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Single and Hybrid Design Polycaprolactone （PCL） Scaffolds： Cell Culture Study

材料科学与工程（中英文A版） 2013年第5期3卷 315-320页

作者： Md enamul Hoque Yong Leng Chuan Ian Pashby Siti Sheren Aini Angela ng Min Hwei Ruszymah Idrus Department of Mechanical Materials and Manufacturing Engineering University of Nottingham Malaysia Campus Malaysia Tissue engineering Centre Universiti Kebangsaan Malaysia Medical Centre Malaysia

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Brain natriuretic peptide is a potent vasodilator in aged human microcircula- tion and shows a blunted response in heart failure patients

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Journal of Geriatric Cardiology 2014年第1期11卷 50-56页

作者： Marie-Louise edvinsson erik Uddman Lars edvinsson Sven e. Andersson Department of emergency and Internal Medicine Institute of Clinical Sciences Lund University Lund University Hospital SE- 221 85 Lund Sweden

Background Brain natriuretic peptide （BNP） is normally present in low levels in the circulation, but it is elevated in parallel with the degree of congestion in heart failure subjects （CHF）. BNP has natriuretic effects and is a potent vasodilator. It is suggested that BNP could be a therapeutic alternative in CHF. However, we postulated that the high levels of circulating BNP in CHF may downregulate the response of microvascular natriuretic receptors. This was tested by comparing 15 CHF patients （BNP 〉 3000 ng/L） with 10 matched, healthy controls. Methods Cutaneous microvascular blood flow in the forearm was measured by laser Doppler Flowmetry. Local heating （＋44°C, 10 min） was used to evoke a maximum local dilator response. Results Non-invasive iontophoretic administration of either BNP or acetylcholine （ACh）, a known endothelium-dependent dilator, elicited an increase in local flow. The nitric oxide synthase inhibitor, l-N-Arginine- methyl-ester （L-NAMe）, blocked the BNP response （in controls）. Interestingly, responses to BNP in CHF patients were reduced to about one third of those seen in healthy controls （increase in flow： 251% in CHF vs. 908% in controls; P 〈 0.001）. In contrast, the vasodilator responses to ACh and to local heating were only somewhat attenuated in CHF patients. Thus, dilator capacity and nitric oxide signalling were not af- fected to the same extent as BNP-mediated dilation, indicating a specific downregulation of the latter response. Conclusions The findings show for the first time that microvascular responses to BNP are markedly reduced in CHF patients. This is consistent with the hypothesis of BNP receptor function is downregulated in CHF.

关键词： Heart failure Cutaneous microcirculation endothelial responses Acetylcholine, Brain natriuretic peptide Nitric oxide

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骨碎补总黄酮通过激活mTOR信号通路促进大鼠腱骨愈合的实验研究

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中国骨伤 2018年第3期31卷 248-253页

作者：张新涛江华基梁祖儒贺飞林廖小卿任玉香张文涛北京大学深圳医院运动医学与康复医学科广东深圳518036 南方医科大学第三附属医院骨科广东广州510630

目的 :探讨骨碎补总黄酮对大鼠腱骨愈合的作用及相关分子机制。方法 :选取10只8周龄雄性SD大鼠(体重180~220 g),培养原代跟腱干细胞,取第3代跟腱干细胞用于实验。向大鼠跟腱干细胞中加入不同浓度(0、0.1、1、10 ng/ml)骨碎补总黄酮处理,... 详细信息

目的 :探讨骨碎补总黄酮对大鼠腱骨愈合的作用及相关分子机制。方法 :选取10只8周龄雄性SD大鼠(体重180~220 g),培养原代跟腱干细胞,取第3代跟腱干细胞用于实验。向大鼠跟腱干细胞中加入不同浓度(0、0.1、1、10 ng/ml)骨碎补总黄酮处理,14 d后分别检测ALP、Runx2、OCN、VeGF、P-S6和P-4e/BP1表达的变化。选取40只8周龄的雄性SD大鼠(体重180~220 g)行大鼠关节外骨隧道-游离肌腱移植造模,术后随机分为实验组和对照组,实验组灌胃骨碎补总黄酮(100 mg·kg-1·d-1),对照组灌胃等量的生理盐水。分别于术后3、6周取材进行生物力学检测腱骨愈合强度,组织学切片观察腱骨愈合情况及新生血管数目。结果:不同浓度的骨碎补总黄酮处理后,ALP染色及活性指标检测提示0 ng/ml组(0.55±0.11)、0.1 ng/ml组(0.87±0.08)、1 ng/ml组(1.18±0.11)、10 ng/ml组(1.48±0.10),各组比较差异有统计学意义(Pe/BP1蛋白表达量逐渐减少(PeGF表达量逐渐增加(P0.05),而6周时实验组(1.36±0.09)N/mm的力学强度明显高于对照组(1.01±0.08)N/mm(Pey纤维生长更加密集,间质钙化程度更高,新骨和血管发生明显增多。结论:骨碎补总黄酮可以通过激活mTOR信号通路,促进肌腱干细胞的成骨分化,在活体可以加快腱骨愈合速度,提高腱骨愈合质量。

