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CD4+/CD56+ Hematodermic Neoplasm Presenting in the Skin: A Tunisian Case Report and Current Review of the Literature

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Open Journal of Blood Diseases 2012年第4期2卷 95-99页

作者： Yosra ben Youssef nessrine ben sayed Kmira Zahra Abir Gmidène Naouel ben Salah Atef ben Abdelkader Nejia Brahem Hlima Sennana Colanda Belajouza Abderrahim Khelif Department of Anatomopathology Farhat Hached University Hospital Sousse Tunisia Department of Clinical Hematology Farhat Hached University Hospital Sousse Tunisia Department of Cytogenetics Farhat Hached University Hospital Sousse Tunisia Department of Cytology Aziza Othmana University Hospital Tunis Tunisia Department of Cytology Farhat Hached University Hospital Sousse Tunisia Department of Dermatology Farhat Hached University Hospital Sousse Tunisia

The CD4+/CD56+ hematodermic neoplasm is a rare aggressive systemic neoplasm for which effective therapies have not yet been established, it is clinically characterized by cutaneous involvement with spread to bone marrow, blood and poor prognosis with current chemotherapy regimens. Our objective is to report diagnosis and treatment difficulties of CD4+/CD56+ hematodermic neoplasm. We describe here a Tunisian man who presented with subcutaneous ulcerated lesion localized in the right leg and multiples generalized nodules. Skin biopsy showed an atypical lymphoid cell infiltration with an angiocentric pattern and extensive necrosis by immuno-histochemical analysis, these cells were positive for CD4, CD56, granzyme B and negative for CD8, CD123, CD20 and CD30. T-cell rearrangement and Epstein-Barr-virus (EBV) in situ hybridation studies were negative. The patient underwent 5 cycles chemotherapy SMILE regimen monthly sandwiched with radiotherapy on the residual lesions of the right leg with great tolerance but he relapsed within 8months with skin, blood, bone marrow, lung, and cerebrospinal involvement. Based on these findings, the patient was diagnosed with CD4+/CD56+ hematodermic neoplasm (blastic NK-like T-cell lymphoma) treated with one course of hyper-CVAD regimen, he died within 20 days with a septic chok. Despite the use of L-Asparaginase and radiotherapy the prognosis is very poor;we suggest the exploration for highly active drugs, hematopoietic stem cell transplantation (HSCT) is crucial to improve survival.

关键词： Blastic NK-Like T-cell Lymphoma Hyper-CVAD SMILE Prognosis Treatment

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FlowBreakdown of Hybrid Nanofluid on a Rigid Surface with Power Law Fluid as Lubricated Layers

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1485-1499页

作者： Mirza Naveed Jahangeer Baig NadeemSalamat Sohail Nadeem NaeemUllah Mohamed Bechir ben Hamida Hassan Ali Ghazwani sayed M.Eldin A.S.Al-Shafay Instituite of Mathematics Khwaja Fareed University of Engineering and Information TechnologyRahim yar Khan64200Pakistan Department of Mathematics Quaid-I-Azam UniversityIslamabad44000Pakistan Department of Mathematics Wenzhou UniversityWenzhou325035China College of Engineering Department of Mechanical EngineeringImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11564Saudi Arabia Research Laboratory of Ionized Backgrounds and Reagents Studies(EMIR) Preparatory Institute for Engineering Studies of Monastir(IPEIM)University of MonastirMonastir5060Tunisia Higher School of Sciences and Technology of Hammam Sousse Department of PhysicsJazan82511Kingdom of Saudia Arabia Department of Mechanical Engineering Faculty of engineeringJazan UniversityP.O.Box 45124JazanKingdom of Saudia Arabia Center of Research Faculty of EngineeringFuture University in EgyptNew Cairo11835Egypt Department of Mechanical Engineering College of EngineeringPrince Sattam bin Abdulaziz UniversityAlkharj16436Saudi Arabia

Thiswork investigates an oblique stagnation point flowof hybrid nanofluid over a rigid surface with power lawfluidas lubricated layers. Copper (Cu) and Silver (Ag) solid particles are used as hybrid particles acting in water H2O asa base fluid. The mathematical formulation of flow configuration is presented in terms of differential systemthat isnonlinear in nature. The thermal aspects of the flow field are also investigated by assuming the surface is a heatedsurface with a constant temperature T. Numerical solutions to the governing mathematical model are calculatedby the RK45 algorithm. The results based on the numerical solution against various flow and thermal controllingparameters are presented in terms of line graphs. The specific results depict that the heat flux increases over thelubricated-indexed parameter.

