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Polymorphisms in oxidative pathway related genes and susceptibility to inflammatory bowel disease

World Journal of Gastroenterology 2017年第47期23卷 8300-8307页

作者： nezha senhaji Sellama Nadifi Younes Zaid Aurora Serrano Daniel Arturo Leon Rodriguez Nadia Serbati Mehdi Karkouri Wafaa Badre Javier Martín Laboratory of Genetic and Molecular Pathology Faculty of Medicine and Pharmacy of CasablancaHassanⅡUniversity Mohammed VI University of Health Sciences Instituto de Parasitología y Biomedicina López-Neyra Consejo Superior de Investigaciones Científicas Department of Pathology CHU Ibn Rochd Department of Gastroenterology CHU Ibn Rochd

AIM To investigate whether common variants in the oxidative pathway genes influence inflammatory bowel disease(IBD) risk among Moroccan patients. METHODS The distribution of(TAAA)n_rs12720460 and(CCTTT)n_rs3833912 NOS2 A microsatellite repeats, HIF-1 A_rs11549467 and NFKB1-94 ins/delA TTG_rs28362491 was analyzed in 507 subjects grouped in 199 IBD and 308 healthy controls. Genotyping was performed withpolymerase chain reaction-fluorescent method and the TaqMan~? allelic discrimination *** The allele and genotype frequencies of HIF1 A_ rs11549467, NFKB1_rs28362491 and NOS2 A_(TAAA)n did not differ significantly between patients and controls. Analysis of NOS2 A_(CCTTT)n markers evidenced differences between patients and healthy controls. A preferential presence of the(CCTTT)8(P = 0.02; OR = 1.71, 95%CI: 1.07-2.74),(CCTTT)14(P = 0.02; OR = 1.71, 95%CI: 1.06-2.76) alleles in IBD,(CCTTT)8(P = 0.008; OR = 1.95, 95%CI: 1.17-3.23) in CD and(CCTTT)7(P = 0.009; OR = 7.61, 95%CI: 1.25-46.08),(CCTTT)11(P = 0.05; OR = 0.51, 95%CI: 0.25-1.01),(CCTTT)14(P = 0.02; OR = 2.05, 95%CI: 1.07-3.94),(CCTTT)15(P = 0.01; OR = 2.25, 95%CI: 1.16-4.35) repeats in UC patients indicated its possible association with higher disease risk which need to be confirmed in a larger sample size. CONCLUSION Our results suggest that the NOS2 A_(CCTTT)n gene variations may influence IBD susceptibility in the Moroccan population.

关键词： HIF1A NFKB1 NOS2A Inflammatory bowel disease Moroccan patients

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Study of glyceraldehyde-3-phosphate dehydrogenase expression in the tumor process of: Breast, cervix and prostate cancers

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Advances in Biological Chemistry 2012年第4期2卷 335-340页

作者： Bouchra Elkhalfi nezha senhaji Hakima Benomar Abdelaziz Soukri Laboratoire d’Anatomo-Cyto-Pathologie Institut Pasteur du Maroc Casablanca Morrocco Laboratoire de Physiologie et Génétique Moléculaire Département de Biologie Faculté des Sciences Université Hassan II Casablanca Morrocco

W Tumor proliferation of cancer cells requires a high intake of oxygen by angiogenesis. Deep cancer cells suffer from asphyxia and meet their energy needs through the enzymes of glycolysis. The anti-angio- genesis approach has been recognized for therapeutic purposes, but the deep cancers, difficult to reach by this therapy, could be targeted by inhibiting an enzyme of the glycolytic cycle. Our work focused on the study of the expression of GAPDH, a key enzyme of glycolysis, in cervix, breast and prostate tumors, for two approaches: Fundamental and targeted therapeutics. 60 samples, taken at the Anatomopathology laboratory of the Pasteur Institute of Morocco, were examined histologically and immunohistochemically, demonstrating the expression and cellular localization of GAPDH. The three organs have shown an overex-pression of GAPDH in tumor tissues. At the cellular level, the localization of GAPDH in cancer tissue is diffuse but mostly nuclear whereas it remains focused at the membrane and/or the cytoplasm in benign tumor tissues. From these results we could assume that GAPDH is involved in the cancer process and draws attention to a possible new nuclear role that could be either specific to one form or different isoforms of GAPDH enzyme.

