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Giant Myositis Ossificans Circumscribed Post Traumatic of Gluteus and Adductor Muscles: Case Report

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Open Journal of Orthopedics 2015年第6期5卷 157-162页

作者： Koné Samba Touré Stanislas Bana Abdoulaye Dogba Eric Doukouré Brahima ngandeu nawé astrid Koffi Gérard Vangah Marius Mègné Estelle Allou Sylvain Service de Chirurgie Orthopédique et Traumatologique C.H.U de Cocody Abidjan Ivory Coast Service d’Anatomie Pathologie du C.H.U de Cocody Abidjan Ivory Coast Service de Rhumatologie C.H.U de Cocody Abidjan Ivory Coast Service de Chirurgie Orthopédique et Traumatologique C.H.U de Bouake Bouake Ivory Coast

Myositis ossificans circumscribed is a bone and cartilage heterotopic non neoplastic proliferation inside the soft tissues. It is a benign focal heterotopic ossification process of soft tissues, and a rare disorder that occurs spontaneously or after local trauma. Clinical and radiographic appearances are quite hustler. A careful histological examination of biopsy straightens diagnosis is necessary. There is no consensus in support (surgical or/and medical). From Benign prognosis, evolution of this pathology is usually favorable. The authors report a case of giant myositis ossificans circumscribed post-traumatic localized on gluteus and adductor muscles of the right hip on a 26-year-old man. Through a review of literature the mechanism, the diagnostic methods and therapeutic will be discussed.

关键词： Giant Myositis Ossifying Gluteus and Adductor Muscles Biopsy

Severe Axonal Peripheral Polyneuropathy Revealing a Systemic Lupus Erythematosus: About One Case

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Open Journal of Rheumatology and Autoimmune Diseases 2015年第2期5卷 36-39页

作者： Mariam Gbané-Koné Mohamed Diomandé Boubacar Ouali Abidou Kawalé Coulibaly astrid nawé ngandeu Edmond Eti Marcel N’zué Kouakou Department of Rheumatology University Hospital Center of Cocody Abidjan C&ocircte d’Ivoire

Aim: We report a case of acute and severe sensorimotor peripheral polyneuropathy (with a severe motor damage) revealing a lupus. Case Presentation: A 48-year-old female patient was interned in rheumatology for a chronic polyarthritis. Four days after her hospitalisation, she was presenting a flask distal and proximal tetraparesia, with rapidly progressive installation. Electromyogram showed severe acute axonal sensorimotor polyneuropathy. The antinuclear antibody was positive as the anti-ds-DNA antibodies. The evolution has been unsatisfactory despite the high-dose corticotherapy and the immunosuppressor. Conclusion: Even if it is rare, peripheral neuropathy can be a lupus discovery circumstance.

关键词： Systemic Lupus Erythematosus EMG Neurolupus Peripheral Polyneuropathy

Autoantibodies in Systemic Lupus Erythematosus, on Black African Subject, in Abidjan

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Open Journal of Rheumatology and Autoimmune Diseases 2015年第2期5卷 28-35页

作者： Mariam Gbané-Koné Baly Ouattara Kouassi Jean Mermoz Djaha Estelle Megne astrid nawé ngandeu Abidou Kawalé Coulibaly Edmond Eti Marcel N’zué Kouakou Department of Rheumatology University Hospital Center of Cocody Abidjan C&#212te d’Ivoire

Aim: To determine the clinical and immunological characteristics of patients with systemic erythematosus lupus in Abidjan. Patients and Method: We studied 117 patients’ files with systemic lupus erythematosus aged 12 to 73 years old, who fulfilled the American College of Rheumatology (ACR)’s criteria. Antinuclear autoantibodies (ANA) were searched by indirect immunofluorescence. Anti-DNA native autoantibodies, extractable nuclear anti-antigens autoantibodies (anti-Sm, anti-SSA, anti-SSB and anti-RNP) and anti-phospholipids autoantibodies have been searched by ELISA technic. Results: The most frequent clinical manifestations were: articular damages (86.32%), cutaneous and mucosal lesions (71.79%) and fever (76.67%). Kidney damages have been noticed in 40.17%. Neurologic manifestations have been observed in 36.75%. Pericarditis and pleurisies have been noticed in 22.22% and 11.97% of cases, and anaemia in 86.32% of cases. ANA have been detected in 94.12% of cases, anti-DNA native’s autoantibodies in 73.53% and anti-Sm autoantibodies in 75% of cases. Anti-SSA and anti-SSB autoantibodies were respectively in 75% and 56.25% of cases. Anti-RNP autoantibodies were in all the patients, and anti-phospholipids autoantibodies were in 37.50% of cases. Conclusion: Systemic lupus erythematosus of Ivorian black subject is characterised by high prevalence of autoantibodies, mostly Anti-RNP.

