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National Science Review 2018年第6期5卷 805-807页

作者： Dake Chen neville smith William Kessler State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of Oceanography

El Nio–Southern Oscillation (ENSO)is by far the most energetic and influential short-term climate variability on our planet, originating from an instability of the large-scale ocean-atmosphere interaction in the tr... 详细信息

关键词： The evolving ENSO observing system TAO

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Impact of endoscopic sinus surgery on otologic symptoms associated with chronic rhinosinusitis

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2017年第1期3卷 -页

作者： neville W.Teo Jess C.Mace Timothy L.smith Peter H.Hwang Department of Otolaryngology Singapore General HospitalSingaporeDepartment of Otolaryngology-Head and Neck SurgeryStanford University School of MedicineStanfordCAUSA Department of Otolaryngology-Head and Neck Surgery Oregon Health & Science UniversityPortlandORUSA Department of Otolaryngology-Head and Neck Surgery Stanford University School of MedicineStanfordCAUSA

OBJECTIVE:To evaluate improvements in otologic symptoms after endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis (CRS), and identify differences in symptoms, if any, between CRS patients with (CRSwNP) and without (CRSsNP) nasal polyposis.;METHODS:Prospective multi-center observational cohort study.;METHODS:Academic tertiary medical centers.;METHODS:Adults with medically recalcitrant CRS who elected ESS were enrolled in a prospective, multi-center, observational cohort study between March, 2011 and October, 2014. Preoperative evaluation of subjects included assessment of clinical characteristics, measures of disease severity, and quality of life evaluation using the 22-item SinoNasal Outcome Test (SNOT-22). Postoperative improvement in otologic symptoms (ear fullness, dizziness, ear pain) scores were evaluated and compared between CRSwNP and CRSsNP subgroups.;RESULTS:395 study patients completed both preoperative and postoperative evaluations, with an average follow-up of 13.9 months after ESS. The prevalence of patients reporting at least one otologic symptom preoperatively (87%) significantly decreased after ESS (63%; p<0.001). Significant postoperative improvement across all otologic scores was also reported (p<0.001). Relative mean improvement in otologic symptom severity was similar for both CRSwNP and CRSsNP, except patients with CRSwNP reported significantly greater postoperative improvement in ear fullness compared to CRSsNP (54% vs. 41%; p=0.039). A total of 61%, 44%, and 43% of patients reported experiencing improvement in "ear fullness", "dizziness" and "ear pain", respectively.;CONCLUSIONS:Sinus surgery significantly improves otologic symptoms associated with CRS. CRSwNP patients reported slightly greater relief of ear fullness than CRSsNP patients following ESS.

关键词： Ear symptoms chronic rhinosinusitis endoscopic sinus surgery

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Methylation of TIMP3 in esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2008年第2期14卷 203-210页

作者： Eric smith neville J De Young Zi-Qiang Tian Maria Caruso Andrew R Ruszkiewicz Jun-Feng Liu Glyn G Jamieson Paul A Drew Discipline of Surgery School of Medicine Faculty of Health Sciences TheUniversity of Adelaide Royal Adelaide Hospital South Australia5005 Australia Department of Thoracic Surgery Fourth Hospital of Hebei Medical University Shijiazhuang050011 Hebei Province China Division of Tissue Pathology Institute of Medical and Veterinary Science AdelaideSouth Australia 5000 Australia School of Nursing and Midwifery Flinders University Bedford Park South Australia 5042 Australia

AIM: To measure the frequency of DNA methylation of the tissue inhibitor of metalloproteinase 3 (TIMP3) promoter and relate this to any change of gene expression in esophageal squamous cell carcinoma in patients from a region of high incidence in China.METHODS: Cancer cell lines were treated with or without the demethylating reagent 5-aza-2’-deoxycytidine. Methylation of the TIMP3 promoter was assessed in three regions by melt curve analysis and its expression was assessed by real-time RT-PCR. Tumors and proximal resection margins were obtained from 64 patients with esophageal squamous cell carcinoma from a region of high incidence in China. Methylation was assessed by melt curve analysis and expression by immunohistochemistry.RESULTS: Methylation in one of the three promoter regions assessed correlated with gene silencing in esophageal cell lines. A degree of methylation of TIMP3 was found in only four esophageal squamous cell carcinomas, and partial loss of TIMP3 protein expression in just one.CONCLUSION: Methylation and loss of expression of TIMP3 occurs infrequently in esophageal squamous cell carcinoma in a region of high incidence in China.

关键词：食管癌鳞状细胞癌 TIMP3 甲基化免疫组织化学

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