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Predicting Protein Subcellular Location Using Digital Signal Processing

Acta biochimica et biophysica Sinica 2005年第2期37卷 88-96页

作者： Yu-xi PAN Da-Wei LI Yun DUAN Zhi-Zhou ZHANG Ming-Qing xU Guo-Yin FENG Lin HE bio-x Life Science Research center,Shanghai Jiaotong University,Shanghai 200030,China Institute for Nutritional Sciences,Shanghai Institutes for biological Sciences.Chinese Academy of Science,Shanghai 200030.China neuropsvchiatric & human genetics group,bio-x center Shanghai Jiaotong University,Shanghai 200030.China bio-xLifeScienceResearchcenter ShanghaiJiaotongUniversityShanghai200030China

The biological functions of a protein are closely related to its attributes in a *** the rapidaccumulation of newly found protein sequence data in databanks,it is highly desirable to develop an auto-mated method for predicting the subcellular location of *** establishment of such a predictor willexpedite the functional determination of newly found proteins and

关键词： sequence order effect digital signal processing digital Fourier transform (DFT) frequency domain covariance discriminant algorithm bioinformatics proteomics

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Answering a century old riddle: brachydactyly type Al

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Cell Research 2004年第3期 179-187页

作者： Bo GAO, Lin HE Institute for Nutritional Sciences, Shanghai Institutes for biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. Neuropsychiatric and human genetics group, bio-x Life Science Research center, Shanghai Jiaotong University, Shanghai 200030, China. Department of biochemistry, Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

In 1903, Farabee analyzed the heredity of the human digital malformation, brachydactyly, the first recorded disorder of the autosomal dominant Mendelian trait. In 1951, Bell classified this type of brachydactyly as type A1 (BDA1). Over 100 cases from different ethnic groups have so far been reported. However, the real breakthrough in identifying the cause of BDA1 has only taken place in the last few years with the progress of the mapping and identification of one of the genes responsible for this disorder, thus providing an answer for a century old riddle. In this article, we attempt to review the current state of knowledge on the genetic features of BDA1 with its century-old history and signalling pathway of IHH, and also discuss genotype-phenotype correlation not only of BDA1, but also of all types of brachydactyly.

关键词： Brachydactyly IHH GDF5 ROR2 BMPRIB.

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Evolutionary implications of Avian Infectious Bronchitis Virus(AIBV)analysis

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Cell Research 2006年第3期16卷 323-327页

作者： Peng Shi~(1,2) Li Yu~2 Yun-xin Fu~3 Jing-Fei Huang~1 Ke-Qin Zhang~2 Ya-ping Zhang~(1,2)1 Laboratory of Cellular and Molecular Evolution,and Molecular biology of Domestic Animals,Kunming lnstitute of Zoology,Chinese Academy of Sciences,Kunming 650223,China 2 Laboratory for Conservation and Utilization of bio-resource,Yunnan University,Kunming 650091,China 3 human genetics center,University of Texas at Houston,Houston,Texas 77030,USA Laboratory of Cellular and Molecular Evolution and Molecular Biology of Domestic Animals Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China.

For developing efficient vaccines,it is essential to identify which amino acid changes are most important to the sur-vival of the *** investigate the amino acid substitution features in the Avian Infectious Bronchitis Virus (AIBV)antigenic domain of a vaccine serotype (DE072) and a virulent viral strain (GA98) to better understand adaptive evo-lution of *** addition,the SARS Coronavirus (SARS-CoV) was also analyzed in the same *** is interestingto find that extreme comparability exists between AIBV and SARS in amino acid substitution *** suggests thatamino acid changes that result in overall shift of residue charge and polarity should be paid special attention to duringthe development of vaccines.

关键词： Avian Infectious Bronchitis Virus SARS Coronavirus positive selection adaptive evolution vaccine development

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Screening and Identification a Novel Protein-lSOC2 that Interacts with P16INK4A

Screening and Identification a Novel Protein-lSOC2 that Inte...

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中国遗传学会“发育、遗传和疾病”研讨会

作者： xiaoyi Huang~1 Zhongcheng Shi~(1,4) Wei Wang~1 Yan Jin~1 Jing Bai~1 Zhenghua Chen~2 Jiujin xu~3 Dekai Zhang~4 Songbin Fu~(1,5) 1.Laboratory of Medical genetics,Harbin Medical University,Harbin,150081,China 2.Post-doctoral Station Beijing Branch of Gansu Yasheng Salt Industrial(group)Co.Ltd,Beijing,China 3.Institute of genetics and Developmental biology,Chinese Academy of Sciences,Beijing China 4.center for Extracellular Matrix biology,Institute of biosciences and Technology,Texas A&M University System Health Sciences center.Houston,Tx 77030,USA. 5.bio-pharmaceutical Key Laboratory of Heilongjiang Province,Harbin,150081,China

As a multiple tumor suppressor,P16plays a important role in proliferation and tumorigenesis by inhibiting the formation of the cdk4/6/cyclin D enzyme complex,which is required for the phosphorylation of RB,ensuring that RB remains in a complex with the E2F transcription *** hypophosphorylated RB binds to and suppresses E2F transcriptional activity and constrains G1 exit,p16 expression results in cell cycle arrest at G1 *** inactivation of P16INK4A has been described in a large majority of human tumors and transformed cell *** of inactivation in many human cancers involved in point mutation,promoter hypermethylation,and,often,*** deletions are unusually prevalent at this locus in very different human *** the main biological function of P16involved in regulation of cell cycle progression at the GI/S boundary,Recent experimental evidence suggested additional biological functions for *** from cell cycle control, P16has been implicated in other fundamental cellular processes,such as angiogenesis,cell senescence, tumor invasion,cell spreading,apoptosis,and cell *** expression or activity of P16partly account for age-related function declines in stem ***,depressing the activity of P16can significantly contribute to cell proliferation and *** the life-span of mamol/Lalian cell,the process of self-renewing and aging may be correlated with some protein interacting with P16to some *** liver maintains more self-renewing capacity than most other organs in adult healthy human *** normally proliferatively quiescent,hepatocyte can rapidly regenerate to restore liver mass when cell loss such as partial hepatectomy,virus infection or inflamol/Lation occurs. This restoration of moderate cell loss and symptosis renewal is largely achieved by hepatocyte ***,hepatocyte transplants in animals showed that hepatocyte can undergo significant clon

关键词： P16INK4A ISOC2 yeast two hybrid protein interaction

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