关键词： Oblique stagnation point flow hybrid nanofluid lubricated layer magnetohydrodynamics

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Infectious causes of fever of unknown origin in developing countries: An international ID-IRI study

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Journal of Intensive Medicine 2024年第1期4卷 94-100页

作者： Hakan Erdem Jaffar AAl-Tawfiq Maha Abid Wissal ben Yahia George Akafity Manar Ezzelarab Ramadan Fatma Amer Amani El-Kholy Atousa Hakamifard Bilal Ahmad Rahimi Farouq Dayyab Hulya Caskurlu Reham Khedr Muhammad Tahir Lysien Zambrano Mumtaz Ali Khan Aun Raza Nagwa Mostafa El-sayed Magdalena Baymakova Aysun Yalci Yasemin Cag Umran Elbahr Aamer Ikram Department of Infectious Diseases&Clinical Microbiology Gulhane School of MedicineTurkish Health Sciences UniversityAnkaraTurkey Specialty Internal Medicine and Quality and Patient Safety Department Johns Hopkins Aramco HealthcareDhahranSaudi Arabia Division of Infectious Diseases Indiana University School of MedicineIndianapolisINUSA Department of Infectious Diseases Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Internal Medicine Department Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Cape Coast Teaching Hospital Cape CoastGhana Medical Parasitology Faculty of MedicineSuez UniversitySuezEgypt Department of Medical Microbiology and Immunology Faculty of MedicineZagazig UniversityZagazigEgypt Department of Clinical Pathology Faculty of MedicineCairo UniversityGizaEgypt Department of Infectious Diseases School of MedicineIsfahan University of Medical SciencesIsfahanIran Department of Infectious Diseases Kandahar University Medical FacultyTeaching HospitalKandaharAfghanistan Department of Infectious Diseases Mohammed Bn Khalifa Bn Salman Alkhalifa Specialist Cardiac CenterAwaliBahrain Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineIstanbul Medeniyet UniversityIstanbulTurkey Department of Pediatric Oncology National Cancer Institute–Cairo UniversityChildren Cancer Hospital EgyptCairoEgypt Department of Medicine Federal General HospitalIslamabadPakistan Institute for Research in Medical Sciences and Right to Health(ICIMEDES) Scientific Research Unit(UIC)Faculty of Medical Sciences(FCM)National Autonomous University of Honduras(UNAH)TegucigalpaHonduras National Institute of Health IslamabadPakistan Shaukat Khanum Memorial Cancer Hospital and Research Center LahorePakistan Medical Parasitology Department Research Institute of OphthalmologyGizaEgypt Department of Infectious Diseases Military Medical AcademySofiaBulgaria Department of Infecti

Background:Fever of unknown origin(FUO)in developing countries is an important dilemma and further research is needed to elucidate the infectious causes of ***:A multi-center study for infectious causes of FUO in lower middle-income countries(LMIC)and lowincome countries(LIC)was conducted between January 1,2018 and January 1,*** total,15 participating centers from seven different countries provided the data,which were collected through the Infectious DiseasesInternational Research Initiative *** adult patients with confirmed infection as the cause of FUO were included in the *** severity parameters were quick Sequential Organ Failure Assessment(qSOFA)≥2,intensive care unit(ICU)admission,vasopressor use,and invasive mechanical ventilation(IMV).Results:A total of 160 patients with infectious FUO were included in the ***,148(92.5%)patients had community-acquired infections and 12(7.5%)had hospital-acquired *** most common infectious syndromes were tuberculosis(TB)(n=27,16.9%),infective endocarditis(n=25,15.6%),malaria(n=21,13.1%),brucellosis(n=15,9.4%),and typhoid fever(n=9,5.6%).Plasmodium falciparum,Mycobacterium tuberculosis,Brucellae,Staphylococcus aureus,Salmonella typhi,and Rickettsiae were the leading infectious agents in this study.A total of 56(35.0%)cases had invasive procedures for *** mean qSOFA score was 0.76±0.94{median(interquartile range[IQR]):0(0–1)}.ICU admission(n=26,16.2%),vasopressor use(n=14,8.8%),and IMV(n=10,6.3%)were not ***,38(23.8%)patients had at least one of the severity *** mortality rate was 15(9.4%),and the mortality was attributable to the infection causing FUO in 12(7.5%)***:In LMIC and LIC,tuberculosis and cardiac infections were the most severe and the leading infections causing FUO.

