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The predictors of long-COVID in the cohort of Turkish Thoracic Society-TURCOVID multicenter registry:One year follow-up results

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Asian Pacific Journal of Tropical Medicine 2022年第9期15卷 400-409页

作者： Serap Argun Baris Oya Baydar Toprak Pelin Duru Cetinkaya Fusun Fakili Nurdan Kokturk Seval Kul Ozgecan Kayalar Yildiz Tutuncu Emel Azak Mutlu Kuluozturk Pinar Aysert Yildiz Pelin Pinar Deniz Oguz Kilinc Ilknur Basyigit Hasim Boyaci Ismail Hanta neslihan kose Gulseren Sagcan Caglar Cuhadaroglu Hacer Kuzu Okur Hasan Selcuk Ozger Begum Ergan Mehtap Hafizoglu Abdullah Sayiner Esra Nurlu Temel Onder Ozturk Tansu Ulukavak Ciftci Ipek Kivilcim Oguzulgen Vildan Avkan Oguz Firat Bayraktar Ozlem Ataoglu Merve Ercelik Pinar Yildiz Gulhan Aysegul Tomruk Erdem Muge Meltem Tor Oya Itil Hasan Bayram Department of Pulmonary Medicine Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Faculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine University of Health SciencesAdana City Training and Research HospitalAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine Faculty of MedicineGazi UniversityAnkaraTurkey Department of Biostatistics Faculty of MedicineGaziantep UniversityGaziantepTurkey Koc University Research Center for Translational Medicine(KUTTAM) Koc University School of MedicineIstanbulTurkey Department of Immunology Koc University Research Center for Translational Medicine(KUTTAM)Koc University School of MedicineIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineKocaeli UniversityKocaeli Turkey Department of Pulmonary Medicine Faculty of MedicineFirat UniversityElazigTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineGazi UniversityAnkaraTurkey Department of Pulmonary Medicine Faculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Pulmonary Medicine Bilecik Training and Research HospitalBilecikTurkey Department of Pulmonary Medicine Altunizade Acibadem HospitalIstanbulTurkey Department of Pulmonary Medicine Faculty of MedicineEge UniversityIzmirTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Pulmonary Medicine Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Internal Medicine Faculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Pulmonary Medicine Faculty of MedicineDuzce UniversityDuzceTurkey Department of Pulmonary Medicine Faculty of MedicineZonguldak Bulent Ecevit UniversityZongu

Objective:To evaluate long-term effects of COVID-19,and to determine the risk factors in long-COVID in a cohort of the Turkish Thoracic Society(TTS)-TURCOVID multicenter ***:Thirteen centers participated with 831 patients;504 patients were enrolled after *** study was designed in three-steps:(1)Phone questionnaire;(2)retrospective evaluation of the medical records;(3)face-to-face ***:In the first step,93.5%of the patients were hospitalized;61.7%had a history of pneumonia at the time of diagnosis.A total of 27.1%reported clinical symptoms at the end of the first ***(17.00%),fatigue(6.30%),and weakness(5.00%)were the most prevalent long-term *** incidence of long-term symptoms was increased by 2.91 fold(95%CI 1.04-8.13,P=0.041)in the presence of chronic obstructive pulmonary disease and by 1.84 fold(95%CI 1.10-3.10,P=0.021)in the presence of pneumonia at initial diagnosis,3.92 fold(95%CI 2.29-6.72,P=0.001)of dyspnea and 1.69 fold(95%CI 1.02-2.80,P=0.040)fatigue persists in the early-post-treatment period and 2.88 fold(95%CI 1.52-5.46,P=0.001)in the presence of emergency service admission in the post COVID *** step 2,retrospective analysis of 231 patients revealed that 1.4%of the chest X-rays had not significantly improved at the end of the first year,while computed tomography(CT)scan detected fibrosis in 3.4%.In step 3,138(27.4%)patients admitted to face-to-face visit at the end of first year;at least one symptom persisted in 49.27%*** most common symptoms were dyspnea(27.60%),psychiatric symptoms(18.10%),and fatigue(17.40%).Thorax CT revealed fibrosis in 2.4%***:COVID-19 symptoms can last for extended lengths of time,and severity of the disease as well as the presence of comorbidities might contribute to increased ***-term clinical issues should be regularly evaluated after COVID-19.

