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Morinda citrifolia L. (noni) and memantine attenuate periventricular tissue injury of the fourth ventricle in hydrocephalic rabbits

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Neural Regeneration Research 2013年第9期8卷 773-782页

作者： Sibel Kktürk Süreyya Ceylan Volkan Etus nezih yasa Savas Ceylan Department of Histology and Embriyology Faculty of MedicineOrdu UniversityOrduTurkey Department of Histology and Embriyology Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Neurosurgery Faculty of MedicineKocaeli UniversityKocaeliTurkey

This study was designed to evaluate the neuroprotective effects of Morinda citrifofia L. （Rubiaceae） commonly known as noni, and memantine （a N-methy-D-aspartate receptor inhibitor） on hydrocephalus-induced neurodegenerative disorders. Kaolin was injected into the cistern magna of male adult New Zealand rabbits to establish a hydrocephalus animal model. Memantine （20 mg/kg, intraperitoneally; memantine-treated group） or noni （5 mL/kg, intragastrically; noni-treated group） was administered daily for 2 weeks. Microtubule-associated protein-2 and caspase-3 immunohistochemistry were performed to detect neuronal degeneration and apoptosis in the periventricular tissue of the fourth ventricle of rabbits. Microtubule-associated protein-2 staining density was significantly decreased in the hydrocephalic group, while the staining density was significantly increased in the memantine- and noni-treated groups, especially in the noni-treated group. Noni treatment decreased the number of caspase-3-positive cells in rabbits with hydrocephalus, while memantine had no effect. These findings suggest that noni exhibits more obvious inhibitory effects on hydrocephalus-induced neurodegenerative disorders than memantine in periventricular tissue of the fourth ventricle.

关键词： neural regeneration neurodegenerative disease traditional Chinese medicine hydrocephalusMorinda citrifolia L. (noni) memantine fourth ventricle periventricular tissue microtubule-associated protein-2 caspase-3 apoptosis grants-supported paper photographs-containing paper neuroregeneration

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First report of the histopathological effect of electrocautery using on the urethral taste rosea during glans penis injury by incision in rabbits

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Asian Journal of Urology 2024年第1期11卷 115-120页

作者： Ozgur Caglar Ayhan Kanat Mehmet Dumlu Aydin nezih Akca Sevilay Ozmen Ataturk University Medical FacultyDepartment of Pediatric SurgeryErzurumTurkey Recep Tayyip Erdogan University Medical FacultyDepartment of NeurosurgeryRizeTurkey Ataturk University Medical FacultyDepartment of NeurosurgeryErzurumTurkey Recep Tayyip Erdogan University Medical FacultyDepartment of UrologyRizeTurkey Ataturk University Medical FacultyDepartment of PathologyErzurumTurkey

Objective:Currently,electrocautery devices have frequently been used in penile surgical *** hypothesized that electrocautery using during penile surgical procedures may harm the taste rosea and the dorsal nerve of the penis or ***:Eighteen young age male New Zealand rabbits were studied:five in the control(Group I,n=5),five in the penile surgery without using electrocautery(sham group,Group II,n=5),eight in the monopolar cautery(study group,Group III,n=8)groups under general *** animals were followed for 3 weeks and *** tissue—pudendal nerve root complexes and dorsal root ganglion of sacral 3 level were examined using stereological *** results were compared ***:The live and degenerated taste bud-like structures and degenerated neuron densities of pudendal ganglia(mean±standard deviation,n/mm^(3))were estimated as 198±24/mm^(3),4±1/mm^(3),and 5±1/mm^(3) in Group I;8±3/mm^(3),174±21/mm^(3),and 24±7/mm^(3) in Group II;and 21±5/mm^(3),137±14/mm^(3),and 95±12/mm^(3) in Group III,*** of taste buds and pudendal ganglia was significantly different between ***:Intact spinal cord and normal parasympathetic and thoracolumbar sympathetic networks are crucial for human sexual *** present study indicates that the glans penis injury by using electrocautery may lead to pudendal ganglia *** damage to taste rosea and retrograde degeneration of the pudendal nerve may be the cause of sexual dysfunction responsible mechanism.