关键词： Cancer GAPDH Immunohistochemistry Expression Isoforms

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The Ciliate Protist <i>Tetrahymena pyriformis</i>as a Cellular Adhesion Model for the Pathogenic Bacterium <i>Staphylococcus aureus</i>

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Advances in Bioscience and Biotechnology 2017年第12期8卷 491-507页

作者： Bouchra El Khalfi Mohammed Benlahfid Sofia Jarmouni nezha senhaji Aurelio Serrano Delgado Abdelaziz Soukri Laboratory of Physiopathology Genetics Molecular and Biotechnology (PGMB) Faculty of Sciences Ain Chock Research Center: Health & Biotechnology University Hassan II of Casablanca Casablanca Morocco Laboratory of Genetic and Molecular Pathology (LGPM) Medical School Hassan II University Casablanca Morocco Institute of Biochemistry Vegetal and Photosynthesis (IBVF-CSIC University of Seville) Seville Spain

Staphylococcus aureus is one of the main pathogenic agents responsible for nosocomial and community-acquired bacterial infections. The pathogenicity of this Gram-positive bacterium is ensured by its different adhesion factors. Collagen and the extracellular glycoprotein adhesin are among the Staphylococcus most important virulence factors. It has been shown that most of the S. aureus strains carry the ica operon, responsible for biofilm production. However, the coexpression of the icaA and the icaD genes is necessary for complete biofilm synthesis. The aim of our study was to study a collection of 15 clinical strains of S. aureus from different sources for the presence of can and icaD genes coding intercellular adhesion proteins. We also intended to estimate the strains’ ability to form biofilms by the red Cong method and to test the adhesion ability of S. aureus to the ciliated protist Tetrahymena pyriformis, which we used as a novel cellular adhesion model. Finally, we checked the adhesion’s inhibition capacity of some plants extracts. The molecular detection of adhesion genes revealed that 80% of strains are cna positive, and 73% are icaD positive. Qualitative biofilm production of S. aureus revealed that 66.6% of strains were slime producers. The adhesion test revealed that 20% of strains are strongly adhering to T. pyriformis and that the Clematis cirrhosa extract has an anti-adhering effect of S. aureus to the ciliate T. pyriformis.

关键词： Staphylococcus aureus Adhering Genes (can and icaD) Tetrahymena pyriformis Biofilm Production Plant Extract Anti-Adhesion Effect

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Geochemical characterization of rare earth elements in sediment profiles from the Oualida lagoon(Morocco)

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Acta Geochimica 2023年第6期42卷 1051-1064页

作者： nezha Mejjad Abdelmourhit Laissaoui Ouafa El Hammoumi Ahmed Fekri Hamid Amsil National Center for Energy Sciences and Nuclear Techniques(CNESTEN)RabatMorocco LGAGE Faculty of Sciences Ben M'sikUniversity of Hassan IICasablancaMorocco

The present work assesses the temporal distribution pattern and geochemical changes of rare earth elements and Yttrium, Scandium, Thorium, and Uranium delivery into the Oualidia lagoon. Two sediment cores were retrieved from the Oualidia lagoon and analyzed using neutron activation analysis. The results indicated that heavy rare earth elements are slightly enriched the sediment cores over light rare earth elements. The highest values of REEs were recorded in the top layers of the cores and depleted with depth, suggesting a possible change in factors controlling their accumulation, including mechanical, chemical, and environmental parameters such as weathering intensity, grain size, and Fe-Mn oxides. The sediments display positive Ce anomalies, which are probably related to the submarine weathering process and detrital input. Noting also the variation of hydrodynamics conditions and confinement of the upstream part of the lagoon played a key role in changing the sediment ***, further investigation of REEs origin in the Oualidia lagoon sediment is required to identify their sources,provenances, and the factors controlling their spatial and vertical distributions. However, these results provide baseline data of occurring changes in REEs geochemical composition and constitute a typical study case to understand the link between sedimentary and geochemistry processes in a lagoonal ecosystem.

关键词： Geochemical characterization Rare earth elements Sediment Oualidia lagoon

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Renormalized Solutions of Nonlinear Parabolic Equations in Weigthed Variable-Exponent Space

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Journal of Partial Differential Equations 2015年第3期28卷 225-252页

作者： YOUSSEF Akdim CHAKIR Allalou nezha El gorch Laboratory LSL Faculty Polydisciplinary of Taza. University Sidi Mohamed BenAbdellah P. O. Box 1223 Taza Gare Marocco.

This article is devoted to study the existence of renormalized solutions for the nonlinear p （x）-parabolic problem in the Weighted-Variable-Exponent Sobolev spaces, without the sign condition and the coercivity cond... 详细信息

关键词： Weighted variable exponent Lebesgue Sobolev space Young's inequality renormal-ized solution parabolic problems.