关键词： Long COVID-19 Dyspnea Fatigue Comorbidity

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Post-discharge mortality in the first wave of COVID-19 in Turkey

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Asian Pacific Journal of Tropical Medicine 2022年第11期15卷 479-484页

作者： Fusun Fakili Pelin Duru Cetinkaya Oya Baydar Serap Argun Baris Nurdan Kokturk Seval Kul Oguz Karcioglu Pinar Aysert Yildiz Ilim Irmak Yonca Sekibag Emel Azak Sait Mulamahmutoglu Caglar Cuhadaroglu Bugra Kerget Burcu Baran Ketencioglu Hasan Selcuk Ozger Gulcihan Ozkan Zeynep Ture Merve Ercelik Tansu Ulukavak Ciftci Ozlem Alici Esra Nurlu Temel Ozlem Ataoglu neslihan kose Muge Meltem Tor Gulsah Gunluoglu Sedat Altin Onder Ozturk Pinar Yildiz Gulhan Ilknur Basyigit Hasim Boyaci I Kivilcim Oguzulgen Sermin Borekci Bilun Gemicioglu Ismail Hanta Hacer Kuzu Okur Gulseren Sagcan Metin Akgun Ali Fuat Kalyoncu Oya Itil Hasan Bayram Department of Pulmonary Medicine Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine University of Health SciencesAdana City Training and Research HospitalFaculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Faculty of MedicineGazi UniversityAnkaraTurkey Department of Biostatistics Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine Halil Sivgin Cubuk State HospitalAnkaraTurkey Department of Infectious Disease Faculty of MedicineGazi UniversityAnkaraTurkey Department of Pulmonary Medicine Faculty of MedicineHacettepe UniversityAnkaraTurkey Department of Pulmonary Medicine Cerrahpasa Faculty of MedicineIstanbul University−CerrahpasaIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Altunizade Acibadem HospitalIstanbulTurkey Department of Pulmonary Medicine Faculty of MedicineAtaturk UniversityErzurumTurkey Department of Pulmonary Medicine Faculty of MedicineErciyes UniversityKayseriTurkey Department of Pulmonary Medicine Maslak Acibadem HospitalIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineErciyes UniversityKayseriTurkey Department of Pulmonary Medicine Faculty of MedicineDuzce UniversityDuzceTurkey Department of Infectious Disease Faculty of MedicineTurkiye Gazetesi Private HospitalIstanbulTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Pulmonary Medicine Bilecik Training and Research HospitalBilecikTurkey Department of Pulmonary Medicine Faculty of MedicineZonguldak Bulent Ecevit UniversityZonguldakTurkey Department of Pulmonary Medicine Universi

Objective:To determine post-discharge mortality and associated factors of the first-wave multicenter Turkish Thoracic Society(TTD)-TURCOVID ***:In this retrospective cohort study,we analyzed the data of 18 of 26 centers included in the first TTD-TURCOVID study,and 1112 cases diagnosed with COVID-19 between 11 March and 31 July 2020 participated in the *** causes of death after COVID-19 discharge were ***:The mean age of the patients was(51.07±16.93)years,with 57.6%male *** the cohort group,89.1%of COVID-19 treatment locations were hospital wards,3.6%were intensive care units(ICUs),and 7.2%were community *** the longterm follow-up,the in-hospital mortality rate was 3.6%(95%CI 2.6-4.8),the post-discharge mortality rate was 2.8%(95%CI 1.9-3.9),and the total mortality was 6.3%(95%CI 5.0-7.8).After discharge,63.3%of mortality overall occurred during the first six *** rates in post-discharge follow-ups were 12.7%(95%CI 8.0-30.6)in cancer patients,10.8%(95%CI 6.3-22.9)in chronic obstructive pulmonary disease patients,11.1%(95%CI 4.4-22.7)in heart failure patients,7.8(95%CI 3.8-14.3)in atherosclerotic heart disease patients,and 2.3%(95%CI 0.8-5.6)in diabetes mellitus *** smokers/ex-smokers,the all-mortality rates were higher than in ***:This multicenter study showed that patients over 65 years of age,males,former/active smoker,ICU stay,lung,heart disease,and malignancy should be followed up for at least the first six months after discharge due to COVID-19.

