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Insulin is necessary for the hypertrophic effect of cholecystokinin-octapeptide following acute necrotizing experimental pancreatitis

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World Journal of Gastroenterology 2004年第15期10卷 2275-2277页

作者： Péter Hegyi Zoltán RakonczayJr Réka Sári László Czakó Norbert Farkas Csaba Góg József Németh János Lonovics Tamás Takács First Department of Medicine Faculty of MedicineUniversity of Szeged Szeged H6722Hungary School of Cell and Molecular BiosciencesMedical SchoolUniversity of NewcastleNewcastle upon TyneNE2 4HHUnited Kingdom First Department of Medicine Faculty of MedicineUniversity of Szeged Szeged H6722Hungary Jr.School of Cell and Molecular BiosciencesMedical SchoolUniversity of NewcastleNewcastle upon TyneNE2 4HHUnited Kingdom First Department of Medicine Faculty of MedicineUniversity of Szeged Szeged H6722Hungary

AIM:In previous experiments we have demonstrated that by administering low doses of cholecystokinin-octapeptide (CCK-8),the process of regeneration following L-arginine (Arg)-induced pancreatitis is *** rats that were also diabetic(induced by streptozotocin,STZ),pancreatic regeneration was not *** aim of this study was to deduce whether the administration of exogenous insulin could in fact restore the hypertrophic effect of CCK-8 in diabetic-pancreatitic rats. METHODS:Male Wistar rats were used for the experiments. Diabetes mellitus was induced by administering 60mg/kg body mass of STZ intraperitoneally(i.p.),then,on d 8, pancreatitis was induced by 200mg/100 g body mass Arg *** at an interval of 1 *** animals were injected subcutaneously twice daily(at 7 *** 7 p.m.)with 1 μg/kg of CCK-8 and/or 2 IU mixed insulin(300g/L short- action and 700g/L intermediate-action insulin) for 14 d after pancreatitis *** this the animals were killed and the serum amylase,glucose and insulin levels as well as the plasma glucagon levels,the pancreatic mass/body mass ratio(pm/bm),the pancreatic contents of DNA,protein,amylase,lipase and trypsinogen were *** tissue samples were examined by light microscopy on paraffin-embedded sections. RESULTS:In the diabetic-pancreatitic rats treatment with insulin and CCK-8 significantly elevated pw/bm and the pancreatic contents of protein,amylase and lipase vs the rats receiving only CCK-8 ***-8 administered in combination with insulin also elevated the number of acinar cells with mitotic activities,whereas CCK-8 alone had no effect on laboratory parameters or the mitotic activities in diabetic-pancreatitic rats. CONCLUSION:Despite the hypertrophic effect of CCK-8 being absent following acute pancreatitis in diabetic-rats, the simultaneous administration of exogenous insulin restored this *** results clearly demonstrate that insulin is necessary for the hypertrophic ef

关键词： Animals Diabetes Mellitus, Experimental Hypoglycemic Agents Insulin Male Pancreatitis, Acute Necrotizing Rats Rats, Wistar Regeneration Research Support, Non-U.S. Gov't Sincalide

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Ethanol inhibits the motility of rabbit sphincter of Oddi in vitro

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World Journal of Gastroenterology 2004年第23期10卷 3470-3474页

作者： Réka Sári Attila Pálv lgyi Zoltán Rakonczay Jr Tamás Takács János Lonovics László Czakó Péter Hegyi Zoltán Szilvássy First Department of Medicine Faculty of MedicineUniversity of Szeged H-6720Koranyi fasor 10Hungary Department of Pharmacology Medical University of Debrecen H-4032Nagyerdei krt98Hungary