关键词：骨碎补黄酮大鼠跟腱

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采用实际气体状态方程的制冷压缩机计算模拟

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压缩机技术 1984年第4期 18-22页

作者： e.H.ng ,A.B.Tramschek ,J.F.T.Maclaren ,熊则男西安交通大学

本文描述了模拟制冷压缩机的模型,工作流体的热力性质由实际气体状态方程表示。对于制冷剂为R12的制冷机,采用Martin-Downing状态方程计算获得的性能参数,与模拟分析获得的相应结果进行了比较。在模拟分析中工作流体是用理想气体方程进... 详细信息

本文描述了模拟制冷压缩机的模型,工作流体的热力性质由实际气体状态方程表示。对于制冷剂为R12的制冷机,采用Martin-Downing状态方程计算获得的性能参数,与模拟分析获得的相应结果进行了比较。在模拟分析中工作流体是用理想气体方程进行描述的。从一种类型的制冷压缩机得到的结果,揭示了许多设计者有兴趣的参数:如:P-V图、气阀升程曲线、质量流动率、阀摩擦系数、循环功、各种损失等等,仅仅在压缩机吸入孔口的制冷剂有着少量的过热,而压缩比较大的时候,证实了使用实际气体状态方程的合理性。

关键词：实际气体状态方程制冷剂热力性质设计者兴趣流体冷冻剂制冷材料个性心理特征制冷压缩机理想气体方程

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体外受精治疗中扫描比较有无输卵管积水患者中子宫内膜和子宫内膜下血流

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世界核心医学期刊文摘（妇产科学分册） 2006年第6期2卷 14-15页

作者： ng e.H.Y. Chan C.C.W. Ho P.C. 张旸 Department of Obstetrics and Gynaecology University of Hong KongQueen MaryHospital Professorial Block Pokfulam Road Hong KongChinaDr.

Objective: To compare endometrial and subendometrial blood flows among patients with and without hydrosalpinx (HSP)- during in vitro fertilization treatment as measured by a three- dimensional power Doppler ultrasound. Design: A prospective observational study. Setting: A tertiary assisted reproduction unit. Patient(s): Twenty- one patients with HSP were compared with 42 matched controls without HSP. Intervention(s): None. Main Outcome Measure(s): endometrial thickness, endometrial pattern, endometrial volume, pulsatility index (PI) and resistance index (RI) of uterine vessels, and the vascularization index (VI), flow index (FI), and vascularization flow index (VFI) of endometrial and subendometrial regions were measured on the day of oocyte retrieval. Result(s): The proportion of the non- multilayered endometrial pattern was significantly higher in the HSP group than in the non- HSP group. Patients in the HSP group had significantly lower endometrial and subendometrial VI and VFI. endometrial thickness, endometrial volume, uterine PI, uterine RI, and endometrial and subendometrial FI were similar between the two groups. No significant differences were observed in endometrial and subendometrial VI, FI, and VFI among patients with unilateral and bilateral HSP. Conclusion(s): A change in endometrial pattern and a decrease in endometrial and subendometrial blood flows may be the reasons for impaired implantation in patients with HSP.