关键词： Urethral taste rosea Tastebuds Pudendalnerve Degeneration Penile surgery

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CVaR-based stochastic wind-thermal generation coordination for Turkish electricity market

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Journal of Modern Power Systems and Clean Energy 2019年第5期7卷 1307-1318页

作者： Aycan AYDOGDU Osman Bulent TOR Ali nezih GUVEN Department of Electrical and Electronics Engineering Middle East Technical UniversityAnkara 06800Turkey The Bucharest University of Economic Studies BucharestRomania

Uncertainties in wind power forecasting,dayahead and imbalance prices for the next day possess a great deal of risks for the profit of generation companies participating in a day-ahead electricity *** companies are exposed to imbalance penalties in the balancing market for unordered mismatches between associated day-ahead power schedule and real-time *** of wind and thermal power plants alleviates the risks raised from wind *** paper proposes a novel optimal coordination strategy by balancing wind power forecasting deviations with thermal units in the Turkish day-ahead electricity *** main focus of this study is to provide an optimal trade-off between the expected profit and the risk under wind uncertainty through conditional value at risk(CVa R)*** problem is formulated as a two-stage mixed-integer stochastic programming problem,where scenario-based wind power approach is used to handle the stochasticity of the wind *** programming approach is utilized to attain the commitment status of thermal *** of the coordination with different day-ahead bidding strategies and trade-off between expected profit and CVa R are examined with comparative scenario studies.

关键词： Conditional value at risk(CVaR) Windthermal coordination Electricity market Wind power Thermal power

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An Investigation of Postmortem Urotensin II Receptor Levels in Brain and Kidney Tissues in a Rat Model of Cardiac Ischemia

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Journal of Forensic Science and Medicine 2018年第1期4卷 1-6页

作者： Mustafa Talip Sener Erol Akpinar Elif Cadirci Zekai Halici Irfan Cinar Ahmet nezih Kok Departments of Forensic Medicine and Pharmacology Faculty of MedicineAtaturk UniversityErzurum 25240Turkey

This study aimed to investigate changes in postmortem urotensin Ⅱ receptor(UTR)levels in brain and kidney tissues in a rat model of cardiac *** rats were divided into two groups:a control group and a cardiac ischemia-induced *** ischemia was created by an intraperitoneal injection of a single lethal dose of isoproterenol(ISO;850 mg/kg).Plasma UT,blood urea nitrogen,and creatinine levels were determined 0 h *** and kidney UTR mRNA expression levels were determined 0,1,3,6,12,24,4&and 72 h *** histopathological appearance of brain and kidney tissues was also *** UT and plasma creatinine levels were increased in the cardiac ischemia-induced group as compared with those in the control group(P<0.001).Ischemia resulted in histopathological changes in brain and cerebellum *** morphological evaluation revealed Purkinje cell degeneration(P=0.037)and dark neurons(P=0.004).The UTR expression level decreased after 1 h postmortem in the brain and after 3 h postmortem in the kidneys in the cardiac ischemia-induced group as compared with that in the control group(P<0.001).The observed changes in UTR expression levels may be valuable in clinical practice in the field of forensic *** changes may be used as a marker in postmortem evaluations of sudden death caused by ischemia-induced cardiac shock.

关键词： Brain cardiac ischemia kidney postmortem urotensin II receptor expression

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Design of task-specific optical systems using broadband diffractive neural networks

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Light(Science & Applications) 2019年第1期8卷 124-137页

作者： Yi Luo Deniz Mengu nezih T.Yardimci Yair Rivenson Muhammed Veli Mona Jarrahi Aydogan Ozcan Electrical and Computer Engineering Department University of California420 Westwood PlazaLos AngelesCA 90095USA Bioengineering Department University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute University of CaliforniaLos AngelesCA 90095USA Department of Surgery David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095USA

Deep learning has been transformative in many fields,motivating the emergence of various optical computing *** optical network is a recently introduced optical computing framework that merges wave optics with deep-learning methods to design optical neural ***-based all-optical object recognition systems,designed through this framework and fabricated by 3D printing,have been reported to recognize handwritten digits and fashion products,demonstrating all-optical inference and generalization to sub-classes of *** previous diffractive approaches employed monochromatic coherent light as the illumination ***,we report a broadband diffractive optical neural network design that simultaneously processes a continuum of wavelengths generated by a temporally incoherent broadband source to all-optically perform a specific task learned using deep *** experimentally validated the success of this broadband diffractive neural network architecture by designing,fabricating and testing seven different multi-layer,diffractive optical systems that transform the optical wavefront generated by a broadband THz pulse to realize(1)a series of tuneable,single-passband and dual-passband spectral filters and(2)spatially controlled wavelength *** the native or engineered dispersion of various material systems with a deep-learning-based design strategy,broadband diffractive neural networks help us engineer the light–matter interaction in 3D,diverging from intuitive and analytical design methods to create taskspecific optical components that can all-optically perform deterministic tasks or statistical inference for optical machine learning.

