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Correlation between visual function and refractive,topographic, pachymetric and aberrometric data in eyes with keratoconus

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1127-1133页

作者： neslihan bayraktar bilen Ibrahim F.Hepsen Carlos G.Arce Department of Ophthalmology Ankara Numune Education and Research Hospital Department of Ophthalmology Gazi University Medical School Ocular Bioengineering & Refractive Surgery Sectors Institute of Vision Department of Ophthalmology Paulista School of Medicine Federal University of So Paulo Research & Development Consultant Zeimer Group AG

AIMTo analyze the relationship between two visual functions and refractive, topographic, pachymetric and aberrometric indicators in eyes with *** distance visual acuity (CDVA), and letter contrast sensitivity (CS) were correlated with refraction, corneal topography, pachymetry, and total corneal wavefront data prospectively in 71 eyes with keratoconus. The topographic indices assessed were simulated keratometry for the flattest and steepest meridians (SimK1 and SimK2), posterior steeper K (Ks), elevation value in best-fit sphere (BFS) maps, squared eccentricity (Є2), aspheric asymmetric index (AAI), pachymetry, thickness progression index (TPI), the amount of pachymetric decentralization (APD), and GalileiTM-keratoconus *** mean CDVA (expressed as logMAR) were 0.25±0.21. The mean CS was 1.25±0.46. The spherical refraction correlated well with CDVA (r=-0.526, P2 and maximum BFS correlated significantly with the visual function (P≤0.001 for all).CONCLUSIONIn this study, CS is more affected than CDVA as a visual function. The quantity and quality of vision is significantly correlated with well-known and new topographic indices. There is not a significant correlation between visual function and pachymetric parameters. The significantly correlated indices can be used in staging keratoconus and to follow the outcome of a treatment.

关键词： keratoconus topographic index contrast sensitivity visual quality corneal aberration

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Telerehabilitation intervention for type 2 diabetes

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World Journal of Diabetes 2020年第6期11卷 218-226页

作者： neslihan Duruturk Department of Physiotherapy and Rehabilitation Baskent UniversityFaculty of Health SciencesAnkara 06790Turkey

Diabetes has become an increasingly important health problem worldwide due to its *** effective treatments for diabetes management have been developed,many patients have difficulty in achieving their therapeutic *** exercise training is suggested to prevent or delay the symptoms and complications of type 2 diabetes along with other medical *** has become necessary to develop new rehabilitation models and practices in order to cope with the changing needs of the *** models using technology can be effective in disease *** may be effective as part of the rehabilitation program in the home environment,especially for patients who are unable to participate in conventional center-based rehabilitation due to transport difficulties or work *** is defined as the delivery of rehabilitation services via telecommunication technology,including phone,internet,and videoconference communications between the patient and health care *** is possible that telerehabilitation may benefit people with type 2 diabetes in similar ways with telemonitoring and interactive health communication *** the applicability of telehealth methods has been proven in previous studies,telerehabi-litation studies in type 2 diabetes are inadequate in the *** larger,multicentered randomized controlled studies,established clinical guidelines can be developed that will ultimately improve patient outcomes.

关键词： Type 2 diabetes Telerehabilitation Exercise Telehealth Healthcare Telecommunication

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Umbilical cord derived mesenchymal stem cell implantation in retinitis pigmentosa: a 6-month follow-up results of a phase 3 trial

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1423-1429页

作者： neslihan Sinim Kahraman Ayse Oner Department of Ophthalmology Kayseri Acibadem HospitalKayseri 38030Turkey

AIM:To investigate the efficacy and the safety of umbilical cord derived mesenchymal stem cell(UC-MSC)implantation in patients with retinitis pigmentosa(RP).METHODS:This prospective,single-center,phase 3 clinical study enrolled 124 eyes of 82 RP *** patients received 5 million UC-MSCs to the suprachoroidal area with a surgical *** were evaluated on the 1st day,1st,and 6th months *** corrected visual acuity(BCVA),anterior segment and fundus examinations,color photography,optical coherence tomography(OCT),and visual field(VF)tests were carried out at each *** fluorescein angiography(FFA)and multifocal electroretinography(mfERG)recordings were performed at the end of the 6th *** and systemic adverse events of the surgical procedure were also ***:All of the 82 patients completed the 6-month follow-up *** of them had any serious systemic or ocular *** were statistically significant improvements in BCVA and VF during the study(all P<0.05).The amplitudes of the P1 waves in the central areas showed significant improvements in mfERG *** were also significant increases in implicit times of P1 waves in the central ***:Suprachoroidal administration of UC-MSCs has beneficial effect on BCVA,VF,and mfERG measurements during the 6-month follow-up *** mediated therapy based on the secretion of growth factors(GFs)seems to be an effective and safe option for degenerative retinal diseases.

