检索结果-南通市图书馆

Spatial search weighting information contained in cell velocity distribution

Chinese Physics b 2024年第2期33卷 522-528页

作者：马一凯李娜陈唯 State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200438China China national Center for bioinformation Beijing 100101China national Genomics Data Center Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China

Cell migration plays a significant role in physiological and pathological *** the characteristics of cell movement is crucial for comprehending biological processes such as cell functionality,cell migration,and cell–cell *** of the fundamental characteristics of cell movement is the specific distribution of cell speed,containing valuable information that still requires comprehensive *** article investigates the distribution of mean velocities along cell trajectories,with a focus on optimizing the efficiency of cell food search in the context of the entire *** confirm that the specific velocity distribution in the experiments corresponds to an optimal search efficiency when spatial weighting is *** simulation results indicate that the distribution of average velocity does not align with the optimal search efficiency when employing average spatial ***,when considering the distribution of central spatial weighting,the specific velocity distribution in the experiment is shown to correspond to the optimal search *** simulations reveal that for any given distribution of average velocity,a specific central spatial weighting can be identified among the possible central spatial weighting that aligns with the optimal search ***,our work presents a method for determining the spatial weights embedded in the velocity distribution of cell *** results have provided new avenues for further investigation of significant topics,such as relationship between cell behavior and environmental conditions throughout their evolutionary history,and how cells achieve collective cooperation through cell-cell communication.

关键词： cell migration foraging efficiency random walk spatial search weight

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Toughened (Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))b_(2)–SiC composites fabricated by one-step reactive sintering with a unique Sib_(6) additive

引用

Journal of Advanced Ceramics 2024年第1期13卷 86-100页

作者： Wei Hao Xinzhe Lu Ling Li Tao Wang Guoliang Ren Huangyue Cai Xiaofeng Zhao Dongyun Wang na Ni Zhejiang Provincial Key Laboratory of Urban Rail Transit intelligent Operation and Maintenance Technology&Equipment Zhejiang Normal UniversityZhejiang 321004China Key Lab of Education Ministry for Power Machinery and Engineering School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

High-entropy diboride has been arousing considerable interest in recent ***,the low toughness and damage tolerance limit its applications as ultra-high-temperature structural *** we report that a unique Sib_(6) additive has been first incorporated as boron and silicon sources to fabricate a high-entropy boride(Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))b_(2)–SiC composite though one-step boro/carbothermal reduction reactive sintering.A synergetic effect of high-entropy sluggish diffusion and SiC secondary phase retarded the grain growth of the(Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))b_(2)–51SiC *** small grain size was beneficial to shorten the diffusion path for mass transport,thereby enhancing the relative density to~99.3%.These results in an increase of fracture toughness from~5.2 in HEbS-1900 to~7.7 MPa·m^(1/2) in HEbS-2000,which corresponded to a large improvement of 48%.The improvement was attributed to a mixed mode of intergranular and transgranular cracking for offering effective pinning in crack propagation,resulting from balanced grain boundary strength collectively affected by improved densification,solid solution strengthening,and incorporation of SiC secondary phase.

关键词： high-entropy diboride silicon hexaboride boro/carbothermal reduction reactive sintering fracture toughness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characteristics of cell motility during cell collision

引用

Chinese Physics b 2024年第2期33卷 72-77页

Quantitative examination of cellular motion and intercellullar interactions possesses substantial relevance for both biology and ***,the effects of intercellular interactions during cellular locomotion remain under-explored in experimental *** such,this study seeks to bridge this research gap,adopting Dictyostelium discoideum(Dicty)cells as a paradigm to investigate variations in cellular motion during reciprocal *** aim to attain a comprehensive understanding of how cell interactions influence cell *** observing and processing the motion trajectories of colliding cells under diverse chemical environments,we calculated the diffusion coefficient(D)and the persistence time(τ),using mean square *** analysis of the relationship dynamics between D andτprior to the collisions reveals intricate and non-monotonic alterations in cell movements during *** quantitatively scrutinizing theτtrend,we were able to categorize the cellular responses to interactions under different ***,we ascertained that the effect of cell interactions during collisions in Dicty cells emulates a classical sigmoid *** discovery suggests that cellular responses might comply with a pattern akin to the Weber–Fechner law.