关键词： neural networks specific

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Features and New Trends in Turkish Poultry Industry

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Journal of Environmental Science and Engineering(A) 2016年第6期5卷 321-326页

作者： nezih Okur Mesut Turkoglu Hasan Eleroglu Serdar Ozlu Ahmet Ucar Department of Poultry Science the University of Abant izzet Baysal Bolu 14280 Turkey Department of Zootechnies the University of Ankara Diskapi Ankara 06110 Turkey Department of lnformatie the University of Cumhuriyet Sarkisla Sivas 58400 Turkey

In this review, features and new trends on Turkish poultry industry are evaluated. Turkish poultry industry has rapidly developed in last years in especially broiler meat and egg production. As a result of these developments, The Turkish poultry sector is recognized as an industry. The industry has advantages such as modem facilities and production methods, thanks to international standards and international markets in close proximity, making it able to compete with the whole world. However, industry has some problems such as the high costs of the production and dependence on extemal inputs for raw materials in feed and breeders. Fortunately, Turkey is an interesting country that can adapt very quickly to emergencies. Turkish poultry industry is trying to adapt to new and difficult conditions and often succeeded. The policies being followed by the elimination of dependence in foreign, measures taken to reduce costs and the growth of the industry are supported in an increasingly manner to increase production and consumption. Thus, it is aimed that the Turkish poultry industry became much more useful industry on reduction in unemployment and finding a solution to the immigration problem by healthier, faster and planned development.

关键词： Turkish poultry industry broiler layer development.

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计算机控制的Ishihara色觉测试法(英文)

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国际眼科杂志 2007年第5期7卷 1223-1228页

作者： Nimet nay Gündogan nezih Durmazlar Koray Gümüs Pinar Geyik zdemir 土耳其安卡拉Boskent大学医学院生理科土耳其安卡拉Hacettepe大学医学院生理科土耳其安卡拉Hacettepe大学医学院眼科土耳其安卡拉Hacettepe大学医学院生物统计学教研室

目的:研究经计算机控制的Ishihara测试法诊断色盲的可靠性及其与经典Ishihara测试法的一致性,计算机控制的Ishihara测试法的敏感性与特异性;并探讨该测试方法在检测先天性色盲或色弱中的潜在价值。方法:用两种方法测试104名大学生的色觉... 详细信息

目的:研究经计算机控制的Ishihara测试法诊断色盲的可靠性及其与经典Ishihara测试法的一致性,计算机控制的Ishihara测试法的敏感性与特异性;并探讨该测试方法在检测先天性色盲或色弱中的潜在价值。方法:用两种方法测试104名大学生的色觉,年龄20～23岁(中位数21岁)。分别采用经计算机控制的Ishihara色板和经典的Ishihara打印色板显露法对个体色觉进行检查。通过上述两种不同的方法评价每个学生对颜色的感知能力,借此探讨计算机控制的Ishihara测试法的特异性,准确性以及与经典法的一致性。结果:本实验共检测到6位男性色盲患者和1位女性色盲患者。调查该女性学生的家族史,发现其母亲为色盲基因携带者,而其父亲为色盲患者。本实验中男性色盲患病率为13.6%(6/44),女性为1.7%(1/60);整个人群总的患病率为6.7%(7/104)。进行本试验前,这些学生并未意识到自己存在色觉功能缺陷。为探讨这两种方法的一致性,分别对色觉正常和患色盲的学生的测试结果进行比较。结果表明:两种实验方法的特异性及敏感性均为100%,一致性达到100%。结论:计算机控制的Ishihara测试法是数字调控性的,但有关色觉测试的基本概念没有改变。该法总的测试时间和误差计分都已标准化,与手动测试法相比有明显的优势;而且该法与被认为是"金标准"的经典测试法的一致性达到100%。这些特征表明,计算机控制的Ishihara测试法是一种新颖和可靠的方法。