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Association between Overexpression of Her-2 and Other Clinicopathologic Prognostic Factors in Breast Cancer in Morocco

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Journal of Cancer Therapy 2012年第5期3卷 787-792页

作者： Zineb Bouchbika Nadia Benchakroun Amina Taleb Hassan Jouhadi nezha Tawfiq Souha Sahraoui Abdellatif Benider Department of Radiotherapy Oncology Ibn Rochd University Hospital and Hassan II University Casablanca Morocco

Background: Breast cancer is the leading cancer among women. The management depends largely on the knowledge of prognostic factors. The aim of our study is to evaluate the overexpression of Her-2/neu in patients with invasive breast carcinoma in Morocco, and to study the association between this overexpression and otherprognostic factors of breast cancer, such as age, tumor size, tumor grade, hormone receptors, vascular space invasion and lymph node status. Methods: This is a transversal study in which we included patients with invasive breast carcinomas treated at University Hospital Ibn Rochd of Casablanca in radiotherapy-oncology departement between January 2008 and December 2010, having had surgery first. Univariate analysis (Chi 2 test and Student’s test) and multivariate (logistic regression) were performed to study this association. Results: The overexpression of Her-2/neu was found in 29.2% of cases. In univariate analysis, Her-2 positive status was significantly correlated with high-grade tumors and large, to a lymph node, vascular space invasion and negative ER/PR. Age alone does not appear as a factor associated with positive Her-2/neu status. In multivariate analysis, the overexpression of Her 2 was significantly associated only with vascular space invasion, high tumor grade and the negativity of estrogen receptors. Conclusion: In our series, only the high grade, the vascular space invasion and the negative hormone receptors are independent factors associated with overexpression of Her 2/neu. Age does not appear as a factor associated with positive Her-2/neu status.

关键词： Breast Cancer Her 2 Neu Prognosis Factors

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Ileo-Ileal Intussusception Caused by an Inflammatory Fibroid Polyp: A Case Report

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Open Journal of Gastroenterology 2022年第7期12卷 170-177页

作者： nezha Elbahaoui Oumayma Lahnaoui Nisrine Boubkri Ilyass Yassine Laraqui Yasmine Mohamd Ouanani Abdelkader Errougani Emergency Surgical Department “UCV” Ibn Sina University Hospital Rabat Morocco Anatomopathology Laboratory Ibn Sina University Hospital Rabat Morocco

Inflammatory fibroid polyps (IFP) are a rare benign entity that arises from the submucosa of the gastrointestinal tract and protrudes into the lumen. The clinical presentation depends on the size and localization. They are particularly found in the ileum, where they are frequently present as an ileal intussusception. We report the case of a 56-year-old female patient who presented with periumbilical pain along with multiple episodes of vomiting and chronic constipation. An abdominal CT scan revealed an ileo-ileal intussusception of an endoluminal hypodense lesion with mesenteric lymphadenopathy. Surgical treatment consisted of segmental ileal resection with primary anastomosis. The histopathological analysis revealed an inflammatory fibroid polyp in the ileum. Although these tumors have no malignant potential, surgery is always indicated in ileo-ileal intussusception to ascertain the histological nature of the lesion.

关键词： Intussusception Inflammatory Fibroid Polyp Surgical Resection

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External validation of the Moroccan Arabic version of the European Organization for Research and Treatment of Cancer colorectal(CR29)module:Monocentric study

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World Journal of Methodology 2023年第4期13卷 259-271页

作者： Houda Bachri Hajar Essangri nezha El Bahaoui Amine Benkabbou Raouf Mohsine Anass Mohammed Majbar Amine Souadka Surgical Oncology Department National Institute of OncologyMohammed Vth University in RabatRabat 10100Morocco Gynecology oncology Department Royal London HospitalBarts NHS HealthLondon SE186EYUnited Kingdom

BACKGROUND Quality of life(QoL)outcomes are a focal endpoint of cancer treatment *** To externally validate the Moroccan Arabic version of the European Organization for Research and Treatment of Cancer(EORTC)QoL Questionnaire(QLQ)for colorectal cancer(CRC)patients(CR29).METHODS Both Moroccan Arabic modules of QLQ-CR29 and QLQ-C30 were administered to Moroccan *** properties were retested by measuring Cronbach’s alpha coefficient for reliability and Intraclass correlation coefficient(ICC)to examine test-retest *** multitrait-scaling analysis was performed to demonstrate the validity of the instrument and known-groups comparison was used to test the score’s ability to discriminate between different groups of *** In total,221 patients were included in our study and 34 patients completed the questionnaire *** Urinary Frequency scale and Stool Frequency scale had good internal consistency with alpha Cronbach coefficients of 0.79 and 0.83 respectively,while the same coefficients were moderately lower for the Blood and Mucus in Stool scale(0.61)and the Body Image scale(0.67).The ICCs ranged from 0.88 to 1 indicating good to excellent *** multitrait scaling analyses,the criterion for item convergent and divergent validity was *** known-group comparison showed statistically significant differences between patients according to age,gender,stoma status,tumor location,and *** The Moroccan Arabic version of the EORTC QLQ-CR29 is a valid and reliable tool that can be used safely for research and clinical purposes in Moroccan CRC patients.

