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Effect of vasoactive intestinal peptide on the wound healing of alkali-burned corneas

International Journal of Ophthalmology(English edition) 2016年第2期9卷 204-210页

作者： nese tuncel Nilgun Yildirim Firdevs Gurer Hikmet Basmak Kubilay Uzuner Varol Sahinturk Huseyin Gursoy Department of Physiology Eskisehir Osmangazi University Medical Faculty Eskisehir 26480 Turkey Department of Ophthalmology Eskisehir Osmangazi University Medical Faculty Eskisehir 26480 Turkey Department of Histology Eskisehir Osmangazi University Medical Faculty Eskisehir 26480 Turkey

AIM： To study the effect of vasoactive intestinal peptide （VIP） on wound healing in experimental alkali burns of the cornea. METHODS： Twenty-seven albino rabbits, weighing 3.2 -0.75 kg were used. Alkali burns were induced on corneas by applying 10 mm Whatman paper No：50 soaked in 1 mol/L NaOH. They have further classified into 5 groups as follows： 1） control group given no treatment （n=5）; 2） VIP given subconjunctivally （n=6）; 3） VIP injected into anterior chamber （n=6）; 4） NaCI 0.9% given subconjunctivally （n=5）; 5） NaCI 0.9% given into the anterior chamber （n=5）. All treatment protocols except control group were followed by topical eye drops composed of VIP at two hourly intervals for one week from 8 *** to 6 p.m, RESULTS： VIP treated groups of rabbits with alkali burns were found to have better wound healing findings histo-pathologically when compared to those of control group who have received no treatment on day 30. No differences were observed between groups in respect to degree of polymorphonuclear leukocytes （PMNL） infiltration and degree of loss of amorphous substrate on day 15. However, PMNL infiltration and degree of loss of amorphous substrate were lower in Groups 2 and 3 when compared to that of control group on day 30 （P〈0.05）. CONCLUSION： We have shown that VIP has positive effects on alkali induced corneal burns. VIP may inhibit PMNL migration to cornea through an immunomodulatory effect. Inhibition of PMNL migration might reduce the release of collagenaees and this might prevent the extracellular amorphous substance loss.

关键词： vasoactive intestinal peptide alkali-burnedcornea wound healing alkali burn rabbit

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Vasoactive intestinal peptide,a promising agent for myopia?

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 211-216页

作者： Ayse Idil Cakmak Hikmet Basmak Huseyin Gursoy Mete Ozkurt Nilgun Yildirim Nilufer Erkasap Mustafa Deger Bilgec nese tuncel Ertugrul Colak Department of Ophthalmology Eskisehir Osmangazi University Medical FacultyEskisehir 26180Turkey Department of Physiology Eskisehir Osmangazi University Medical FacultyEskisehir 26180Turkey Department of Biostatistics Eskisehir Osmangazi University Medical FacultyEskisehir 26180Turkey

AIM： To investigate the role of vasoactive intestinal peptide（VIP） in form-deprivation myopia（FDM）.METHODS： FDM was created in three groups of eight chicks by placing a translucent diffuser on their right *** injections of saline and VIP were applied once a day into the occluded eyes of groups 2 and 3,*** and axial length（AL） measurements were performed on the first and 8^th days of diffuser *** retina mR NA levels of the VIP receptors and the ZENK protein in right eyes of the three groups and left eyes of the first group on day 8 were determined using real time polymerase chain reaction（PCR）.RESULTS： The median final refraction（D） in right eyes were-13.75（-16.00,-12.00）,-11.50（-12.50,-7.50）,and-1.50（-4.75,-0.75） in groups 1,2,and 3,respectively（P〈0.001）.The median AL（mm） in right eyes were 10.65（10.00,11.10）,9.90（9.70,10.00）,and 9.20（9.15,9.25） in groups 1,2,and 3,respectively（P〈0.001）.The median delta-delta cycle threshold（CT） values for the VIP2 receptors were 1.07（0.82,1.43）,1.22（0.98,1.65）,0.29（0.22,0.45） in right eyes of groups 1,2,and 3,and 1.18（0.90,1.37） in left eyes of group 1,respectively（P=0.001）.The median delta-delta CT values for the ZENK protein were 1.07（0.63,5.03）,3.55（2.20,5.55）,undetectable in right eyes of groups 1,2,and 3 and 1.89（0.21,4.73） in left eyes of group 1,respectively（P=0.001）.CONCLUSION： VIP has potential inhibitory effects in the development of FDM.

关键词： vasoactive intestinal peptide form-deprivation myopia myopia chicks ZENK protein vasoactive intestinal peptide receptor

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