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Gait and Glasgow Coma Scale scores can predict functional recovery in patients with traumatic brain injury

Neural Regeneration Research 2012年第25期7卷 1978-1984页

作者： Sevil Bilgin Arzu Guclu-Gunduz Hakan Oruckaptan nezire kose Bülent Celik Department of Physiotherapy and Rehabilitation Faculty of Health SciencesHacettepe UniversityAnkaraTurkey Department of Physiotherapy and Rehabilitation Faculty of Health SciencesGazi UniversityAnkaraTurkey Department of Neurosurgery Faculty of MedicineHacettepe UniversityAnkaraTurkey Department of Biostatistics Faculty of Health SciencesGazi UniversityAnkaraTurkey

Fifty-one patients with mild （n -- 14）, moderate （n = 10） and severe traumatic brain injury （n = 27） received early rehabilitation. Level of consciousness was evaluated using the Glasgow Coma Score Functional level was determined using the Glasgow Outcome Score, whilst mobility was evaluated using the Mobility Scale for Acute Stroke. Activities of daily living were assessed using the Barthel Index. Following Bobath neurodevelopmental therapy, the level of consciousness was significantly improved in patients with moderate and severe traumatic brain injury, but was not greatly influenced in patients with mild traumatic brain injury. Mobility and functional level were significantly improved in patients with mild, moderate and severe traumatic brain injury. Gait recovery was more obvious in patients with mild traumatic brain injury than in patients with moderate and severe traumatic brain injury. Activities of daily living showed an improvement but this was insignificant except for patients with severe traumatic brain injury. Nevertheless, complete recovery was not acquired at discharge. Multiple regression analysis showed that gait and Glasgow Coma Scale scores can be considered predictors of functional outcomes following traumatic brain injury.

关键词： brain injury traumatic brain injury rehabilitation early rehabilitation function prognosis GlasgowComa Scale Glasgow Outcome ScaLe functional level neural regeneration

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Early rehabilitation improves neurofunctional outcome after surgery in children with spinal tumors

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Neural Regeneration Research 2014年第2期9卷 129-134页

作者： nezire kose Ozge Muezzinoglu Sevil Bilgin Sevilay Karahan Ilkay Is kay Burcak Bilginer Department of Physiotherapy and Rehabilitation Faculty of Health SciencesHacettepe University Department of Biostatistics Faculty of Health SciencesHacettepe University Department of Neurosurgery Faculty of MedicineHacettepe University

To investigate the effect of early rehabilitation on neurofunctional outcome after surgery in chil- dren with spinal tumors, this study reviewed the medical charts and radiographic records of 70 pediatric patients （1-17 years old） who received spinal tumor surgical removal. The peddiatric patients received rahabilitation treatment at 4 （range, 2-7） days after surgery for 10 （range, 7-23） days. Results from the Modified McCormick Scale, Functional Independence Measure for Chil- dren, American Spinal Injury Association Impairment Scale and Karnofsky Performance Status Scale demonstrated that the sensory function, motor function and activity of daily living of pedi- atric children who received early rehabilitation were significantly improved. Results also showed that tumor setting and level localization as well as patients＇s clinical symptoms have no influences on neurofunctional outcomes.

关键词： nerve regeneration spinal cord injury spinal cord tumor children rehabilitation func-tion sense motor retrospective analysis neural regeneration

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Outcomes of early physiotherapy in patients with cerebral aneurysms treated by surgical clipping or endovascular embolization

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Neural Regeneration Research 2012年第24期7卷 1900-1905页

作者： Arzu Guclu-Gunduz Sevil Bilgin nezire Kse Hakan Oruckaptan Department of Physiotherapy and Rehabilitation Faculty of Health SciencesGazi UniversityAnkaraTurkey Department of Physiotherapy and Rehabilitation Faculty of Health SciencesHacettepe UniversityAnkaraTurkey Department of Neurosurgery Faculty of MedicineHacettepe UniversityAnkaraTurkey

Early physiotherapy was given to 124 patients with ruptured or unruptured cerebral aneurysms who were treated by surgical clipping or endovascular *** were divided into four groups according to their Hunt and Hess grade at admission and aneurysm treatment modality： Group 1,Hunt and Hess grade≤II and surgical clipping;Group 2,Hunt and Hess grade≤II and endovascular embolization;Group 3,Hunt and Hess grade≥III and surgical clipping;Group 4,Hunt and Hess grade≥III and endovascular *** of consciousness was evaluated using the Glasgow Coma Scale,functional status using the Glasgow Outcome Scale,level of the mobility using the Mobility Scale for acute stroke patients,and independence in activities of daily living using the Barthel *** early physiotherapy,the level of consciousness and functional status improved significantly in Groups 1,3,and 4;mobility improved significantly in all groups;and independence in activities of daily living improved significantly in Groups 1 and *** discharge, Groups 1 and 2 had better functional status than Groups 3 and *** of consciousness,functional status,mobility and independence in activities of daily living improved after early physiotherapy. These findings suggest that early physiotherapy improved the prognosis of patients with cerebral aneurysms who were treated by surgical clipping or endovascular *** with a worse clinical status at presentation had a poorer functional status at *** outcome of physiotherapy was not affected by whether surgical clipping or endovascular embolization was chosen for treatment of the aneurysm.

关键词： cerebral aneurysm Hunt and Hess grade Glasgow Coma Scale Glasgow Outcome Scale functional status surgical clipping endovascular treatment physiotherapy neural regeneration

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单纯餐后高血糖症的非靶向代谢组学研究

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医学研究杂志 2022年第7期51卷 67-71,148页

作者：娜孜热木·夏甫开提孙威杨蕾沈静肖辉新疆医科大学 830000

目的利用非靶向代谢组学检测技术,对乌鲁木齐市单纯餐后高血糖患者建立代谢图谱,为糖尿病前期诊断和寻找新的生物学标志物提供依据。方法选择2020年9月11日~2021年1月31日期间,乌鲁木齐市某三甲医院行健康体检的受检者共计374例,随后... 详细信息

目的利用非靶向代谢组学检测技术,对乌鲁木齐市单纯餐后高血糖患者建立代谢图谱,为糖尿病前期诊断和寻找新的生物学标志物提供依据。方法选择2020年9月11日~2021年1月31日期间,乌鲁木齐市某三甲医院行健康体检的受检者共计374例,随后按照性别、年龄组间匹配原则选择60例患者分为IPH组、T2DM组和正常对照组。采用超高效液相色谱-四级杆飞行时间质谱仪(UPLC-QTOF/MS)对不同分组研究对象空腹血清样本进行非靶向的代谢组学研究。结果 3组空腹血清样本中比较,共鉴定出1205个差异代谢物质,包括脂类与类脂分子(28%)、有机酸(9%)、有机氮化合物(11%)、苯类化合物(11%)及其他代谢物,这些差异标志物在94条KEGG通路中富集,5条代谢通路显著富集(P≤0.05)。此外,IPH组与T2DM组和正常对照组两两比较分别得到24个和255个差异显著代谢物。结论初步确定几种甘油磷脂类[1,2-二乙酰甘油-3-磷酸(PA、PE)和单甲基磷酸乙醇胺(PE-NMe)]、去氧胆酸和胆酸、以及氨基酸类(谷氨酰胺、苯丙氨酸、L-苯丙氨酰)等生物学标志物可以是诊断IPH患者的参考差异标志物。

关键词：糖尿病单纯餐后高血糖症代谢组学

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