关键词： COVID-19 Post-discharge Mortality Comorbidity

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Telerehabilitation intervention for type 2 diabetes

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World Journal of Diabetes 2020年第6期11卷 218-226页

作者： neslihan Duruturk Department of Physiotherapy and Rehabilitation Baskent UniversityFaculty of Health SciencesAnkara 06790Turkey

Diabetes has become an increasingly important health problem worldwide due to its *** effective treatments for diabetes management have been developed,many patients have difficulty in achieving their therapeutic *** exercise training is suggested to prevent or delay the symptoms and complications of type 2 diabetes along with other medical *** has become necessary to develop new rehabilitation models and practices in order to cope with the changing needs of the *** models using technology can be effective in disease *** may be effective as part of the rehabilitation program in the home environment,especially for patients who are unable to participate in conventional center-based rehabilitation due to transport difficulties or work *** is defined as the delivery of rehabilitation services via telecommunication technology,including phone,internet,and videoconference communications between the patient and health care *** is possible that telerehabilitation may benefit people with type 2 diabetes in similar ways with telemonitoring and interactive health communication *** the applicability of telehealth methods has been proven in previous studies,telerehabi-litation studies in type 2 diabetes are inadequate in the *** larger,multicentered randomized controlled studies,established clinical guidelines can be developed that will ultimately improve patient outcomes.

关键词： Type 2 diabetes Telerehabilitation Exercise Telehealth Healthcare Telecommunication

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Umbilical cord derived mesenchymal stem cell implantation in retinitis pigmentosa: a 6-month follow-up results of a phase 3 trial

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1423-1429页

作者： neslihan Sinim Kahraman Ayse Oner Department of Ophthalmology Kayseri Acibadem HospitalKayseri 38030Turkey

AIM:To investigate the efficacy and the safety of umbilical cord derived mesenchymal stem cell(UC-MSC)implantation in patients with retinitis pigmentosa(RP).METHODS:This prospective,single-center,phase 3 clinical study enrolled 124 eyes of 82 RP *** patients received 5 million UC-MSCs to the suprachoroidal area with a surgical *** were evaluated on the 1st day,1st,and 6th months *** corrected visual acuity(BCVA),anterior segment and fundus examinations,color photography,optical coherence tomography(OCT),and visual field(VF)tests were carried out at each *** fluorescein angiography(FFA)and multifocal electroretinography(mfERG)recordings were performed at the end of the 6th *** and systemic adverse events of the surgical procedure were also ***:All of the 82 patients completed the 6-month follow-up *** of them had any serious systemic or ocular *** were statistically significant improvements in BCVA and VF during the study(all P<0.05).The amplitudes of the P1 waves in the central areas showed significant improvements in mfERG *** were also significant increases in implicit times of P1 waves in the central ***:Suprachoroidal administration of UC-MSCs has beneficial effect on BCVA,VF,and mfERG measurements during the 6-month follow-up *** mediated therapy based on the secretion of growth factors(GFs)seems to be an effective and safe option for degenerative retinal diseases.