AIM:The rote of the sphincter of Oddi(SO)in ethanol (ETOH)-induced pancreatitis is *** aim was to characterise the effect of E-I-OH on basal and stimulated SO motility. METHODS:SOs removed from white rabbits were placed in an organ bath(Krebs solution,pH7.4,37℃).The effects of 2 mL/L,4 mL/L,6 mL/L and 8 mL/L of ETOH on the contractile responses of the sphincter were determined. SOs were stimulated with either 0.1 μmol/L carbachol,1 μmol/L erythromycin or 0.1 μmol/L cholecystokinin(CCK). RESULTS:ETOH at a dose of 4 mL/L significantly decreased the baseline contractile amplitude from 11.98±0.05 mN to 11.19±0.07 ***,no significant changes in the contractile frequency were ***(0.6%) significantly decreased both the baseline amplitude and the frequency compared to the control group(10.50±0.01 mN, 12.13±0.10 mN and 3.53±0.13 c/min,5.5±0.13 cycles(c)/min, respectively).Moreover,0.8% of ETOH resulted in complete relaxation of the ***(0.1 μmol/L)or erythromycin (1 μmol/L)stimulated the baseline amplitudes(by 82% and 75%,respectively)and the contractile frequencies (by 150% and 106%,respectively).In the carbachol or erythromydn-stimulated groups 2-6 mL/L of E-IOH significantly inhibited both the amplitude and the ***, a 4-5 min administration of 6 mL/L ETOH suddenly and completely relaxed the ***(0.1 μmol/L)stimulated the baseline amplitude from 12.37±0.05 mN to 27.40±1.82 mN within 1.60±0.24 *** this peak,the amplitude decreased to 17.17±0.22 mN and remained constant during the *** frequency peaked at 12.8±0.2 c/min, after which the constant frequency was 9.43±0.24 c/min throughout the rest of the *** at a dose of 4 mL/L significantly decreased the amplitude from 16.13±0.23 mN to 14.93±0.19 ***,no significant changes in the contractile frequency were *** at a dose of 6 mL/L inhibited both the amplitudes and the frequencies in the CCK-stimulated group,while 8 mL/L of E

关键词： Animals Carbachol Central Nervous System Depressants Cholecystokinin Cholinergic Agonists Erythromycin Ethanol Gastrointestinal Agents Gastrointestinal Motility In Vitro Male Rabbits Research Support, Non-U.S. Gov't Sphincter of Oddi

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Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of Oddi

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World Journal of Gastroenterology 2005年第21期11卷 3264-3266页

作者： Attila Pálv(o|¨)lgyi Réka Sári József Németh Annamária Szabolcs István Nagy Péter Hegyi János Lonovics Zoltán Szilvássy First Department of Medicine Faculty of Medicine University of SzegedH-6720 SzegedKorányi fasor 8-10 Hungary Department of Pharmacology Medical University of Pécs H-7643 Pécs Szigeti u. 12 Hungary First Department of Medicine Faculty of Medicine University of Szeged H-6720 Szeged Korányi fasor 8-10 Hungary Department of Pharmacology Medical University of Debrecen H-4032 DebrecenNagyerdei krt.98Hungary

AIM: The sphincter of Oddi (SO) plays an important role in delivery of bile into the duodenum. To establish whether vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) were involved in phasic contractile activity of the rabbit SO stimulated by cholecystokinin-octapeptide (CCK-8). METHODS: Isolated SO muscle rings were cleaned of fat and mounted horizontally on two small L-shaped hooks one of which was connected to a force transducer for the measurement of isometric *** experiments were carried out in a thermostatically controlled (37±0.2℃) organ bath (5 mL) containing Krebs *** organ fluid was gassed with 95% O2 and 50 mL/L CO2 to keep the pH at 7.40±0.05. Contractile responses to CCK-8 (1 μmol/L) were evaluated in the presence and absence of NG-nitro-L-arginine (LNNA), an inhibitor of NO synthase (100 μmol/L), and (p-chloro-D-Phe6-Leu17)-VIP (VlPa, 30 μmol/L), a VIP receptor antagonist. RESULTS: CCK-8 stimulated the phasic activity of the SO. NO synthase inhibition increased the frequency and amplitude of contractions with a slight increase in developed tension. Pre-incubation with VlPa also attenuated this CCK-8 effect. The combined application of LNNA and VlPa abolished the phasic activity of the muscle rings with a marked increase in tension in response to CCK-8. CONCLUSION: VIP and NO together contribute to an increase in phasic activity of SO.

