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Circadian rhythm dysfunction and psychopathology in the offspring of parents with bipolar disorder:a highrisk study in the Chinese population

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General Psychiatry 2024年第3期37卷 388-400页

作者： Binbin Lei Hongliang Feng Lulu Yang Jing Wang Jie Chen Weidong Song Chao Jiang Kun Zhang Qunfeng Wang Jessie Chi Ching Tsang ngan yin chan Yaping Liu Joey W.Y.chan Jiyang Pan Bin Zhang Tao Li Kathleen Ries Merikangas Jihui Zhang Yun Kwok Wing Guangdong Cardiovascular Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina Guangdong Mental Health Center Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdongChina Li Chiu Kong Family Sleep Assessment Unit Department of PsychiatryFaculty of MedicineThe Chinese University of Hong KongHong KongChina Center for Sleep and Circadian Medicine The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Psychiatry Faculty of MedicineThe Chinese University of Hong KongNew TerritoriesHong KongChina Key Laboratory of Neurogenetics and channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou Medical UniversityGuangzhouGuangdongChina Shenzhen Nanshan Center for Chronic Diseases Control(Shenzhen Nanshan Mental Health Center) ShenzhenChina Department of Clinical Psychology Shenzhen Fuyong People's HospitalShenzhenChina Department of Mental Illness Prevention and Treatment Shenzhen Longgang Center for Chronic Diseases ControlShenzhenChina Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Sleep Medical Center The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdongChina Department of Psychiatry Nanfang HospitalSouthern Medical UniversityGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceGuangzhouGuangdongChina Department of Neurobiology Affiliated Mental Health Center&Hangzhou Seventh People's HospitalZhejiang University School of MedicineHangzhouZhejiangChina Genetic Epidemiology Research Branch Intramural Research ProgramNational Institute of Mental HealthBethesdaMarylandUSA

Background Understanding the evolution of circadian rhythm dysfunction and psychopathology in the high-risk population has important implications for the prevention of bipolar ***,some of the previous studies on the emergence of psychopathologies and circadian dysfunction among high-risk populations were inconsistent and *** To examine the prevalence rates of sleep and circadian dysfunctions,mental disorders and their symptoms in the offspring of parents with(O-BD)and without bipolar disorder(O-control).Methods The study included 191 O-BD and 202 O-control subjects aged 6-21 years from the Greater Bay Area,*** diagnoses and symptoms of sleep/circadian rhythm and mental disorders were assessed by the Diagnostic Interview for Sleep Patterns and Disorders,and the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version,*** estimating equations and shared frailty proportional hazards models of survival analysis were applied to compare the outcomes in the *** Adjusting for age,sex and region of recruitment,there was a significantly higher risk of delayed sleep phase symptoms(9.55%vs 2.58%,adjusted OR:4.04)in O-BD than in O-control.O-BD had a nearly fivefold higher risk of mood disorders(11.70%vs 3.47%,adjusted OR:4.68)and social anxiety(6.28%vs 1.49%,adjusted OR:4.70),a fourfold higher risk of depressive disorders(11.17%vs 3.47%,adjusted OR:3.99)and a threefold higher risk of mood symptoms(20.74%vs 10.40%,adjusted OR:2.59)than *** analysis revealed that O-BD children(aged under 12 years)had a nearly 2-fold higher risk of any mental and behavioural symptoms than O-control,while there was a nearly 4-fold higher risk of delayed sleep phase symptoms,a 7.5-fold higher risk of social anxiety and a 3-fold higher risk of mood symptoms in O-BD adolescents(aged 12 years and over).Conclusions There was an increase in delayed sleep phase symptoms in O-BD

关键词： prevention dysfunction bipolar

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从光学到SAR:基于多级跨模态对齐的SAR图像舰船检测算法

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遥感学报 2024年第7期28卷 1789-1801页

作者：何佳月宿南徐从安尹璐廖艳苹闫奕名哈尔滨工程大学信息与通信工程学院哈尔滨150001 海军航空大学信息融合研究所烟台264001 北京市遥感信息研究所北京100192

合成孔径雷达(SAR)舰船检测是近年来的研究热点。然而,与光学图像不同,SAR成像的特点会导致不直观的特征表示。此外,由于SAR图像数据量不足,现有的基于大量标记SAR图像的方法可能难以达到较好的检测效果。为了解决这些问题,本文提出了... 详细信息

合成孔径雷达(SAR)舰船检测是近年来的研究热点。然而,与光学图像不同,SAR成像的特点会导致不直观的特征表示。此外,由于SAR图像数据量不足,现有的基于大量标记SAR图像的方法可能难以达到较好的检测效果。为了解决这些问题,本文提出了一种基于多级跨模态对齐的SAR图像舰船检测算法MCMA-Net(Multi-level Cross-Modality Alignment Network),通过将光学模态中丰富的知识迁移到SAR模态来增强SAR图像的特征表示。该算法首先设计了一个基于邻域—全局注意力的特征交互网络ngan(Neighborhood-Global Attention Network),通过对骨干网络的浅层特征采用邻域注意力机制进行局部交互、对深层特征采取全局自注意力机制进行全局上下文交互,在兼顾全局上下文建模能力的同时,提升局部特征的编码能力,使得网络在不同层级更合理的关注相应的信息,从而能够促进后续的多级别模态对齐。其次,本文设计了一个多级模态对齐模块MLMA(Multi-level Modality Alignment),通过从局部级别到全局级别再到实例级别的对两种模态不同隐含空间中的特征进行对齐,促进模型有效地学习模态不变特征,缓解了光学图像和SAR图像之间的模态鸿沟,实现了从光学模态到SAR模态的知识传输。大量的实验证明我们的算法优于现阶段的检测算法,取得了最好的实验结果。

关键词：遥感 SAR 目标检测跨模态特征对齐注意力机制

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