关键词： Rectal neoplasm Colorectal cancer Health-related quality of life Patient reported outcome measures European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-CR29 European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30

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Epidemiological Profile and Therapeutics Results of Bladder Carcinoma in Women

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Open Journal of Epidemiology 2022年第1期12卷 68-74页

作者： Maryam Zaouit Hassan Jouhadi Tarik Chekrine Zineb Bouchbika Nadia Benchekroun nezha Tawfiq Souha Sahraoui Aabdellatif Benider Mohamed Center VI for Cancer Treatment CHU Ibn Rochd Casablanca Morocco

Introduction: The incidence of bladder cancer in women has steadily increased in recent years. The objective of our work is to study the epidemiological profile of bladder cancer in women in our population and the factors favoring its occurrence. Methods: This is a retrospective study carried out at the Mohamed Center VI for cancer treatment, involving 27 women during a two-year period from January 2019 to December 2020. We studied the epidemiological characteristics in these patients, the risk factors and the revealing symptoms. Results: The average age of patients was 67.5 years old and 66.66% of the patients were over 65 years old. One patient had in her antecedents a tumor of the upper excretory tract and 2 patients had an associated renal tumor. The notion of smoking was found in 3 patients. The time to treatment was less than 6 months in 44.4% of cases, between 6 and 12 months in 18.5% of cases, and more than a year in 37% of cases. The symptoms were marked by hematuria in 96.3% of cases, and irritative disorders in 81.4% of cases. In our series;the tumor was unifocal in 77.77% of the cases, and multifocal in the remainder of the cases. Urethrohydronephrosis was found in 74% of cases. Histologically, it was an urothelial carcinoma in 81.48% of cases. The tumor was locally advanced in 11.11% of cases, and metastatic in 11.11% of cases. Lymph node involvement was found in 33.33% of cases. 48.1% of cases underwent surgery. The operative procedure consisted of a partial cystectomy in 46.1% of cases, and only 18.5% was suitable for trimodal treatment. Conclusion: Few studies have addressed the epidemiology of bladder cancer in women due to the low incidence, but it is currently increasing steadily in recent years. These modifications are explained by the change in social habits in women.

关键词： Bladder Carcinoma Women Epidemiology Therapeutics Results

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Biotransformation of Ternary Mixture of Organic Industrial Waste into Poultry Feed

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Journal of Agricultural Science and Technology(A) 2018年第3期8卷 171-181页

作者： Lakhal Dounia Bahlaouan Bouchaib Boutaleb Nadia Fathi Asmaa Taiek Taha Abouakil nezha Lazar Said El Antri Said Laboratory of Biochemistry Environment and AgriFood (URAC36) University Hassan Ⅱ 20650 Casablanca Morocco Higher Institutes of the Nursing Professions and Techniques of Health (ISPITS) 20250 Casablanca Morocco

The objective of present study was to produce poultry feed with a best quality using ternary mixture of industrial wastes： fish industry waste, sugar industry waste （molasses） and yeast waste after 15 d biotransformation using response surface methodology to design and analyze the experiment data. Changes in the nutritional quality and biochemical properties viz., pH, dry matter, conductivity, total organic carbon, total nitrogen, phosphorus, trimethylamine, protein, fat, carbohydrate, histamine, aflatoxins and minerals were evaluated during a biotransformation period of 15 d. The experimental findings revealed that the formulation including 50% of fish waste, 12.5% of molasses and 37.50% of yeast waste were found to be best quality poultry waste. It was characterized as odorless, with a stable pH, rich in protein, fat and carbohydrate as well as no alterations of bacteria and absence aflatoxins from the fifth day on ward. The nutritional value of the developed poultry fees was studied on a population of broiler chickens by incorporating with barley flour and eggshell. The product possesses a better nutritional quality comparable to commercially feed.

关键词： Fish waste ternary mixture biotransformation poultry feed response surface

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