe tradeoffs of the discrete time-cost tradeoff problem, and an extreme mode-based set dominant theory is elaborated so that an upper bound is determined to cut discrete time-cost tradeoff problems generated by using the proposed decomposition approach. An extreme mode-based set dominant decomposition algorithm (eMsDDA) is then proposed. experimental simulations for instance JsPDCPT_FT10, which is designed based on a JsP benchmark FT10, demonstrate the effectiveness of the proposed theory and the decomposition approach.

关键词： job-shop scheduling discretely controllable processing times time-cost tradeoff decomposition

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Determination of 3-MeO-PCP in human blood and urine in a fatal intoxication case,with a specific focus on metabolites identification

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Forensic sciences Research 2021年第4期6卷 208-214页

作者： Nadia Arbouche pascal Kintz Cecile Zagdoun Laurie Gheddar Jean-sébastien Raul Alice Ameline ainstitut de Médecine Légale strasbourgFrance X-Pertise consulting MittelhausbergenFrance UnitéMédico-Judiciaire hôpital emile MullerMulhouseFrance

3-Methoxyphencyclidine(3-MeO-PCP)is a new psychoactive substance that belongs to the phencyclidines family,first identified in europe in *** drug presents a stronger binding to N-methyl-D-aspartate(NMDA)receptors when compared to phencyclidine,which results in more potent effects,even at low *** few articles have been published regarding 3-MeO-PCP in forensic *** this paper,the authors present a fatal 3-MeO-PCP intoxication *** addition to the detection of the parent drug,metabolites were investigated in urine and,for the first time in the scientific literature,in blood.3-MeO-PCP and its metabolites were quantitated by liquid chromatography-tandem mass spectrometry system(LC-Ms/Ms).Identification was confirmed by liquid chromatography-high resolution mass spectrometry(LC-HRMs).3-MeO-PCP tested positive.in femoral blood(3525 ng/mL)and urine(7384 ng/mL).The femoral blood concentration was higher than the fatal concentrations range already reported in the literature(from 50 to 3200 ng/mL).3-MeO-PCP metabolites,including O-demethyl-3-MeO-PCP,piperidine-OH-3-MeO-PCP,O-demethyl-piperidine-di-OH-3-MeO-PCP and piperidine-di-OH-3-MeO-PCP,were detected in *** addition,two new metabolites,O-demethyl-piperidine-OH-3-MeO-PCP and O-demethyl-cyclohexyl-OH,were identified in both blood and ***,due to the lack of reference material on the market,it was not possible to measure the concentration of these ***,the ratios between the metabolites and the parent drug were useful to estimate their analytical response and *** this time,considering the low ratios(etween metabolites and parent drug,metabolites testing does not seem useful to increase the detection window of the drug.

关键词： Forensic sciences forensic toxicology 3-MeO-PCP metabolites fatal intoxication blood urine

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One-dimensional lanthanide complexes bridged by nitronyl nitroxide radical ligands with non-chelating nitrogen donors： structure and magnetic characterization

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中国科学：化学 2012年第6期42卷 911-912页

作者： sUTTeR Jean-pascal Université de Toulouse

A series of new lanthanide-radical complexes [{Ln(hfac)3}2(NITPhIM)2] (Ln = Nd (1), eu (2), Tb (3), er (4); hfac = hexafluoroacetylacetonate; NITPhIM = 2-[4-(1-imidazole)phenyl]-4,4,5,5- tetramethylimidazoline-1- oxyl-3- oxide) have been prepared and characterized. single crystal X-ray diffraction analyses reveal that these complexes are.isostructural with one-dimensional chain structures. These consist in Ln(hfac)3 units bridged by the paramagnetic ligands by the means of coordination of their nitronyl nitroxide groups and imidazole rings. Interestingly, each Ln ion is either bound to two nitronyl nitroxide groups or to two imidazole units, and the different Ln centers alternate along the chain. Magnetic studies show that complex 3 exhibits a single-chain magnet behavior.

关键词：氮氧自由基稀土配合物链结构磁性一维 X-射线衍射分析表征螯合

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effect of hydration on the surface basicity and catalytic activity of Mg-rare earth mixed oxides for aldol condensation

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Journal of Rare earths 2018年第4期36卷 359-366页

作者： Zheng Wang pascal Fongarland Guanzhong Lu Wangcheng Zhan Nadine essayem Key Laboratory for Advanced Materials and Research Institute of Industrial Catalysis School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Institut de Recherches sur la Catalyse et l'environnement de Lyon(IRCeLYON) CNRS-Universite Lyon 12 Avenue Albert Einstein69626 Villeurbanne CedexFrance

Magnesium and rare earth mixed oxides（Mg3 ReOx（Re=La, Y. Ce）） were prepared and characterized by Xray diffraction（XRD）, N_2 adsorption-desorption, infrared spectra and microcalorimetry of CO_2. The results reveal that the Mg_3 CeO_x catalyst is present in the form of Mg-Ce-O solid solution,while the Mg3 LaOx and Mg_3 YO_x catalysts are probably rare earth oxides dispersed on MgO surface. As a result, among the calcined Mg_3 ReO_x catalysts, the Mg_3 CeO_x catalyst presents the highest rate constant for acetone aldolization, which is well correlated to its more homogeneous distribution of basic sites. In contrary, the Mg_3 YO_x catalyst exhibit the lowest catalytic activity for acetone aldolization. Upon hydration pre-treatment, the basic properties on the surface of the Mg_3 ReO_x catalysts were changed markedly. The Mg_3 YO_x catalyst after hydration treatment shows the highest amount of basic sites on catalyst surface, and then exhibits the highest activity among the hydrated Mg_3 ReO_x catalysts. These results make it possible to fine-tune basic sites for acetone aldolization.

关键词： Mg-rare earth mixed oxide Hydration treatment Water tolerance Aldol condensation solid base catalyst Rare earths

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Temperature modifies activity, inter-individual relationships and group structure in a fish

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Current Zoology 2017年第2期63卷 175-183页

作者： Tatiana COLCHeN Fabrice TeLeTCHeA pascal FONTAINe Alain PAsQUeT Université de Lorraine Unité de Recherche Animal et Fonctionnalités des Produits Animaux USC INRA 340 F-54506 Vandceuvre-Iès-Nancy Cedex 09 France CNRs (National Center for scientific Research) Délégation Régionale Centre est. 17 Rue Notre Dame des Pauvres F-54500 Vandceuvre-Iès-Nancy France

A host of abiotic factors modify fish social behavior. However, few studies have characterized the effects of temperature on behavior. In this study, brown trout salmo trutta fry were reared at 5 dif- ferent temperatures （4℃, 6℃, 8℃, 10℃, and 12℃）. In order to characterize group structure, 3 be- havioral parameters were investigated： group social structure （based on inter-individual distances）, inter-individual relationships （based on physical contacts）, and individual activity. These behavioral parameters were studied at the emergence stage, which corresponds to a switch from a social gre- garious life in the gravel to a solitary one in the water column. Data analysis showed that the inter- individual distances increased with increasing temperature, particularly the nearest neighbor distance. The mean number of physical contacts between fry increased at both low and high tem- peratures. At high temperatures, most fry moved apart from each other after a physical contact. swimming activity decreased at both the lower and upper temperatures （18% of activity at 4℃, 38% at 8℃, and 12% at 12℃）. This study showed that temperature modifies brown trout fry activity, inter-individual relationships, and social behavior, which all affect group cohesion before emer- gence and can influence their survival and dispersal.

关键词： early development emergence freshwater species group structure relationships.

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