关键词： Sub-Saharan Africa Systemic Lupus Erythematosus Extractable Nuclear Anti-Antigens Autoantibodies Anti-Phospholipids Autoantibodies ELISA

Effect of Binge Drinking on Glucose Metabolism in Occasional Drinkers: An Experimental Study

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Open Journal of Endocrine and Metabolic Diseases 2018年第1期8卷 49-58页

作者： nawé Justine astrid ngandeu Armand Mbanya Eric Lontchi-Yimagou Vicky Kamwa Jean Louis Nguewa Jean-Claude Katte Andrea Michèle Audrey Omengue Simeon-Pierre Choukem Mesmin Dehayem Jean-Claude Mbanya Eugene Sobngwi Yaounde Central Hospital National Obesity Center Yaoundé Cameroon Cocody’s CHU Abidjan Ivory Coast Diabetes Research and Training Center and Division of Endocrinology Department of Medicine Albert Einstein College of Medicine New York NY USA Laboratories of Molecular Medicine and Metabolism Biotechnology Center University of Yaoundé Yaoundé Cameroon Inserm UMRS 1138 Cordeliers Research Centre University of Paris Paris France Department of Internal Medicine Faculty of Medicine and Biomedical Sciences University of Yaoundé Yaoundé Cameroon Departments of Internal Medicine and Pediatrics Faculty of Health Sciences University of Buea Buea Cameroon Health and Human Development (2HD) Research Group Douala Cameroon

Binge drinking is a major public health problem that affects all age groups. Its relation to the risk of impaired glucose metabolism and diabetes is unclear due to controversial findings in animal models and lack of studies in humans. We performed an experimental study on 10 adult volunteers (7M/3F) under the age of 40 who were occasional binge drinkers. In all participants, we performed a baseline two-hour euglycemic hyperinsulinemic clamp at 80 mU•m−2•min−1 at baseline for comparison with an age and sex matched control population of non-drinkers. On a second occasion, before and after ingestion of 78 g of alcohol (beer) in 2 hrs we also measured insulin sensitivity using a 15-minute short insulin tolerance test in drinkers. Blood glucose was also measured every 15 mins over 2 hours during alcohol ingestion. Volunteers were aged 27.6 ± 5.7 years, with a BMI of 23.1 ± 2.8 kg/m2, and ALAT of 24.7 ± 3.0 UI/L. Insulin sensitivity evaluated by the clamp technique was higher in occasional drinkers (M = 12.7 ± 3.4 mg•kg−1•min−1 vs. 8.0 ± 2.3 mg•kg−1•min−1 in non-drinkers, p = 0.011). Acute alcohol ingestion was associated with a non-significant trends towards improved glucose disappearance during short insulin tolerance test (KITT 2.53% ± 0.22%/min before vs. 3.11% ± 1.15%/min after;p = 0.122). Beer consumption induced a significant increase in capillary glycaemia of 78% (p = 0.001). Bingeing was associated with reduced insulin secretion (Homa-β 113.5 ± 22.7 vs. 155.4 ± 57.6;p = 0.047). Binge drinking may induce an increase in insulin sensitivity but acutely decrease insulin secretion.

关键词： Glucose Metabolism Binge Drinking Insulin Sensitivity Insulin Secretion

Systemic Form of Juvenile Idiopathic Arthritis: Epidemiological, Clinical, Paraclinical and Therapeutic Aspects of 13 Cases in Abidjan

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Open Journal of Rheumatology and Autoimmune Diseases 2017年第2期7卷 103-110页

作者： Mohamed Diomandé Abidou Kawélé Coulibaly astrid nawé ngandeu Cyprien Kouakou Ehaulier Soh Christian Louis Kouakou Kouassi Jean Mermoz Djaha Mariam Gbané-Koné Baly Ouattara Edmond Eti Jean Claude Daboiko Marcel N’zué Kouakou Department of Rheumatology University Hospital Center of Cocody Abidjan C&#244te d’Ivoire Department of Pediatrics University Hospital Center of Cocody Abidjan C&#244te d’Ivoire Department of Rheumatology University Hospital Center of Bouaké Bouaké C&#244te d’Ivoire

Objective: To describe the epidemiological, clinical, paraclinical and therapeutic aspects of systemic juvenile idiopathic arthritis observed in Abidjan. Materials and Method: This retrospective and descriptive study covered 13 children suffering from systemic juvenile idiopathic arthritis selected in the Rheumatology Department of University Hospital Center of Cocody in Abidjan (Cote d’Ivoire) from January 2005 to December 2015. We were interested to the sociodemographical, clinical, paraclinical and therapeutic aspects. Results: The systemic form of the juvenile idiopathic arthritis represented 0.2% of the 4608 rheumatologic diseases and 70.58% of the JIA. We selected 6 boys and 7 girls, with an average age of 10.8 years and mostly going to school (84.61%). The diagnostic delay was 18 months. The main clinical signs were fever and joint damage observed each in 100% of cases, impaired general condition (92.30%) and tumor syndrome (83.33%). Biological signs were characterized by hyperleukocytosis (69.20%) and the presence of a biologic inflammatory syndrome (on average, erythrocyte sedimentation rate 59.6 mm and C Reactive Protein 56.4 mg/l). The cervical damage was the essential functional complication (38.46%). The major treatment has been a therapeutic combination based on corticotherapy and methotrexate (100%) with 1 death case by macrophage activation syndrome. Conclusion: Systemic juvenile idiopathic arthritis is rarely diagnosed in the rheumatologic practice in Abidjan. It concerns children relatively big, and is characterized by a febrile polyarthritis with impaired general condition and tumor syndrome. This systemic form is treated by corticotherapy and methotrexate.

关键词： Systemic Idiopathic Juvenile Arthritis Juvenile Idiopathic Arthritis Profile Children Abidjan