关键词： cell mediated therapy retinitis pigmentosa suprachoroidal umbilical cord derived mesenchymal stem cells visual function

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Traditional manufacturing of clay brick used in the historical buildings of Diyarbakir （Turkey）

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Frontiers of Architectural Research 2017年第3期6卷 346-359页

作者： neslihan Dalklilic Adnan Nabikogiu Faculty of Architecture Department of Architecture Dicle University Diyarbakir Turkey

Clay brick is the most common construction materia（ used in the historical buildings of Diyarbaklr （Turkey）. Many clay brick manufacturing workshops and numerous brick masters have emerged. Diyarbakir currently has two clay brick workshops that face the problem of being closed down. Therefore, manufacturing of clay brick by traditional methods may be forgotten in Diyarbakir. This study investigates the manufacturing phases of traditional clay bricks in Diyarbakir＇s local workshops, which have not been documented. The manufacturin8 phases of the clay bricks in Diyarbaklr were examined for the first time based on in-situ observations, investigations, and interviews. The research indicated the general phases of clay brick manufacturing. Raw materials are first prepared, formed, and dried. The firing of clay bricks is then performed through hacking, heating, burning, coolins, and de-hacking. The clay bricks are finally packaged and dispatched. The traditional manufacturing of clay brick methods in Diyarbaklr is similar in many regions of the world. The clay bricks are currently and extensfvely used in the restoration of historic structures. Therefore, their production must be continuous.

关键词： Clay brick Diyarbaklr Historical structures Traditional construction techniques Traditional material

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Interaction between Janus Green B and bovine serum albumin:Electrochemistry and spectroscopy studies

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Chinese Chemical Letters 2011年第6期22卷 717-720页

作者： neslihan zdemir Serkan zdemir Ender Bier Ondokuz Mayrs University Faculty of Arts and Sciences Department of Chemistry

In this study,voltammetric and spectroscopic investigation of the interaction between Janus Green B（JGB） and bovine serum albumin（BSA） was *** interaction was observed at Britton-Robinson buffer（pH 7.0）.When JGB was added to solution containing BSA,the peak currents of BSA decrease with the increasing of JGB concentrations which is due to the interaction of JGB and *** binding constant of JGB with BSA was obtained by voltammetric ***,this interaction was supported by means of UV-vis spectroscopic *** UV-vis absorption spectra of JGB in the presence of BSA decrease with the increasing of BSA concentrations.

关键词： Voltammetry Bovine serum albumin Janus Green B Interaction

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Traveling wave structures of some fourth-order nonlinear partial differential equations

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Journal of Ocean Engineering and Science 2023年第2期8卷 124-132页

作者： Handenur Esen neslihan Ozdemir Aydin Secer Mustafa Bayram Department of Mathematical Engineering Yildiz Technical UniversityIstanbul34220Turkey Department of Software Engineering Istanbul Gelisim UniversityIstanbulTurkey Department of Computer Engineering Biruni UniversityIstanbulTurkey

This study presents a large family of the traveling wave solutions to the two fourth-order nonlinear partial differential equations utilizing the Riccati-Bernoulli sub-ODE *** this method,utilizing a traveling wave transformation with the aid of the Riccati-Bernoulli equation,the fourth-order equation can be transformed into a set of algebraic *** the set of algebraic equations,we acquire the novel exact solutions of the integrable fourth-order equations presented in this research *** physical interpretation of the nonlinear models are also detailed through the exact solutions,which demonstrate the effectiveness of the presented *** Bäcklund transformation can produce an infinite sequence of solutions of the given two fourth-order nonlinear partial differential ***,3D graphs of some derived solutions in this paper are depicted through suitable parameter values.

关键词： Fourth-order equations Riccati-Bernoulli sub-ODE method Traveling wave solution Bäcklund transformation

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Documentation and analysis of structural elements of traditional houses for conservation of cultural heritage in Siverek(Sanliurfa,Turkey)

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Frontiers of Architectural Research 2020年第2期9卷 385-402页

作者： neslihan Dalkilic Adnan Nabikoglu Department of Architecture Faculty of ArchitectureDicle UniversityDiyarbakirTurkey

This study deals with the architectural properties of traditional Siverek houses,which are important in the larger corpus of Southeastern Anatolian *** historical city center of Siverek has partly preserved its authentic character with its monumental buildings and traditional *** the considerable number of traditional courtyard houses in Siverek,no detailed survey has been conducted on *** this work,these traditional houses in the historical Siverek City center are identified and documented for the first *** plans,facades,and structural systems are examined in detail,and the structural elements are comprehensively *** document the architectural features of these traditional Siverek houses and introduce the cultural heritage of the *** details provide information for proper decision-making regarding the preparation of restitution and restoration projects and selecting materials and techniques that suit the structures to be restored.