关键词： Ishihara色觉测试法计算机控制的Ishihara色觉测试法色盲

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一种新的计算机适应色觉试验(英文)

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国际眼科杂志 2007年第2期7卷 309-314页

作者： Nimet ünay Gündogan nezih Durmazlar Aysegül Kocak Altintas Koray Gümüs 土耳其Ba■kent大学医学院生理科土耳其Hacettepe大学医学院生理科土耳其S.B.Ankara Ataturk教研医院眼科土耳其Hacettepe大学医学院眼科

目的:提出一种新的计算机适应色觉试验(NCACVT)并且解释它在实际应用中的可靠性和重要性。方法:法-孟二式100色度试验(FM100HT)和Holmgren试验已经被改良并且适应计算机应用。经典的Ishihara假同色法试验方法(IPPT)已被假定是色盲的一... 详细信息

目的:提出一种新的计算机适应色觉试验(NCACVT)并且解释它在实际应用中的可靠性和重要性。方法:法-孟二式100色度试验(FM100HT)和Holmgren试验已经被改良并且适应计算机应用。经典的Ishihara假同色法试验方法(IPPT)已被假定是色盲的一个简便的筛选检查工具;因此依照Ishihara试验结果,受试者被分为色觉有缺陷组(第1组)和对照组(第2组)。第1组为色觉有缺陷者13例(男12例,女1例),年龄在19～29(平均21)岁,而第2组为对照组,13个受试者色觉无缺陷(男8例,女5例),年龄在19～28(平均22)岁。为了研究两组人的色觉敏感性,所有的受试者都要进行FM100HT和NCACVT试验。将经典的IPPT,FM100HT和NCACVT的试验结果用统计学方法进行比较。在这两组中NCACVT和FM100HT的误差计分用秩和检验来分析。结果:在误差计分中的差别分别在统计学上是有显著意义的(U=169,P<0.05;U=153P<0.05)。根据NCACVT来诊断色觉缺陷的临界点是通过使用接受机器作特征曲线(ROC)而被发现是23。根据23这个临界点的误差计分,在筛选检查色觉缺陷方面,发现NCACVT具有100%的敏感性和100%的特异性。结论:根据Harper和Reeves,这些特点使得这个试验成为一个可靠的、有创意的眼科实践筛选试验。

关键词：色觉计算机适应色觉试验法-孟二式100色度试验 Holmgren试验

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高度近视伴色觉缺失的家系分析(英文)

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国际眼科杂志 2007年第3期7卷 602-608页

作者： Nimet nay Gündogan Ay■e Gül Koak Altinta■ nezih Durmazlar Koray Gümüs Zerrin Yilmaz Kemal Ksemehmetoglu Baskent大学医学院生理科 Atatürk教研医院眼科 Hacettepe大学医学院生理科 Hacettepe大学医学院眼科 Baskent大学医学院医学遗传科 Hacettepe大学医学院病理科

目的:评估高度近视伴色觉缺失患者的遗传学特征和临床表现方法:就同一家族4代42个成员中有8位患者给予了详细的眼科检查,Ishihara盘和FM100H试验检测患者有无红绿色觉缺失,全视野视网膜电图评价其视网膜功能。结果:患者8位均因高度近视... 详细信息

目的:评估高度近视伴色觉缺失患者的遗传学特征和临床表现方法:就同一家族4代42个成员中有8位患者给予了详细的眼科检查,Ishihara盘和FM100H试验检测患者有无红绿色觉缺失,全视野视网膜电图评价其视网膜功能。结果:患者8位均因高度近视视力下降,其中6例有红绿色觉缺失,眼底检查显示以弥漫性视网膜脉络膜萎缩为特征的近视改变。2例患者ERG检查出现视杆细胞的暗适应异常和视锥细胞的反应消失,根据家系,红绿色觉缺失属X连锁的隐性遗传。结论:在这个家族成员中,同时发生的高度近视和色觉缺失可能有共同的遗传学基础。

关键词：高度近视色觉缺失先天性色盲

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