关键词： cell migration random walk cell-cell interaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Confluence of ZnO and PTFE binder for Enhancing Performance of Thin-Film Lithium-ion batteries

引用

Energy & Environmental Materials 2024年第5期7卷 52-60页

作者： Subhashree behera Swathi ippili Venkatraju Jella na-Yeong Kim Seong Cheol Jang Ji-Won Jung Soon-Gil Yoon Hyun-Suk Kim Department of Materials Science and Engineering Chungnam National University School of Materials Science and Engineering University of Ulsan Department of Energy and Materials Engineering Dongguk University

Developing anode materials with high specific capacity and cycling stability is vital for improving thin-film lithium-ion batteries. Thin-film zinc oxide （ZnO）holds promise due to its high specific capacity, but it suffers from volume changes and structural stress during cycling, leading to poor battery performance. in this research, we ingeniously combined polytetrafluoroethylene （PTFE） with ZnO using a radio frequency （RF）magnetron co-sputtering method, ensuring a strong bond in the thin-film composite electrode. PTFE effectively reduced stress on the active material and mitigated volume change effects during Li+ion intercalation and deintercalation. The composite thin films are thoroughly characterized using advanced techniques such as X-ray diffraction, scanning electron microscopy,and X-ray photoelectron spectroscopy for investigating correlations between material properties and electrochemical behaviors. Notably, the ZnO/PTFE thin-film electrode demonstrated an impressive specific capacity of1305 mAh g-1(=7116 mAh cm-3) at a 0.5C rate and a remarkable capacity retention of 82%from the 1st to the 100th cycle, surpassing the bare ZnO thin film （50%）. This study provides valuable insights into using binders to stabilize active materials in thin-film batteries, enhancing battery performance.

关键词： li-ion batteries metal oxides anodes polytetrafluoroethylene (PTFE) thin films

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

HPLC Fingerprint Combined with Chemometrics and Network Pharmacology for Q-Markers Prediction Analysis of Saposhnikovia divaricata

引用

Journal of Analysis and Testing 2024年第1期8卷 83-94页

作者： Renguo Zhang Xinjian Liu Tong Wang Jie Yu Mengyuan Wang Jianmin Sun Xueling Yu na Niu Ligang Chen College of Chemistry Chemical Engineering and Resource UtilizationKey Laboratory of Forest Plant EcologyNortheast Forestry UniversityHarbin 150040China

Saposhnikovia divaricata(SD)has high medicinal and edible value,but relatively little research has been done on its qual-ity markers(Q-markers).To further clarify the Q-markers of SD with their corresponding pharmacodynamic *** this experiment,14 batches of SD were identified and screened for Q-marker candidate components using a comb.na.ion of HPLC fingerprint with similarity analysis,principal component analysis,hierarchical cluster analysis,and partial least squares discriminant ***,network pharmacology was used to predict Q-markers and core *** results showed that 5-O-methylvisammioside,cimifugin,and prim-O-glucosylcimifugin could be used as Q-markers of SD;while,MAPK1,MAPK3,PiK3CA,JUN,and MAPK8 were the core targets of SD for drug *** further evaluate the bind-ing efficiency of Q-markers,molecular docking of the main active ingredients of SD to the core targets was *** results showed that the compounds bind well to their targets,and binding energies were all less than-5 kcal/*** Q-markers obtained from the screening were closely related to the core target genes,which could achieve therapeutic effects by modulating the relevant signaling *** study offers a reference for the establishment of a set of quality control evaluation system for SD potential Q-markers prediction analysis,and lays the foundation for elucidating the mechanism of actionunderlying itspharmacodynamic substance.