关键词： Sphincter of Oddi CCK VIP NO LNNA

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Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors

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World Journal of Pediatrics 2023年第10期19卷 992-1008页

作者： Barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter Róbert Dóczi Dóra Lakatos Anna Dirner Mátyás Vidermann Péter Filotás Réka Szalkai-Dénes István Szegedi katalin Bartyik Krisztina Míta Gábor Réka Simon Péter Hauser György Péter Csongor Kiss Miklós Garami István Peták Oncompass Medicine Hungary Kft Retek Str.34Budapest 1024Hungary Division of Pediatric Hematology-Oncology Department of PediatricsFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Pediatrics Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Onco-Hematology Department Velkey LászlóPaediatric Health CentreMiskolcHungary Department of Paediatrics Semmelweis UniversityBudapestHungary Onco-Hematology Department Heim Pál Children’s HospitalBudapestHungary Department of Pharmacology and Pharmacotherapy Semmelweis UniversityBudapestHungary Department of Pharmaceutical Sciences University of Illinois at ChicagoChicagoUSA Genomate Health CambridgeMAUSA

Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support *** drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted *** has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical *** aim of this study was to evaluate the utility of DDA in pediatric *** Between 2017 and 2020,103 high-risk pediatric cancer patients(rithm for therapeutic decision ***,a molecular tumor board(MTB)evaluated the results to provide therapy *** Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing *** identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug *** reached 88%(29/33)by 2020 due to the continuous updates of the evidence *** approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed *** of WES results for targeted panels missed important mutations affecting therapy *** DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine car

关键词： Computational decision support Pediatric tumors Precision oncology Tumor board

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Effect of herpesvirus infection on pancreatic duct cell secretion

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World Journal of Gastroenterology 2005年第38期11卷 5997-6002页

作者： Péter Hegyi Balázs rdg Zoltán Rakonczai Jr Tamás Takács János Lonovics Annamária Szabolcs Réka Sári András Tóth Julius G Papp András Varró Mária K Kovács Mike A Gray Barry E Argent Zsolt Boldogki First Department of Medicine Department of Biology Division of Cardiovascular Pharmacology School of Cell and Molecular Biosciences

AIM： To examine the effect of acute infection caused by herpesvirus （pseudorabies virus, PRV） on pancreatic ductal secretion. METHODS： The virulent Ba-DupGreen （BDG） and non- virulent ka-RREp01acgfp （KEG） genetically modified strains of PRV were used in this study and both of them contain the gene for green fluorescent protein （GFP）. Small intra/ interlobular ducts were infected with BDG virus （10^7 PFU/mL for 6 h） or with KEG virus （10^10 PFU/mL for 6 h）, while non-infected ducts were incubated only with the culture media. The ducts were then cultured for a further 18 h. The rate of HCO3 secretion [base efflux -λ（B）] was determined from the buffering capacity of the cells and the initial rate of intracellular acidification （1） after sudden blockage of basolateral base loaders with dihydro-4,4,- diisothiocyanatostilbene-2,2,-disulfonic acid （500 μmol/L） and amiloride （200 μmol/L）, and （2） after alkali loading the ducts by exposure to NH4Cl. All the experiments were performed in HCO3-buffered ringer solution at 37 ℃ （n = 5 ducts for each experimental condition）. Viral structural proteins were visualized by immunohistochemistry. Virallyencoded GFP and immunofluorescence signals were recorded by a confocal laser scanning microscope.RESULTS： The BDG virus infected the majority of accessible cells of the duct as judged by the appearance of GFP and viral anUgens in the ductal cells. KEG virus caused a similarly high efficiency of infection. After blockage of basolateral base loaders, BDG infection significantly elevated -λB-） 24 h after the infection, compared to the non-infected group. However, KEG infection did not modify -λB-）. After alkali loading the ducts, -λB-） was significantly elevated in the BDG group compared to the control group 24 h after the infection. As we found with the inhibitor stop method, no change was observed in the group KEG compared to the non-infected group. CONCLUSION： Incubation with the BDG or KEG strains of PRV results in an effective i

关键词： Pancreas Hypersecretion Ductal cells Infection Pseudorabies virus

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Exposure of Mercury from Gold Ming Area: A Case Study in Tendo and Aby Lagoon in Côte d’Ivoire

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Journal of Environmental Protection 2022年第9期13卷 613-627页

