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Interleukin (IL) 5 levels and eosinophilia in patients with intestinal parasitic diseases

World Journal of Gastroenterology 2004年第24期10卷 3643-3646页

作者： Sebnem Ustun nevin turgay Songul Bayram Delibas Hatice Ertabaklar Department of Gastroenterology School of MedicineUniversity of Ege35100 BornovaIzmirTurkey Department of Parasitology School of MedicineUniversity of Ege35100 BornovaIzmirTurkey Department of Parasitology School of MedicineUniversity of Dokuz EylulIzmirTurkey Department of Microbiology School of MedicineUniversity of Aydin MenderesAydinTurkey

AIM:Intestinal parasitic diseases are commonly accompanied with diarrhoeal symptoms and allergic *** occurs as a result of IL-5 synthesized from Th2 cells during allergic ***-5 acts as a factor activating eosinophils. The aim of this study was to compare the IL-5 cytokine measurements in serum samples and cell *** also to compare eosinophilia observed in helminth infections and protozoon infections accompanied with allergy. METHODS:Twenty-three patients who presented with diarrhoeal symptoms and allergic complaints were tested positive for intestinal parasites,as well as 21 controls with allergic complaints who did not have any intestinal parasites were included in this ***-5 production in in vitro cell cultures prepared by using phytohemaglutinin (PHA) to stimulate peripheral blood mononuclear cells (PBMC) obtained from the blood samples taken from these patients were compared with the IL-5 level in ***, the IL-5 production in protozoon and helminth infections was also *** eosinophil values in 1 mm^3 of blood were calculated by means of peripheral smear in both groups within the scope of the study. RESULTS:Parasites such as helminth detected in 15 (65.2%) and protozoon in 8 (34.8%) of the patients were included in this *** regards the values of the sera in both patients with parasite infection and controls,the IL-5 production was found to be higher in the cell culture supernatant (P0.05). CONCLUSION:It was found that IL-5 cyto

关键词： Adult Cells, Cultured Diarrhea Eosinophilia Female Helminthiasis Humans Hypersensitivity Interleukin-5 Male Middle Aged Protozoan Infections Th2 Cells

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