关键词： Developing countries Fever of unknown origin Infection

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Analytic Beta-Wavelet Transform-Based Digital Image Watermarking for Secure Transmission

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Computers, Materials & Continua 2022年第3期70卷 4657-4673页

作者： Hesham Alhumyani Ibrahim Alrube Sameer Alsharif Ashraf Afifi Chokri ben Amar Hala S.El-sayed Osama S.Faragallah Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityP.O.11099Taif21944Saudi Arabia Department of Electrical Engineering Faculty of EngineeringMenoufia UniversityShebin El-Kom32511Egypt Department of Information Technology College of Computers and Information TechnologyTaif UniversityP.O.11099Taif21944Saudi Arabia

The rapid development in the information technology field has introduced digital watermark technologies as a solution to prevent unauthorized copying and redistribution of *** article introduces a self-embedded image verification and integrity *** images are firstly split into dedicated segments of the same block ***,different Analytic Beta-Wavelet(ABW)orthogonal filters are utilized for embedding a self-segment watermark for image segment using a predefined *** orthogonal filter coefficients are estimated to improve image reconstruction under different block *** conduct a comparative study comparing the watermarked images using three kinds of ABW filters for block sizes 64×64,128×128,and 256×*** embed the watermark using the ABW-based image watermarking method in the 2-level middle frequency sub-bands of the ABW digital image *** imperceptibility and robustness of the ABW-based image watermarking method image is evaluated based on the Peak Signal to Noise Ratio(PSNR)and Correlation coefficient *** the implementation results,we came to know that this ABW-based image watermarking method can withstand many image manipulations compared to other existing methods.

关键词： Watermarking ABW median filtering JPEG compression PSNR

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Blockchain Driven Metaheuristic Route Planning in Secure Vehicular Adhoc Networks

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Computers, Materials & Continua 2022年第12期73卷 6461-6477页

作者： Siwar ben Haj Hassine Saud SAlotaibi Hadeel Alsolai Reem Alshahrani Lilia Kechiche Mrim M.Alnfiai Amira sayed A.Aziz Manar Ahmed Hamza Department of Computer Science College of Science&Art at MahayilKing Khalid UniversitySaudi Arabia Department of Information Systems College of Computing and Information SystemUmm Al-Qura UniversitySaudi Arabia Department of Information Systems College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Science College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Sciences and Technology Taif UniversityTaif P.O.Box 11099Taif21944Saudi Arabia Department of Information Technology College of Computers and Information TechnologyTaif UniversityTaif P.O.Box 11099Taif21944Saudi Arabia Department of Digital Media Faculty of Computers and Information TechnologyFuture University in EgyptNew Cairo11835Egypt Department of Computer and Self Development Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAlKharjSaudi Arabia

Nowadays,vehicular ad hoc networks(VANET)turn out to be a core portion of intelligent transportation systems(ITSs),that mainly focus on achieving continual Internet connectivity amongst vehicles on the *** VANET was utilized to enhance driving safety and build an ITS in modern *** safety is a main portion of VANET,the privacy and security of these messages should be *** this aspect,this article presents a blockchain with sunflower optimization enabled route planning scheme(BCSFO-RPS)for secure *** presented BCSFO-RPSmodel focuses on the identification of routes in such a way that vehicular communication is *** addition,the BCSFO-RPS model employs SFO algorithm with a fitness function for effectual identification of ***,the proposed BCSFO-RPS model derives an intrusion detection system(IDS)encompassing two processes namely feature selection and *** detect intrusions,correlation based feature selection(CFS)and kernel extreme machine learning(KELM)classifier is *** performance of the BCSFO-RPS model is tested using a series of experiments and the results reported the enhancements of the BCSFO-RPS model over other approaches with maximum accuracy of 98.70%.

关键词： VANET sunflower optimization machine learning blockchain intrusion detection

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A Rare Entity of Accelerated Chronic Lymphocytic Leukemia: A Report of Two Cases and Review of Literature

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Health 2023年第8期15卷 861-870页

作者： Zahra Kmira ben Yahya Noura Chembah Wafa ben sayed Nesrine Chiba Dorra Bouteraa Walid Zaier Monia ben Youssef Yosra Haifa Regaieg Khelif Abderrahim Department of Clinical Hematology Farhat Hached University Hospital Sousse Tunisia Department of Pathology Farhat Hached University Hospital Sousse Tunisia

Background: Accelerated-chronic lymphocytic leukemia (A-CLL) is a rare disease entity as it represents less than 1% of all reported cases of chronic lymphoid leukemia (CLL). Moreover, it is most likely an under diagnosed entity due to its rarity and the non-standardized practice of lymph node biopsy in CLL. Purpose: The aims of our work are to establish the diagnosis of A-CLL and to study the prognosis and treatment of this rare entity. Method: here, we report the clinical presentation and the follow up of two cases of A-CLL. Results: Distinguishing Richter transformation (RT) from A-CLL is important as it may result in a major change in disease management. The prognosis of A-CLL is intermediate between CLL and RT. The prognosis is mainly poor due to a predominance of poor prognostic markers including an increasing number of p53-positive cases. Conclusion: To this date, no prospective study has been led to define the best treatment for A-CLL. The shorter survival of A-CLL when compared to typical CLL implies the need of a more aggressive treatment.