关键词：子宫内膜输卵管积水血流指数体外受精患者阻力指数(RI) 治疗扫描内膜厚度多普勒超声

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仅患多囊卵巢与患多囊卵巢综合征的中国妇女超声参数是否不同

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世界核心医学期刊文摘（妇产科学分册） 2006年第8期2卷 30-31页

作者： ng e.H.Y. Chan C.C.W. Ho P.C. 朱磊 Department of Obstetrics and Gynaecology University of Hong Kong Hong Kong China

Objective: We aimed to compare antral follicle count (AFC), ovarian volume, ovarian stromal blood flow between Chinese women with polycystic ovary (PCO) only and polycystic ovary syndrome (PCOS) and to evaluate the effect of age on these ultrasound parameters in these women. Study design: In the second to fourth day of the period, they underwent a transvaginal three-dimensional scanning with power Doppler to determine total AFC, total ovarian volume, total ovarian vascu-larization index (VI), flow index (FI) and vascularization flow index (VFI). Hormonal profile was also measured. Results: A total of 71 Chinese women were recruited in the study: 39 women with PCO only and 32 women with *** with PCO only had significantly lower AFC, ovarian volume, ovarian VI, serum LH, testosterone and DHeAS concentrations but higher serum SHBG concentration when compared with PCOS women. When women with PCO only and PCOS were considered together, the rate of decline of AFC over age was 0.905 follicle per year (95% CI = 0.008- 1.803, p = 0.048) and there was no significant decline of ovarian volume and total ovarian VI, FI and VFI over age. Conclusion: PCO only represents a milder end of the PCOS spectrum.

关键词：多囊卵巢综合征超声参数中国妇女窦状卵泡黄体生成素硫酸脱氢表雄酮血管化多普勒超声检查研

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收缩性心力衰竭给予螺内酯的不同应用剂量效果分析

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系统医学 2017年第2期2卷 40-42页

作者：杨柳张晶吉化集团公司总医院二院心内科吉林吉林132021 吉化集团公司总医院心内科吉林吉林132021

目的研究收缩性心力衰竭给予螺内酯的不同应用剂量的临床效果。方法选取2013年11月—2015年11月该院收治的84例收缩性心力衰竭患者随机分为对照组与研究组,每组42例。对照组给予小剂量螺内酯,研究组给予大剂量螺内酯。对比两组心功能指... 详细信息

目的研究收缩性心力衰竭给予螺内酯的不同应用剂量的临床效果。方法选取2013年11月—2015年11月该院收治的84例收缩性心力衰竭患者随机分为对照组与研究组,每组42例。对照组给予小剂量螺内酯,研究组给予大剂量螺内酯。对比两组心功能指标、6 min步行距离、NT-pro BNP水平及不良反应。结果治疗前,研究组LVeF及e/A较于对照组差异无统计学意义(P>0.05);治疗后研究组各指标分别为(43.4±4.0)%及(1.2±0.3),相较于对照组,研究组改善更确切(Png/L,优于对照组(P0.05)。结论收缩性心力衰竭给予大剂量螺内酯治疗有助于患者心功能的改善,抑制心室重构,降低BNP水平,安全性好。

关键词：收缩性心力衰竭螺内酯心功能

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Significance of serum leptin and adiponectin levels in egyptian patients with chronic hepatitis C virus associated hepatic steatosis and fibrosis

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World Journal of Hepatology 2013年第2期5卷 74-81页

作者： Tarek e Korah Sawsan el-Sayed Maathir K elShafie Ghada e Hammoda Manal A Safan Department of Internal Medicine Faculty of MedicineMenoufiya University32511 MenoufiyaEgypt Department of Tropical Medicine Faculty of MedicineMenoufiya University32511 MenoufiyaEgypt Department of Medical Biochemistry Faculty of MedicineMenoufiya University32511 MenoufiyaEgypt

AIM:To study serum levels of leptin and adiponectin in patients with chronic hepatitis C virus infection genotype-4(HCV-4) related steatosis and ***:We prospectively studied 45 untreated men with chronic HCV-4,with proven steatosis(group Ⅰ,30 patients),and fibrosis(group Ⅱ,15 patients),on liver *** addition,15 healthy men(group Ⅲ),matched for age,and body mass index were ***,we excluded another five patients with steatohepatitis,and six patients with *** measured total serum leptin and adiponectin levels,as potential predictors for liver steatosis and ***,a correlation between these adipokines and various clinical and laboratory data were *** subjects were selected from Tropical and Internal medicine departments,Menoufiya University Hospital,Menoufiya,egypt,during the period from February 2010 to August ***:In group Ⅰ,severity of hepatic steatosis was mild,moderate,and severe,in 19 patients(63.5%),8 patients(26.5%),and 3 patients(10%),*** contrast,in group Ⅱ,hepatic fibrosis was found to be in stage 1,2,and 3,in 6 patients(40%),in 6 patients(40%),and in 3 patients(20%),*** comparing group Ⅰ with group Ⅱ,there was a significant decrease in serum adiponectin levels(131.4 ± 7.91 pg/mL vs 436 ± 9.75 pg/mL,P e there was no significant difference between both groups regarding serum leptin levels(34.69 ± 7.69 ng/mL vs 35.17 ± 1.06 ng/mL,P > 0.05).However,in the same group,when compared with group Ⅲ,there was a significant increase in serum leptin levels(34.69 ± 7.69 ng/mL vs 10.69 ± 0.84 ng/mL,P e there was a significant decrease in serum adiponectin levels(131.4 ± 7.91 pg/mL vs 342.4 ± 44.48 pg/mL,P en compared with group Ⅲ,there was a significant increase in serum leptin and adiponectin levels(35.17 ± 1.06 ng/mL vs 10.69 ± 0.84 ng/mL,P espectively),while the