关键词： Saposhnikovia divaricata Q-markers Fingerprint Chemometrics Network pharmacology Molecular docking

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Wettability and corrosion behavior between alkaline slag from sodium smelting of vanadium-titanium magnetite and refractory substrates

引用

Journal of iron and Steel Research international 2024年第6期31卷 1399-1410页

作者： Fei Zhao Zhi-wei bian Hong-xin Zhao De-sheng Chen Zhang-fu Yuan Yu-lan Zhen Li-na Wang Tao Qi Collaborative innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China national Engineering Research Center of Green Recycling for Strategic Metal Resources Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Hebei Zhongke Tongchuang Vanadium&Titanium Technology Co. Ltd.Hengshui 053000HeheiChina

The sodium smelting of vanadium-titanium magnetite can achieve the comprehensive utilization of Fe,V,and ***,the generation of alkaline slag during this process may cause damage to refractory *** wettability and corrosion behavior of alkaline slag on three types of refractory(MgO-C,SiC,and high alumina refractory)substrates were investigated at temperatures up to 1200℃.The effects of duration on the wettability of molten slag on SiC substrates were also *** showed that the high alumina refractory exhibited better wettability with the molten slag than the others,and thus,it is easier to be *** results of scanning electron microscopy coupled with energy dispersive spectroscopy showed that MgO-C and high alumina refractory substrates were severely *** was a visible and regular interfacial reaction layer between the slag and SiC refractory substrate,which was produced by the redox reaction between the metal oxides in the slag and the SiC refractory *** the increase in holding time,the interface layer expands and silico-ferrite phases are generated at the *** redox reaction between Fe_(2)O_(3) and SiC substrate is the main reason for the *** comparing the differences in wettability and corrosion behavior between the alkaline slag from sodium smelting of vanadium-titanium magnetite and MgO-C,SiC and high alumina refractories,it is concluded that SiC refractory has good corrosion resistance to the *** oxides in the slag accelerate the oxidation rate of SiC refractory.

关键词： Wettability Corrosion Alkaline slag-Contact angle Vanadium-titanium magnetite Refractory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

引用

Signal Transduction and Targeted Therapy 2024年第1期9卷 259-270页

作者： Yan Sun Xiu-na Yang Shuang-Shuang Yang Yi-Zhu Lyu bing Zhang Kai-Wen Liu na Li Jia-Chen Cui Guang-Xiang Huang Cheng-Lin Liu Jie Xu Jian-Qing Mi Zhu Chen Xiao-Hu Fan Sai-Juan Chen Shuo Chen Shanghai institute of Hematology National Research Center for Translational MedicineState Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai institute for Advanced immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Hematology Second Hospital of Dalian Medical UniversityDalian 116023China national Facility for Protein Science Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Legend biotech China Nanjing 211112China Shanghai immune Therapy institute Shanghai Cancer InstituteState Key Laboratory of Oncogenes and Related GenesRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Wondercel biotechnology Shenzhen 518052China

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity,safeguarding receptor activation,and facilitating amplification of signal transduction across the cellular ***,cell-surface antigeninduced multimerization(dubbed AiM herein)has not yet been consciously leveraged in chimeric antigen receptor(CAR)engineering for enriching T cell-based *** co-developed ciltacabtagene autoleucel(cilta-cel),whose CAR incorporates two b-cell maturation antigen(bCMA)-targeted nanobodies in tandem,for treating multiple *** we elucidated a structural and functional model in which bCMA-induced cilta-cel CAR multimerization amplifies myeloma-targeted T cell-mediated *** analysis of bCMA–nanobody complexes revealed atomic details of antigen–antibody hetero-multimerization whilst analytical ultracentrifugation and small-angle X-ray scattering characterized interdependent bCMA apposition and CAR juxtaposition in ***-induced nanobody CAR multimerization enhanced cytotoxicity,alongside elevated immune synapse formation and cytotoxicity-mediating cytokine release,towards myeloma-derived *** results provide a framework for contemplating the AiM approach in designing next-generation CARs.

关键词： cytotoxicity Antigen elevated

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

DLX3(Q178R)mutation delays osteogenic differentiation via H19/miR-29c-3p/KDM5b axis in TDO-iPSCs-derived MSCs

引用

Genes & Diseases 2024年第4期11卷 49-52页

作者： Liying Dong na Zhao Dongmei Wang Meng Wang Yixin Zhang Liangjie Sun Chong Ding Yixiang Wang Zeyun Ma Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China Department of Oral and Maxillofacial Surgery Peking University School and Hospital of StomatologyBeijing 100081China national Engineering Laboratory for Digital and Material Technology of Stomatology Peking University School and Hospital of StomatologyBeijing 100081China beijing Key Laboratory of Digital Stomatology Peking University School and Hospital of StomatologyBeijing 100081China The Second Clinical Division Peking University School and Hospital of StomatologyBeijing 100081China Department of ViP Service Peking University School and Hospital of StomatologyBeijing 100081China Department of Restorative Dentistry and biomaterials Sciences Harvard School of Dental MedicineBostonMA 02115USA Department of Prosthodontics Fudan UniversityShanghai 200001China Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Shanghai Stomatological HospitalFudan UniversityShanghai 200001China