作者： Stéphane Jean Claon Serge Kouakou Kouassi Séka Arsène M’bassidje Laurent Kipré Séri Luc Kouakou Kouadio Joseph Allico Djaman Public Health and Hydrology Laboratory Félix Houphou&euml t-Boigny University Abidjan C&ocirc te d’Ivoire Water Quality Control and Analysis Laboratory National Drinking Water Office Abidjan C&ocirc te d’Ivoire Biology and Health Laboratory Félix Houphou&euml t-Boigny University Abidjan C&ocirc te d’Ivoire Environmental Sciences Laboratory Nanguy Abrogoua University Abidjan C&ocirc te d’Ivoire Department of Medical and Fundamental Biochemistry Institut Pasteur of C&ocirc te d’Ivoire Abidjan C&ocirc te d’Ivoire

Lagoons of West African countries are seriously threatened by rapid artisanal and small-scale gold mining (ASGM) that exposes lagoons to mercury pollution. In this study, the mercury level in the sediments of the Tendo and Aby lagoons in Côte d’Ivoire had been evaluated. A total of 87 samples from 25 stations located on Tendo and Aby lagoons were analyzed by atomic fluorescence spectrometry. The mean Hg concentrations obtained in the sediments of Tendo and Aby lagoons were 0.89 ± 0.26 mg⋅kg-1 and 0.70 ± 0.18 mg⋅kg-1, respectively. Hg concentrations evaluated in the bays of Tendo and Aby during the dry season were 1.38 ± 0.45 mg⋅kg-1 and 1.07 ± 0.31 mg⋅kg-1, respectively. The minimum and maximum total Hg concentrations in the sediments from 25 stations were 0.04 and 3.56 mg⋅kg-1, respectively. Mercury contamination in lagoons during ASGM poses risks of pollution for the lagoon ecosystem and also poses health risks for the population living near these lagoons.

关键词： ASGM Mercury Sediments Côte d’Ivoire Pollution

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考虑电力业务重要性的电力通信网关键节点识别

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电工技术学报 2019年第11期34卷 2384-2394页

作者：李昌超康忠健于洪国郑世超 ri Kihong 中国石油大学(华东)信息与控制工程学院

为了能够准确辨识出电力通信网的关键节点,给出了一种识别电力通信网关键节点的分析方法。首先,通过分析电力业务对电力通信网的要求和对电力网的影响,建立多层评估模型,采用量化赋值的方式对评价指标进行量化处理,提出针对非对称不完... 详细信息

为了能够准确辨识出电力通信网的关键节点,给出了一种识别电力通信网关键节点的分析方法。首先,通过分析电力业务对电力通信网的要求和对电力网的影响,建立多层评估模型,采用量化赋值的方式对评价指标进行量化处理,提出针对非对称不完全层次结构的层次分析法和基于云模型原理的改进熵权法,建立电力业务综合重要度评估体系;其次,结合实际电力业务分布情况建立加权网络,通过改进的权值降低法识别网络关键节点;最后,通过对两个实际电力通信网络的仿真验证了该方法的正确性。

关键词：电力网电力通信网电力业务网络拓扑加权网络

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White luminescence of Ho^(3+)/Tm^(3+)/Yb^(3+)-codoped CaWO_4 synthesized via citrate complex route assisted by microwave irradiation

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Transactions of Nonferrous Metals Society of China 2014年第S1期24卷 134-140页

作者： Hyun CHO Seok Min HWANG Jae Bin LEE Dong Hyun ka Tae Wan KIM Bo Seul LEE Ji Young LEE Jung-Il LEE Jeong Ho RYU Department of Nanomechatronics Engineering Pusan National University50 Cheonghak-ri Miryang Gyeongnam 627-706 Korea Department of Materials Science and Engineering Korea National University of Transportation Chungju Chungbuk 380-702 Korea