关键词： Leptin Adiponectin Hepatitis C virus Hepatic steatosis Hepatic fibrosis

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中性粒细胞CD64是新生儿早期感染的敏感诊断标志

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世界核心医学期刊文摘（儿科学分册） 2005年第3期1卷 57-58页

作者： ng P.C. 阿明 Department of Pediatrics Clinical Sciences BuildingPrince of Wales Hospital Shatin N. T. HongKong

这项前瞻性研究的目的是为了评价中性粒细胞CD64表达对新生儿早期临床感染的诊断价值,并供以后研究进行参考对照。本研究将出生后72 h以内、怀疑受到感染的新生儿纳入观察对象。分别在0 h和24 h测定C-反应蛋白(CRP)和中性粒细胞CD64的... 详细信息

这项前瞻性研究的目的是为了评价中性粒细胞CD64表达对新生儿早期临床感染的诊断价值,并供以后研究进行参考对照。本研究将出生后72 h以内、怀疑受到感染的新生儿纳入观察对象。分别在0 h和24 h测定C-反应蛋白(CRP)和中性粒细胞CD64的表达水平。分别对CRP、CD64及这两个标志物联合对新生儿脓毒症预测的敏感性、特异性、阳性预测价值和阴性预测价值(NPV)进行了比较。

关键词： CD64 诊断标志预测价值早期临床出生后脓毒症早期感染中性粒细胞观察对象特异性

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Degradation of indomethacin in river water under stress and non-stress laboratory conditions:degradation products,long-term evolution and adsorption to sediment

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Journal of environmental Sciences 2017年第1期29卷 13-20页

作者： Juan J.Jimenez Maria I.Sanchez Rafael Pardo Beatriz e.Munoz Department of Analytical Chemistry Faculty of SciencesCampus Miguel DelibesUniversity of ValladolidPaseo de Belen 747012 ValladolidSpain I.U.CINQUIMA Campus Miguel DelibesUniversity of ValladolidPaseo de Belen 547011 ValladolidSpain Department of Analytical Chemistry School of Industrial EngineersUniversity of ValladoliclFrancisco Mendizdbal 147014 ValladolidSpain

The pharmaceutical compound indomethacin is not totally removed in wastewater treatment plants,whose effluents flow into aquatic environments;concentrations in the 0.1-100 ng/L range are commonly found in surface waters,and its fate is ***,biological,photochemical and thermal degradation assays were conducted under stress and non-stress conditions to estimate its degradation rate in river water and establish its degradation products over *** results revealed that direct sunlight irradiation promoted the complete degradation of indomethacin（2 μg/L） in less than 6 hr,but indomethacin was detected over a period of 4 months when water was kept under the natural day-night cycle and the exposure to sunlight was partially limited,as occurs inside a body of *** biological degradation in water was negligible,while the hydrolysis at pH 7.8 was *** were monitored by ultra-pressure liquid chromatography/quadrupole time-of-flight/mass spectrometry after solid-phase extraction,and six degradation products were found;their structures were proposed based on the molecular formulae and fragmentation observed in high-resolution tandem mass spectra.4-Chlorobenzoic and 2-acetamido-5-methoxybenzoic acids were the long-term transformation products,persisting for at least 30 weeks in water kept under non-stress ***,the degradation in the presence of sediment was also monitored over time,with some differences being *** adsorption coefficients of indomethacin and degradation products on river sediment were calculated;long-term degradation products did not have significant adsorption to sediment.

关键词： Indomethacin Degradation products River water Adsorption coefficients High-resolution mass spectrometry

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