Tricho-dento-osseous(TDO)syndrome is a rare autosomal dominant disease resulting from distal-less homeobox 3(DLX3)mutation.1,2 Accumulative bone density in alveolar bone is a clinically favorable phenotype for TDO ***... 详细信息

关键词： patients clinically alveolar

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

EbV-associated lymphoproliferative disease post-CAR-T cell therapy

引用

Frontiers of Medicine 2024年第2期18卷 394-398页

作者： Shiyuan Zhang Xiaoxi Zhou Shangkun Zhang na Wang Tongcun Zhang Donghua Zhang Qilin Ao Yang Cao Liang Huang Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China immunotherapy Research Center for Hematologic Diseases of Hubei Province Wuhan430030China institute of biology and Medicine College of Life and Health SciencesWuhan University of Science and TechnologyWuhan430081China Department of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin300020China Tianjin institutes of Health Science Tianjin301600China

Epstein–barr virus(EbV)-associated lymphoproliferative diseases(EbV-LPDs)are common complications that occur after solid organ transplantation or allogeneic hematopoietic stem-cell transplantation(HSCT).However,their occurrence and treatment post-chimeric antigen receptor-modified T(CAR-T)cell therapy has not been *** patients had been diagnosed with EbV-positive aggressive b-cell lymphoma and experienced relapses after multiple lines of *** receiving CAR-T cell therapy in tandem with autologous HSCT,the patients achieved complete ***,with a median time of 38.5 months after CAR-T cell therapy,b-cell-derived EbV-LPDs were diagnosed,and they were relieved through the administration of immune checkpoint inhibitor or b-cell-depleting ***,our report suggests that EbV-LPDs may represent a long-term adverse event after CAR-T cell therapy,especially in patients who previously had EbV-positive disorders,and they can be resolved by immune normalization strategy or b-cell depleting therapy.

关键词： EbV-associated lymphoproliferative disease chimeric antigen receptor T-cell autologous stem cell transplantation immune checkpoint inhibitor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Eubacterium coprostanoligenes alleviates chemotherapy-induced intestinal mucositis by enhancing intestinal mucus barrier

引用

Acta Pharmaceutica Sinica b 2024年第4期14卷 1677-1692页

作者： Dongsheng bai Jiawei Zhao Runde Wang Jiaying Du Chen Zhou Chunyang Gu Yuxiang Wang Lulu Zhang Yue Zhao na Lu State Key Laboratory of natural Medicines Jiangsu Key Laboratory of Carcinogenesis and InterventionDepartment of PhysiologySchool of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Clinical Pharmacology School of PharmacyNanjing Medical UniversityNanjing 211166China

Chemotherapy-induced mucositis represents a severe adverse outcome of cancer treatment,significantly curtailing the efficacy of these treatments and,in some cases,resulting in fatal *** identifying intestinal epithelial cell damage as a key factor in chemotherapy-induced mucositis,the paucity of effective treatments for such damage is *** our study,we discovered that Eubacterium coprostanoligenes promotes mucin secretion by goblet cells,thereby fortifying the integrity of the intestinal mucus *** enhanced barrier function serves to resist microbial invasion and sub-sequently reduces the inflammatory ***,this effect remains unobtrusive to the anti-tumor efficacy of chemotherapy ***,*** up-regulates the expression of AUF1,leading to the stabilization of Muc2 mRna and an increase in mucin synthesis in goblet *** espe-cially significant finding is that *** activates the AhR pathway,thereby promoting the expression of *** summary,our results strongly indicate that *** enhances the intestinal mucus barrier,effec-tively alleviating chemotherapy-induced intestinal mucositis by activating the AhR/AUFl pathway,consequently enhancing Muc2 mRna stability.

关键词： Chemotherapy Mucositis Eubacterium coprostanoligenes MUC2 AUF1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：