关键词： Courtyard house Siverek Traditional house Restoration

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Novel markers in predicting Brucella sacroiliitis:The platelet large cell ratio and basal immature reticulocyte fraction

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Asian Pacific Journal of Tropical Medicine 2023年第1期16卷 39-44页

作者： neslihan Celik Esra Laloğlu Hülya Aslan Depertmant of Infection Diseases and Clinical Microbiology Health Sciences University Erzurum Regional Education and Research HospitalErzurumYakutiyeTurkey Department of Biochemistry Ataturk University School of Medicine25240ErzurumYakutiyeTurkey Depertmant of Microbiology Health Sciences University Erzurum Regional Education and Research HospitalErzurumYakutiyeTurkey

Objective:To present platelet large cell ratio(P-LCR),reticulocyte,and immature reticulocyte fraction(IRF)values as novel parameters in diagnosis and response to treatment in patients developing ***:Sixty-eight patients with clinical symptoms and Brucella standard tube agglutination(Wright)or Brucella Coombs agglutination test titers≥1:160 were included in the *** groups were established,one developing sacroiliitis and another with no sacroiliitis development.P-LCR,reticulocyte,and IRF levels were measured using a Sysmex XN-9000 device(Japan).These were then compared between the two ***:Reticulocyte(P=0.037)and IRF(P=0.026)levels were significantly lower among the patients developing sacroiliitis compared to the non-sacroiliitis group,while P-LCR(P=0.003)levels were significantly higher.P-LCR had the most powerful correlation with sacroiliitis *** negative correlation was observed between reticulocyte,IRF levels and ***:Elevated P-LCR levels were observed as a marker of persisting inflammation in patients developing sacroiliitis,while low reticulocyte and IRF levels secondary to bone marrow involvement were *** three parameters emerged as highly significant markers in terms of diagnosis and reflecting responses to treatment in organ involvement such as sacroiliitis in *** are presented as inexpensive,and easily accessible novel parameters.

关键词： Brucella sacroiliitis P-LCR Reticulocyte IRF

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Leptin treatment ameliorates acute lung injury in rats with cerulein-induced acute pancreatitis

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World Journal of Gastroenterology 2007年第21期13卷 2932-2938页

作者： Fatma Ayca Gultekin Mustafa Kerem Ertan Tatlicioglu Aysel Aricioglu Cigdem Unsal neslihan Bukan Gazi University School of MedicineDepartment of General SurgeryBesevler 06510AnkaraTurkey Gazi University School of MedicineDepartment of BiochemistryBesevler 06510AnkaraTurkey Gazi University School of MedicineDepartment of PathologyBesevler 06510AnkaraTurkey

AIM:To determine the effect of exogenous leptin on acute lung injury (ALI) in cerulein-induced acute pancreatitis (AP). METHODS:Forty-eight rats were randomly divided into 3 groups. AP was induced by intraperitoneal (i.p.) injection of cerulein (50 μg/kg) four times,at 1 h intervals. The rats received a single i.p. injection of 10 μg/kg leptin (leptin group) or 2 mL saline (AP group) after cerulein injections. In the sham group,animals were given a single i.p. injection of 2 mL saline. Experimental samples were collected for biochemical and histological evaluations at 24 h and 48 h after the induction of AP or saline administration. Blood samples were obtained for the determination of amylase,lipase,tumor necrosis factor (TNF)-a,interleukin (IL)-1β,macrophage inflammatory peptide (MIP)-2 and soluble intercellular adhesion molecule (sICAM)-1 levels,while pancreatic and lung tissues were removed for myeloperoxidase (MPO) activity,nitric oxide (NOx) level,CD40 expression and histological evaluation. RESULTS:Cerulein injection caused severe AP,confirmed by an increase in serum amylase and lipase levels,histopathological findings of severe AP,and pancreatic MPO activity,compared to the values obtained in the sham group. In the leptin group,serum levels of MIP-2,sICMA-1,TNF-a,and IL-1b,pancreatic MPO activity,CD40 expression in pancreas and lung tissues,and NOx level in the lung tissue were lower compared to those in the AP group. Histologically,pancreatic and lungdamage was less severe following leptin administration. CONCLUSION:Exogenous leptin attenuates inflammatory changes,and reduces pro-inflammatory cytokines,nitric oxide levels,and CD40 expression in ceruleininduced AP and may be protective in AP associated ALI.

关键词： Leptin Acute pancreatitis Lung injury CD40 Cytokines

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Do business groups affect corporate cash holdings?Evidence from a transition economy

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China Journal of Accounting Research 2016年第1期9卷 1-24页

作者： Weixing Cai Cheng(Colin) Zeng Edward Lee neslihan Ozkan Dongling School of Economics and Management University of Science and Technology Alliance Manchester Business School University of Manchester School of Economics Finance and Management University of Bristol

We examine whether business groups' influence on cash holdings depends on ownership. Group affiliation can increase firms' agency costs or benefit firms by providing an internal capital market, especially in transition economies characterized by weak investor protection and difficult external capital acquisition. A hand-collected dataset of Chinese firms reveals that group affiliation decreases cash holdings, alleviating the free-cash-flow problem of agency *** ownership and control of listed firms moderate this benefit, which is more pronounced when the financial market is less liquid. Group affiliation facilitates related-party transactions, increases debt capacity and decreases investmentcash-flow sensitivity and overinvestment. In transitional economies, privately controlled firms are more likely to benefit from group affiliation than statecontrolled firms propped up by the government.

关键词： Business groups Cash holdings China State ownership Monetary policy

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