关键词： Accelerated Chronic Lymphocytic Leukemia Richter Transformation Prognosis Treatment

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Evaluation of Flooding Risk in Greater Dhaka District Using Satellite Data and Geomorphological Land Classification Map

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Journal of Geoscience and Environment Protection 2016年第9期4卷 110-127页

作者： Marju ben sayed Shigeko Haruyama Graduate School of Bioresources Mie University Tsu City Japan

Flood is a common feature in rapidly urbanizing Dhaka city and its surrounding areas. In this research, evaluation of flood risk of Greater Dhaka in Bangladesh has been developed by using an integrated approach of GIS and remote sensing. The objective of the study is to measure the flooding risk based on the satellite data and geomorphological land classification map under the land use/land cover change from 1995 to 2015 related with the urbanization of Dhaka city. Comparing with each landform, land cover unit and historical rainfall data the flooding return period has been calculated. Terrace, natural levee and back swamp has been divided into three sub categories. Especially the built-up zone which is closer to the river channel, former river course and the back swamps are mostly vulnerable to flood inundation. This study revealed that, 70% of Greater Dhaka district within moderate to very high hazard zone, especially surrounding city like Manikganj Sadar Upazila areas. It is expected that, this study could contribute to effective flood forecasting, relief and emergency management for future flood event.

关键词： Land Use/Land Cover Change Manikganj Sadar Upazila Greater Dhaka GIS Flood

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Dynamics of Land Use/Cover Change in Manikganj District, Bangladesh: A Case Study of Manikganj Sadar Upazila

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Journal of Geographic Information System 2015年第6期7卷 579-587页

作者： Marju ben sayed Shigeko Haruyama Department of Environment Science and Technology Mie University Tsu Japan

This study revealed land use/cover change of Manikganj Sadar Upazila concerning with urbanization of Dhaka city. The study area also offers better residential opportunity and food support for Dhaka city. The major focus of this study is to find out the spatial and temporal changes of land use/cover and its effects on urbanization while Dhaka city is an independent variable. For analyzing land use/cover change GIS and remote sensing technique were used. The maps showed that, between 1989 and 2009 built-up areas increased approximately +12%, while agricultural land decreased -7%, water bodies decreased about -2% and bare land decreased about -2%. The significant change in agriculture land use is observed in the south-eastern and north eastern site of the city because of nearest distance and better transportation facilities with Dhaka city. This study will contribute to the both the development of sustainable urban land use planning decisions and also for forecasting possible future changes in growth patterns.

关键词： Land Use/Cover Change Manikganj Sadar Upazila Union Urban Sprawl Remote Sensing

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Severe hemorrhagic colitis in a patient with chronic myeloid leukemia in the blastic phase after dasatinib use

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World Journal of Gastrointestinal Pathophysiology 2013年第3期4卷 59-62页

作者： Zahra Kmira ben sayed Nesrine Zaghouani Houneida ben Fredj Wafa Slama Aida ben Youssef Yosra Zaier Monia Badreddine Sriha Khelif Abderrahim Department of Clinical Hematology University Hospital Farhat Hached Sousse 4000 Tunisia Department of Radiology University Hospital Farhat Hached Sousse 4000 Tunisia Department of Gastroenterology University Hospital Sahloul Sousse 4000 Tunisia Department of Anatomopathology University Hospital Farhat Hached Sousse 4000 Tunisia

Dasatinib is a second-line tyrosine kinase inhibitor used in patients with imatinib resistant or intolerant chronic myeloid leukemia (CML) and Philadelphia chromosomepositive acute leukemia. Gastrointestinal bleeding may occur in up to 7% of patients using dasatinib, although, severe dasatinib-related acute colitis had rarely been reported. Here, we present the case of a 36-year-old female who progressed to acute myeloid leukemia after fourteen months of receiving imatinib for CML in the chronic phase and was treated with a dasatinib-containing chemotherapy regimen. On day 34 of treatment, the patient developed moderate abdominal pain and bloody diarrhea with mucous. Analyses of stool specimens were negative for parasites, Clostridium difficile , and other pathogenic bacteria. The cytomegalovirus pp65 antigen was negative in her blood leukocytes. A colonoscopy revealed acute colitis, and a mucosal biopsy showed nonspecific colitis. The patient was treated with broad-spectrum antibiotics, bowel rest and hydration, and dasatinib treatment was stopped. Her bloody diarrhea improved within 72 h. After confirming cytological remission, the patient received initial course of consolidation, and dasatinib treatment was reinstated. However, hemorrhagic colitis recurred. After discontinuing dasatinib, herhemorrhagic colitis drastically improved and did not recur following the administration of nilotinib. The characteristics of our patient suggest that dasatinib treatment can lead to hemorrhagic colitis, which typically resolves after discontinuation of the drug.

关键词： Philadelphia chromosome Chronic myeloid leukemia Dasatinib Colitis

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