关键词： cell mediated therapy retinitis pigmentosa suprachoroidal umbilical cord derived mesenchymal stem cells visual function

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Experimental and Theoretical Spectral(FT-IR,Raman,NMR,UV-Vis and NLO)Analysis of a Potential Anti-Tumor Drug：1-Methyl-6-Nitro-1H-Benzimidazole

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光谱学与光谱分析 2018年第6期38卷 1963-1969页

作者： Halil Oturak neslihan Kaya Kιnaytürk Cagrι Cιrak DepartmentofPhysics SüleymanDemirelUniversityIsparta32100Turkey ExperimentalandObservationalResearchandApplicationCentre SüleymanDemirelUniversityIsparta32100Turkey DepartmentofPhysics ErzincanUniversityErzincan24100Turkey

In the present work,the experimental and the theoretical spectroscopic properties of 1-Methyl-6-Nitro-1H-Benzimidazole were *** FT-IR(400~4 000cm^(-1))and FT-Raman spectra(100~4 000cm^(-1))of 1-Methyl-6-Nitro-1H-Benzimidazole in the solid phase were ***,experimental NMR and UV spectra of titled molecule were *** interpret the experimental data,geometric parameters,vibrational frequencies,NMR,UV spectra and NLO analysis of the optimized molecule were calculated using ab initio Hartree–Fock(HF)method and density functional theory(B3LYP)method with the 6-31++G(d,p)and 6-311++G(d,p)basis *** bands were assigned based on the potential energy distribution using the VEDA *** theoretical results showed good agreement with the experimental values.

关键词：光谱学英文摘要

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Traditional manufacturing of clay brick used in the historical buildings of Diyarbakir （Turkey）

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Frontiers of Architectural Research 2017年第3期6卷 346-359页

作者： neslihan Dalklilic Adnan Nabikogiu Faculty of Architecture Department of Architecture Dicle University Diyarbakir Turkey

Clay brick is the most common construction materia（ used in the historical buildings of Diyarbaklr （Turkey）. Many clay brick manufacturing workshops and numerous brick masters have emerged. Diyarbakir currently has two clay brick workshops that face the problem of being closed down. Therefore, manufacturing of clay brick by traditional methods may be forgotten in Diyarbakir. This study investigates the manufacturing phases of traditional clay bricks in Diyarbakir＇s local workshops, which have not been documented. The manufacturin8 phases of the clay bricks in Diyarbaklr were examined for the first time based on in-situ observations, investigations, and interviews. The research indicated the general phases of clay brick manufacturing. Raw materials are first prepared, formed, and dried. The firing of clay bricks is then performed through hacking, heating, burning, coolins, and de-hacking. The clay bricks are finally packaged and dispatched. The traditional manufacturing of clay brick methods in Diyarbaklr is similar in many regions of the world. The clay bricks are currently and extensfvely used in the restoration of historic structures. Therefore, their production must be continuous.

关键词： Clay brick Diyarbaklr Historical structures Traditional construction techniques Traditional material

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Interaction between Janus Green B and bovine serum albumin:Electrochemistry and spectroscopy studies

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Chinese Chemical Letters 2011年第6期22卷 717-720页

作者： neslihan zdemir Serkan zdemir Ender Bier Ondokuz Mayrs University Faculty of Arts and Sciences Department of Chemistry

In this study,voltammetric and spectroscopic investigation of the interaction between Janus Green B（JGB） and bovine serum albumin（BSA） was *** interaction was observed at Britton-Robinson buffer（pH 7.0）.When JGB was added to solution containing BSA,the peak currents of BSA decrease with the increasing of JGB concentrations which is due to the interaction of JGB and *** binding constant of JGB with BSA was obtained by voltammetric ***,this interaction was supported by means of UV-vis spectroscopic *** UV-vis absorption spectra of JGB in the presence of BSA decrease with the increasing of BSA concentrations.