The nanocrystalline Ho3+/Tm3+/Yb3+ co-doped CaWO4 upconversion(UC) phosphors were successfully synthesized by a modified citrate complex method using microwave irradiation. The citrate complex precursors were heat-treated at temperature ranging from 300 to 700 °C for 3 h. Crystallization of the Ho3+/Tm3+/Yb3+ co-doped CaWO4 was detected at 400 °C, and entirely completed at 600 °C. The Ho3+/Tm3+/Yb3+ co-doped CaWO4 heat-treated at 600 °C showed primarily spherical and homogeneous morphology. Under the laser excitation of 980 nm, Ho3+/Tm3+/Yb3+ co-doped CaWO4 shows the bright white upconversion(UC) emission visible to the naked eye, which is composed of a blue emission at 475 nm from Tm3+, and green and red emissions at 543 and 651 nm respectively from Ho3+. The coordinates of Ho3+/Tm3+/Yb3+ co-doped CaWO4 in the Commission International De'eclairage(CIE) chromaticity diagram could be controlled from a cool to a warm white color depending on the Tm3+ and Ho3+ concentrations. The UC luminescent properties on Tm3+ and Ho3+ concentrations and related mechanism based on laser pump power were discussed in detail.

关键词： upconversion CaWO4 microwave irradiation white luminescence

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双源CT头颈部联合动脉成像时的CTA参数优化方法及效果分析

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中西医结合心血管病电子杂志 2020年第3期8卷 3-3页

作者：梁卡丽戴贵东西南医科大学附属中医医院西南医科大学附属医院

目的分析CTA参数优化方法及成像质量的影响。方法选取2017年3月-2019年6月,在我院治疗疑似头颈部动脉病变的100例患者,所有患者均进行CTA检查,将其分为两组。A组50例,阈值50HU,螺距0.9,触发点为主动脉弓升部;B组50例,阈值100HU,螺距0.7... 详细信息

目的分析CTA参数优化方法及成像质量的影响。方法选取2017年3月-2019年6月,在我院治疗疑似头颈部动脉病变的100例患者,所有患者均进行CTA检查,将其分为两组。A组50例,阈值50HU,螺距0.9,触发点为主动脉弓升部;B组50例,阈值100HU,螺距0.7,触发点为颈动脉主干。结果 A组患者的双侧颈、椎动脉起始段图像质量均明显高于B组(P<0.05)。结论适当调节CTA参数可提高图像质量,有利于临床诊断。

关键词： CTA 参数优化图像质量

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Comparison of modified injection molding and conventional machining in biodegradable behavior of perforated cannulated magnesium hip stents

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Journal of Materials Science & Technology 2021年第4期63卷 145-160页

作者： Haiyue Zu Kelvin Chau Temitope Olumide Olugbade Lulu Pan Chris Halling Dreyer Dick Ho-Kiu Chow Le Huang Lizhen Zheng Wenxue Tong Xu Li Ziyi Chen Xuan He ri Zhang Jie Mi Ye Li Bingyang Dai Jiali Wang Jiankun Xu Kevin Liu Jian Lu Ling Qin Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyThe Chinese University of Hong KongShatin999077Hong Kong Special Administrative RegionChina Zoltrix Material International Limited Wan ChaiHong Kong Island999077Hong Kong Special Administrative RegionChina Department of Mechanical and Biomedical Engineering City University of Hong KongKowloon999077Hong Kong Special Administrative RegionChina Orthopaedic Research Laboratory Department of Orthopaedics&TraumatologyOdense University HospitalInstitute of Clinical ResearchUniversity of Southern DenmarkOdense C5000Denmark Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongShatin999077Hong Kong Special Administrative RegionChina

In this study,perforated cannulated magnesium(Mg)hip stents were fabricated via modified Mg injection molding and conventional machining,***,the stent canal was filled with paraffin to simulate injection of *** microstructure,mechanical performance,corrosion behavior,and biocompatibility were comparably *** electron microscopy(SEM)and energy dispersive spectroscopy(EDS)showed higher affinity of interstitial element such as oxygen and carbon as consequences of routine molding *** immersion in SBF,machining stents showed reduced degradation rate and increased deposition of calcium phosphate compared to molding *** resistance was improved via ***,the hemolysis and in vitro osteoblast cell culture models showed favourable biocompatibility in machining stents compared to molding ones,which was improved by paraffin-filling treatment as *** results implied that the feasibility of the prepared machining stents as the potential in vivo orthopaedic application where slower degradation is required,which could be enhanced by designing canal-filling injection of biomaterials as well.

关键词： corrosion microstructure injection

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