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Isolation, purification and partial characterization of a glycoside from the j.maican ball moss plant (<i>Tillandsia recurvata</i>L.)

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Advances in Biological Chemistry 2012年第3期2卷 274-282页

作者： Henry I. C. Lowe Charah T. Watson Simone Badal ngeh j. toyang j.seph Bryant Bio-Tech R & D Institute Kingston Jamaica Institute of Human Virology School of Medicine University of Maryland Baltimore USA Natural Products Institute University of the West Indies Mona Jamaica

Initial isolation and characterization screens have been carried out on the j.maican ball moss (Tillandsia recurvata L.) plant producing a novel complex gly-cosidic compound. This complex glycoside may be responsible for the promising anti-cancer and anti-inflammatory properties of this ball moss plant. A combination of supercritical fluid processing and chromatographic purification was used to produce the isolate. LC-MS analysis showed the presence of a compound with a molecular weight of ~800 and mass spectral (MS-MS and MS-MS-MS) data indicate that this compound may be a glycoside with a molecular mass of 1601.1 Da (negative ionization mode) and possibly contain up to two sialic acids, based on the doubly-charged state of the molecule at neutral pH conditions. 2D-TOCSY NMR spectrum lends evidence to the presence of at least one likely amide to aliphatic proton correlation, indicating the presence of a sialic acid moiety. The main structure of this therapeutic compound appears similar to a soyasaponin.

关键词： j.maican Ball Moss Tillandsia recurvata Anti-Cancer Anti-Inflammatory LC-MS High-Resolution Mass Spectrometry Total Correlation Spectroscopy (TOCSY)

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Promising Efficacy of the <i>Cola acuminata</i>Plant: A Mini Review

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Advances in Biological Chemistry 2014年第4期4卷 240-245页

作者： Henry I. C. Lowe Charah T. Watson Simone Badal Patrice Peart ngeh j. toyang j.seph Bryant Bio-Tech R & D Institute Kingston Jamaica Educational and Scientific Corporation Florida USA Institute of Human Virology University of Maryland School of Medicine Baltimore USA

Cola acuminata also known as the bissy nut extract was originally endemic to Africa but is now present in a number of tropical countries including j.maica. Despite its rich history of ethnomedicinal use and promising bioactivity, there still exists limited research on this plant. Exploring and compiling the ethnomedicinal usage, identified bioactivities and isolates of C. acuminata will prove useful in steering future directional research with the hope of reaping the plant’s full beneficial properties. The plant’s traditional use encompass;cancer treatment, an antidote for poisoning, suppressing one’s appetite, increasing alertness, treating migraine and motion sickness, obtaining a state of euphoria in addition to being used in certain traditional practices. Because of the plant’s copious ethnomedicinal use, researchers were led to believe that the low incidence of prostate cancer evidenced amongst Asians could be as a result of phytochemicals present in the bissy nut. Research conducted in our lab confirmed the anti-cancer potential of the plant and recent research has identified a number of secondary metabolites present in C. acuminata which could be responsible for the observed bioactivities. The plant has also shown promise as an anti-microbial agent. This paper confirms the efficacy of the bissy nut plant both as an ethnomedicine as well as warranting further research that may prove useful both in the pharmaceutical and nutraceutical industries.

关键词： Bissy Cola acuminata Prostate Cancer Breast Cancer Cytotoxic

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压电晶体生物传感器

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国外科学仪器 1990年第4期 15-20页

作者： j. ngeh-Ngwainbi 卜海之何薇中国人民解放军军事医学科学院

本文综述了压电晶体生物传感器的最新研究进展。象酶,类脂物、抗体及抗原等生物物质已被用作专一性涂层,从而可以测定不同的物质。文中介绍了蛋白质涂层的制备方法及其应用,包括微量免疫测定、微生物测定、DNA 杂交、酶检测及气相生物... 详细信息

本文综述了压电晶体生物传感器的最新研究进展。象酶,类脂物、抗体及抗原等生物物质已被用作专一性涂层,从而可以测定不同的物质。文中介绍了蛋白质涂层的制备方法及其应用,包括微量免疫测定、微生物测定、DNA 杂交、酶检测及气相生物传感器等内容。尽管压电免疫化学传感器使用方便,具有广阔的发展前景,但是到目前为止,人们对生物反应中与晶体频率测量相关的不同现象还缺乏足够的理解,有待进一步研究。

关键词：压电晶体生物传感器传感器

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急性脑血管病或卒中老年患者对非典型呼吸道病原体(肺炎衣原体、肺炎支原体、嗜肺军团菌)感染负担的病例对照研究

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 53-54页

作者： ngeh j. Goodbourn C. 赵正卿 Dept. of Geriatric andStroke Med. Warwick Hospital Lakin Rd Warwick CV345BW United Kingdom

Background and Purpose:Multiple studies have suggested an association between Chlamydia pneumoniae and Mycoplasma pneumoniae infectio n and cardiovascular disease. We investigated whether the risk of cerebrovascula r disease is associated with Legionella pneumophila infection and the aggregate number/infectious burden of these atypical respiratory ***:One hu ndred patients aged >65 years admitted with acute stroke or transient ischemic a ttack (TIA) and 87 control patients admitted concurrently with acute noncardiopu lmonary,noninfective conditions were recruited prospectively. Using enzyme-link ed immunosorbent assay (ELISA) kits, we previously reported the seroprevalences of C pneumoniae and M pneumoniae in these patients. We have now determined these roprevalences of L pneumophila IgG and IgM in this cohort of patients using ELI SA. Results:The seroprevalences of L pneumophila IgG and IgM were 29%(n=91) an d 12%(n=81) in the stroke/TIA group and 22%(n=86) and 10%(n=72) in the contro ls, respectively. Using logistic regression to adj.st for age, sex, hypertension , smoking, diabetes, ischemic heart disease, and ischemic ECG, the odds ratios f or stroke/TIA in relation to L pneumophila IgG and IgM were 1.52 (95%CI,0.70 to 3.28; P=0.29) and 1.49 (95%CI, 0.45 to 4.90; P=0.51),respectively. The odds ra tios in relation to IgG seropositivity for 1, 2, or 3 atypical respiratory patho gens after adj.stment were 3.89 (95%CI, 1.13 to 13.33), 2.00 (95%CI, 0.64 to 6 .21), and 6.67 (95%CI, 1.22 to 37.04), respectively (P=0.06).Conclusions:L pne umophila seropositivity is not significantly associated with stroke/TIA. However , the risk of stroke/TIA appears to be associated with the aggregate number of c hronic infectious burden of atypical respiratory pathoeens such as C pneumoniae, M pneumoniae, and L pneumophila.

关键词：急性脑血管病肺炎衣原体嗜肺军团菌呼吸道病原体急性卒中病例对照研究短暂性缺血血清阳性率感染负荷 atypical

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