关键词： Voltammetry Bovine serum albumin Janus Green B Interaction

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Traveling wave structures of some fourth-order nonlinear partial differential equations

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Journal of Ocean Engineering and Science 2023年第2期8卷 124-132页

作者： Handenur Esen neslihan Ozdemir Aydin Secer Mustafa Bayram Department of Mathematical Engineering Yildiz Technical UniversityIstanbul34220Turkey Department of Software Engineering Istanbul Gelisim UniversityIstanbulTurkey Department of Computer Engineering Biruni UniversityIstanbulTurkey

This study presents a large family of the traveling wave solutions to the two fourth-order nonlinear partial differential equations utilizing the Riccati-Bernoulli sub-ODE *** this method,utilizing a traveling wave transformation with the aid of the Riccati-Bernoulli equation,the fourth-order equation can be transformed into a set of algebraic *** the set of algebraic equations,we acquire the novel exact solutions of the integrable fourth-order equations presented in this research *** physical interpretation of the nonlinear models are also detailed through the exact solutions,which demonstrate the effectiveness of the presented *** Bäcklund transformation can produce an infinite sequence of solutions of the given two fourth-order nonlinear partial differential ***,3D graphs of some derived solutions in this paper are depicted through suitable parameter values.

关键词： Fourth-order equations Riccati-Bernoulli sub-ODE method Traveling wave solution Bäcklund transformation

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Novel markers in predicting Brucella sacroiliitis:The platelet large cell ratio and basal immature reticulocyte fraction

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Asian Pacific Journal of Tropical Medicine 2023年第1期16卷 39-44页

作者： neslihan Celik Esra Laloğlu Hülya Aslan Depertmant of Infection Diseases and Clinical Microbiology Health Sciences University Erzurum Regional Education and Research HospitalErzurumYakutiyeTurkey Department of Biochemistry Ataturk University School of Medicine25240ErzurumYakutiyeTurkey Depertmant of Microbiology Health Sciences University Erzurum Regional Education and Research HospitalErzurumYakutiyeTurkey

Objective:To present platelet large cell ratio(P-LCR),reticulocyte,and immature reticulocyte fraction(IRF)values as novel parameters in diagnosis and response to treatment in patients developing ***:Sixty-eight patients with clinical symptoms and Brucella standard tube agglutination(Wright)or Brucella Coombs agglutination test titers≥1:160 were included in the *** groups were established,one developing sacroiliitis and another with no sacroiliitis development.P-LCR,reticulocyte,and IRF levels were measured using a Sysmex XN-9000 device(Japan).These were then compared between the two ***:Reticulocyte(P=0.037)and IRF(P=0.026)levels were significantly lower among the patients developing sacroiliitis compared to the non-sacroiliitis group,while P-LCR(P=0.003)levels were significantly higher.P-LCR had the most powerful correlation with sacroiliitis *** negative correlation was observed between reticulocyte,IRF levels and ***:Elevated P-LCR levels were observed as a marker of persisting inflammation in patients developing sacroiliitis,while low reticulocyte and IRF levels secondary to bone marrow involvement were *** three parameters emerged as highly significant markers in terms of diagnosis and reflecting responses to treatment in organ involvement such as sacroiliitis in *** are presented as inexpensive,and easily accessible novel parameters.

关键词： Brucella sacroiliitis P-LCR Reticulocyte IRF

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Documentation and analysis of structural elements of traditional houses for conservation of cultural heritage in Siverek(Sanliurfa,Turkey)

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Frontiers of Architectural Research 2020年第2期9卷 385-402页

作者： neslihan Dalkilic Adnan Nabikoglu Department of Architecture Faculty of ArchitectureDicle UniversityDiyarbakirTurkey

This study deals with the architectural properties of traditional Siverek houses,which are important in the larger corpus of Southeastern Anatolian *** historical city center of Siverek has partly preserved its authentic character with its monumental buildings and traditional *** the considerable number of traditional courtyard houses in Siverek,no detailed survey has been conducted on *** this work,these traditional houses in the historical Siverek City center are identified and documented for the first *** plans,facades,and structural systems are examined in detail,and the structural elements are comprehensively *** document the architectural features of these traditional Siverek houses and introduce the cultural heritage of the *** details provide information for proper decision-making regarding the preparation of restitution and restoration projects and selecting materials and techniques that suit the structures to be restored.

关键词： Courtyard house Siverek Traditional house Restoration

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